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Accepting PhD Students

20082018
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Personal profile

Willing to supervise PhD

and PostDocs

 

I welcome motivated PhD students and PostDocs with a biological science background who are interested in cancer biology and drug discovery. If you would like to apply for a scholarship to join my lab please contact me well in advance.

Research interests

My research group is working at the interface of basic and translational cancer research.

I am interested in the metastatic tumour niche, particularly of breast cancer, and the interaction of tumour cells with the microenvironment, such as fibroblasts and immune cells. By combining metastasis models with in vitro 2D and 3D co-culture models, live cell- and high content imaging, we aim to identify novel strategies to target the tumour and/or stroma for the prevention or suppression of metastatic cancer and to overcome treatment-resistant tumour progression.

Metastatic Cancer

The majority of cancer-related deaths are due to metastatic disease and only 15% of stage IV breast cancer patients survive more than 5 years. Despite advances in identifying major drivers of primary tumour growth and the development of novel targeted therapies, there remains an unmet clinical need to develop treatment strategies targeting metastatic disease and intrinsic and acquired resistance. It is now well established that successful tumour progression involves a close crosstalk between tumour cells and the stromal microenvironment, including fibroblasts, pericytes, endothelial and immune cells but also the extracellular matrix (ECM). Furthermore, there is growing evidence that the stroma can modulate therapy resistance.

Education/Academic qualification

Malignant Diseases, Doctor of Philosophy, Medical University of Vienna

Toxicology, Master of Science, Medical University of Vienna

Chemistry, Master of Chemistry, University of Vienna

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 2008 2018

Generation and characterisation of two D2A1 mammary cancer sublines to model spontaneous and experimental metastasis in a syngeneic BALB/c host

Jungwirth, U., van Weverwijk, A., Melake, M. J., Chambers, A. F., Gao, Q., Fivaz, M. & Isacke, C. M., 18 Jan 2018, In : Disease Models & Mechanisms. 11, 1, dmm031740.

Research output: Contribution to journalArticle

Open Access
Tumors
Assays
Theoretical Models
Cells
Breast Neoplasms
8 Citations (Scopus)

Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models

Göschl, S., Schreiber-Brynzak, E., Pichler, V., Cseh, K., Heffeter, P., Jungwirth, U., Jakupec, M. A., Berger, W. & Keppler, B. K., 22 Mar 2017, In : Metallomics. 9, 3, p. 309-322 14 p.

Research output: Contribution to journalArticle

Open Access
oxaliplatin
Platinum
Tumors
Flow cytometry
Reducing Agents
14 Citations (Scopus)

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46

Jungwirth, U., Gojo, J., Tuder, T., Walko, G., Holcmann, M., Schöfl, T., Nowikovsky, K., Wilfinger, N., Schoonhoven, S., Kowol, C. R., Lemmens-Gruber, R., Heffeter, P., Keppler, B. K. & Berger, W., Oct 2014, In : Molecular Cancer Therapeutics. 13, 10, p. 2436-49 14 p.

Research output: Contribution to journalArticle

Gallium
Calpain
Integrins
Focal Adhesions
Cell Death
20 Citations (Scopus)

Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells

Trondl, R., Flocke, L. S., Kowol, C. R., Heffeter, P., Jungwirth, U., Mair, G. E., Steinborn, R., Enyedy, É. A., Jakupec, M. A., Berger, W. & Keppler, B. K., Mar 2014, In : Molecular Pharmacology. 85, 3, p. 451-9 9 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Neoplasms
Up-Regulation
Phosphotransferases
Transcription Factor CHOP
8 Citations (Scopus)

Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes

Valiahdi, S. M., Egger, A. E., Miklos, W., Jungwirth, U., Meelich, K., Nock, P., Berger, W., Hartinger, C. G., Galanski, M., Jakupec, M. A. & Keppler, B. K., Feb 2013, In : Journal of Biological Inorganic Chemistry. 18, 2, p. 249-60 12 p.

Research output: Contribution to journalArticle

Cytotoxicity
Tumors
DNA
Platinum
Cells