Projects per year
Personal profile
Research interests
Synthetic chemistry is the cornerstone of the natural sciences where it serves as a fundamental technology for the preparation of structurally complex materials on a molecular scale. Complexity in molecules is often associated with chirality - the fundamental property of a structure that renders it non-superimposable on its mirror image. The synthesis of chiral molecules is a challenging undertaking and we are interested in developing novel, atom efficient strategies for the asymmetric synthesis of highly desirable chiral fragments. Towards this aim, my research interests can be categorised into four main areas - asymmetric synthesis, biotransformations, combinatorial chemistry and bioorganic chemistry.
Research workers within my group will be exposed to a wide range of 'state of the art' synthetic and analytical techniques which are ideally suited to a career in both academia and industry. For more information visit the Bull Group homepage.
Research Interests
- Asymmetic Synthesis
- Biotransformations
- Combinatorial Chemistry
- Bioorganic Synthesis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Network
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Peptidomimetic Sulfinamide Foldamers That Are ‘Chiral at Sulfur’
21/06/21 → 20/06/24
Project: UK charity
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IAA - Novel PMD repellents against DEET and insecticide resistant mosquitos
Engineering and Physical Sciences Research Council
1/10/21 → 30/04/22
Project: Research council
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IAA - New antibiotics for the treatment of drug-resistant bacterial infections
Engineering and Physical Sciences Research Council
1/09/21 → 30/06/22
Project: Research council
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IAA - PMD Mosquito Repellents
Engineering and Physical Sciences Research Council
1/10/20 → 30/06/21
Project: Research council
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An "oFF-ON-OFF" fluorescence protein-labeling probe for real-time visualization of the degradation of short-lived proteins in cellular systems
Reja, S. I., Hori, Y., Kamikawa, T., Yamasaki, K., Nishiura, M., Bull, S. D. & Kikuchi, K., 7 Feb 2022, In: Chemical Science. 13, 5, p. 1419-1427 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5′-triphosphate in Cellular Applications
Wu, L., Liu, J., Tian, X., Groleau, R. R., Feng, B., Yang, Y., Sedgwick, A. C., Han, H. H., Wang, Y., Wang, H. M., Huang, F., Bull, S. D., Zhang, H., Huang, C., Zang, Y., Li, J., He, X. P., Li, P., Tang, B., James, T. D., & 1 others , 12 Jan 2022, In: Journal of the American Chemical Society. 144, 1, p. 174-183 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Multi-objective Bayesian optimisation of a two-step synthesis of p-cymene from crude sulphate turpentine
Jorayev, P., Russo, D., Tibbetts, J. D., Schweidtmann, A. M., Deutsch, P., Bull, S. D. & Lapkin, A. A., 16 Jan 2022, In: Chemical Engineering Science. 247, 116938.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Polymer Indicator Displacement Assay: Electrochemical Glucose Monitoring Based on Boronic Acid Receptors and Graphene Foam Competitively Binding with Poly-Nordihydroguaiaretic Acid
Wikeley, S., Przybylowski, J., Lozano-Sanchez, P., Caffio, M., James, T., Bull, S., Fletcher, P. & Marken, F., 21 Feb 2022, In: The Analyst. 147, 4, p. 661-670 10 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Downloads (Pure) -
Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3Deoxy-hexulosonic Acid
Royer, S. F., Gao, X., Groleau, R., van der Kamp, M. W., Bull, S., Danson, M. J. & Crennell, S., 16 Sep 2022, In: ACS Catalysis. 12, 18, p. 11444-11455 12 p.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Data from "A bodipy based hydroxylamine sensor"
James, T. (Creator), Sedgwick, A. (Creator), Chapman, R. (Data Collector), Kim, G. (Data Collector), Yoon, J. (Supervisor), Bull, S. (Supervisor) & Peacock, L. (Data Collector), University of Bath, 2017
DOI: 10.15125/BATH-00381
Dataset
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Data for thesis "Diagnostic and Theranostic Sensor Systems"
Odyniec, M. (Creator), Bull, S. (Creator) & James, T. (Creator), University of Bath, 1 Apr 2020
DOI: 10.15125/BATH-00702
Dataset
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Boronate based fluorescence (ESIPT) probe for peroxynitrite
Sedgwick, A. (Creator), Sun, X. (Creator), Kim, G. (Creator), Yoon, J. (Creator), Bull, S. (Creator) & James, T. (Creator), University of Bath, 2016
DOI: 10.15125/BATH-00252
Dataset
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Selective Electrochemiluminescent Sensing of Saccharides using Boronic Acid-Modified Coreactant
James, T. (Creator), Li, H. (Data Collector), Sedgwick, A. (Data Collector), Li, M. (Data Collector), Blackburn, R. (Data Collector), Bull, S. (Project Member), Arbault, S. (Project Member), James, T. (Project Leader) & Sojic, N. (Project Leader), University of Bath, 2016
DOI: 10.15125/BATH-00254
Dataset
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A Simple Protocol for NMR Analysis of the Enantiomeric Excess of Chiral Diols Using an Achiral Diboronic Acid Template
Tickell, D. (Creator), Lampard, E. (Creator), Lowe, J. (Creator), James, T. (Creator) & Bull, S. (Creator), University of Bath, 2016
DOI: 10.15125/BATH-00211
Dataset