Photo of Susan Crennell

Susan Crennell

Dr

  • 4 SOUTH 0.26

20022021
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Research Output 2002 2018

2018
2 Citations (Scopus)

Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase

Buddrus, L., Andrews, E. S. V., Leak, D., Danson, M., Arcus, V. L. & Crennell, S., 1 Mar 2018, In : Acta Crystallographica Section F:Structural Biology Communications. 74, 3, p. 179-186 8 p.

Research output: Contribution to journalArticle

Open Access
Pyruvate Decarboxylase
pyruvates
enzymes
Crystal structure
Bins
2 Citations (Scopus)

Distinctive phosphoinositide- A nd Ca 2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain

Posner, M. G., Upadhyay, A., Ishima, R., Kalli, A. C., Harris, G., Kremerskothen, J., Sansom, M. S. P., Crennell, S. J. & Bagby, S., 15 Jun 2018, In : The Journal of biological chemistry. 293, 24, p. 9335-9344 10 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositols
Membranes
Nuclear magnetic resonance
Calcium
Titration
7 Downloads (Pure)
Open Access
File
phospho-2-keto-3-deoxy-gluconate aldolase
Thermoplasmales
Aldehyde-Lyases
Sulfolobus solfataricus
Fructose-Bisphosphate Aldolase
2 Citations (Scopus)

Structural insights of RmXyn10A - A prebiotic-producing GH10 xylanase with a non-conserved aglycone binding region

Aronsson, A., Guler, F., Petoukhov, M., Crennell, S., Svergun, D., Linares-Pasten, J. & Nordbery Karlsson, E., 1 Feb 2018, In : Biochimica Et Biophysica Acta-Proteins and Proteomics. 1866, 2, p. 292-306 15 p.

Research output: Contribution to journalArticle

Open Access
Prebiotics
Glycoside Hydrolases
Arabinose
X ray scattering
Substitution reactions
2 Citations (Scopus)
4 Downloads (Pure)

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

Chen, Z., Marce Villa, P., Resende, R., Alzari, P. M., Frasch, A. C., Van Den Elsen, J., Crennell, S. & Watts, A., 5 Oct 2018, In : European Journal of Medicinal Chemistry. 158, p. 25-33 9 p.

Research output: Contribution to journalArticle

Open Access
File
Organophosphonates
Molecular modeling
Drug therapy
Kinetics
Chagas Disease
2016
4 Citations (Scopus)
54 Downloads (Pure)

Crystal structure of pyruvate decarboxylase from Zymobacter palmae

Buddrus, L., Andrews, E. S. V., Leak, D. J., Danson, M. J., Arcus, V. L. & Crennell, S. J., 1 Sep 2016, In : Acta Crystallographica Section F:Structural Biology Communications. 72, 9, p. 700-706

Research output: Contribution to journalArticle

Open Access
File
Pyruvate Decarboxylase
Thiamine Pyrophosphate
pyruvates
Bins
Pyruvic Acid

Identifying the wall-degrading enzymes responsible for microspore release from the pollen tetrad in Arabidopsis thaliana

Tratt, J., Crennell, S., Qi, B., Scott, R. & Doughty, J., 18 Mar 2016.

Research output: Contribution to conferencePoster

2 Citations (Scopus)
84 Downloads (Pure)

Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius

Extance, J., Danson, M. J. & Crennell, S. J., 29 Aug 2016, In : Protein Science. 25, 11, p. 2045-2053

Research output: Contribution to journalArticle

Open Access
File
acetaldehyde dehydrogenase (acylating)
Geobacillus
Dimers
Alcohol Dehydrogenase
Coenzymes
2014
9 Citations (Scopus)
104 Downloads (Pure)
Open Access
File
Geobacillus
Glycoside Hydrolases
Enzymes
Xylosidases
Xylans
19 Citations (Scopus)
83 Downloads (Pure)
File
Citrate (si)-Synthase
Rigidity
Crystallography
Citric Acid Cycle
Carbon
10 Citations (Scopus)
84 Downloads (Pure)

Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex

Marrott, N., Marshall, J. J. T., Svergun, DI., Crennell, S., Hough, D. W., Van Den Elsen, J. & Danson, M., 1 Nov 2014, In : Biochemical Journal. 463, 3, p. 405-412 8 p.

Research output: Contribution to journalArticle

Open Access
File
Keto Acids
Oxidoreductases
Multienzyme Complexes
Thermoplasma
Dihydrolipoamide Dehydrogenase
2013
8 Citations (Scopus)
84 Downloads (Pure)

Post-translational modification in the archaea: structural characterization of multi-enzyme complex lipoylation

Posner, M. G., Upadhyay, A., Crennell, S., Watson, A. J. A., Dorus, S., Danson, M. J. & Bagby, S., 15 Jan 2013, In : Biochemical Journal. 449, 2, p. 415-425 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lipoylation
Archaea
Post Translational Protein Processing
Enzymes
Protein C
16 Citations (Scopus)
70 Downloads (Pure)

Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius

Extance, J., Crennell, S. J., Eley, K., Cripps, R., Hough, D. W. & Danson, M. J., Oct 2013, In : Acta Crystallographica Section D-Biological Crystallography. 69, 10, p. 2104-2115 12 p.

Research output: Contribution to journalArticle

Open Access
File
Geobacillus
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
NAD
Acyl Coenzyme A
2012
9 Citations (Scopus)

The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly

Marrott, N. L., Marshall, J. J. T., Svergun, D. I., Crennell, S. J., Hough, D. W., Danson, M. J. & van den Elsen, J. M. H., Mar 2012, In : FEBS Journal. 279, 5, p. 713-723 11 p.

Research output: Contribution to journalArticle

Multienzyme Complexes
Keto Acids
Oxidoreductases
Proteins
Point groups
2011
11 Citations (Scopus)
Complement 3d Receptors
Complement Inactivating Agents
X-Rays
Ligands
Complement C3
4 Citations (Scopus)
80 Downloads (Pure)

Contribution of inter-subunit interactions to the thermostability of Pyrococcus furiosus citrate synthase

Moore, V., Kanu, A., Byron, O., Campbell, G., Danson, M. J., Hough, D. W. & Crennell, S. J., May 2011, In : Extremophiles. 15, 3, p. 327-336 10 p.

Research output: Contribution to journalArticle

Open Access
File
Pyrococcus furiosus
Citrate (si)-Synthase
Guanidine
Dimerization
Mutant Proteins
2010
28 Citations (Scopus)
Mutagenesis
Fructose-Bisphosphate Aldolase
Biocatalysts
Site-Directed Mutagenesis
Carbon
2008
63 Citations (Scopus)

Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering

Pelat, T., Bedouelle, H., Rees, A. R., Crennell, S., Lefranc, M. P. & Thullier, P., 2008, In : Journal of Molecular Biology. 384, 5, p. 1400-1407 8 p.

Research output: Contribution to journalArticle

Computer Simulation
Primates
Antibodies
Genes
Benchmarking
2006
16 Citations (Scopus)
14 Citations (Scopus)

Identification of amino acids essential for catalytic activity of pneumococcal neuraminidase A

Yesilkaya, H., Soma-Haddrick, S., Crennell, S. J. & Andrew, P. W., 2006, In : Research in Microbiology. 157 Jul-Aug, 6, p. 569-574 6 p.

Research output: Contribution to journalArticle

2003
6 Citations (Scopus)

Citrate synthase from Thermus aquaticus: a thermostable bacterial enzyme with a five-membered inter-subunit ionic network

Karlsson, E. N., Crennell, S. J., Higgins, C., Nawaz, S., Yeoh, L., Hough, D. W. & Danson, M. J., 2003, In : Extremophiles. 7, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

Thermus
Citrate (si)-Synthase
Enzymes
Pyrococcus furiosus
Hot Temperature
7 Citations (Scopus)

The Modular Organisation and Stability of a Thermostable Family 10 xylanase

Abou-Hachem, M., Olsson, F., Williamson, M. P., Linse, S., Crennell, S. J., Hreggvidsson, G. O., Kreistjansson, J. K., Holst, O. & Nordberg Karlsson, E., 2003, In : Biocatalysis and Biotransformation. 21, p. 253-260 8 p.

Research output: Contribution to journalArticle

2002
97 Citations (Scopus)

Probing the sialic acid binding site of the hemagglutinin-neuraminidase of Newcastle disease virus: Identification of key amino acids involved in cell binding, catalysis, and fusion

Connaris, H., Takimoto, T., Russell, R., Crennell, S., Moustafa, I., Portner, A. & Taylor, G., 2002, In : Journal of Virology. 76, 4, p. 1816-1824 9 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
taxonomic keys
Newcastle disease virus
sialic acids
sialidase
110 Citations (Scopus)

Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion

Takimoto, T., Taylor, G. L., Connaris, H. C., Crennell, S. J. & Portner, A., 2002, In : Journal of Virology. 76, 24, p. 13028-13033 6 p.

Research output: Contribution to journalArticle

Respirovirus
Membrane Fusion
sialidase
Cell Fusion
Hemagglutinins
34 Citations (Scopus)

The structure of Rhodothermus marinus Cel12A, a highly thermostable family 12 endoglucanase, at 1.8 angstrom resolution

Crennell, S. J., Hreggvidsson, G. O. & Karlsson, E. N., 2002, In : Journal of Molecular Biology. 320, 4, p. 883-897 15 p.

Research output: Contribution to journalArticle