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Research Output 2001 2019

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2019
2 Citations (Scopus)

BU10038 as a safe opioid analgesic with fewer side effects after systemic and intrathecal administration in primates

Kiguchi, N., Ding, H., Cami-Kobeci, G., Sukhtankar, D. D., Czoty, P. W., DeLoid, H. B., Hsu, F. -C., Toll, L., Husbands, S. & Ko, M. C., 1 Mar 2019, In : British Journal of Anaesthesia.

Research output: Contribution to journalArticle

Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys

Flynn, S. M., Epperly, P. M., Davenport, A. T., Cami-Kobeci, G., Husbands, S. M., Ko, M. C. & Czoty, P. W., 10 Apr 2019, In : Neuropsychopharmacology. 2019, 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Long-lasting effects of methocinnamox on opioid self-administration in rhesus monkeys

Maguire, D. R., Gerak, L. R., Woods, J. H., Husbands, S., Disney, A. & France, C. P., 1 Jan 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 88-99 12 p., 252353.

Research output: Contribution to journalArticle

2018
6 Citations (Scopus)

Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice

Almatroudi, A. M. I., Ostovar, M., Bailey, C., Husbands, S. & Bailey, S., 1 Jul 2018, In : British Journal of Pharmacology. 175, 14, p. 2869-2880 12 p.

Research output: Contribution to journalArticle

Open Access
File
Buprenorphine
kappa Opioid Receptor
Narcotic Antagonists
mu Opioid Receptor
Analgesia
6 Citations (Scopus)

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 binding site in human brain

Tyacke, R. J., Myers, J. F. M., Venkataraman, A., Mick, I., Turton, S., Passchier, J., Husbands, S. M., Rabiner, E. A., Gunn, R. N., Murphy, P. S., Parker, C. A. & Nutt, D. J., 1 Oct 2018, In : Journal of Nuclear Medicine. 59, 10, p. 1597-1602 6 p.

Research output: Contribution to journalArticle

Open Access

Synthesis, biological evaluation, and SAR studies of 14β-phenylacetyl substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones derivatives: Ligands with mixed NOP and opioid receptor profile

Kumar, V., Polgar, W. E., Cami-Kobeci, G., Thomas, M. P., Khroyan, T. V., Toll, L. & Husbands, S. M., 19 Sep 2018, In : Frontiers in Psychiatry . 9, SEP, p. 1-10 10 p., 430.

Research output: Contribution to journalArticle

Open Access
Open Access
kappa Opioid Receptor
Narcotic Antagonists
Opioid Receptors
Depression
Opioid Analgesics
17 Citations (Scopus)

The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

Hill, R., Disney, A., Conibear, A., Sutcliffe, K., Dewey, W., Husbands, S., Bailey, C., Kelly, E. & Henderson, G., 1 Jul 2018, In : British Journal of Pharmacology. 175, 13, p. 2653-2661 9 p.

Research output: Contribution to journalArticle

Open Access
File
mu Opioid Receptor
Respiration
Morphine
Arrestin
Tidal Volume
2017

Additive effects of 3,4-methylenedioxymethamphetamine (MDMA) and compassionate imagery on self-compassion in recreational users of ecstasy

Kamboj, S. K., Wallden, Y. S. E., Falconer, C. J., Alotaibi, M. R. M., Blagbrough, I., Husbands, S. & Freeman, T., 6 Nov 2017, In : Mindfulness. 9, 4, p. 1134-1145 12 p.

Research output: Contribution to journalArticle

Open Access
N-Methyl-3,4-methylenedioxyamphetamine
Imagery (Psychotherapy)
self-criticism
empathy
facial expression
3 Citations (Scopus)
Open Access
File
Gastrointestinal Transit
Irritable Bowel Syndrome
Opioid Receptors
Abdominal Pain
Diarrhea
2016
36 Citations (Scopus)

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

Ding, H., Czoty, P. W., Kiguchi, N., Cami-Kobeci, G., Sukhtankar, D. D., Nader, M. A., Husbands, S. M. & Ko, M-C., 13 Sep 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. E5511-5518 8 p.

Research output: Contribution to journalArticle

Open Access
File
Peptide Receptors
Opioid Peptides
Primates
Opioid Analgesics
Haplorhini
4 Citations (Scopus)

Behavioural tasks sensitive to acute abstinence and predictive of smoking cessation success: a systematic review and meta-analysis

Grabski, M., Curran, H. V., Nutt, D. J., Husbands, S. M., Freeman, T. P., Fluharty, M. & Munafò, M. R., Dec 2016, In : Addiction. 111, 12, p. 2134-2144

Research output: Contribution to journalArticle

Open Access
Smoking Cessation
Meta-Analysis
Confidence Intervals
Smoking
Task Performance and Analysis
2015
5 Citations (Scopus)
Open Access
File
11 Citations (Scopus)

Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice

Zielińska, M., Ben Haddou, T., Cami-Kobeci, G., Sałaga, M., Jarmuż, A., Padysz, M., Kordek, R., Spetea, M., Husbands, S. M. & Fichna, J., 15 Oct 2015, In : European Journal of Pharmacology. 765, p. 582-90 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

BU08073 a buprenorphine analog with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice

Khroyan, T. V., Wu, J., Polgar, W. E., Cami-Kobeci, G., Fotaki, N., Husbands, S. M. & Toll, L., Jan 2015, In : British Journal of Pharmacology. 172, 2, p. 668-680 13 p.

Research output: Contribution to journalArticle

Open Access
File
Buprenorphine
Narcotic Antagonists
mu Opioid Receptor
Opioid Receptors
Opioid Analgesics
9 Citations (Scopus)

C7β-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at Mu opioid receptors

Cueva, J. P., Roche, C., Ostovar, M., Kumar, V., Clark, M. J., Hillhouse, T. M., Lewis, J. W., Traynor, J. R. & Husbands, S. M., 28 May 2015, In : Journal of Medicinal Chemistry. 58, 10, p. 4242-4249 8 p.

Research output: Contribution to journalArticle

File
Buprenorphine
Peptide Receptors
Narcotic Antagonists
mu Opioid Receptor
Opioid Analgesics
28 Citations (Scopus)

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

Almatroudi, A., Husbands, S. M., Bailey, C. P. & Bailey, S. J., 1 Jul 2015, In : Journal of Psychopharmacology . 29, 7, p. 812-821 10 p.

Research output: Contribution to journalArticle

Open Access
File
Buprenorphine
Naltrexone
Antidepressive Agents
kappa Opioid Receptor
Opiate Alkaloids

Meet our editorial board member

Husbands, S., 1 Aug 2015, In : Mini-Reviews in Medicinal Chemistry. 15, 10, p. 797 1 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Lowe, J. D., Sanderson, H. S., Cooke, A. E., Ostovar, M., Tsisanova, E., Withey, S. L., Chavkin, C., Husbands, S. M., Kelly, E., Henderson, G. & Bailey, C. P., Aug 2015, In : Molecular Pharmacology. 88, 2, p. 347-356

Research output: Contribution to journalArticle

Open Access
File
G-Protein-Coupled Receptor Kinase 3
G-Protein-Coupled Receptor Kinase 2
Locus Coeruleus
mu Opioid Receptor
Ala(2)-MePhe(4)-Gly(5)-enkephalin
23 Citations (Scopus)

Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors

Blazer, L. L., Storaska, A. J., Jutkiewicz, E. M., Turner, E. M., Calcagno, M., Wade, S. M., Wang, Q., Huang, X-P., Traynor, J. R., Husbands, S. M., Morari, M. & Neubig, R. R., 16 Sep 2015, In : ACS Chemical Neuroscience. 6, 6, p. 911-919 8 p.

Research output: Contribution to journalArticle

Open Access
File
RGS Proteins
Parkinson Disease
GTP-Binding Protein Regulators
Raclopride
Pharmacologic Actions
278 Citations (Scopus)

Structural insights into μ-opioid receptor activation

Huang, W., Manglik, A., Venkatakrishnan, A. J., Laeremans, T., Feinberg, E. N., Sanborn, A. L., Kato, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., Granier, S., Gmeiner, P., Husbands, S. M., Traynor, J. R., Weis, W. I., Steyaert, J., Dror, R. O. & Kobilka, B. K., 20 Aug 2015, In : Nature. 524, 7565, p. 315-321 7 p.

Research output: Contribution to journalArticle

Open Access
File
mu Opioid Receptor
Chemical activation
Adrenergic beta-2 Receptors
Morphinans
Muscarinic M2 Receptors
2014
23 Citations (Scopus)
Open Access
File
Buprenorphine
Naltrexone
Drug Combinations
Cocaine
Morphine
11 Citations (Scopus)

Characterization of BU09059: A novel potent selective κ-receptor antagonist

Casal-Dominguez, J. J., Furkert, D., Ostovar, M., Teintang, L., Clarke, M. J., Traynor, J. R., Husbands, S. M. & Bailey, S. J., 19 Mar 2014, In : ACS Chemical Neuroscience. 5, 3, p. 177-184 8 p.

Research output: Contribution to journalArticle

Open Access
File
kappa Opioid Receptor
Pharmacodynamics
Narcotic Antagonists
Opioid Receptors
Psychiatry
17 Citations (Scopus)

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline Binding Sites in Rhesus Brain

Parker, C. A., Nabulsi, N., Holden, D., Lin, S-F., Cass, T., Labaree, D., Kealey, S., Gee, A. D., Husbands, S. M., Quelch, D., Carson, R. E., Nutt, D. J., Huang, Y. & Tyacke, R. J., 1 May 2014, In : The Journal of Nuclear Medicine. 55, 5, p. 838-844 7 p.

Research output: Contribution to journalArticle

Open Access
File
Imidazolines
Binding Sites
Ligands
Brain
Macaca mulatta
3 Citations (Scopus)

Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics

Ju, M., Scott-ward, T. S., Liu, J., Khuituan, P., Li, H., Cai, Z., Husbands, S. M. & Sheppard, D. N., 1 Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 265-278 13 p.

Research output: Contribution to journalArticle

File
Sodium Potassium Chloride Symporter Inhibitors
Cystic Fibrosis Transmembrane Conductance Regulator
Furosemide
Xipamide
Bumetanide
9 Citations (Scopus)
Open Access
File
Opioid Receptors
Opioid Analgesics
Recurrence
Street Drugs
Therapeutics
20 Citations (Scopus)
Gastrointestinal Motility
Irritable Bowel Syndrome
Diarrhea
Pain
Gastrointestinal Transit
13 Citations (Scopus)

Palladium-mediated oxidative carbonylation reactions for the synthesis of 11C-radiolabelled ureas

Kealey, S., Husbands, S. M., Bennacef, I., Gee, A. D. & Passchier, J., Apr 2014, In : Journal of Labelled Compounds & Radiopharmaceuticals. 57, 4, p. 202-208 7 p.

Research output: Contribution to journalArticle

Carbonylation
Palladium
Amines
Urea
Carbon Monoxide
2 Citations (Scopus)

Pyrrolo- and pyridomorphinans: Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists

Kumar, V., Clark, M. J., Traynor, J. R., Lewis, J. W. & Husbands, S. M., 1 Aug 2014, In : Bioorganic and Medicinal Chemistry. 22, 15, p. 4067-4072

Research output: Contribution to journalArticle

File
Naltrexone
Narcotic Antagonists
Oxymorphone
Opioid Analgesics
delta Opioid Receptor
6 Citations (Scopus)

Selectively promiscuous opioid ligands: Discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity

Kumar, V., Ridzwan, I. E., Grivas, K., Lewis, J. W., Clark, M. J., Meurice, C., Jimenez-Gomez, C., Pogozheva, I., Mosberg, H., Traynor, J. R. & Husbands, S. M., 22 May 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4049-4057 9 p.

Research output: Contribution to journalArticle

Open Access
File
Peptide Receptors
Opioid Peptides
Opioid Receptors
Opioid Analgesics
Ligands
2013
34 Citations (Scopus)
Peptide Receptors
mu Opioid Receptor
Neuralgia
Buprenorphine
Ligands
17 Citations (Scopus)

Imaging imidazoline-I binding sites in porcine brain using C-BU99008

Kealey, S., Turner, E. M., Husbands, S. M., Salinas, C. A., Jakobsen, S., Tyacke, R. J., Nutt, D. J., Parker, C. A. & Gee, A. D., Jan 2013, In : The Journal of Nuclear Medicine. 54, 1, p. 139-144 6 p.

Research output: Contribution to journalArticle

Imidazolines
Swine
Binding Sites
Brain
Ligands
8 Citations (Scopus)

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor

Casal-Dominguez, J. J., Clark, M., Traynor, J. R., Husbands, S. M. & Bailey, S. J., Feb 2013, In : Journal of Psychopharmacology. 27, 2, p. 192-202 11 p.

Research output: Contribution to journalArticle

Open Access
File
naltrindole
kappa Opioid Receptor
Ligands
Ileum
Injections
25 Citations (Scopus)

Orvinols with mixed kappa/mu opioid receptor agonist activity

Greedy, B. M., Bradbury, F., Thomas, M. P., Grivas, K., Cami-Kobeci, G., Archambeau, A., Bosse, K., Clark, M. J., Aceto, M., Lewis, J. W., Traynor, J. R. & Husbands, S. M., 2013, In : Journal of Medicinal Chemistry. 56, 8, p. 3207-3216 10 p.

Research output: Contribution to journalArticle

Open Access
File
kappa Opioid Receptor
mu Opioid Receptor
Ligands
Cocaine
Analgesics
2012
18 Citations (Scopus)

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline 2 binding site

Tyacke, R. J., Fisher, A., Robinson, E. S., Grundt, P., Turner, E. M., Husbands, S. M., Hudson, A. L., Parker, C. A. & Nutt, D. J., Jun 2012, In : Synapse. 66, 6, p. 542-551 10 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Binding Sites
Ligands
In Vitro Techniques
2-imidazoline
23 Citations (Scopus)

Small molecule inhibitors of regulators of G protein signaling (RGS) proteins

Turner, E. M., Blazer, L. L., Neubig, R. R. & Husbands, S. M., 9 Feb 2012, In : ACS Medicinal Chemistry Letters. 3, 2, p. 146-150 5 p.

Research output: Contribution to journalArticle

Open Access
File
RGS Proteins
Solubility
Molecules
GTP-Binding Protein Regulators
Lead compounds
2011

(11)C Urea synthesis via palladium(II)-mediated oxidative carbonylation of amines

Kealey, S., Gee, A. D., Husbands, S. M., Bennacef, I. & Passchier, J., Sep 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, Supplement 1, p. S108

Research output: Contribution to journalArticle

36 Citations (Scopus)

A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins

Blazer, L. L., Zhang, H. M., Casey, E. M., Husbands, S. M. & Neubig, R. R., 19 Apr 2011, In : Biochemistry. 50, 15, p. 3181-3192 12 p.

Research output: Contribution to journalArticle

RGS Proteins
GTP-Binding Protein Regulators
Cysteine
Molecules
Alkylating Agents

Anxiolytic effects of novel kappa-opioid receptor antagonists in the elevated plus maze

Bailey, S. J., Casal-Dominguez, J. J. & Husbands, S. M., 2011, In : Journal of Psychopharmacology. 25, 8, p. A76

Research output: Contribution to journalArticle

Copper(I) tris(pyrazolyl)borate complexes for use in positron emission tomograhpy

Kealey, S., Jennings, L. E., Miller, P. W., Gee, A. D., Plisson, C., White, A. J. P., Husbands, S. & Long, N. J., Jun 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, 7, p. 392-392 1 p.

Research output: Contribution to journalArticle

Positrons
Carbon Monoxide
Copper
phosphine
Electrons

Copper(I) tris(pyrazolyl)borate complexes for use in positron emission tomography

Long, N., Kealey, S., Jennings, L., Miller, P., Gee, A., Plisson, C., White, A. & Husbands, S. M., Sep 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, Supplement 1, p. S98

Research output: Contribution to journalArticle

53 Citations (Scopus)

Microfluidic reactions using C-11 carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer

Kealey, S., Plisson, C., Collier, T. L., Long, N. J., Husbands, S. M., Martarello, L. & Gee, A. D., 2011, In : Organic and Biomolecular Chemistry. 9, 9, p. 3313-3319 7 p.

Research output: Contribution to journalArticle

Positron emission tomography
Microfluidics
Carbon Monoxide
Positron-Emission Tomography
carbon monoxide

Solution (11)C carbonylation chemistry for the synthesis of a PET tracer - (11)C MK0233

Kealey, S., Plisson, C., Collier, T. L., Long, N. J., Husbands, S. M. & Gee, A. D., Sep 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, Supplement 1, p. S107

Research output: Contribution to journalArticle

21 Citations (Scopus)

Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine

Cami-Kobeci, G., Polgar, W. E., Khroyan, T. V., Toll, L. & Husbands, S. M., 13 Oct 2011, In : Journal of Medicinal Chemistry. 54, 19, p. 6531-6537 7 p.

Research output: Contribution to journalArticle

Open Access
File
Buprenorphine
Peptide Receptors
Opioid Analgesics
mu Opioid Receptor
Substance-Related Disorders

Synthesis and in vivo evaluation of (11)C BU99008 as a ligand for the imidazoline I(2) binding site

Kealey, S., Husbands, S. M., Casey, E., Salinas, C. A., Parker, C. A., Jakobsen, S., Tyacke, R. J., Nutt, D. J. & Gee, A. D., Sep 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, Supplement 1, p. S304

Research output: Contribution to journalArticle

Universal opioid receptor ligands - buprenorphine and related orvinols

Cami-Kobeci, G., Polgar, W. E., Khroyan, T. V., Toll, L. & Husbands, S. M., 2011, In : Pharmacological Reports. 63, 1, p. 210 1 p.

Research output: Contribution to journalArticle

2010

In vivo characterisation of 5'-amino and amidino-alkyl,naltrindole derivatives at the kappa-opioid receptor

Bailey, S. J., Casal-Dominguez, J. J., Bradbury, F. A., Traynor, J. R. & Husbands, S. M., Aug 2010, In : Journal of Psychopharmacology. 24, Supplement 3, p. A42

Research output: Contribution to journalArticle