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2020

OREX-1019: a novel treatment for opioid use disorder and relapse prevention

Maguire, D., Gerak, L., Cami-Kobeci, G., Husbands, S., France, C., Belli, B. & Flynn, P., 1 Feb 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 205-215

Research output: Contribution to journalArticle

Open Access
2019

19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids

Naqi, H., Woodman, T., Husbands, S. & Blagbrough, I., 28 Jun 2019, In : Analytical Methods. 11, 24, p. 3090-3100 11 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Naqi, H., Husbands, S. & Blagbrough, I., 7 Oct 2019, In : Analytical Methods. 11, 37, p. 4795-4807 13 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)

BU10038 as a safe opioid analgesic with fewer side effects after systemic and intrathecal administration in primates

Kiguchi, N., Ding, H., Cami-Kobeci, G., Sukhtankar, D. D., Czoty, P. W., DeLoid, H. B., Hsu, F. -C., Toll, L., Husbands, S. & Ko, M. C., 1 Jun 2019, In : British Journal of Anaesthesia. 122, 6, p. e146-e156

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
7 Downloads (Pure)

Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys

Flynn, S. M., Epperly, P. M., Davenport, A. T., Cami-Kobeci, G., Husbands, S. M., Ko, M. C. & Czoty, P. W., 10 Apr 2019, In : Neuropsychopharmacology. 44, 8, p. 1476-1484 9 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
14 Downloads (Pure)

Long-lasting effects of methocinnamox on opioid self-administration in rhesus monkeys

Maguire, D. R., Gerak, L. R., Woods, J. H., Husbands, S., Disney, A. & France, C. P., 1 Jan 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 88-99 12 p., 252353.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
9 Downloads (Pure)

Methocinnamox Produces Long-Lasting Antagonism of the Behavioral Effects of µ-Opioid Receptor Agonists but Not Prolonged Precipitated Withdrawal in Rats

Gerak, L. R., Minervini, V., Latham, E., Ghodrati, S., Lillis, K. V., Wooden, J., Disney, A., Husbands, S. M. & France, C. P., 1 Nov 2019, In : The Journal of pharmacology and experimental therapeutics. 371, 2, p. 507-516 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
17 Downloads (Pure)
Open Access
2 Citations (Scopus)

Synthetic Cannabinoid Receptor Agonists Detection using Fluorescence Spectral Fingerprinting

May, B., Naqi, H., Tipping, M., Scott, J., Husbands, S., Blagbrough, I. & Pudney, C., 15 Oct 2019, In : Analytical Chemistry. 91, 20, p. 12971-12979 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice

Almatroudi, A. M. I., Ostovar, M., Bailey, C., Husbands, S. & Bailey, S., 1 Jul 2018, In : British Journal of Pharmacology. 175, 14, p. 2869-2880 12 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
48 Downloads (Pure)

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 binding site in human brain

Tyacke, R. J., Myers, J. F. M., Venkataraman, A., Mick, I., Turton, S., Passchier, J., Husbands, S. M., Rabiner, E. A., Gunn, R. N., Murphy, P. S., Parker, C. A. & Nutt, D. J., 1 Oct 2018, In : Journal of Nuclear Medicine. 59, 10, p. 1597-1602 6 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Synthesis, biological evaluation, and SAR studies of 14β-phenylacetyl substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones derivatives: Ligands with mixed NOP and opioid receptor profile

Kumar, V., Polgar, W. E., Cami-Kobeci, G., Thomas, M. P., Khroyan, T. V., Toll, L. & Husbands, S. M., 19 Sep 2018, In : Frontiers in Psychiatry . 9, SEP, p. 1-10 10 p., 430.

Research output: Contribution to journalArticle

Open Access
Open Access

The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

Hill, R., Disney, A., Conibear, A., Sutcliffe, K., Dewey, W., Husbands, S., Bailey, C., Kelly, E. & Henderson, G., 1 Jul 2018, In : British Journal of Pharmacology. 175, 13, p. 2653-2661 9 p.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)
9 Downloads (Pure)
2017

Additive effects of 3,4-methylenedioxymethamphetamine (MDMA) and compassionate imagery on self-compassion in recreational users of ecstasy

Kamboj, S. K., Wallden, Y. S. E., Falconer, C. J., Alotaibi, M. R. M., Blagbrough, I., Husbands, S. & Freeman, T., 6 Nov 2017, In : Mindfulness. 9, 4, p. 1134-1145 12 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Methyl-orvinol—Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome

Zielińska, M., Jarmuż, A., Wasilewski, A., Cami-Kobeci, G., Husbands, S. & Fichna, J., 1 Apr 2017, In : Pharmacological Reports. 69, 2, p. 350-357 8 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
67 Downloads (Pure)
2016

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

Ding, H., Czoty, P. W., Kiguchi, N., Cami-Kobeci, G., Sukhtankar, D. D., Nader, M. A., Husbands, S. M. & Ko, M-C., 13 Sep 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. E5511-5518 8 p.

Research output: Contribution to journalArticle

Open Access
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48 Citations (Scopus)
88 Downloads (Pure)

Behavioural tasks sensitive to acute abstinence and predictive of smoking cessation success: a systematic review and meta-analysis

Grabski, M., Curran, H. V., Nutt, D. J., Husbands, S. M., Freeman, T. P., Fluharty, M. & Munafò, M. R., Dec 2016, In : Addiction. 111, 12, p. 2134-2144

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
2015
Open Access
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6 Citations (Scopus)
131 Downloads (Pure)

Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice

Zielińska, M., Ben Haddou, T., Cami-Kobeci, G., Sałaga, M., Jarmuż, A., Padysz, M., Kordek, R., Spetea, M., Husbands, S. M. & Fichna, J., 15 Oct 2015, In : European Journal of Pharmacology. 765, p. 582-90 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

Cueva, J. P., Roche, C., Ostovar, M., Kumar, V., Clark, M. J., Hillhouse, T. M., Lewis, J. W., Traynor, J. R. & Husbands, S. M., 28 May 2015, In : Journal of Medicinal Chemistry. 58, 10, p. 4242-4249 8 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
101 Downloads (Pure)

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

Almatroudi, A., Husbands, S. M., Bailey, C. P. & Bailey, S. J., 1 Jul 2015, In : Journal of Psychopharmacology . 29, 7, p. 812-821 10 p.

Research output: Contribution to journalArticle

Open Access
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34 Citations (Scopus)
130 Downloads (Pure)

Meet our editorial board member

Husbands, S., 1 Aug 2015, In : Mini-Reviews in Medicinal Chemistry. 15, 10, p. 797 1 p.

Research output: Contribution to journalArticle

Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Lowe, J. D., Sanderson, H. S., Cooke, A. E., Ostovar, M., Tsisanova, E., Withey, S. L., Chavkin, C., Husbands, S. M., Kelly, E., Henderson, G. & Bailey, C. P., Aug 2015, In : Molecular Pharmacology. 88, 2, p. 347-356

Research output: Contribution to journalArticle

Open Access
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33 Citations (Scopus)
92 Downloads (Pure)

Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors

Blazer, L. L., Storaska, A. J., Jutkiewicz, E. M., Turner, E. M., Calcagno, M., Wade, S. M., Wang, Q., Huang, X-P., Traynor, J. R., Husbands, S. M., Morari, M. & Neubig, R. R., 17 Jun 2015, In : ACS Chemical Neuroscience. 6, 6, p. 911-919 8 p.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
143 Downloads (Pure)

Structural insights into μ-opioid receptor activation

Huang, W., Manglik, A., Venkatakrishnan, A. J., Laeremans, T., Feinberg, E. N., Sanborn, A. L., Kato, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., Granier, S., Gmeiner, P., Husbands, S. M., Traynor, J. R., Weis, W. I., Steyaert, J., Dror, R. O. & Kobilka, B. K., 20 Aug 2015, In : Nature. 524, 7565, p. 315-321 7 p.

Research output: Contribution to journalArticle

Open Access
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377 Citations (Scopus)
85 Downloads (Pure)
2014
Open Access
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29 Citations (Scopus)
186 Downloads (Pure)

BU08073 a buprenorphine analog with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice

Khroyan, T. V., Wu, J., Polgar, W. E., Cami-Kobeci, G., Fotaki, N., Husbands, S. M. & Toll, L., 23 Dec 2014, In : British Journal of Pharmacology. 172, 2, p. 668-680 13 p.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
99 Downloads (Pure)

Characterization of BU09059: A novel potent selective κ-receptor antagonist

Casal-Dominguez, J. J., Furkert, D., Ostovar, M., Teintang, L., Clarke, M. J., Traynor, J. R., Husbands, S. M. & Bailey, S. J., 19 Mar 2014, In : ACS Chemical Neuroscience. 5, 3, p. 177-184 8 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
126 Downloads (Pure)

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline Binding Sites in Rhesus Brain

Parker, C. A., Nabulsi, N., Holden, D., Lin, S-F., Cass, T., Labaree, D., Kealey, S., Gee, A. D., Husbands, S. M., Quelch, D., Carson, R. E., Nutt, D. J., Huang, Y. & Tyacke, R. J., 1 May 2014, In : The Journal of Nuclear Medicine. 55, 5, p. 838-844 7 p.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
104 Downloads (Pure)

Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics

Ju, M., Scott-ward, T. S., Liu, J., Khuituan, P., Li, H., Cai, Z., Husbands, S. M. & Sheppard, D. N., 1 Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 265-278 13 p.

Research output: Contribution to journalArticle

File
3 Citations (Scopus)
122 Downloads (Pure)
Open Access
File
13 Citations (Scopus)
69 Downloads (Pure)

Novel mixed NOP/MOP agonist BU08070 alleviates pain and inhibits gastrointestinal motility in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms

Sobczak, M., Cami-Kobeci, G., Sałaga, M., Husbands, S. M. & Fichna, J., 5 Aug 2014, In : European Journal of Pharmacology. 736, p. 63-69 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Palladium-mediated oxidative carbonylation reactions for the synthesis of 11C-radiolabelled ureas

Kealey, S., Husbands, S. M., Bennacef, I., Gee, A. D. & Passchier, J., Apr 2014, In : Journal of Labelled Compounds & Radiopharmaceuticals. 57, 4, p. 202-208 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pyrrolo- and pyridomorphinans: Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists

Kumar, V., Clark, M. J., Traynor, J. R., Lewis, J. W. & Husbands, S. M., 1 Aug 2014, In : Bioorganic and Medicinal Chemistry. 22, 15, p. 4067-4072

Research output: Contribution to journalArticle

File
2 Citations (Scopus)
46 Downloads (Pure)

Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity

Kumar, V., Ridzwan, I. E., Grivas, K., Lewis, J. W., Clark, M. J., Meurice, C., Jimenez-Gomez, C., Pogozheva, I., Mosberg, H., Traynor, J. R. & Husbands, S. M., 22 May 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4049-4057 9 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
34 Downloads (Pure)
2013
38 Citations (Scopus)

Imaging imidazoline-I binding sites in porcine brain using C-BU99008

Kealey, S., Turner, E. M., Husbands, S. M., Salinas, C. A., Jakobsen, S., Tyacke, R. J., Nutt, D. J., Parker, C. A. & Gee, A. D., Jan 2013, In : The Journal of Nuclear Medicine. 54, 1, p. 139-144 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor

Casal-Dominguez, J. J., Clark, M., Traynor, J. R., Husbands, S. M. & Bailey, S. J., Feb 2013, In : Journal of Psychopharmacology. 27, 2, p. 192-202 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
144 Downloads (Pure)

Orvinols with mixed kappa/mu opioid receptor agonist activity

Greedy, B. M., Bradbury, F., Thomas, M. P., Grivas, K., Cami-Kobeci, G., Archambeau, A., Bosse, K., Clark, M. J., Aceto, M., Lewis, J. W., Traynor, J. R. & Husbands, S. M., 2013, In : Journal of Medicinal Chemistry. 56, 8, p. 3207-3216 10 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
155 Downloads (Pure)
2012

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline 2 binding site

Tyacke, R. J., Fisher, A., Robinson, E. S., Grundt, P., Turner, E. M., Husbands, S. M., Hudson, A. L., Parker, C. A. & Nutt, D. J., Jun 2012, In : Synapse. 66, 6, p. 542-551 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversible μ opioid receptor antagonist effects

Moynihan, H. A., Derrick, I., Broadbear, J. H., Greedy, B. M., Aceto, M. D., Harris, L. S., Purington, L. C. S., Thomas, M. P., Woods, J. H., Traynor, J. R., Husbands, S. M. & Lewis, J. W., 26 Nov 2012, In : Journal of Medicinal Chemistry. 55, 22, p. 9868-9874 7 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Small molecule inhibitors of regulators of G protein signaling (RGS) proteins

Turner, E. M., Blazer, L. L., Neubig, R. R. & Husbands, S. M., 9 Feb 2012, In : ACS Medicinal Chemistry Letters. 3, 2, p. 146-150 5 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
102 Downloads (Pure)
2011

(11)C Urea synthesis via palladium(II)-mediated oxidative carbonylation of amines

Kealey, S., Gee, A. D., Husbands, S. M., Bennacef, I. & Passchier, J., Sep 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, Supplement 1, p. S108

Research output: Contribution to journalArticle

A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins

Blazer, L. L., Zhang, H. M., Casey, E. M., Husbands, S. M. & Neubig, R. R., 19 Apr 2011, In : Biochemistry. 50, 15, p. 3181-3192 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Anxiolytic effects of novel kappa-opioid receptor antagonists in the elevated plus maze

Bailey, S. J., Casal-Dominguez, J. J. & Husbands, S. M., 2011, In : Journal of Psychopharmacology. 25, 8, p. A76

Research output: Contribution to journalArticle

Copper(I) tris(pyrazolyl)borate complexes for use in positron emission tomograhpy

Kealey, S., Jennings, L. E., Miller, P. W., Gee, A. D., Plisson, C., White, A. J. P., Husbands, S. & Long, N. J., Jun 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, 7, p. 392-392 1 p.

Research output: Contribution to journalArticle

Copper(I) tris(pyrazolyl)borate complexes for use in positron emission tomography

Long, N., Kealey, S., Jennings, L., Miller, P., Gee, A., Plisson, C., White, A. & Husbands, S. M., Sep 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, Supplement 1, p. S98

Research output: Contribution to journalArticle