Projects per year
Personal profile
Research interests
Memberships of Professional Bodies
Biochemical Society, BSDB, Genetics Society, Anatomical Society, Indian Society of Cell Biology (Life member)
Current Funding
- Motor Neurone Disease Association - Mouse models for ALS
Collaborations
We are involved in a number of collaborative studies both within UK and abroad:
- Structure function studies on Angiogenic molecules and DNA binding proteins - Professor K.R. Acharya, Biology and Biochemistry, University of Bath.
- Comparative genomics and complementary studies on Zebrafish models - Dr Greg Elgar, Reader QMW, London and Dr Anand Chandrasekhar, Assoc Professor, University of Missouri, Columbia, USA.
Current Research Interests
Multi-cellular organisms including mammals begin life as a single cell, the fertilized egg, which undergoes a series of changes to give rise to the complex adult organism. This includes growth, division, cell migration and morphogenesis. These events are highly regulated and organised both spatially and temporally. We are attempting to understand the molecular basis underlying these events in murine organogenesis. There are three major areas of research in my laboratory:
- Stem cells and the molecular and cellular basis for the co-ordinated regulation of proliferation, cell differentiation and patterning in the intestinal epithelium
- The Role of the Cdx, polycomb and trithorax group of genes in the regulation of axial skeletal and nervous system development
- Angiogenins and cytotoxic RNAses in Disease and in health
Read about our work
New dementia research will use latest in stem cell technology
Study gives clues to causes of Motor Neurone Disease
Find 'offers motor neurone hope'
Discovery offers hope of halting Motor Neurone Disease progression
You can also watch a podcast of our motor neurone disease work.
Willing to supervise PhD
Enquires regarding Ph.D. opportunities are welcome. We are also open to collaborative PhD projects with other researchers or industrial partners.
Potential PhD projects are in the following areas
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Modeling human diseases such as Ciliopathies and Motor neuron disease in mice and fish (Zebrafish and Killifish)
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Regulation of intestinal and brain stem cell Homeostasis
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Development of the central nervous system
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Stem cell derived organoid models of development and disease
Fingerprint Dive into the research topics where Vasanta Subramanian is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Harnessing CRISPR/Cas9 technology to develop new models of Alzheimer's disease
Project: Research-related funding
Research Output
Crystal structure of peptide-bound neprilysin reveals key binding interactions
Moss, S., Subramanian, V. & Acharya, K. R., 12 Sep 2019, In : FEBS Letters. 10 p.Research output: Contribution to journal › Article
Mice with a conditional deletion of Talpid3 (KIAA0586) - a model for Joubert Syndrome
Bashford, A. L. & Subramanian, V., 18 Jul 2019, In : The Journal of Pathology. 248, 4, p. 396-408 13 p.Research output: Contribution to journal › Article
Open Access
2
Citations
(Scopus)
The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature
Ferguson, R., Holloway, D. E., Chandrasekhar, A., Acharya, K. R. & Subramanian, V., 1 Feb 2019, In : Scientific Reports. 9, 1, p. 1-15 15 p., 1107.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)
The secretion of the angiogenic and neurotrophic factor angiogenin is COPII and microtubule dependent
Ferguson, R. & Subramanian, V., 15 Aug 2019, In : Experimental Cell Research. 381, 2, p. 265-279 15 p.Research output: Contribution to journal › Article
A comparative bioinformatic analysis of C9orf72
Iyer, S., Acharya, K. R. & Subramanian, V., 19 Feb 2018, In : PeerJ. 6, 2, p. e4391 e4391.Research output: Contribution to journal › Article
Open Access
2
Citations
(Scopus)
Thesis
An investigation into the roles of Talpid3 and primary cilia in the developing brain
Author: Bashford, A., 25 Nov 2015Supervisor: Subramanian, V. (Supervisor) & Acharya, K. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
Structure-function studies on Clostridium botulinum neurotoxins
Author: Davies, J., 29 May 2019Supervisor: Subramanian, V. (Supervisor) & Acharya, K. (Supervisor)
Student thesis: Doctoral Thesis › PhD