Projects per year
Personal profile
Research interests
My lab has interests in several different research areas, including structural biology, protein engineering, biosensing, biomolecular interactions with 2D materials such as graphene, and nanopore sequencing.
Ongoing research projects include: research towards a novel anti-inflammatory, vasculo-protective agent - based on our discovery of a new mode of action of Staphylococcus aureus effector protein Efb involving disruption of host blood cell complexes (funded by BHF); autoantibody detection using autoantigen fragments immobilised on gold (funded by Bath Institute for Rheumatic Diseases); investigation of tumour immune landscapes using nanopore sequencing (part funded by Oxford Nanopore Technologies); analysis of protein dynamics at the single molecule level; biofunctionalisation of graphene and other materials; structure and function of proteins involved in organ size control, stem cell maintenance, and 3D body shape.
Teaching interests
I teach on units in all years of the undergraduate degree programmes. This includes BB10003 Biochemistry I, BB10004 Biochemistry II, BB10213 Practical Biochemistry, BB20015 Biochemical Problems and Bioinformatics (convenor), BB20020 Protein Structure, BB30169 Concepts in Systems Biology, BB40048 Enzyme Mechanism and Evolution, BB40085 Medical Biochemistry (convenor), BB40109 Structural Biology in Biotechnology and Medicine.
I also look after the Department's Personal Tutoring System.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 8 Finished
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HACE1 -Substrate Capture Analysis and Activity Enghancement by Deep Mutational Scanning of HACE1
1/05/16 → 31/07/19
Project: UK charity
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Structural, Biochemical and Computational Studies of KIBRA Protein-Protein and Membrane Interactions
Biotechnology and Biological Sciences Research Council
1/08/12 → 29/01/16
Project: Research council
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Delivery Fund - GRABA
Engineering and Physical Sciences Research Council
1/04/12 → 31/03/13
Project: Research council
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Delivery Fund - GRABA
Engineering and Physical Sciences Research Council
1/04/12 → 30/06/12
Project: Research council
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A peptide from the staphylococcal protein Efb binds P-selectin and inhibits the interaction of platelets with leukocytes
Wallis, S., Wolska, N., Englert, H., Posner, M., Upadhyay, A., Renne, T., Eggleston, I., Bagby, S. & Pula, G., 31 Mar 2022, In: Journal of Thrombosis and Haemostasis. 20, 3, p. 729-741 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Comparative genomics of Bordetella pertussis isolates from New Zealand, a country with an uncommonly high incidence of whooping cough.
Ring, N., Davies, H., Morgan, J., Sundaresan, M., Tiong, A., Preston, A. & Bagby, S., 27 Jan 2022, In: Microbial Genomics. 8, 1, 29 p., MGEN-D-21-00373R1.Research output: Contribution to journal › Article › peer-review
Open Access -
Towards Comprehensive Understanding of Bacterial Genetic Diversity: Large Scale Amplifications in Bordetella pertussis and Mycobacterium tuberculosis.
Abrahams, J., Weigand, M., Ring, N., MacArthur, I., Etty, J., Peng, S., Williams, M., Bready, B., Catalano, A., Davis, J., Kaiser, M., Oliver, J., Sage, J., Bagby, S., Tondella, M. L., Gorringe, A. & Preston, A., 31 Dec 2022, In: Microbial Genomics. 8, 2, p. 1-15 15 p., 000761.Research output: Contribution to journal › Article › peer-review
Open Access -
An overview of the clinical use of cabozantinib in the treatment of advanced non-clear-cell renal cell carcinoma (NCCRCC)
D'Angelo, A., Bagby, S., Di Pierro, G., Chirra, M., Nobili, S., Mini, E., Villari, D. & Roviello, G., 31 May 2020, In: Critical Reviews in Oncology/Hematology. 149, 102921.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Citation (SciVal)11 Downloads (Pure) -
Cabozantinib as a second-line treatment option in hepatocellular carcinoma
D’Angelo, A., Sobhani, N., Bagby, S., Casadei-Gardini, A. & Roviello, G., 2 Jun 2020, In: Expert Review of Clinical Pharmacology. 13, 6, p. 623-629 7 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (SciVal)8 Downloads (Pure)