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Personal profile

Research interests

Synthetic chemistry is the cornerstone of the natural sciences where it serves as a fundamental technology for the preparation of structurally complex materials on a molecular scale. Complexity in molecules is often associated with chirality - the fundamental property of a structure that renders it non-superimposable on its mirror image. The synthesis of chiral molecules is a challenging undertaking and we are interested in developing novel, atom efficient strategies for the asymmetric synthesis of highly desirable chiral fragments. Towards this aim, my research interests can be categorised into four main areas - asymmetric synthesis, biotransformations, combinatorial chemistry and bioorganic chemistry.

Research workers within my group will be exposed to a wide range of 'state of the art' synthetic and analytical techniques which are ideally suited to a career in both academia and industry. For more information visit the Bull Group homepage.

Research Interests

  • Asymmetic Synthesis
  • Biotransformations
  • Combinatorial Chemistry
  • Bioorganic Synthesis

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Projects

RS International COST share with Japan

Bull, S.

The Royal Society

18/03/1912/03/21

Project: Research council

Strand 1b Smaller Scale 2019

James, T., Bull, S., Li, X., Sun, J., Feng, L., Xu, S., Li, M., Pu, K. & Chi, R.

11/01/2011/01/20

Project: Research-related funding

“Smart Materials and Molecules for Sustainable Chemical Technologies and Clean Energy”

Hintermair, U., James, T., Bull, S., Islam, S., Hill, M., Kasprzyk-Hordern, B., Marken, F., Squires, A., Kohn, R., Johnson, A., Krewald, V., Düren, T., Eslava, S., White, T. J., Chye, J., Dong, Z., Pumera, M., Su, H. & Chi, R.

30/05/1730/07/18

Project: Research-related funding

Research Output

A Three-Component Derivatization Protocol for Determining the Enantiopurity of Sulfinamides by 1H and 19F NMR Spectroscopy

Groleau, R. R., Chapman, R. S. L., Ley-Smith, H., Liu, L., James, T. D. & Bull, S. D., 17 Jan 2020, In : Journal of Organic Chemistry. 85, 2, p. 1208-1215

Research output: Contribution to journalArticle

Open Access

Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols

Wu, L., Tian, X., Groleau, R. R., Wang, J., Han, H. H., Reeksting, S. B., Sedgwick, A. C., He, X. P., Bull, S. D. & James, T. D., 2020, In : RSC Advances. 10, 23, p. 13496-13499 4 p.

Research output: Contribution to journalArticle

Open Access

Protein encapsulation: A new approach for improving the capability of small-molecule fluorogenic probes

Han, H. H., Sedgwick, A. C., Shang, Y., Li, N., Liu, T., Li, B. H., Yu, K., Zang, Y., Brewster, J. T., Odyniec, M. L., Weber, M., Bull, S. D., Li, J., Sessler, J. L., James, T. D., He, X. P. & Tian, H., 28 Jan 2020, In : Chemical Science. 11, 4, p. 1107-1113 7 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Protein Encapsulation: A Nanocarrier Approach to the Fluorescence Imaging of an Enzyme-Based Biomarker

Jia, Z., Han, H. H., Sedgwick, A. C., Williams, G. T., Gwynne, L., Brewster, J. T., Bull, S. D., Jenkins, A. T. A., He, X. P., Schönherr, H., Sessler, J. L. & James, T. D., 3 Jun 2020, In : Frontiers in Chemistry. 8, 389.

Research output: Contribution to journalArticle

Open Access
Open Access

Datasets

A Simple Protocol for NMR Analysis of the Enantiomeric Excess of Chiral Diols Using an Achiral Diboronic Acid Template

Tickell, D. (Creator), Lampard, E. (Creator), Lowe, J. (Creator), James, T. (Creator), Bull, S. (Creator), University of Bath, 2016

Dataset

Boronate based fluorescence (ESIPT) probe for peroxynitrite

Sedgwick, A. (Creator), Sun, X. (Creator), Kim, G. (Creator), Yoon, J. (Creator), Bull, S. (Creator) & James, T. (Creator), University of Bath, 2016

Dataset

Data from "A bodipy based hydroxylamine sensor"

James, T. (Creator), Sedgwick, A. (Creator), Chapman, R. (Data Collector), Kim, G. (Data Collector), Yoon, J. (Supervisor), Bull, S. (Supervisor) & Peacock, L. (Data Collector), University of Bath, 2017

Dataset

Thesis

Alcohol Dehydrogenases from the thermophile Geobacillus thermoglucosidasius

Author: Williams, L., 23 Nov 2016

Supervisor: Bull, S. (Supervisor) & Danson, M. (Supervisor)

Student thesis: Doctoral ThesisPhD

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A Novel Methodology for the Asymmetric Synthesis of beta-Lactams and beta-Amino Acids

Author: Evans, C., 30 Jun 2012

Supervisor: Bull, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Benzoxaboroles and Boronic Acids for Sensing Applications

Author: Lampard, E., 12 Jan 2018

Supervisor: James, T. (Supervisor) & Bull, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Carbohydrate Directed Photoaffinity Labelling

Author: Fowle, C., 24 Jan 2018

Supervisor: James, T. (Supervisor) & Bull, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Catalytic Conversion of Terpene Feedstocks into value-added Chemicals and Commodity Chemicals

Author: Cunningham, W., 20 Sep 2018

Supervisor: Bull, S. (Supervisor) & Plucinski, P. (Supervisor)

Student thesis: Doctoral ThesisPhD

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