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Research Output 1994 2019

2019
52 Downloads (Pure)

The Role of Vascular Endothelial Growth Factor in Systemic Sclerosis

Flower, V. A., Barratt, S. L., Ward, S. & Pauling, J. D., 2019, In : Current Rheumatology Reviews. 15, 2, p. 99-109 11 p.

Research output: Contribution to journalReview article

Open Access
File
Systemic Scleroderma
Vascular Endothelial Growth Factor A
Protein Isoforms
Precision Medicine
Disease Management
2017
8 Citations (Scopus)
42 Downloads (Pure)

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium

Colleypriest, B. J., Burke, Z. D., Griffiths, L. P., Chen, Y., Yu, W-Y., Jover, R., Bock, M., Biddlestone, L., Quinlan, J. M., Ward, S. G., Mark Farrant, J., Slack, J. M. W. & Tosh, D., 1 Jan 2017, In : Differentiation. 93, p. 39-49 11 p.

Research output: Contribution to journalArticle

Open Access
File
Barrett Esophagus
Metaplasia
Organ Culture Techniques
Epithelium
Phenotype
3 Citations (Scopus)

Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration.

Ball, J., Vlisidou, I., Blunt, M., Wood, W. & Ward, S., 1 May 2017, In : The Journal of Immunology. 198, 9, p. 3679-3689 11 p.

Research output: Contribution to journalArticle

Open Access
Hydrogen Peroxide
T-Lymphocytes
Chemotaxis
src-Family Kinases
Chemokine Receptors
13 Citations (Scopus)

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

Kassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. & Van Den Elsen, J., 23 Feb 2017, In : Scientific Reports. 7, p. 1-12 12 p., 42874.

Research output: Contribution to journalArticle

Open Access
Macrophage Migration-Inhibitory Factors
Alzheimer Disease
Glucose
Hyperglycemia
Aptitude
1 Citation (Scopus)
29 Downloads (Pure)

The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor

Ward, S., Roux, B., Bauer, C., McNeish, A. & Cottrell, G., 28 Sep 2017, In : Open Access Scientific Reports. 7, 1, p. 1-18 18 p., 12389.

Research output: Contribution to journalArticle

Open Access
File
Receptor Activity-Modifying Protein 2
Calcitonin Receptor-Like Protein
Adrenomedullin
Ubiquitination
Adrenomedullin Receptors

Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma

Miles, J., Applebee, C., Leboucher, P., Lopez-Fernandez, S., Lee, D-J., Guarch, R., Ward, S., Parker, P., Lopez, J. & Larijani, B., 1 Dec 2017, In : BBA Clinical. 8, p. 97-102 14 p.

Research output: Contribution to journalArticle

Open Access
Proto-Oncogene Proteins c-akt
Renal Cell Carcinoma
Neoplasms
Immunohistochemistry
Activation Analysis
2014
4 Citations (Scopus)
52 Downloads (Pure)

Phosphoinositide 3-Kinase Alpha-Dependent Regulation of Branching Morphogenesis in Murine Embryonic Lung: Evidence for a Role in Determining Morphogenic Properties of FGF7

Carter, E., Miron-Buchacra, G., Goldoni, S., Danahay, H., Westwick, J., Watson, M. L., Tosh, D. & Ward, S. G., 2 Dec 2014, In : PLoS ONE. 9, 12, p. 1-22 22 p., e113555.

Research output: Contribution to journalArticle

Open Access
1-Phosphatidylinositol 4-Kinase
phosphatidylinositol 3-kinase
Phosphatidylinositols
Morphogenesis
morphogenesis
15 Citations (Scopus)
141 Downloads (Pure)

PI3K inhibitors as potential therapeutics for autoimmune disease

Ball, J., Archer, S. & Ward, S., Aug 2014, In : Drug Discovery Today. 19, 8, p. 1195-1199 5 p.

Research output: Contribution to journalArticle

Open Access
File
1-Phosphatidylinositol 4-Kinase
Autoimmune Diseases
Immunosuppressive Agents
Immune System
Anti-Inflammatory Agents
2013
18 Citations (Scopus)
Cell-Penetrating Peptides
Therapeutic Uses
Innate Immunity
Epithelial Cells
Peptides
6 Citations (Scopus)

Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naïve human CD4+ T lymphocytes

Foster, J. G., Carter, E., Kilty, I., Mackenzie, A. B. & Ward, S. G., 15 Feb 2013, In : The Journal of Immunology. 190, 4, p. 1551-1559 9 p.

Research output: Contribution to journalArticle

Superoxides
Phosphatidylserines
Adenosine Triphosphate
T-Lymphocytes
Down-Regulation
2012
34 Citations (Scopus)
Infrared lasers
Speckle
Lasers
Imaging techniques
Perfusion
11 Citations (Scopus)

Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels

Harris, S. J., Ciuclan, L., Finan, P. M., Wymann, M. P., Walker, C., Westwick, J., Ward, S. G. & Thomas, M. J., Dec 2012, In : European Journal of Immunology. 42, 12, p. 3394-3404 11 p.

Research output: Contribution to journalArticle

Interleukin-17
T-Lymphocytes
Phosphorylation
Cytokines
Phosphatidylinositol 3-Kinases
74 Citations (Scopus)

Inhibition of PI3K signaling Spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies

Foster, J. G., Blunt, M. D., Carter, E. & Ward, S. G., 1 Oct 2012, In : Pharmacological Reviews. 64, 4, p. 1027-1054 28 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Phosphatidylinositol 3-Kinases
Autoimmune Diseases
Therapeutics
Protein Isoforms
14 Citations (Scopus)
83 Downloads (Pure)
Open Access
File
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositol 3-Kinases
Immune System
Pharmacology
Lipids
3 Citations (Scopus)

Phosphoinositide 3-kinases and leukocyte migration

Ward, S. G., 2012, In : Current Immunology Reviews. 8, 2, p. 154-160 7 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Leukocytes
T-Lymphocytes
Cell Movement
Chemotactic Factors

Spurs in the hunt for new immunomodulatory drug targets

Ward, S. G. & O'Neill, L. A., Aug 2012, In : Current Opinion in Pharmacology. 12, 4, p. 439-443

Research output: Contribution to journalArticle

20 Citations (Scopus)
105 Downloads (Pure)

Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia

Blunt, M. D. & Ward, S. G., Aug 2012, In : Current Opinion in Pharmacology. 12, 4, p. 444-451

Research output: Contribution to journalArticle

Open Access
File
src Homology Domains
Phosphatidylinositol 3-Kinases
Immune System
Protein Isoforms
Leukemia
2011
16 Citations (Scopus)

Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility

Harris, S. J., Parry, R. V., Foster, J. G., Blunt, M. D., Wang, A., Marelli-Berg, F., Westwick, J. & Ward, S. G., 15 Apr 2011, In : The Journal of Immunology. 186, 8, p. 4936-4945 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Cell Movement
T-Lymphocytes
Lipids
Microvilli
42 Citations (Scopus)

Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes

Korniejewska, A., McKnight, A. J., Johnson, Z., Watson, M. L. & Ward, S. G., Apr 2011, In : Immunology. 132, 4, p. 503-515 13 p.

Research output: Contribution to journalArticle

T-Lymphocytes
CXCR3 Receptors
Phosphorylation
Ligands
Chemokine Receptors
12 Citations (Scopus)

Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes

Ward, S. G., Westwick, J. & Harris, S., Jul 2011, In : Immunology Letters. 138, 1, p. 15-18 4 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphoric Monoester Hydrolases
Protein Isoforms
T-Lymphocytes
Lipids
27 Citations (Scopus)

Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1

Dowden, J., Pike, R. A., Parry, R. V., Hong, W., Muhsen, U. A. & Ward, S. G., 26 Oct 2011, In : Organic and Biomolecular Chemistry. 9, 22, p. 7814-7821 8 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
inhibitors
Binding Sites
proteins
Molecules
2010
3 Citations (Scopus)

Analysis of CXCR3 and atypical variant expression and signalling in human T lymphocytes

Korniejewska, A., Watson, M. L. & Ward, S. G., 2010, T-Cell Trafficking. Marelli-Berg, F. M. & Nourshargh, S. (eds.). Humana Press, Vol. 606. p. 125-147 23 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

T-Lymphocytes
Chemokines
Chemokine CXCL11
Chemokine CXCL9
Anti-Inflammatory Agents
17 Citations (Scopus)

Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells

Willox, I., Mirkina, I., Westwick, J. & Ward, S. G., Aug 2010, In : Molecular Immunology. 47, 14, p. 2367-2377 11 p.

Research output: Contribution to journalArticle

Fetal Blood
Phosphatidylinositol 3-Kinases
Mast Cells
Protein Isoforms
Chemokine Receptors
18 Citations (Scopus)

Fine tuning T lymphocytes: A role for the lipid phosphatase SHIP-1

Parry, R. V., Harris, S. J. & Ward, S. G., 1 Mar 2010, In : Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics. 1804, 3, p. 592-597 6 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
T-Lymphocytes
Lipids
Autoimmune Diseases
Immune System
8 Citations (Scopus)

Modulation of P-glycoprotein activity by the substituted quinoxalinone compound QA3 in adriamycin-resistant K562/A02 cells

Sun, L. R., Zhong, J. L., Cui, S. X., Li, X., Ward, S. G., Shi, Y. Q., Zhang, X. F., Cheng, Y. N., Gao, J. J. & Qu, X. J., 2010, In : Pharmacological Reports. 62, 2, p. 333-342 10 p.

Research output: Contribution to journalArticle

K562 Cells
Multiple Drug Resistance
P-Glycoprotein
varespladib methyl
Doxorubicin
21 Citations (Scopus)

Protein arginine methylation: a new handle on T lymphocytes?

Parry, R. V. & Ward, S. G., 2010, In : Trends in Immunology. 31, 4, p. 164-169 6 p.

Research output: Contribution to journalArticle

Methylation
Arginine
T-Lymphocytes
Transferases
Proteins
48 Citations (Scopus)

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases

Dowden, J., Hong, W., Parry, R. V., Pike, R. A. & Ward, S. G., Apr 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 7, p. 2103-2105 3 p.

Research output: Contribution to journalArticle

2009
24 Citations (Scopus)

Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia

Colleypriest, B. J., Palmer, R. M., Ward, S. G. & Tosh, D., Jul 2009, In : Trends in Molecular Medicine. 15, 7, p. 313-322 10 p.

Research output: Contribution to journalArticle

Barrett Esophagus
Inflammation
Metaplasia
Genes
Adenocarcinoma
40 Citations (Scopus)

Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration

Wang, S. B., Cheng, Y. N., Cui, S. X., Zhong, J. L., Ward, S. G., Sun, L. R., Chen, M. H., Kokudo, N., Tang, W. & Qu, X. J., 2009, In : Clinical & Experimental Metastasis. 26, 5, p. 469-477 9 p.

Research output: Contribution to journalArticle

Cell Movement
Endothelial Cells
Growth
Hepatocellular Carcinoma
Vascular Endothelial Growth Factor A
37 Citations (Scopus)

How does inflammation cause Barrett's metaplasia?

Colleypriest, B. J., Ward, S. G. & Tosh, D., Dec 2009, In : Current Opinion in Pharmacology. 9, 6, p. 721-726 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation

Ward, S. G. & Marelli-Berg, F. M., 2009, In : Biochemical Journal. 418, 1, p. 13-27 15 p.

Research output: Contribution to journalArticle

T-cells
Chemokines
Navigation
T-Lymphocytes
Antigens
2 Citations (Scopus)

Millipede-like lymphocyte crawling: feeling the way with filopodia

Ward, S. G., 20 Mar 2009, In : Immunity. 30, 3, p. 315-317 3 p.

Research output: Contribution to journalArticle

Pseudopodia
Emotions
Lymphocytes
Transendothelial and Transepithelial Migration
Locomotion
4 Citations (Scopus)

New insights into mechanisms of gastrointestinal inflammation and cancer

Ward, S. G. & Mrsny, R. J., 2009, In : Current Opinion in Pharmacology. 9, 6, p. 677-679 3 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Inflammation
22 Citations (Scopus)

PI3K isoforms as drug targets in inflammatory diseases: Lessons from pharmacological and genetic strategies

Harris, S. J., Foster, J. G. & Ward, S. G., Nov 2009, In : Current Opinion in Investigational Drugs. 10, 11, p. 1151-1162 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Protein Isoforms
Pharmacology
Anti-Inflammatory Agents
Pharmaceutical Preparations
7 Citations (Scopus)

Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells

Sun, L. R., Li, X., Cheng, Y. N., Yuan, H. Y., Chen, M. H., Tang, W., Ward, S. G. & Qu, X. J., 2009, In : Biomedicine & Pharmacotherapy. 63, 3, p. 202-208 7 p.

Research output: Contribution to journalArticle

Quinoxalines
K562 Cells
Multiple Drug Resistance
varespladib methyl
Doxorubicin
2008
33 Citations (Scopus)

Des-gamma-carboxy prothrombin increases the expression of angiogenic factors in human hepatocellular carcinoma cells

Gao, F. J., Cui, S. X., Chen, M. H., Cheng, Y. N., Sun, L. R., Ward, S. G., Kokudo, N., Tang, W. & Qu, X. J., 2008, In : Life Sciences. 83, 23-24, p. 815-820 6 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Prothrombin
Hepatocellular Carcinoma
Cells
Cell growth
30 Citations (Scopus)

Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists

Webb, A., Johnson, A., Fortunato, M., Platt, A., Crabbe, T., Christie, M. I., Watt, G. F., Ward, S. G. & Jopling, L. A., Oct 2008, In : Journal of Leukocyte Biology. 84, 4, p. 1202-1212 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Galloyl cyclic-imide derivative CH1104I inhibits tumor invasion through suppressing matrix metalloproteinase activity

Chen, M-H., Cui, S-X., Cheng, Y-N., Sun, L-R., Li, Q-B., Xu, W-F., Ward, S. G., Tang, W. & Qu, X-J., 2008, In : Anti-Cancer Drugs. 19, 10, p. 957-965 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2

Wang, S. B., Cheng, Y. N., Wang, F. S., Sun, L. R., Liu, C. H., Chen, G. J., Li, Y. H., Ward, S. G. & Qu, X. J., 2008, In : Biomedicine & Pharmacotherapy. 62, 5, p. 297-302 6 p.

Research output: Contribution to journalArticle

Ink
Matrix Metalloproteinase 2
Polysaccharides
Matrix Metalloproteinase 9
Cell Movement
5 Citations (Scopus)

Long term cannabinoid receptor (CBI) blockade in obesity: Implications for the development of colorectal cancer

Wright, K. L., Robertson, D. A. F., Moyer, M. P. & Ward, S. G., 2008, In : International Journal of Cancer. 122, 8, p. 1920-1921 2 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
Anti-Inflammatory Agents
Inflammation
Pharmaceutical Preparations
Physiological Phenomena
Biological Science Disciplines
58 Citations (Scopus)

Phosphoinositide lipid phosphatases: Natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes

Harris, S. J., Parry, R. V., Westwick, J. & Ward, S. G., 2008, In : Journal of Biological Chemistry. 283, 5, p. 2465-2469 5 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
T-cells
Phosphatidylinositols
Phosphoric Monoester Hydrolases
Phosphotransferases
2007

P13Kγ is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA

Smith, L. D., Hickman, E. S., Parry, R. V., Westwick, J. & Ward, S. G., 2007, In : Cellular Signalling. 19, p. 2528-2539 12 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond

Medina-Tato, D. A., Ward, S. G. & Watson, M. L., 2007, In : Immunology. 121, p. 448-461 14 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

PI3K gamma is the dominant isoform involved in migratory responses of human T lymphocytes: Effects of ex vivo maintenance and limitations of non-viral delivery of siRNA

Smith, L. D., Hickman, E. S., Parry, R. V., Westwick, J. & Ward, S. G., 2007, In : Cellular Signalling. 19, 12, p. 2528-2539 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Small Interfering RNA
Protein Isoforms
Maintenance
T-Lymphocytes
30 Citations (Scopus)

Signalling to suit function: tailoring phosphoinositide 3-kinase during T-cell activation

Parry, R. V., Riley, J. L. & Ward, S. G., 2007, In : Trends in Immunology. 28, 4, p. 161-168 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
T-Lymphocytes
Inducible T-Cell Co-Stimulator Protein
CTLA-4 Antigen
Proto-Oncogene Proteins c-akt
47 Citations (Scopus)

Temporal variation in CB2R levels following T lymphocyte activation: Evidence that cannabinoids modulate CXCL12-induced chemotaxis

Coopman, K., Smith, L. D., Wright, K. L. & Ward, S. G., 2007, In : International Immunopharmacology. 7, 3, p. 360-371 12 p.

Research output: Contribution to journalArticle

Cannabinoids
Chemotaxis
Lymphocyte Activation
Cannabinoid Receptors
T-Lymphocytes
72 Citations (Scopus)

The PI3K inhibitor arsenal: choose your weapon!

Crabbe, T., Welham, M. & Ward, S., 2007, In : Trends in Biochemical Sciences. 32, 10, p. 450-456 7 p.

Research output: Contribution to journalArticle

Arsenals
Weapons
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphotransferases
2 Citations (Scopus)

T-lymphocyte navigation and migration: beyond the PI3K paradigm

Smith, L., Webb, A. & Ward, S. G., 2007, In : Biochemical Society Transactions. 35, p. 193-198 6 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
T-cells
Phosphatidylinositols
Navigation
Phosphotransferases
2006

Cross-regulation between class IA phosphatidyl inositol 3-kinase p110 beta and p110 delta isoforms

Medina-Tato, D. A., Ward, S. G. & Watson, M. L., 2006, In : Inflammation Research. 55, Suppl 2, p. S124-S124

Research output: Contribution to journalArticle