Tony James

Royal Society Wolfson Research Merit Award Holder, Fellow of the Royal Society of Chemistry, Prof

  • 1 SOUTH 0.21

Accepting PhD Students

1987 …2022
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Research Output 1987 2020

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2020

A fluorogenic probe for tracking GSH flux in developing neurons

Zong, H., Peng, J., Li, X. R., Liu, M., Hu, Y., Li, J., Zang, Y., Li, X. & James, T. D., 7 Jan 2020, In : Chemical communications (Cambridge, England). 56, 4, p. 515-518 4 p.

Research output: Contribution to journalArticle

Open Access

A Three-Component Derivatization Protocol for Determining the Enantiopurity of Sulfinamides by 1H and 19F NMR Spectroscopy

Groleau, R. R., Chapman, R. S. L., Ley-Smith, H., Liu, L., James, T. D. & Bull, S. D., 17 Jan 2020, In : Journal of Organic Chemistry. 85, 2, p. 1208-1215

Research output: Contribution to journalArticle

Open Access

Colorimetric assay for the rapid determination of free-base nicotine in e-liquid

Huang, Y. J., Deng, Q. X., Lan, H. Q., Fang, Z. Z., Chen, H., Lin, Y., Xu, H. C., James, T. D. & Xie, W., 14 Jan 2020, In : Analytical Methods. 12, 2, p. 193-199 7 p.

Research output: Contribution to journalArticle

Correction: Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

Dou, W. T., Liu, L. F., Gao, J., Zang, Y., Chen, G. R., Field, R. A., James, T. D., Li, J. & He, X. P., 14 Jan 2020, In : Chemical Communications. 56, 4, p. 664-664 1 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Mechanistic insights into the origin of substituent-directed product Z–E selectivity for gold-catalyzed [4+1]-annulations of 1,4-diyn-3-ols with isoxazoles: A DFT study

Wang, K., Liu, Y., Wu, Q., Liu, L., Li, Y., James, T. D., Chen, G. & Bi, S., 1 Jan 2020, In : Molecular Catalysis. 480, p. 1-9 9 p., 110647.

Research output: Contribution to journalArticle

Protein encapsulation: A new approach for improving the capability of small-molecule fluorogenic probes

Han, H. H., Sedgwick, A. C., Shang, Y., Li, N., Liu, T., Li, B. H., Yu, K., Zang, Y., Brewster, J. T., Odyniec, M. L., Weber, M., Bull, S. D., Li, J., Sessler, J. L., James, T. D., He, X. P. & Tian, H., 28 Jan 2020, In : Chemical Science. 11, 4, p. 1107-1113 7 p.

Research output: Contribution to journalArticle

Open Access
2019
1 Citation (Scopus)

A boronic acid-based fluorescent hydrogel for monosaccharide detection

Xu, S., Sedgwick, A. C., Elfeky, S. A., Chen, W., Jones, A. S., Williams, G. T., Jenkins, A. T. A., Bull, S. D., Fossey, J. S. & James, T. D., 21 May 2019, In : Frontiers of Chemical Science and Engineering.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

A far-red fluorescent probe for sensing laccase in fungi and its application in developing an effective biocatalyst for the biosynthesis of antituberculous dicoumarin

Tian, Z., Yan, Q., Feng, L., Deng, S., Wang, C., Cui, J., Wang, C., Zhang, Z., James, T. D. & Ma, X., 7 Apr 2019, In : Chemical Communications. 55, 27, p. 3951-3954 4 p.

Research output: Contribution to journalArticle

Open Access

A Leucine Aminopeptidase-Activated Theranostic Prodrug for Cancer Diagnosis and Chemotherapy

Wang, F., Hu, S., Sun, Q., Fei, Q., Ma, C., Lu, C., Nie, J., Chen, Z., Ren, J., Chen, G. R., Yang, G., He, X. P. & James, T. D., 18 Nov 2019, In : ACS Applied Bio Materials. 2, 11, p. 4904-4910 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A practical graphitic carbon nitride (g-C3N4)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions

Li, M., Wang, B., An, X., Li, Z., Zhu, H., Mao, B., Calatayud, D. G. & James, T. D., 1 Nov 2019, In : Dyes and Pigments. 170, 107476.

Research output: Contribution to journalArticle

A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

Wu, L., Tian, X., Han, H. H., Wang, J., Groleau, R. R., Tosuwan, P., Wannalerse, B., Sedgwick, A. C., Bull, S. D., He, X. P. & James, T. D., 9 Dec 2019, In : ChemistryOpen. 8, 12, p. 1407-1409 3 p.

Research output: Contribution to journalArticle

Open Access
1 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
29 Downloads (Pure)
Open Access
File

Correction to: Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2 (Journal of the American Chemical Society (2019) 141 (1126-1134) DOI: 10.1021/jacs.8b12136)

Ning, J., Liu, T., Dong, P., Wang, W., Ge, G., Wang, B., Yu, Z., Shi, L., Tian, X., Huo, X., Feng, L., Wang, C., Sun, C., Cui, J., James, T. D. & Ma, X., 21 Aug 2019, In : Journal of the American Chemical Society. 141, 33, p. 1-1 1 p., 13278.

Research output: Contribution to journalArticle

Coumarin-based fluorescent 'AND' logic gate probes for the detection of homocysteine and a chosen biological analyte

Wu, L., Gardiner, J. E., Kumawat, L. K., Han, H. H., Guo, R., Li, X., He, X. P., Elmes, R. B. P., Sedgwick, A. C., Bull, S. D. & James, T. D., 27 Aug 2019, In : RSC Advances. 9, 45, p. 26425-26428 4 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Dual enzyme activated fluorescein based fluorescent probe

Odyniec, M. L., Gardiner, J. E., Sedgwick, A. C., He, X. P., Bull, S. D. & James, T. D., 1 Mar 2019, In : Frontiers of Chemical Science and Engineering.

Research output: Contribution to journalArticle

Open Access

Endoplasmic Reticulum Targeting Ratiometric Fluorescent Probe for Carboxylesterase 2 Detection in Drug-Induced Acute Liver Injury

Tian, X., Yan, F., Zheng, J., Cui, X., Feng, L., Li, S., Jin, L., James, T. D. & Ma, X., 17 Dec 2019, In : Analytical Chemistry. 91, 24, p. 15840-15845 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

ESIPT-based fluorescence probe for the ratiometric detection of superoxide

Wu, L., Liu, L., Han, H. H., Tian, X., Odyniec, M. L., Feng, L., Sedgwick, A. C., He, X. P., Bull, S. D. & James, T. D., 21 Feb 2019, In : New Journal of Chemistry. 43, 7, p. 2875-2877 3 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe

Shi, D., Chen, S., Dong, B., Zhang, Y., Sheng, C., James, T. D. & Guo, Y., 7 Apr 2019, In : Chemical Science. 10, 13, p. 3715-3722 8 p.

Research output: Contribution to journalArticle

Open Access

Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

Dou, W. T., Liu, L. F., Gao, J., Zang, Y., Chen, G. R., Field, R. A., James, T. D., Li, J. & He, X. P., 14 Nov 2019, In : Chemical communications (Cambridge, England). 55, 88, p. 13235-13238 4 p.

Research output: Contribution to journalArticle

Open Access

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships

Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells

Gwynne, L., Sedgwick, A. C., Gardiner, J. E., Williams, G. T., Kim, G., Maillard, J. Y., Jenkins, T., Bull, S. D., Sessler, J. L., Yoon, J. & James, T. D., 30 Apr 2019, In : Frontiers in Chemistry. 7, APR, p. 1-6 6 p., 255.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)
7 Downloads (Pure)

Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

Ning, J., Liu, T., Dong, P., Wang, W., Ge, G., Wang, B., Yu, Z., Shi, L., Tian, X., Huo, X., Feng, L., Wang, C., Sun, C., Cui, J-N., James, T. D. & Ma, X., 16 Jan 2019, In : Journal of the American Chemical Society. 141, 2, p. 1126-1134 9 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)

Multiphoton fluorescence lifetime imaging microscopy (FLIM) and super-resolution fluorescence imaging with a supramolecular biopolymer for the controlled tagging of polysaccharides

Ge, H., Cortezon-Tamarit, F., Wang, H. C., Sedgwick, A. C., Arrowsmith, R. L., Mirabello, V., Botchway, S. W., James, T. D. & Pascu, S. I., 21 May 2019, In : Nanoscale. 11, 19, p. 9498-9507 10 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

Yan, F., Tian, X., Luan, Z., Feng, L., Ma, X. & James, T. D., 14 Feb 2019, In : Chemical communications (Cambridge, England). 55, 13, p. 1955-1958 4 p.

Research output: Contribution to journalArticle

Open Access
66 Downloads (Pure)

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103263.

Research output: Contribution to journalArticle

Open Access
File

Peroxynitrite Activated Drug Conjugate Systems Based on a Coumarin Scaffold Toward the Application of Theranostics

Odyniec, M. L., Han, H. H., Gardiner, J. E., Sedgwick, A. C., He, X. P., Bull, S. D. & James, T. D., 5 Dec 2019, In : Frontiers in Chemistry. 7, 775.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

Feng, L., Yan, Q., Zhang, B., Tian, X., Wang, C., Yu, Z., Cui, J., Guo, D., Ma, X. & James, T. D., 25 Mar 2019, In : Chemical Communications. 55, 24, p. 3548-3551 4 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Ratiometric two-photon fluorescent probe for: In situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Jiang, A., Chen, G., Xu, J., Liu, Y., Zhao, G., Liu, Z., Chen, T., Li, Y. & James, T. D., 28 Sep 2019, In : Chemical Communications. 55, 76, p. 11358-11361 4 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species

Wu, L., Sedgwick, A. C., Sun, X., Bull, S. D., He, X. P. & James, T. D., 17 Sep 2019, In : Accounts of Chemical Research. 52, 9, p. 2582-2597 16 p.

Research output: Contribution to journalArticle

Open Access

Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

Patenall, B. L., Williams‡, G. T., Gwynne, L., Stephens, L. J., Lampard, E. V., Hathaway, H. J., Thet, N. T., Young, A. E., Sutton, M. J., Short, R. D., Bull, S. D., James, T. D., Sedgwick, A. C. & Jenkins, A. T. A., 12 Dec 2019, In : Chemical Communications. 55, 100, p. 15129-15132 4 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Target Enzyme-Activated Two-Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two-Dimensional Design Strategy

Ning, J., Wang, W., Ge, G., Chu, P., Long, F., Yang, Y., Peng, Y., Feng, L., Ma, X. & James, T. D., 15 Jul 2019, In : Angewandte Chemie - International Edition. 58, 29, p. 9959-9963 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Voltammetric characterisation of diferrocenylborinic acid in organic solution and in aqueous media when immobilised into a titanate nanosheet film

Konhefr, M., Sedgwick, A. C., James, T. D., Lacina, K., Skládal, P., Putra, B. R., Harito, C., Bavykin, D. V., Walsh, F. C., Raithby, P. R., Kociok-Köhn, G. & Marken, F., 14 Aug 2019, In : Dalton transactions (Cambridge, England : 2003). 48, 30, p. 11200-11207 8 p.

Research output: Contribution to journalArticle

Open Access
2018
3 Citations (Scopus)
22 Downloads (Pure)

A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells

Jiang, Q., Li, X-R., Wang, C-K., Cheng, J., Tan, C., Cui, T-T., Lu, N-N., James, T. D., Han, F. & Li, X., 21 Feb 2018, In : Chemical communications (Cambridge, England). 54, 15, p. 1857-1860 4 p.

Research output: Contribution to journalArticle

Open Access
File
Peptidylprolyl Isomerase
Imaging techniques
Communication
Substrates
Fluorescent Dyes
26 Citations (Scopus)

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Wu, L., Wang, Y., James, T. D., Jia, N. & Huang, C., 4 Jun 2018, In : Chemical Communications. 54, 44, p. 5518-5521 4 p.

Research output: Contribution to journalArticle

Open Access
Fluorescence
Cells
Fluorophores
Neurology
Fluorescent Dyes
3 Citations (Scopus)

A naphthoimidazolium-cholesterol derivative as a ratiometric fluorescence based chemosensor for the chiral recognition of carboxylates

Zhang, X., Ko, G., Joung, J. F., Li, M., Jeong, Y., Swamy, K. M. K., Lee, D., Liu, Y., Lee, S., Park, S., James, T. D. & Yoon, J., 22 Nov 2018, In : Chemical communications (Cambridge, England). 54, 94, p. 13264-13267 4 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

'AND'-based fluorescence scaffold for the detection of ROS/RNS and a second analyte

Odyniec, M. L., Sedgwick, A. C., Swan, A. H., Weber, M., Tang, T. M. S., Gardiner, J. E., Zhang, M., Jiang, Y. B., Kociok-Kohn, G., Elmes, R. B. P., Bull, S. D., He, X. P. & James, T. D., 27 Jun 2018, In : Chemical Communications. 54, p. 8466-8469 4 p.

Research output: Contribution to journalArticle

Open Access
Scaffolds
Fluorescence
Biomarkers
Esterases
Fluorescent Dyes
29 Citations (Scopus)

An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates

Sedgwick, A. C., Dou, W. T., Jiao, J. B., Wu, L., Williams, G. T., Jenkins, A. T. A., Bull, S. D., Sessler, J. L., He, X. P. & James, T. D., 31 Oct 2018, In : Journal of the American Chemical Society. 140, 43, p. 14267-14271 5 p.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)
1 Downloads (Pure)

A quick and selective rhodamine based “smart probe” for “signal-on” optical detection of Cu2+ and Al3+ in water, cell imaging, computational studies and solid state analysis

Rai, A., Singh, A. K., Tripathi, K., Sonkar, A. K., Chauhan, B. S., Srikrishna, S., James, T. D. & Mishra, L., 1 Aug 2018, In : Sensors and Actuators B: Chemical. 266, p. 95-105 11 p.

Research output: Contribution to journalArticle

Open Access
File
Rhodamines
rhodamine
solid state
Imaging techniques
Water
19 Citations (Scopus)
13 Downloads (Pure)
Open Access
Fructose
Bolts
Boronic Acids
Acids
Fluorescence
5 Citations (Scopus)
21 Downloads (Pure)

A simple umbelliferone based fluorescent probe for the detection of nitroreductase

Sedgwick, A. C., Hayden, A., Hill, B., Bull, S. D., Elmes, R. B. P. & James, T. D., 1 Jun 2018, In : Frontiers of Chemical Science and Engineering. 12, 2, p. 311-314 4 p.

Research output: Contribution to journalArticle

Open Access
File
7-hydroxycoumarin
Nitroreductases
Fluorescent Dyes
Enzymes
Fluorophores
6 Citations (Scopus)
28 Downloads (Pure)

Biodegradable macroporous scaffold with nano-crystal surface microstructure for highly effective osteogenesis and vascularization

Chu, L., Jiang, G., Hu, X., James, T. D., He, X-P., Li, Y. & Tang, T., 21 Mar 2018, In : Journal of Materials Chemistry B . 6, 11, p. 1658-1667 10 p.

Research output: Contribution to journalArticle

Open Access
File
Scaffolds
Scaffolds (biology)
Crystals
Microstructure
Calcium
8 Citations (Scopus)

Boronate-Based Fluorescence Probes for the Detection of Hydrogen Peroxide

Lampard, E. V., Sedgwick, A. C., Sun, X., Filer, K. L., Hewins, S. C., Kim, G., Yoon, J., Bull, S. D. & James, T. D., 1 Mar 2018, In : ChemistryOpen. 7, 3, p. 262-265 4 p.

Research output: Contribution to journalArticle

Open Access

Correction: A bodipy based hydroxylamine sensor (Chemical Communications (2017) 53 (10441-10443) DOI: 10.1039/C7CC05872A)

Sedgwick, A. C., Chapman, R. S. L., Gardiner, J. E., Peacock, L. R., Kim, G., Yoon, J., Bull, S. D. & James, T. D., 4 Oct 2018, In : Chemical Communications. 54, 77, p. 10922 1 p.

Research output: Contribution to journalArticle

Open Access

Correction: Boronate based fluorescence (ESIPT) probe for peroxynitrite(Chem. Commun. (2016) 52 (12350–12352) DOI: 10.1039/C6CC06829D)

Sedgwick, A. C., Sun, X., Kim, G., Yoon, J., Bull, S. D. & James, T. D., 28 Sep 2018, In : Chemical Communications. 54, 76, p. 10775 1 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
30 Downloads (Pure)

Dual-function cellulose composites for fluorescence detection and removal of fluoride

Li, M., Liu, Z., Wang, H. C., Sedgwick, A. C., Gardiner, J. E., Bull, S. D., Xiao, H. N. & James, T. D., 1 Feb 2018, In : Dyes and Pigments. 149, p. 669-675 7 p.

Research output: Contribution to journalArticle

Open Access
File
Fluorides
Cellulose
Fluorescence
Adsorption
Composite materials
2 Citations (Scopus)

Dye Displacement Assay for Saccharides using Benzoxaborole Hydrogels

Lampard, E. V., Sedgwick, A. C., Sombuttan, T., Williams, G. T., Wannalerse, B., Jenkins, A. T. A., Bull, S. D. & James, T. D., 1 Mar 2018, In : ChemistryOpen. 7, 3, p. 266-268 3 p.

Research output: Contribution to journalArticle

Open Access
Hydrogels
Assays
Coloring Agents
Boronic Acids
Monosaccharides
28 Citations (Scopus)

ESIPT-based fluorescence probe for the rapid detection of hypochlorite (HOCl/ClO-)

Wu, L., Yang, Q., Liu, L., Sedgwick, A. C., Cresswell, A. J., Bull, S. D., Huang, C. & James, T. D., 4 Jul 2018, In : Chemical Communications. 54, 61, p. 8522-8525 4 p.

Research output: Contribution to journalArticle

Open Access
Hypochlorous Acid
Fluorescence
Water
Logic gates
Potable water
14 Citations (Scopus)

ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND' biological thiols

Wu, L., Han, H. H., Liu, L., Gardiner, J. E., Sedgwick, A. C., Huang, C., Bull, S. D., He, X. P. & James, T. D., 14 Oct 2018, In : Chemical Communications. 54, 80, p. 11336-11339 4 p.

Research output: Contribution to journalArticle

Open Access