• 4 SOUTH 0.67

20012018
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Personal profile

Research interests

Memberships of Professional Bodies

Biochemical Society, BSDB, HUGO, AWISE, Anatomical Society, Indian Society of Cell Biology (Life member)

Current Funding

  • Medical Research Council UK- Polycomb Genes and Stem cells
  • Wellcome Trust - Zebrafish Models for Motor Neuron disease
  • Motor Neurone Disease Association - Mouse models for ALS
  • Department of Science Technology, India - collaborative grant for stem cell workshops under the CP-STIO program

Collaborations

We are involved in a number of collaborative studies both within UK and abroad:

  • Structure function studies on Angiogenic molecules and DNA binding proteins - Professor K.R. Acharya, Biology and Biochemistry, University of Bath.
  • Comparative genomics and complementary studies on Zebrafish models - Dr Greg Elgar, Reader QMW, London and Dr Anand Chandrasekhar, Assoc Professor, University of Missouri, Columbia, USA.
  • Stem cells and bowel reconstruction- Dr Karen Edler, Chemistry, University of Bath, UK and Dr Anwar Jardine, University of Capetown, South Africa.
  • Polycomb genes and Development- Professor H Von Melchener, Frankfurt, Germany
  • Fragile X sites and mouse models- Professor N Moschonas, University of Patras, Dr G Chalepakis, University of Crete and Dr Lilika Sarafidou
  • Polycomb and Trithorax genes and Flaviviruses - Professor S Vijaya, Indian Institute of Science

Current Research Interests

Multi-cellular organisms including mammals begin life as a single cell, the fertilized egg, which undergoes a series of changes to give rise to the complex adult organism. This includes growth, division, cell migration and morphogenesis. These events are highly regulated and organised both spatially and temporally. We are attempting to understand the molecular basis underlying these events in murine organogenesis. There are three major areas of research in my laboratory:

  • Stem cells and the molecular and cellular basis for the co-ordinated regulation of proliferation, cell differentiation and patterning in the intestinal epithelium
  • The Role of the Cdx, polycomb and trithorax group of genes in the regulation of axial skeletal and nervous system development
  • Angiogenins and cytotoxic RNAses in Disease and in health

Read about our work

New dementia research will use latest in stem cell technology

Study gives clues to causes of Motor Neurone Disease

Find 'offers motor neurone hope'

Discovery offers hope of halting Motor Neurone Disease progression

You can also watch a podcast of our motor neurone disease work.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Motor Neuron Disease Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Neurodegenerative diseases Chemical Compounds
Neurons Chemical Compounds
Ribonucleases Medicine & Life Sciences
Pancreatic Ribonuclease Medicine & Life Sciences
Zebrafish Medicine & Life Sciences
Cryoultramicrotomy Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2006 2018

Research Output 2001 2018

A comparative bioinformatic analysis of C9orf72

Iyer, S., Acharya, K. R. & Subramanian, V. 19 Feb 2018 In : PeerJ. 6, p. e4391

Research output: Contribution to journalArticle

Open Access
Neurodegenerative diseases
Bioinformatics
Computational Biology
bioinformatics
Introns

Embryoid body arrays: Parallel cryosectioning of spheroid/embryoid body samples for medium through-put analysis

Ferguson, R. & Subramanian, V. 1 Apr 2018 In : Stem Cell Research. 28, p. 125-130 6 p.

Research output: Contribution to journalArticle

Open Access
Cryoultramicrotomy
Embryoid Bodies
Organoids
Histological Techniques
Organogenesis
Neprilysin
Neurotensin
Protein Conformation
Enkephalins
Metalloproteases
Amyotrophic Lateral Sclerosis
Mutation
Proteins
Motor Neuron Disease
Missense Mutation
Open Access
Dynamins
neurotrophins
Angiogenesis Inducing Agents
Nerve Growth Factors
uptake mechanisms