Sue Wonnacott

Fellow of the British Pharmacological Society , Prof

  • 4 SOUTH 0.44

Accepting PhD Students

1994 …2022
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Personal profile

Research interests

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated cation channels that as so-called because they are activated by the neurotransmitter acetylcholine and the tobacco alkaloid nicotine. A gene family generates 16 subunits in mammals that combine to form a diversity of subtypes of nAChR, finely tuned for different cellular and physiological functions. The distinct subtypes that are expressed in the brain have elicited interest in understanding their roles in normal brain function and their contributions to diseases, including addiction, Alzheimers’s and Parkinson’s diseases and schizophrenia, where they are potential therapeutic targets. Although much remains to be discovered nAChRs are important modulators of synaptic activity, through the presynaptic regulation of neurotransmitter release and postsynaptic modulation of local calcium concentrations, for example. Thus nAChRs, notably the alpha7 subtype, can impact on synaptic mechanisms of information processing and memory storage such as long term potentiation.

We study the molecular and cellular mechanisms governed by nAChRs in neuronal systems, often in the context of a behavioural paradigm (such as conditioned place preference as a model of drug-paired learning). This interdisciplinary research is highly collaborative, currently with Dr Chris Bailey (Dept of Pharmacy and Pharmacology) and Prof David Heal (RenaSci, Nottingham). We also have a long-standing interest in the discovery and characterisation of novel ligands for nAChRs, in collaboration with Prof Tim Gallagher (University of Bristol).

From 2010-2017 Prof Wonnacott was Associate Dean for Graduate Studies in the Faculty of Science.

Education/Academic qualification

Biochemistry, Doctor of Philosophy, King's College London

19721975

Biochemistry, Bachelor of Science, University College London

19681971

Neurochemistry, Master of Science, King's College London

19711972

External positions

Advanced Grant Panel, European Research Council

20162019

Studentship Panel, NC3Rs

20162018

Reader for L’Oréal-UNESCO For Women In Science Fellowships.

20162018

Senior Editor, British Journal of Pharmacology

20122018

Keywords

  • neuroscience
  • nicotine
  • addiction
  • receptors
  • brain

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2004 2022

NERC GW4+ Doctoral Training Partnership

Wonnacott, S.

1/09/1431/08/22

Project: Research-related fundingPGR Training Grant

Biomarkers
Immune system
Neurology
Metabolism
Image sensors

Research Output 1994 2018

66 Citations

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

Curtis, M. J., Alexander, S., Cirino, G., Docherty, J. R., George, C. H., Giembycz, M. A., Hoyer, D., Insel, P. A., Izzo, A. A., Ji, Y., MacEwan, D. J., Sobey, C. G., Stanford, S. C., Teixeira, M. M., Wonnacott, S. & Ahluwalia, A., 1 Apr 2018, In : British Journal of Pharmacology. 175, 7, p. 987-993 7 p.

Research output: Contribution to journalEditorial

Research Design
Guidelines
Peer Review
Compliance
Pharmacology

Goals and practicalities of immunoblotting and immunohistochemistry: Editorial: A guide for submission to the British Journal of Pharmacology

Alexander, S. P. H., Roberts, R. E., Broughton, B. R. S., Sobey, C. G., George, C. H., Stanford, S. C., Cirino, G., Docherty, J. R., Giembycz, M. A., Hoyer, D., Insel, P. A., Izzo, A. A., Ji, Y., MacEwan, D. J., Mangum, J., Wonnacott, S. & Ahluwalia, A., 1 Feb 2018, In : British Journal of Pharmacology. 175, 3, p. 407-411 5 p.

Research output: Contribution to journalEditorial

2 Citations
Open Access
File
AMPA Receptors
Nicotinic Receptors
Morphine
Hippocampus
Recurrence

Nicotinic acetylcholine receptors

Wonnacott, S., Bermudez, I. & Millar, N., 2018, In : British Journal of Pharmacology. 175, 11, p. 1785 4 p.

Research output: Contribution to journalEditorial

Open Access
Nicotinic Receptors
Cholinergic Receptors
Greece
Research
Islands

Thesis

Effects of nicotinic ligands on the acute and chronic actions of Amyloid-β in vitro

Author: Innocent, N., 1 Sep 2009

Supervisor: Wonnacott, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Flavonoids as regulators of amyloid precursor protein processing

Author: Cox, C., 14 May 2014

Supervisor: Williams, R. (Supervisor) & Wonnacott, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Nicotinic acetylcholine receptor modulation of noradrenaline release in the rodent brain

Author: Kennett, A., 30 Sep 2011

Supervisor: Wonnacott, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

The role of nicotinic acetylcholine receptors in motivated behaviour

Author: Wright, V., 11 Dec 2015

Supervisor: Wonnacott, S. (Supervisor), Bailey, C. (Supervisor) & Heal, D. (External person) (Supervisor)

Student thesis: Doctoral ThesisPhD

File

α7 Nicotinic Acetylcholine Receptor-Mediated Calcium Signalling in Neuronal Cells

Author: Brown, J., 1 Apr 2014

Supervisor: Wonnacott, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File