• 5 WEST 3.04

20012023
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Research Output 2001 2019

2019
2 Citations (Scopus)

19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids

Naqi, H., Woodman, T., Husbands, S. & Blagbrough, I., 28 Jun 2019, In : Analytical Methods. 11, 24, p. 3090-3100 11 p.

Research output: Contribution to journalArticle

Open Access
Open Access
1 Citation (Scopus)
5 Downloads (Pure)
Open Access
File

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships

Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.

Research output: Contribution to journalArticle

Influence of Aromatic Structure on the Thermal Behaviour of Lignin

Rowlandson, J. L., Woodman, T. J., Tennison, S. R., Edler, K. J. & P. Ting, V., 16 Jan 2019, In : Waste and Biomass Valorization.

Research output: Contribution to journalArticle

11 Downloads (Pure)

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103263.

Research output: Contribution to journalArticle

Open Access
File
9 Downloads (Pure)

The Optimized Production of 5-(Hydroxymethyl)furfural and Related Products from Spent Coffee Grounds

Prates Pereira, A., Woodman, T., Brahmbhatt, P. & Chuck, C., 15 Aug 2019, In : Applied Sciences. 9, 16, 22 p., 3369.

Research output: Contribution to journalArticle

Open Access
File
2018
2 Citations (Scopus)
11 Downloads (Pure)

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Sep 2018, In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journalArticle

Open Access
File
Acyl Coenzyme A
Enzyme activity
Coenzyme A
Assays
Esters
2017
38 Downloads (Pure)

A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 21 Apr 2017, (Unpublished).

Research output: Contribution to conferenceAbstract

File
Coenzyme A
Inhibitory Concentration 50
Acyl Coenzyme A
Prostatic Neoplasms
S 10
5 Citations (Scopus)

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 7 May 2017, In : Chemical Communications. 53, 37, p. 5087-5090 4 p.

Research output: Contribution to journalArticle

Open Access
Assays
Ibuprofen
Fatty acids
Fatty Acids
Degradation
17 Downloads (Pure)

High-Throughput Screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Petrova, Y., Mattan, H., Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 21 Apr 2017.

Research output: Contribution to conferencePoster

File
Libraries
Prostatic Neoplasms
Pharmaceutical Preparations
Acyl Coenzyme A
Ibuprofen
12 Citations (Scopus)
Open Access
Ring opening polymerization
Ligands
Geometry
Nuclear magnetic resonance spectroscopy
Metals

Methods (amacr)

Lloyd, M., Jevglevskis, M., Lee, G. L., Woodman, T. & Threadgill, M., 22 Jun 2017, Patent No. US20170176436 A1, Priority date 3 Feb 2014

Research output: Patent

6 Citations (Scopus)
16 Downloads (Pure)
Open Access
File
Ring opening polymerization
Ligands
Metals
Polymerization
dilactide
2016
20 Downloads (Pure)

A convenient colorimetric assay for alpha-methylacyl-CoA racemase (AMACR; P504S) and testing for inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 21 May 2016, (Unpublished).

Research output: Contribution to conferencePoster

File
25 Downloads (Pure)

A Convenient Colorimetric Assay For Alpha-Methylacyl-CoA Racemase (AMACR; P504S) And Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., Threadgill, M., James, T., Woodman, T. & Lloyd, M., Jun 2016.

Research output: Contribution to conferencePoster

Open Access
File
21 Downloads (Pure)

A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 27 Apr 2016, (Unpublished).

Research output: Contribution to conferencePoster

File
14 Citations (Scopus)
91 Downloads (Pure)

Aminopiperidine based complexes for lactide polymerisation

McKeown, P., Davidson, M. G., Lowe, J. P., Mahon, M. F., Thomas, L. H., Woodman, T. J. & Jones, M. D., 28 Mar 2016, In : Dalton Transactions . 45, 12, p. 5374-5387

Research output: Contribution to journalArticle

Open Access
File
Polymerization
Ligands
Aluminum
Hafnium
Metals

An efficient assay for ferulic acid esterase and para-coumaric acid esterases in plants at physiologically relevant activities

Parveen, I., Donnison, I. S., Insole, J., Winters, A. L., Dalton, S. J., Woodman, T. & Threadgill, M., 2016, In : Chemistry & Biology Interface. 6, 5, p. 300-311

Research output: Contribution to journalArticle

coumaric acids
esterases
assays
p-nitrophenol
Miscanthus
8 Citations (Scopus)
53 Downloads (Pure)

A study on the AMACR catalysed elimination reaction and its application to inhibitor testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T. D., Woodman, T. J. & Lloyd, M. D., Jan 2016, In : Organic and Biomolecular Chemistry. 14, 2, p. 612-622

Research output: Contribution to journalArticle

Open Access
File
inhibitors
elimination
Acyl Coenzyme A
Coenzyme A
Assays
27 Downloads (Pure)

A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. & Lloyd, M., 27 Apr 2016, (Unpublished).

Research output: Contribution to conferencePoster

File
10 Citations (Scopus)
95 Downloads (Pure)
Open Access
File

High-throughput screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Petrova, Y., Matan, H., Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 27 Apr 2016, (Unpublished).

Research output: Contribution to conferencePoster

Methods (AMACR)

Lloyd, M., Jevglevskis, M., Lee, G. L., Woodman, T. & Threadgill, M., 14 Dec 2016, Patent No. EP3102694 A1, Priority date 3 Feb 2014

Research output: Patent

2015
22 Downloads (Pure)

A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 11 Nov 2015, (Unpublished).

Research output: Contribution to conferencePoster

File
21 Downloads (Pure)

A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. & Lloyd, M., 11 Nov 2015, (Unpublished).

Research output: Contribution to conferencePoster

File

High-throughput screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Petrova, Y., Matan, H., Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 11 Nov 2015, (Unpublished).

Research output: Contribution to conferencePoster

62 Citations (Scopus)
52 Downloads (Pure)
Open Access
Metals
Polymerization
Ligands
Ion exchange
Nuclear magnetic resonance
19 Downloads (Pure)

Methods (AMACR).

Lloyd, M., Woodman, T., Jevglevskis, M., Threadgill, M. & Lee, G. L., 6 Aug 2015, Patent No. WO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1) , 2 Feb 2015, Priority date 3 Feb 2014, Priority No. 1401817.0

Research output: Patent

File
Substrates
Carbon
Medical imaging
Hydrogen
alpha-methylacyl-CoA racemase

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 2015, (Unpublished).

Research output: Contribution to conferencePoster

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. & Lloyd, M., 2015, (Unpublished).

Research output: Contribution to conferencePoster

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. & Lloyd, M., 2015, (Unpublished).

Research output: Contribution to conferencePoster

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. & Lloyd, M., 2015.

Research output: Contribution to conferencePoster

None

Lloyd, M., Woodman, T., Jevglevskis, M., Threadgill, M. & Lee, G. L., 2015, Patent No. US 15/115,851

Research output: Patent

11 Citations (Scopus)
62 Downloads (Pure)
File
phosphine
Chemical activation
Reducing Agents
Fluorides
Hydrides
4 Citations (Scopus)
102 Downloads (Pure)
Open Access
File
Microemulsions
Spectrum Analysis
Skin
Nuclear magnetic resonance
Spectroscopy
20 Citations (Scopus)
33 Downloads (Pure)
Open Access
File
Amines
Ligands
Polymerization
ROP
dilactide
6 Citations (Scopus)
145 Downloads (Pure)
Open Access
File
2013
4 Citations (Scopus)
98 Downloads (Pure)

Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., 1 Dec 2013, In : Biochemical Pharmacology. 86, 11, p. 1621-1625 5 p.

Research output: Contribution to journalArticle

Open Access
File
Acyl Coenzyme A
Coenzyme A
Hydrolysis
Esters
Acids
5 Citations (Scopus)
89 Downloads (Pure)
Open Access
File
Diamines
diamines
naphthalene
Protons
Nuclear magnetic resonance
9 Citations (Scopus)

Regioselective opening of myo-inositol orthoesters: Mechanism and synthetic utility

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. & Potter, B. V. L., 15 Mar 2013, In : Journal of Organic Chemistry. 78, 6, p. 2275-2288

Research output: Contribution to journalArticle

Deuterium
Inositol
Esters
Acids
Nuclear magnetic resonance spectroscopy
39 Citations (Scopus)

α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S

Lloyd, M. D., Jevglevskis, M., Lee, G. L., Wood, P. J., Threadgill, M. D. & Woodman, T. J., Apr 2013, In : Progress in Lipid Research. 52, 2, p. 220-230 11 p.

Research output: Contribution to journalArticle

Acyl Coenzyme A
Peroxisome Proliferator-Activated Receptors
Proton transfer
Oncology
Ibuprofen
2012
22 Downloads (Pure)

Acyl-CoA ∝-proton exchange by ∝-methylacyl-CoA racemase

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. & Lloyd, M. D., 2012.

Research output: Contribution to conferenceOther

File
21 Citations (Scopus)

Applications of NMR in the characterization of pharmaceutical microemulsions

Hathout, R. M. & Woodman, T. J., 10 Jul 2012, In : Journal of Controlled Release. 161, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Drug Delivery Systems
Solubility
Biological Availability
Water
19 Downloads (Pure)

Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. & Lloyd, M. D., 2012.

Research output: Contribution to conferencePoster

File
22 Downloads (Pure)

Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human Acyl-CoA thioesterases 1 and 2

Qu, X., Leung, A., Allan, A. C., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., 2012.

Research output: Contribution to conferenceOther

File
2011
25 Citations (Scopus)
104 Downloads (Pure)

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. & Lloyd, M. D., 14 Jul 2011, In : Chemical Communications. 47, 26, p. 7332-7334 3 p.

Research output: Contribution to journalArticle

Open Access
File
Ibuprofen
Coenzyme A
Esters
Acids
Substrates