Research output per year
Research output per year
- 28 results
Search results
-
2022
Staphylococcal complement evasion protein Sbi stabilises C3d dimers by inducing an N-terminal helix swap
Dunphy, R., Wahid, A., Back, C., Martin, B., Watts, A., Dodson, C., Crennell, S. & Van Den Elsen, J., 25 May 2022, In: Frontiers in Immunology. 13, 892234.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (SciVal)8 Downloads (Pure) -
Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3Deoxy-hexulosonic Acid
Royer, S. F., Gao, X., Groleau, R., van der Kamp, M. W., Bull, S., Danson, M. J. & Crennell, S., 16 Sept 2022, In: ACS Catalysis. 12, 18, p. 11444-11455 12 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (SciVal) -
2021
Insights into the structure-function relationships of dimeric C3d fragments
Wahid, A., Dunphy, R., Macpherson, A., Gibson, B., Kulik, L., Whale, K., Back, C., Hallam, T., Alkhawaja, B., Martin, B., Meschede, I., Laabei, M., Lawson, A., Holers, V. M., Watts, A., Crennell, S., Harris, C., Marchbank, K. & Van Den Elsen, J., 9 Aug 2021, In: Frontiers in Immunology. 12, 714055.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (SciVal)88 Downloads (Pure) -
The allosteric modulation of Complement C5 by knob domain peptides
Macpherson, A., Laabei, M., Ahdash, Z., Graewert, M., Birtley, J., Schulze, M.-S., Crennell, S., Robinson, S., Holmes, B., Oleinikovas, V., Nilsson, P., Snowdon, J., Ellis, V., Mollnes, T. E., Deane, C., Svergun, D., Lawson, A. & Van Den Elsen, J., 11 Feb 2021, In: eLife. 10, p. 1-49 49 p., e63586.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (SciVal) -
2018
Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase
Buddrus, L., Andrews, E. S. V., Leak, D., Danson, M., Arcus, V. L. & Crennell, S., 1 Mar 2018, In: Acta Crystallographica Section F:Structural Biology Communications. 74, 3, p. 179-186 8 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (SciVal) -
Distinctive phosphoinositide- A nd Ca 2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain
Posner, M. G., Upadhyay, A., Ishima, R., Kalli, A. C., Harris, G., Kremerskothen, J., Sansom, M. S. P., Crennell, S. J. & Bagby, S., 15 Jun 2018, In: The Journal of biological chemistry. 293, 24, p. 9335-9344 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (SciVal) -
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases: The Structures of Picrophilus torridus 2-Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2-Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2-Keto-3-deoxy-6-phosphogluconate
Zaitsev, V., Johnsen, U., Reher, M., Ortjohann, M., Taylor, G., Danson, M., Schönheit, P. & Crennell, S., 3 Jul 2018, In: Biochemistry. 57, 26, p. 3797-3806 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (SciVal)171 Downloads (Pure) -
Structural insights of RmXyn10A - A prebiotic-producing GH10 xylanase with a non-conserved aglycone binding region
Aronsson, A., Guler, F., Petoukhov, M., Crennell, S., Svergun, D., Linares-Pasten, J. & Nordbery Karlsson, E., 1 Feb 2018, In: Biochimica Et Biophysica Acta-Proteins and Proteomics. 1866, 2, p. 292-306 15 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (SciVal) -
The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase
Chen, Z., Marce Villa, P., Resende, R., Alzari, P. M., Frasch, A. C., Van Den Elsen, J., Crennell, S. & Watts, A., 5 Oct 2018, In: European Journal of Medicinal Chemistry. 158, p. 25-33 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (SciVal)139 Downloads (Pure) -
2016
Crystal structure of pyruvate decarboxylase from Zymobacter palmae
Buddrus, L., Andrews, E. S. V., Leak, D. J., Danson, M. J., Arcus, V. L. & Crennell, S. J., 1 Sept 2016, In: Acta Crystallographica Section F:Structural Biology Communications. 72, 9, p. 700-706Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (SciVal)167 Downloads (Pure) -
Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius
Extance, J., Danson, M. J. & Crennell, S. J., 29 Aug 2016, In: Protein Science. 25, 11, p. 2045-2053Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (SciVal)197 Downloads (Pure) -
2014
A novel β-xylosidase structure from Geobacillus thermoglucosidasius: The first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds
Espina Silva, G., Eley, K., Pompidor, G., Schneider, T. R., Crennell, S. J. & Danson, M. J., 1 May 2014, In: Acta Crystallographica Section D-Biological Crystallography. 70, 5, p. 1366-1374 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (SciVal)6563 Downloads (Pure) -
Structures of mesophilic and extremophilic citrate synthases reveal rigidity and flexibility for function
Wells, S. A., Crennell, S. J. & Danson, M. J., Oct 2014, In: Proteins: Structure, Function, and Bioinformatics. 82, 10, p. 2657-2670 14 p.Research output: Contribution to journal › Article › peer-review
File28 Citations (SciVal)344 Downloads (Pure) -
Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex
Marrott, N., Marshall, J. J. T., Svergun, D., Crennell, S., Hough, D. W., Van Den Elsen, J. & Danson, M., 1 Nov 2014, In: Biochemical Journal. 463, 3, p. 405-412 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (SciVal)279 Downloads (Pure) -
2013
Post-translational modification in the archaea: structural characterization of multi-enzyme complex lipoylation
Posner, M. G., Upadhyay, A., Crennell, S., Watson, A. J. A., Dorus, S., Danson, M. J. & Bagby, S., 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 415-425 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (SciVal)316 Downloads (Pure) -
Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius
Extance, J., Crennell, S. J., Eley, K., Cripps, R., Hough, D. W. & Danson, M. J., Oct 2013, In: Acta Crystallographica Section D-Biological Crystallography. 69, 10, p. 2104-2115 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (SciVal)333 Downloads (Pure) -
2012
The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly
Marrott, N. L., Marshall, J. J. T., Svergun, D. I., Crennell, S. J., Hough, D. W., Danson, M. J. & van den Elsen, J. M. H., Mar 2012, In: FEBS Journal. 279, 5, p. 713-723 11 p.Research output: Contribution to journal › Article › peer-review
15 Citations (SciVal) -
2011
A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d
Clark, E. A., Crennell, S., Upadhyay, A., Zozulya, A. V., Mackay, J. D., Svergun, D. I., Bagby, S. & van den Elsen, J. M. H., Jan 2011, In: Molecular Immunology. 48, 4, p. 452-462Research output: Contribution to journal › Article › peer-review
18 Citations (SciVal) -
Contribution of inter-subunit interactions to the thermostability of Pyrococcus furiosus citrate synthase
Moore, V., Kanu, A., Byron, O., Campbell, G., Danson, M. J., Hough, D. W. & Crennell, S. J., May 2011, In: Extremophiles. 15, 3, p. 327-336 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (SciVal)238 Downloads (Pure) -
2010
Structurally informed site-directed mutagenesis of a stereochemically promiscuous aldolase to afford stereochemically complementary biocatalysts
Royer, S. F., Haslett, L., Crennell, S. J., Hough, D. W., Danson, M. J. & Bull, S. D., 25 Aug 2010, In: Journal of the American Chemical Society. 132, 33, p. 11753-11758 6 p.Research output: Contribution to journal › Article › peer-review
40 Citations (SciVal) -
2008
Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering
Pelat, T., Bedouelle, H., Rees, A. R., Crennell, S., Lefranc, M. P. & Thullier, P., 2008, In: Journal of Molecular Biology. 384, 5, p. 1400-1407 8 p.Research output: Contribution to journal › Article › peer-review
83 Citations (SciVal) -
2006
Dimerisation and an increase in active site aromatic groups as adaptations to high temperatures: X-ray solution scattering and substrate-bound crystal structures of Rhodothermus marinus endoglucanase Cel12A
Crennell, S. J., Cook, D., Minns, A., Svergun, D., Andersen, R. L. & Karlsson, E. N., 2006, In: Journal of Molecular Biology. 356, 1, p. 57-71 15 p.Research output: Contribution to journal › Article › peer-review
20 Citations (SciVal) -
Identification of amino acids essential for catalytic activity of pneumococcal neuraminidase A
Yesilkaya, H., Soma-Haddrick, S., Crennell, S. J. & Andrew, P. W., 2006, In: Research in Microbiology. 157 Jul-Aug, 6, p. 569-574 6 p.Research output: Contribution to journal › Article › peer-review
14 Citations (SciVal) -
2003
Citrate synthase from Thermus aquaticus: a thermostable bacterial enzyme with a five-membered inter-subunit ionic network
Karlsson, E. N., Crennell, S. J., Higgins, C., Nawaz, S., Yeoh, L., Hough, D. W. & Danson, M. J., 2003, In: Extremophiles. 7, 1, p. 9-16 8 p.Research output: Contribution to journal › Article › peer-review
9 Citations (SciVal) -
The Modular Organisation and Stability of a Thermostable Family 10 xylanase
Abou-Hachem, M., Olsson, F., Williamson, M. P., Linse, S., Crennell, S. J., Hreggvidsson, G. O., Kreistjansson, J. K., Holst, O. & Nordberg Karlsson, E., 2003, In: Biocatalysis and Biotransformation. 21, p. 253-260 8 p.Research output: Contribution to journal › Article › peer-review
11 Citations (SciVal) -
2002
Probing the sialic acid binding site of the hemagglutinin-neuraminidase of Newcastle disease virus: Identification of key amino acids involved in cell binding, catalysis, and fusion
Connaris, H., Takimoto, T., Russell, R., Crennell, S., Moustafa, I., Portner, A. & Taylor, G., 2002, In: Journal of Virology. 76, 4, p. 1816-1824 9 p.Research output: Contribution to journal › Article › peer-review
133 Citations (SciVal) -
Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion
Takimoto, T., Taylor, G. L., Connaris, H. C., Crennell, S. J. & Portner, A., 2002, In: Journal of Virology. 76, 24, p. 13028-13033 6 p.Research output: Contribution to journal › Article › peer-review
138 Citations (SciVal) -
The structure of Rhodothermus marinus Cel12A, a highly thermostable family 12 endoglucanase, at 1.8 angstrom resolution
Crennell, S. J., Hreggvidsson, G. O. & Karlsson, E. N., 2002, In: Journal of Molecular Biology. 320, 4, p. 883-897 15 p.Research output: Contribution to journal › Article › peer-review
56 Citations (SciVal)