Personal profile

Research interests

My lab has interests in several different research areas, including structural biology, protein engineering, biomolecular interactions with 2D materials such as graphene, and nanopore sequencing.

Ongoing research projects include: structure and function of ubiquitin ligase HACE1 (funded by BHF); structure and function of proteins involved in organ size control, stem cell maintenance, and 3D body shape; towards a novel anti-inflammatory, vasculo-protective agent - based on our discovery of a new mode of action of Staphylococcus aureus effector protein Efb involving disruption of host blood cell complexes (funded by BHF); biofunctionalisation of graphene; nanopore sequencing applied to bacterial genome sequencing (Bordetella pertussis), and tumour infiltrating lymphocytes (part funded by Oxford Nanopore Technologies). 

Teaching interests

I teach on units in all years of the undergraduate degree programmes. This includes BB10003 Biochemistry I, BB10004 Biochemistry II, BB10213 Practical Biochemistry, BB20015 Biochemical Problems and Bioinformatics (convenor), BB20020 Protein Structure, BB30169 Concepts in Systems Biology, BB40048 Enzyme Mechanism and Evolution, BB40085 Medical Biochemistry (convenor), BB40109 Structural Biology in Biotechnology and Medicine.

I also look after the Department's Personal Tutoring System.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2005 2020

Global Mobility Scheme - Molecular Mechanisms Involving Large Protein Complexes

Bagby, S.

1/07/141/12/15

Project: Research-related fundingInternational Relations Office Funding

Structure and function of RASSF7, both tumour suppressor and oncogene?

Bagby, S. & Chalmers, A.

1/07/131/04/14

Project: Research-related fundingInternally Funded Research

Membrane Proteins
Long-Term Memory
Proteins
Neurons
AMPA Receptors

Research Output 1988 2018

Distinctive phosphoinositide and Ca binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain

Posner, M. G., Upadhyay, A., Ishima, R., Kalli, A. C., Harris, G., Kremerskothen, J., Sansom, M. S. P., Crennell, S. J. & Bagby, S. 3 May 2018 In : The Journal of biological chemistry.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositols
Membranes
Nuclear magnetic resonance
Calcium
Titration
Open Access

Protein dynamics revealed by CPMG dispersion

Bagby, S. & Ishima, R. Jul 2017 Modern Magnetic Resonance, 2nd edition. Webb, G. (ed.). 9783319283876: Springer

Research output: Chapter in Book/Report/Conference proceedingChapter

gills
nuclear magnetic resonance spectroscopy
proteins
methodology