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Research Output

2020

OREX-1019: a novel treatment for opioid use disorder and relapse prevention

Maguire, D., Gerak, L., Cami-Kobeci, G., Husbands, S., France, C., Belli, B. & Flynn, P., 1 Feb 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 205-215

Research output: Contribution to journalArticle

Open Access
2019

19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids

Naqi, H., Woodman, T., Husbands, S. & Blagbrough, I., 28 Jun 2019, In : Analytical Methods. 11, 24, p. 3090-3100 11 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Naqi, H., Husbands, S. & Blagbrough, I., 7 Oct 2019, In : Analytical Methods. 11, 37, p. 4795-4807 13 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)

BU10038 as a safe opioid analgesic with fewer side effects after systemic and intrathecal administration in primates

Kiguchi, N., Ding, H., Cami-Kobeci, G., Sukhtankar, D. D., Czoty, P. W., DeLoid, H. B., Hsu, F. -C., Toll, L., Husbands, S. & Ko, M. C., 1 Jun 2019, In : British Journal of Anaesthesia. 122, 6, p. e146-e156

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
7 Downloads (Pure)

Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys

Flynn, S. M., Epperly, P. M., Davenport, A. T., Cami-Kobeci, G., Husbands, S. M., Ko, M. C. & Czoty, P. W., 10 Apr 2019, In : Neuropsychopharmacology. 44, 8, p. 1476-1484 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
14 Downloads (Pure)

Long-lasting effects of methocinnamox on opioid self-administration in rhesus monkeys

Maguire, D. R., Gerak, L. R., Woods, J. H., Husbands, S., Disney, A. & France, C. P., 1 Jan 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 88-99 12 p., 252353.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
9 Downloads (Pure)

Methocinnamox Produces Long-Lasting Antagonism of the Behavioral Effects of µ-Opioid Receptor Agonists but Not Prolonged Precipitated Withdrawal in Rats

Gerak, L. R., Minervini, V., Latham, E., Ghodrati, S., Lillis, K. V., Wooden, J., Disney, A., Husbands, S. M. & France, C. P., 1 Nov 2019, In : The Journal of pharmacology and experimental therapeutics. 371, 2, p. 507-516 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
17 Downloads (Pure)
Open Access
2 Citations (Scopus)

Synthetic Cannabinoid Receptor Agonists Detection using Fluorescence Spectral Fingerprinting

May, B., Naqi, H., Tipping, M., Scott, J., Husbands, S., Blagbrough, I. & Pudney, C., 15 Oct 2019, In : Analytical Chemistry. 91, 20, p. 12971-12979 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice

Almatroudi, A. M. I., Ostovar, M., Bailey, C., Husbands, S. & Bailey, S., 1 Jul 2018, In : British Journal of Pharmacology. 175, 14, p. 2869-2880 12 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
48 Downloads (Pure)

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 binding site in human brain

Tyacke, R. J., Myers, J. F. M., Venkataraman, A., Mick, I., Turton, S., Passchier, J., Husbands, S. M., Rabiner, E. A., Gunn, R. N., Murphy, P. S., Parker, C. A. & Nutt, D. J., 1 Oct 2018, In : Journal of Nuclear Medicine. 59, 10, p. 1597-1602 6 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Synthesis, biological evaluation, and SAR studies of 14β-phenylacetyl substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones derivatives: Ligands with mixed NOP and opioid receptor profile

Kumar, V., Polgar, W. E., Cami-Kobeci, G., Thomas, M. P., Khroyan, T. V., Toll, L. & Husbands, S. M., 19 Sep 2018, In : Frontiers in Psychiatry . 9, SEP, p. 1-10 10 p., 430.

Research output: Contribution to journalArticle

Open Access
Open Access

The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

Hill, R., Disney, A., Conibear, A., Sutcliffe, K., Dewey, W., Husbands, S., Bailey, C., Kelly, E. & Henderson, G., 1 Jul 2018, In : British Journal of Pharmacology. 175, 13, p. 2653-2661 9 p.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)
9 Downloads (Pure)
2017

Additive effects of 3,4-methylenedioxymethamphetamine (MDMA) and compassionate imagery on self-compassion in recreational users of ecstasy

Kamboj, S. K., Wallden, Y. S. E., Falconer, C. J., Alotaibi, M. R. M., Blagbrough, I., Husbands, S. & Freeman, T., 6 Nov 2017, In : Mindfulness. 9, 4, p. 1134-1145 12 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Methyl-orvinol—Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome

Zielińska, M., Jarmuż, A., Wasilewski, A., Cami-Kobeci, G., Husbands, S. & Fichna, J., 1 Apr 2017, In : Pharmacological Reports. 69, 2, p. 350-357 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
67 Downloads (Pure)
2016

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

Ding, H., Czoty, P. W., Kiguchi, N., Cami-Kobeci, G., Sukhtankar, D. D., Nader, M. A., Husbands, S. M. & Ko, M-C., 13 Sep 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. E5511-5518 8 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
88 Downloads (Pure)

Behavioural tasks sensitive to acute abstinence and predictive of smoking cessation success: a systematic review and meta-analysis

Grabski, M., Curran, H. V., Nutt, D. J., Husbands, S. M., Freeman, T. P., Fluharty, M. & Munafò, M. R., Dec 2016, In : Addiction. 111, 12, p. 2134-2144

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Behavioural tasks sensitive to acute abstinence and predictive of smoking cessation success: a systematic review and meta-analysis

Grabski, M., Curran, H. V., Nutt, D. J., Husbands, S. M., Freeman, T. P., Fluharty, M. & Munafò, M. R., Dec 2016, In : Addiction. 111, 12, p. 2134-2144 11 p.

Research output: Contribution to journalReview article

Open Access
2015
Open Access
File
6 Citations (Scopus)
131 Downloads (Pure)

Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice

Zielińska, M., Ben Haddou, T., Cami-Kobeci, G., Sałaga, M., Jarmuż, A., Padysz, M., Kordek, R., Spetea, M., Husbands, S. M. & Fichna, J., 15 Oct 2015, In : European Journal of Pharmacology. 765, p. 582-90 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

Cueva, J. P., Roche, C., Ostovar, M., Kumar, V., Clark, M. J., Hillhouse, T. M., Lewis, J. W., Traynor, J. R. & Husbands, S. M., 28 May 2015, In : Journal of Medicinal Chemistry. 58, 10, p. 4242-4249 8 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
101 Downloads (Pure)

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

Almatroudi, A., Husbands, S. M., Bailey, C. P. & Bailey, S. J., 1 Jul 2015, In : Journal of Psychopharmacology . 29, 7, p. 812-821 10 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
130 Downloads (Pure)

Meet our editorial board member

Husbands, S., 1 Aug 2015, In : Mini-Reviews in Medicinal Chemistry. 15, 10, p. 797 1 p.

Research output: Contribution to journalArticle

NOVEL OPIOID COMPOUNDS AND THEIR USES

Lewis, J., Husbands, S. & Toll, L., 11 Jun 2015, Patent No. WO2015082932 (A1) , 5 Dec 2014, Priority date 2 Dec 2013, Priority No. 61/912,169

Research output: Patent

Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Lowe, J. D., Sanderson, H. S., Cooke, A. E., Ostovar, M., Tsisanova, E., Withey, S. L., Chavkin, C., Husbands, S. M., Kelly, E., Henderson, G. & Bailey, C. P., Aug 2015, In : Molecular Pharmacology. 88, 2, p. 347-356

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
92 Downloads (Pure)

Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors

Blazer, L. L., Storaska, A. J., Jutkiewicz, E. M., Turner, E. M., Calcagno, M., Wade, S. M., Wang, Q., Huang, X-P., Traynor, J. R., Husbands, S. M., Morari, M. & Neubig, R. R., 17 Jun 2015, In : ACS Chemical Neuroscience. 6, 6, p. 911-919 8 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
143 Downloads (Pure)

Structural insights into μ-opioid receptor activation

Huang, W., Manglik, A., Venkatakrishnan, A. J., Laeremans, T., Feinberg, E. N., Sanborn, A. L., Kato, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., Granier, S., Gmeiner, P., Husbands, S. M., Traynor, J. R., Weis, W. I., Steyaert, J., Dror, R. O. & Kobilka, B. K., 20 Aug 2015, In : Nature. 524, 7565, p. 315-321 7 p.

Research output: Contribution to journalArticle

Open Access
File
374 Citations (Scopus)
85 Downloads (Pure)

The antidepressant-like effects of BU10119, a novel kappa opioid receptor antagonist, in the novelty-induced hypophagia task in mice

Bailey, S., Almatroudi, A. M. I., Bailey, C. & Husbands, S., 2015, Neuroscience Meeting Planner : Society for Neuroscience. 774.09

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2014
Open Access
File
29 Citations (Scopus)
185 Downloads (Pure)

BU08073 a buprenorphine analog with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice

Khroyan, T. V., Wu, J., Polgar, W. E., Cami-Kobeci, G., Fotaki, N., Husbands, S. M. & Toll, L., 23 Dec 2014, In : British Journal of Pharmacology. 172, 2, p. 668-680 13 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
97 Downloads (Pure)

Characterization of BU09059: A novel potent selective κ-receptor antagonist

Casal-Dominguez, J. J., Furkert, D., Ostovar, M., Teintang, L., Clarke, M. J., Traynor, J. R., Husbands, S. M. & Bailey, S. J., 19 Mar 2014, In : ACS Chemical Neuroscience. 5, 3, p. 177-184 8 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
126 Downloads (Pure)

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline Binding Sites in Rhesus Brain

Parker, C. A., Nabulsi, N., Holden, D., Lin, S-F., Cass, T., Labaree, D., Kealey, S., Gee, A. D., Husbands, S. M., Quelch, D., Carson, R. E., Nutt, D. J., Huang, Y. & Tyacke, R. J., 1 May 2014, In : The Journal of Nuclear Medicine. 55, 5, p. 838-844 7 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
104 Downloads (Pure)

Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics

Ju, M., Scott-ward, T. S., Liu, J., Khuituan, P., Li, H., Cai, Z., Husbands, S. M. & Sheppard, D. N., 1 Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 265-278 13 p.

Research output: Contribution to journalArticle

File
3 Citations (Scopus)
121 Downloads (Pure)
Open Access
File
13 Citations (Scopus)
69 Downloads (Pure)

Novel mixed NOP/MOP agonist BU08070 alleviates pain and inhibits gastrointestinal motility in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms

Sobczak, M., Cami-Kobeci, G., Sałaga, M., Husbands, S. M. & Fichna, J., 5 Aug 2014, In : European Journal of Pharmacology. 736, p. 63-69 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Palladium-mediated oxidative carbonylation reactions for the synthesis of 11C-radiolabelled ureas

Kealey, S., Husbands, S. M., Bennacef, I., Gee, A. D. & Passchier, J., Apr 2014, In : Journal of Labelled Compounds & Radiopharmaceuticals. 57, 4, p. 202-208 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pyrrolo- and pyridomorphinans: Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists

Kumar, V., Clark, M. J., Traynor, J. R., Lewis, J. W. & Husbands, S. M., 1 Aug 2014, In : Bioorganic and Medicinal Chemistry. 22, 15, p. 4067-4072

Research output: Contribution to journalArticle

File
2 Citations (Scopus)
46 Downloads (Pure)

Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity

Kumar, V., Ridzwan, I. E., Grivas, K., Lewis, J. W., Clark, M. J., Meurice, C., Jimenez-Gomez, C., Pogozheva, I., Mosberg, H., Traynor, J. R. & Husbands, S. M., 22 May 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4049-4057 9 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
34 Downloads (Pure)

The antidepressant-like effects of combination buprenorphine/naltrexone in the novelty-induced hypophagia task in mice

Bailey, S., Almatroudi, A. M. I., Bailey, C. & Husbands, S., 2014, Neuroscience Meeting Planner: Society for Neuroscience. Online

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The therapeutic potential of small-molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel

Liu, J., Cami-Kobeci, G., Wang, Y., Khuituan, P., Cai, Z., Li, H., Husbands, S. M. & Sheppard, D. N., 18 Sep 2014, Ion Channel Drug Discovery. Cox, B. & Gosling, M. (eds.). 39 ed. Royal Society of Chemistry, p. 156-185 30 p. (RSC Drug Discovery Series; vol. 2015-January, no. 39).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
2013

Buprenorphine and related orvinols

Husbands, S. M., 2013, Research and Development of Opioid-Related Ligands. Ko, M-C. & Husbands, S. M. (eds.). Washington, DC: American Chemical Society, p. 127-144 (ACS Symposium Series; vol. 1131).

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)
38 Citations (Scopus)

Imaging imidazoline-I binding sites in porcine brain using C-BU99008

Kealey, S., Turner, E. M., Husbands, S. M., Salinas, C. A., Jakobsen, S., Tyacke, R. J., Nutt, D. J., Parker, C. A. & Gee, A. D., Jan 2013, In : The Journal of Nuclear Medicine. 54, 1, p. 139-144 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor

Casal-Dominguez, J. J., Clark, M., Traynor, J. R., Husbands, S. M. & Bailey, S. J., Feb 2013, In : Journal of Psychopharmacology. 27, 2, p. 192-202 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
143 Downloads (Pure)

ORVINOL AND THEVINOL DERIVATIVES USEFUL IN THE TREATMENT OF DRUG AND ALCOHOL ABUSE

Lewis, J. & Husbands, S., 17 Jan 2013, IPC No. A61K31/485; A61P25/32; A61P25/36; C07D489/12;, Patent No. WO2013007986 (A1), 5 Jul 2012, Priority date 8 Jul 2011, Priority No. 1111775.1

Research output: Patent