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Tony Perry

Prof

  • 3 SOUTH 0.26

19982020

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Personal profile

Research interests

Research over-view

The question at the centre of our research is how two gametes - sperm and egg - transform into an embryo when they combine in mammalian fertilisation: the gamete-to-embryo transition.  This is a fundamental process with major implications for the regulation of cellular potency and broad translational potential in the areas of infertility and stem cell biology.  We integrate embryological and molecular approaches developed by us in a mouse model.  Using piezo-actuated micromanipulation, we can achieve high rates of transgenesis via a method we developed (published in Science), generate offspring from 'dead' sperm and perform nuclear transfer cloning; at Bath, we produced England's first cloned mouse; indeed, this was the first adult to be cloned from an adult cell in any species (<http://www.egg2embryo.com/>).  Recently, we demonstrated the birth of offspring via a distinctive epigenetic pathway when sperm are injected into parthenogenetic embryos.  This finding overturns a centuries-old dogma established by Karl Ernst von Baer that animals develop from eggs and challenges the model of lineage specification proposed by twentieth century biologist, Conrad Waddington ('Waddington's Canal').  Our analytical methods include fluorescence imaging and sub-cellular transcriptomics.  We are developing next-generation genome editing, nanobiology and stem cell approaches and hold that regenerative medicine will remain impracticable without a thorough mechanistic understanding of the establishment of totipotency during the gamete-to-embryo transition.

 

 

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Projects

  • Research Output

    Tracking intracellular forces and mechanical property changes in mouse one-cell embryo development

    Duch, M., Torras, N., Asami, M., Suzuki, T., Arjona, M., Gómez-Martínez, R., VerMilyea, M., Castilla, R., Plaza, J. A. & Perry, A., 25 May 2020, In : Nature Materials. 14 p.

    Research output: Contribution to journalArticle

    Switchable genome editing via genetic code expansion

    Suzuki, T., Asami, M., Patel, S. G., Luk, L. Y. P. L., Tsai, Y-H. & Perry, A., 3 Jul 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 10051.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)

    Assisted reproductive technologies to prevent human mitochondrial disease transmission

    Greenfield, A., Braude, P., Flinter, F., Lovell-Badge, R., Ogilvie, C. & Perry, A., 14 Dec 2017, In : Nature Biotechnology. 35, p. 1059-1068 10 p.

    Research output: Contribution to journalArticle

  • 27 Citations (Scopus)

    Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes

    Suzuki, T., Asami, M., Hoffmann, M., Lu, X., Gužvić, M., Klein, C. A. & Perry, A. C. F., 13 Sep 2016, In : Nature Communications. 7, p. 1-15 15 p., 12676.

    Research output: Contribution to journalArticle

    Open Access
    File
    12 Citations (Scopus)
    157 Downloads (Pure)

    Asymmetric parental genome engineering by Cas9 during mouse meiotic exit

    Suzuki, T., Asami, M. & Perry, A. C. F., 23 Dec 2014, In : Scientific Reports. 4, 7621.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 28 Citations (Scopus)
    129 Downloads (Pure)

    Thesis

    Wnt/β-catenin signalling facilitates cell fate decision making in the early mouse embryo

    Author: Corujo Simon, E., 7 Jun 2018

    Supervisor: Munoz-Descalzo, S. (Supervisor) & Perry, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File