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19982019
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Research Output 1998 2019

2019

METHOD OF CAS9 MEDIATED GENOME ENGINEERING

Perry, A., Suzuki, T. & Asami, M., 2019, Patent No. WO 2016/097751, 18 Dec 2015, Priority date 18 Dec 2014, Priority No. 1422636.9

Research output: Patent

2018

Characterisation and use of a functional Gadd45g bacterial artificial chromosome

Warr, N., May, J., Teboul, L., Suzuki, T., Asami, M., Perry, A., Wells, S. & Greenfield, A., 23 Nov 2018, In : Scientific Reports. 8, 1, 17318.

Research output: Contribution to journalArticle

Open Access

Gene drives accelerate evolution – but we need brakes

Perry, A., 5 Jul 2018, The Conversation.

Research output: Contribution to specialist publicationArticle

Intracytoplasmic sperm injection (ICSI): applications and insights

Suzuki, T. & Perry, A. C. F., 4 Jan 2018, Intracytoplasmic Sperm Injection. Palermo, G. D. & Sills, E. S. (eds.). Cham, Switzerland: Springer International Publishing, p. 169-181 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

intracytoplasmic sperm injection
totipotency
fertilization (reproduction)
oocytes
spermatozoa
3 Citations (Scopus)

Switchable genome editing via genetic code expansion

Suzuki, T., Asami, M., Patel, S. G., Luk, L. Y. P. L., Tsai, Y-H. & Perry, A., 3 Jul 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 10051.

Research output: Contribution to journalArticle

Open Access
Genetic Code
Clustered Regularly Interspaced Short Palindromic Repeats
Complementary RNA
Genes
Lysine
2017
22 Citations (Scopus)

Assisted reproductive technologies to prevent human mitochondrial disease transmission

Greenfield, A., Braude, P., Flinter, F., Lovell-Badge, R., Ogilvie, C. & Perry, A., 14 Dec 2017, In : Nature Biotechnology. 35, p. 1059-1068 10 p.

Research output: Contribution to journalArticle

Mitochondrial Diseases
Assisted Reproductive Techniques
Mitochondria
Mitochondrial DNA
Zygote
2016
18 Citations (Scopus)

DNA methylation dynamics in mouse preimplantation embryos revealed by mass spectrometry

Okamoto, Y., Yoshida, N., Suzuki, T., Shimozawa, N., Asami, M., Matsuda, T., Kojima, N., Perry, A. C. F. & Takada, T., 11 Jan 2016, In : Scientific Reports. 6, 19134.

Research output: Contribution to journalArticle

Open Access
5-methyldeoxycytidine
Blastocyst
DNA Methylation
Mass Spectrometry
Fertilization
10 Citations (Scopus)
109 Downloads (Pure)

Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes

Suzuki, T., Asami, M., Hoffmann, M., Lu, X., Gužvić, M., Klein, C. A. & Perry, A. C. F., 13 Sep 2016, In : Nature Communications. 7, p. 1-15 15 p., 12676.

Research output: Contribution to journalArticle

Open Access
File
2015
68 Citations (Scopus)

CRISPR germline engineering-the community speaks

Bosley, K., Botchan, M., Bredenoord, A., Carroll, D., Charo, R. A., Charpentier, E., Cohen, R., Corn, J., Doudna, J., Feng, G., Greely, H., Isasi, R., Ji, W., Kim, J-S., Knoppers, B., Lanphier, E., Li, J., Lovell-Badge, R., Martin, G. S., Moreno, J. & 6 others, Naldini, L., Pera, M., Perry, A., Venter, J. C., Zhang, F. & Zhou, Q., 12 May 2015, In : Nature Biotechnology. 33, 5, p. 478-486

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Establishment and Use of Mouse Haploid ES Cells

Leeb, M., Perry, T. & Wutz, A., Jun 2015, In : Current Protocols in Mouse Biology . 5, p. 155 - 185 31 p.

Research output: Contribution to journalArticle

Haploidy
Mammalian Embryo
Diploidy
Stem Cells
Embryonic Structures
2014
25 Citations (Scopus)
91 Downloads (Pure)

Asymmetric parental genome engineering by Cas9 during mouse meiotic exit

Suzuki, T., Asami, M. & Perry, A. C. F., 23 Dec 2014, In : Scientific Reports. 4, p. 7621

Research output: Contribution to journalArticle

Open Access
File
Guide RNA
Spermatozoa
Genome
Complementary RNA
Embryonic Structures
2013

A caffeine fix for human nuclear transfer?

Perry, A. C. F., Aug 2013, In : Nature Biotechnology. 31, 8, p. 717-719 3 p.

Research output: Contribution to journalArticle

Caffeine
Cloning
Organism Cloning
2012
70 Citations (Scopus)

Il2rg gene-targeted severe combined immunodeficiency pigs

Suzuki, S., Iwamoto, M., Saito, Y., Fuchimoto, D., Sembon, S., Suzuki, M., Mikawa, S., Hashimoto, M., Aoki, Y., Najima, Y., Takagi, S., Suzuki, N., Suzuki, E., Kubo, M., Mimuro, J., Kashiwakura, Y., Madoiwa, S., Sakata, Y., Perry, A. C. F., Ishikawa, F. & 1 others, Onishi, A., 14 Jun 2012, In : Cell Stem Cell. 10, 6, p. 753-758 6 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
Swine
Genes
Interleukin Receptor Common gamma Subunit
Heterologous Transplantation

Practical Manual of In Vitro Fertilization: Livestock production via micromanipulation

Onishi, A. & Perry, T., 2012, Practical Manual of In Vitro Fertilization : Livestock production via micromanipulation . 7 ed. Springer, Vol. 41. p. 371 375 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011
35 Citations (Scopus)

Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres

VerMilyea, M. D., Maneck, M., Yoshida, N., Blochberger, I., Suzuki, E., Suzuki, T., Spang, R., Klein, C. A. & Perry, A. C. F., 4 May 2011, In : EMBO Journal. 30, 9, p. 1841-1851 11 p.

Research output: Contribution to journalArticle

Blastomeres
Zygote
Transcriptome
Siblings
Embryonic Structures
2010
46 Citations (Scopus)

Full-term mouse development by abolishing Zn2+-dependent metaphase II arrest without Ca2+ release

Suzuki, T., Yoshida, N., Suzuki, E., Okuda, E. & Perry, A. C. F., 15 Aug 2010, In : Development. 137, 16, p. 2659-2669 11 p.

Research output: Contribution to journalArticle

Metaphase
Fertilization
Oocytes
Cyclin B
Birth Rate
47 Citations (Scopus)

Mouse Emi2 as a distinctive regulatory hub in second meiotic metaphase

Suzuki, T., Suzuki, E., Yoshida, N., Kubo, A., Li, H., Okuda, E., Amanai, M. & Perry, A. C. F., 1 Oct 2010, In : Development. 137, 19, p. 3281-3291 11 p.

Research output: Contribution to journalArticle

Metaphase
Xenopus
Oocytes
Proto-Oncogene Proteins c-mos
Calcium-Calmodulin-Dependent Protein Kinases
2008
36 Citations (Scopus)

Second meiotic arrest and exit in frogs and mice

Perry, A. C. F. & Verlhac, M. H., 2008, In : EMBO Reports. 9, 3, p. 246-251 6 p.

Research output: Contribution to journalArticle

Xenopus
Fertilization
Anura
Oocytes
Embryonic Development
2007
31 Citations (Scopus)

Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice

Yoshida, N., Amanai, M., Fukui, T., Kajikawa, E., Brahmajosyula, M., Iwahori, A., Nakano, Y., Shoji, S., Diebold, J., Hessel, H., Huss, R. & Perry, A. C. F., 2007, In : Development. 134, 21, p. 3941-3952 12 p.

Research output: Contribution to journalArticle

Parthenogenesis
Fertilization
Spermatozoa
Metaphase
Oocytes
34 Citations (Scopus)

Epigenetic discrimination by mouse metaphase II oocytes mediates asymmetric chromatin remodeling independently of meiotic exit

Yoshida, N., Brahmajosyula, M., Shoji, S., Amanai, M. & Perry, A. C. F., 2007, In : Developmental Biology. 301, 2, p. 464-477 14 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Metaphase
Epigenomics
Oocytes
Histones
75 Citations (Scopus)

Piezo-actuated mouse intracytoplasmic sperm injection (ICSI)

Yoshida, N. & Perry, A. C. F., 2007, In : Nature Protocols. 2, 2, p. 296-304 9 p.

Research output: Contribution to journalArticle

Intracytoplasmic Sperm Injections
Micromanipulation
Piezoelectricity
Cloning
Freezing
2006
103 Citations (Scopus)

A restricted role for sperm-borne microRNAs in mammalian fertilization

Amanai, M., Brahmajosyula, M. & Perry, A. C. F., 2006, In : Biology of Reproduction. 75, 6, p. 877-884 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Fertilization
Spermatozoa
Oocytes
RNA Interference
7 Citations (Scopus)

Induced pluripotency and cellular alchemy

Perry, A. C. F., 2006, In : Nature Biotechnology. 24, 11, p. 1363-1364 2 p.

Research output: Contribution to journalArticle

Alchemy
Fibroblasts
17 Citations (Scopus)

Injection of mammalian metaphase II oocytes with short interfering RNAs to dissect meiotic and early mitotic events

Arnanai, M., Shoji, S., Yoshida, N., Brahmajosyula, M. & Perry, A. C. F., 2006, In : Biology of Reproduction. 75, 6, p. 891-898 8 p.

Research output: Contribution to journalArticle

Metaphase
RNA Interference
Small Interfering RNA
Oocytes
Injections
126 Citations (Scopus)

Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20

Shoji, S., Yoshida, N., Amanai, M., Ohgishi, M., Fukui, T., Fujimoto, S., Nakano, Y., Kajikawa, E. & Perry, A. C. F., 2006, In : EMBO Journal. 25, 4, p. 834-845 12 p.

Research output: Contribution to journalArticle

Cytostatic Agents
Oocytes
Metaphase
Proto-Oncogene Proteins c-mos
Maturation-Promoting Factor
66 Citations (Scopus)

Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion

Ishikawa, F., Shimazu, H., Shultz, L. D., Fukata, M., Nakamura, R., Lyons, B., Shimoda, K., Shimoda, S., Kanemaru, T., Nakamura, K. I., Ito, H., Kaji, Y., Perry, A. C. F. & Harada, M., 2006, In : FASEB Journal. 20, 7, p. 950-952 3 p.

Research output: Contribution to journalArticle

Cell Fusion
Hematopoietic Stem Cells
Stem cells
Cardiac Myocytes
Fusion reactions
2005
5 Citations (Scopus)

Progress in human somatic-cell nuclear transfer

Perry, A. C. F., 2005, In : The New England Journal of Medicine. 353, 1, p. 87-88 2 p.

Research output: Contribution to journalArticle

2004
1 Citation (Scopus)

ES cells and nuclear transfer cloning

Perry, T. & Studer, L., 2004, Handbook of Stem Cells: Volume 1. Lanza, R., Blau, H., Melton, D., Moore, M., Donnall-Thomas, E., Verfaillie, C., Weissman, I. & West, M. (eds.). Elsevier Academic Press Inc, p. 623-634

Research output: Chapter in Book/Report/Conference proceedingChapter

108 Citations (Scopus)

Mammalian phospholipase C zeta induces oocyte activation from the sperm perinuclear matrix

Fujimoto, S., Yoshida, N., Fukui, T., Amanai, M., Isobe, T., Itagaki, C., Izumi, T. & Perry, A. C. F., 2004, In : Developmental Biology. 274, 2, p. 370-383 14 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Oocytes
Spermatozoa
Sperm Head
Microinjections
6 Citations (Scopus)

Nuclear transfer cloning and the United Nations

Perry, A. C. F., 2004, In : Nature Biotechnology. 22, 12, p. 1506-1508 3 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Regeneration of the infarcted heart with stem cells derived by nuclear transplantation

Lanza, R., Moore, M. A. S., Wakayama, T., Perry, A. C. F., Shieh, J. H., Hendrikx, J., Leri, A., Chimenti, S., Monsen, A., Nurzynska, D., West, M. D., Kajstura, J. & Anversa, P., 2004, In : Circulation Research. 94, 6, p. 820-827 8 p.

Research output: Contribution to journalArticle

Nuclear Transfer Techniques
Regeneration
Stem Cells
Muscle Cells
Embryonic Structures
2002

Cloning of mice

Wakayama, T. & Perry, A. C. F., 2002, Principles of Cloning. Cibelli, J., Lanza, R. P., Campbell, K. H. S. & West, M. D. (eds.). Elsevier Academic Press Inc, p. 301-341

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Citations (Scopus)

Untimely ends and new beginnings in mouse cloning

Perry, A. C. F. & Wakayama, T., 2002, In : Nature Genetics. 30, 3, p. 243-244 2 p.

Research output: Contribution to journalArticle

Organism Cloning
Mammals
Pneumonia
Necrosis
Clone Cells
2001
474 Citations (Scopus)

Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer

Wakayama, T., Tabar, V., Rodriguez, I., Perry, A. C. F., Studer, L. & Mombaerts, P., 2001, In : Science. 292, 5517, p. 740-743 4 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Cell Line
Germ Cells
Serotonergic Neurons
Hybrid Cells
50 Citations (Scopus)

Efficient metaphase II transgenesis with different transgene archetypes

Perry, A. C. F., Rothman, A., de las Heras, J. I., Feinstein, P., Mombaerts, P., Cooke, H. J. & Wakayama, T., 2001, In : Nature Biotechnology. 19, 11, p. 1071-1073 3 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Metaphase
Biotechnology
Chromosomes
Transgenes

Mammalian cloning by nuclear microinjection

Perry, A. C. F., 2001, The Cloning Sourcebook. Klotzko, A. J. (ed.). Oxford, U. K.: Oxford University Press, p. 28-42

Research output: Chapter in Book/Report/Conference proceedingChapter

2000
195 Citations (Scopus)

Ageing: cloning of mice to six generations

Wakayama, T., Shinkai, Y., Tamashiro, K. L. K., Niida, H., Blanchard, D. C., Blanchard, R. J., Ogura, A., Tanemura, K., Tachibana, M., Perry, A. C. F., Colgan, D. F., Mombaerts, P. & Yanagimachi, R., 2000, In : Nature. 407, 6802, p. 318-319 2 p.

Research output: Contribution to journalArticle

mice
telomeres
shortenings
oocytes
chromosomes
28 Citations (Scopus)

Hijacking oocyte DNA repair machinery in transgenesis?

Perry, A. C. F., 2000, In : Molecular Reproduction and Development. 56, 2, p. 319-324 6 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Mammalian oocyte activation by the synergistic action of discrete sperm head components: Induction of calcium transients and involvement of proteolysis

Perry, A. C. F., Wakayama, T., Cooke, I. M. & Yanagimachi, R., 2000, In : Developmental Biology. 217, 2, p. 386-393 8 p.

Research output: Contribution to journalArticle

Sperm Head
Proteolysis
Oocytes
Calcium
Spermatozoa
8 Citations (Scopus)

Molecular cloning and phylogenetic analysis of a cDNA encoding the cat (Felis domesticus) Ig epsilon constant region

Weber, E. R., Helps, C. R., Foster, A. P., Perry, A. C. F., Gruffydd-Jones, T. J., Hall, L., Harbour, D. A. & Duffus, W. P. H., 2000, In : Veterinary Immunology and Immunopathology. 76, 3-4, p. 299-308 10 p.

Research output: Contribution to journalArticle

Immunoglobulin Constant Regions
Felis
Felidae
Molecular Cloning
molecular cloning
679 Citations (Scopus)

Pig cloning by microinjection of fetal fibroblast nuclei

Onishi, A., Iwamoto, M., Akita, T., Mikawa, S., Takeda, K., Awata, T., Hanada, H. & Perry, A. C. F., 2000, In : Science. 289, 5482, p. 1188-1190 3 p.

Research output: Contribution to journalArticle

fibroblasts
molecular cloning
swine
piglets
xenotransplantation
1999
100 Citations (Scopus)
17 Citations (Scopus)
351 Citations (Scopus)

Mammalian transgenesis by intracytoplasmic sperm injection

Perry, T., Wakayama, T., Kishikawa, H., Kasai, T., Okabe, M., Toyoda, Y. & Yamnagimachi, R., 14 May 1999, In : Science. 284, 5417, p. 1180-1183

Research output: Contribution to journalArticle

395 Citations (Scopus)

Mice cloned from embryonic stem cells

Wakayama, T., Rodriguez, I., Perry, A. C. F., Yanagimachi, R. & Mombaerts, P., 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 26, p. 14984-14989 6 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Organism Cloning
Cell Line
Clone Cells
Surrogate Mothers
24 Citations (Scopus)

The novel epididymal secretory protein, ESP13.2 in Macaca fascicularis

Perry, T., Jones, R., Coadwell, J., Moisyadi, S. & Hall, L., 1999, In : Biology of Reproduction. 61, p. 965-972

Research output: Contribution to journalArticle

1998
1823 Citations (Scopus)

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

Wakayama, T., Perry, A. C. F., Zuccotti, M., Johnson, K. R. & Yanagimachi, R., 1998, In : Nature. 394, 6691, p. 369-374 6 p.

Research output: Contribution to journalArticle

Cumulus Cells
Cell Nucleus
Oocytes
Sheep
Sertoli Cells