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Susan Crennell

Dr

  • 4 SOUTH 0.26

20022021
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Research Output 2002 2018

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Article
2018
2 Citations (Scopus)

Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase

Buddrus, L., Andrews, E. S. V., Leak, D., Danson, M., Arcus, V. L. & Crennell, S., 1 Mar 2018, In : Acta Crystallographica Section F:Structural Biology Communications. 74, 3, p. 179-186 8 p.

Research output: Contribution to journalArticle

Open Access
Pyruvate Decarboxylase
pyruvates
enzymes
Crystal structure
Bins
2 Citations (Scopus)

Distinctive phosphoinositide- A nd Ca 2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain

Posner, M. G., Upadhyay, A., Ishima, R., Kalli, A. C., Harris, G., Kremerskothen, J., Sansom, M. S. P., Crennell, S. J. & Bagby, S., 15 Jun 2018, In : The Journal of biological chemistry. 293, 24, p. 9335-9344 10 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositols
Membranes
Nuclear magnetic resonance
Calcium
Titration
15 Downloads (Pure)
Open Access
File
phospho-2-keto-3-deoxy-gluconate aldolase
Thermoplasmales
Aldehyde-Lyases
Sulfolobus solfataricus
Fructose-Bisphosphate Aldolase
4 Citations (Scopus)

Structural insights of RmXyn10A - A prebiotic-producing GH10 xylanase with a non-conserved aglycone binding region

Aronsson, A., Guler, F., Petoukhov, M., Crennell, S., Svergun, D., Linares-Pasten, J. & Nordbery Karlsson, E., 1 Feb 2018, In : Biochimica Et Biophysica Acta-Proteins and Proteomics. 1866, 2, p. 292-306 15 p.

Research output: Contribution to journalArticle

Open Access
Prebiotics
Glycoside Hydrolases
Arabinose
X ray scattering
Substitution reactions
3 Citations (Scopus)
10 Downloads (Pure)

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

Chen, Z., Marce Villa, P., Resende, R., Alzari, P. M., Frasch, A. C., Van Den Elsen, J., Crennell, S. & Watts, A., 5 Oct 2018, In : European Journal of Medicinal Chemistry. 158, p. 25-33 9 p.

Research output: Contribution to journalArticle

Open Access
File
Organophosphonates
Molecular modeling
Drug therapy
Kinetics
Chagas Disease
2016
5 Citations (Scopus)
71 Downloads (Pure)

Crystal structure of pyruvate decarboxylase from Zymobacter palmae

Buddrus, L., Andrews, E. S. V., Leak, D. J., Danson, M. J., Arcus, V. L. & Crennell, S. J., 1 Sep 2016, In : Acta Crystallographica Section F:Structural Biology Communications. 72, 9, p. 700-706

Research output: Contribution to journalArticle

Open Access
File
Pyruvate Decarboxylase
Thiamine Pyrophosphate
pyruvates
Bins
Pyruvic Acid
2 Citations (Scopus)
107 Downloads (Pure)

Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius

Extance, J., Danson, M. J. & Crennell, S. J., 29 Aug 2016, In : Protein Science. 25, 11, p. 2045-2053

Research output: Contribution to journalArticle

Open Access
File
acetaldehyde dehydrogenase (acylating)
Geobacillus
Dimers
Alcohol Dehydrogenase
Coenzymes
2014
10 Citations (Scopus)
119 Downloads (Pure)
Open Access
File
Geobacillus
Glycoside Hydrolases
Enzymes
Xylosidases
Xylans
19 Citations (Scopus)
111 Downloads (Pure)
File
Citrate (si)-Synthase
Rigidity
Crystallography
Citric Acid Cycle
Carbon
10 Citations (Scopus)
108 Downloads (Pure)

Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex

Marrott, N., Marshall, J. J. T., Svergun, DI., Crennell, S., Hough, D. W., Van Den Elsen, J. & Danson, M., 1 Nov 2014, In : Biochemical Journal. 463, 3, p. 405-412 8 p.

Research output: Contribution to journalArticle

Open Access
File
Keto Acids
Oxidoreductases
Multienzyme Complexes
Thermoplasma
Dihydrolipoamide Dehydrogenase
2013
8 Citations (Scopus)
109 Downloads (Pure)

Post-translational modification in the archaea: structural characterization of multi-enzyme complex lipoylation

Posner, M. G., Upadhyay, A., Crennell, S., Watson, A. J. A., Dorus, S., Danson, M. J. & Bagby, S., 15 Jan 2013, In : Biochemical Journal. 449, 2, p. 415-425 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lipoylation
Archaea
Post Translational Protein Processing
Enzymes
Protein C
17 Citations (Scopus)
88 Downloads (Pure)

Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius

Extance, J., Crennell, S. J., Eley, K., Cripps, R., Hough, D. W. & Danson, M. J., Oct 2013, In : Acta Crystallographica Section D-Biological Crystallography. 69, 10, p. 2104-2115 12 p.

Research output: Contribution to journalArticle

Open Access
File
Geobacillus
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
NAD
Acyl Coenzyme A
2012
9 Citations (Scopus)

The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly

Marrott, N. L., Marshall, J. J. T., Svergun, D. I., Crennell, S. J., Hough, D. W., Danson, M. J. & van den Elsen, J. M. H., Mar 2012, In : FEBS Journal. 279, 5, p. 713-723 11 p.

Research output: Contribution to journalArticle

Multienzyme Complexes
Keto Acids
Oxidoreductases
Proteins
Point groups
2011
11 Citations (Scopus)
Complement 3d Receptors
Complement Inactivating Agents
X-Rays
Ligands
Complement C3
5 Citations (Scopus)
105 Downloads (Pure)

Contribution of inter-subunit interactions to the thermostability of Pyrococcus furiosus citrate synthase

Moore, V., Kanu, A., Byron, O., Campbell, G., Danson, M. J., Hough, D. W. & Crennell, S. J., May 2011, In : Extremophiles. 15, 3, p. 327-336 10 p.

Research output: Contribution to journalArticle

Open Access
File
Pyrococcus furiosus
Citrate (si)-Synthase
Guanidine
Dimerization
Mutant Proteins
2010
29 Citations (Scopus)
Mutagenesis
Fructose-Bisphosphate Aldolase
Biocatalysts
Site-Directed Mutagenesis
Carbon
2008
64 Citations (Scopus)

Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering

Pelat, T., Bedouelle, H., Rees, A. R., Crennell, S., Lefranc, M. P. & Thullier, P., 2008, In : Journal of Molecular Biology. 384, 5, p. 1400-1407 8 p.

Research output: Contribution to journalArticle

Computer Simulation
Primates
Antibodies
Genes
Benchmarking
2006
16 Citations (Scopus)
14 Citations (Scopus)

Identification of amino acids essential for catalytic activity of pneumococcal neuraminidase A

Yesilkaya, H., Soma-Haddrick, S., Crennell, S. J. & Andrew, P. W., 2006, In : Research in Microbiology. 157 Jul-Aug, 6, p. 569-574 6 p.

Research output: Contribution to journalArticle

2003
7 Citations (Scopus)

Citrate synthase from Thermus aquaticus: a thermostable bacterial enzyme with a five-membered inter-subunit ionic network

Karlsson, E. N., Crennell, S. J., Higgins, C., Nawaz, S., Yeoh, L., Hough, D. W. & Danson, M. J., 2003, In : Extremophiles. 7, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

Thermus
Citrate (si)-Synthase
Enzymes
Pyrococcus furiosus
Hot Temperature
8 Citations (Scopus)

The Modular Organisation and Stability of a Thermostable Family 10 xylanase

Abou-Hachem, M., Olsson, F., Williamson, M. P., Linse, S., Crennell, S. J., Hreggvidsson, G. O., Kreistjansson, J. K., Holst, O. & Nordberg Karlsson, E., 2003, In : Biocatalysis and Biotransformation. 21, p. 253-260 8 p.

Research output: Contribution to journalArticle

2002
99 Citations (Scopus)

Probing the sialic acid binding site of the hemagglutinin-neuraminidase of Newcastle disease virus: Identification of key amino acids involved in cell binding, catalysis, and fusion

Connaris, H., Takimoto, T., Russell, R., Crennell, S., Moustafa, I., Portner, A. & Taylor, G., 2002, In : Journal of Virology. 76, 4, p. 1816-1824 9 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
taxonomic keys
Newcastle disease virus
sialic acids
sialidase
113 Citations (Scopus)

Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion

Takimoto, T., Taylor, G. L., Connaris, H. C., Crennell, S. J. & Portner, A., 2002, In : Journal of Virology. 76, 24, p. 13028-13033 6 p.

Research output: Contribution to journalArticle

Respirovirus
Membrane Fusion
sialidase
Cell Fusion
Hemagglutinins
34 Citations (Scopus)

The structure of Rhodothermus marinus Cel12A, a highly thermostable family 12 endoglucanase, at 1.8 angstrom resolution

Crennell, S. J., Hreggvidsson, G. O. & Karlsson, E. N., 2002, In : Journal of Molecular Biology. 320, 4, p. 883-897 15 p.

Research output: Contribution to journalArticle