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Research interests

Research over-view

The question at the centre of our research is how two gametes - sperm and egg - transform into an embryo when they combine in mammalian fertilisation: the gamete-to-embryo transition.  This is a fundamental process with major implications for the regulation of cellular potency and broad translational potential in the areas of infertility and stem cell biology.  We integrate embryological and molecular approaches developed by us in a mouse model.  Using piezo-actuated micromanipulation, we can achieve high rates of transgenesis via a method we developed (published in Science), generate offspring from 'dead' sperm and perform nuclear transfer cloning; at Bath, we produced England's first cloned mouse; indeed, this was the first adult to be cloned from an adult cell in any species (<>).  Recently, we demonstrated the birth of offspring via a distinctive epigenetic pathway when sperm are injected into parthenogenetic embryos.  This finding overturns a centuries-old dogma established by Karl Ernst von Baer that animals develop from eggs and challenges the model of lineage specification proposed by twentieth century biologist, Conrad Waddington ('Waddington's Canal').  Our analytical methods include fluorescence imaging and sub-cellular transcriptomics.  We are developing next-generation genome editing, nanobiology and stem cell approaches and hold that regenerative medicine will remain impracticable without a thorough mechanistic understanding of the establishment of totipotency during the gamete-to-embryo transition.



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Research Output


Perry, A., Suzuki, T. & Asami, M., 2019, Patent No. WO 2016/097751, 18 Dec 2015, Priority date 18 Dec 2014, Priority No. 1422636.9

Research output: Patent

Characterisation and use of a functional Gadd45g bacterial artificial chromosome

Warr, N., May, J., Teboul, L., Suzuki, T., Asami, M., Perry, A., Wells, S. & Greenfield, A., 23 Nov 2018, In : Scientific Reports. 8, 1, 17318.

Research output: Contribution to journalArticle

Open Access

Gene drives accelerate evolution – but we need brakes

Perry, A., 5 Jul 2018, The Conversation.

Research output: Contribution to specialist publicationArticle

Intracytoplasmic sperm injection (ICSI): applications and insights

Suzuki, T. & Perry, A. C. F., 4 Jan 2018, Intracytoplasmic Sperm Injection. Palermo, G. D. & Sills, E. S. (eds.). Cham, Switzerland: Springer International Publishing, p. 169-181 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

  • Switchable genome editing via genetic code expansion

    Suzuki, T., Asami, M., Patel, S. G., Luk, L. Y. P. L., Tsai, Y-H. & Perry, A., 3 Jul 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 10051.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Citations (Scopus)


    Wnt/β-catenin signalling facilitates cell fate decision making in the early mouse embryo

    Author: Corujo Simon, E., 7 Jun 2018

    Supervisor: Munoz-Descalzo, S. (Supervisor) & Perry, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD