Projects per year
Personal profile
Research interests
My lab has interests in several different research areas, including structural biology, protein engineering, biomolecular interactions with 2D materials such as graphene, and nanopore sequencing.
Ongoing research projects include: structure and function of ubiquitin ligase HACE1 (funded by BHF); structure and function of proteins involved in organ size control, stem cell maintenance, and 3D body shape; towards a novel anti-inflammatory, vasculo-protective agent - based on our discovery of a new mode of action of Staphylococcus aureus effector protein Efb involving disruption of host blood cell complexes (funded by BHF); biofunctionalisation of graphene and other materials; nanopore sequencing applied to bacterial genome sequencing (Bordetella pertussis), and tumour infiltrating lymphocytes (part funded by Oxford Nanopore Technologies).
Teaching interests
I teach on units in all years of the undergraduate degree programmes. This includes BB10003 Biochemistry I, BB10004 Biochemistry II, BB10213 Practical Biochemistry, BB20015 Biochemical Problems and Bioinformatics (convenor), BB20020 Protein Structure, BB30169 Concepts in Systems Biology, BB40048 Enzyme Mechanism and Evolution, BB40085 Medical Biochemistry (convenor), BB40109 Structural Biology in Biotechnology and Medicine.
I also look after the Department's Personal Tutoring System.
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Projects
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HACE1 -Substrate Capture Analysis and Activity Enghancement by Deep Mutational Scanning of HACE1
1/05/16 → 31/07/19
Project: UK charity
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Global Mobility Scheme - Molecular Mechanisms Involving Large Protein Complexes
1/07/14 → 1/12/15
Project: Research-related funding
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Structure and function of RASSF7, both tumour suppressor and oncogene?
Bagby, S. & Chalmers, A.
1/07/13 → 1/04/14
Project: Research-related funding
Research Output
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An overview of the clinical use of cabozantinib in the treatment of advanced non-clear-cell renal cell carcinoma (NCCRCC)
D'Angelo, A., Bagby, S., Di Pierro, G., Chirra, M., Nobili, S., Mini, E., Villari, D. & Roviello, G., May 2020, In: Critical Reviews in Oncology/Hematology. 149, 102921.Research output: Contribution to journal › Review article › peer-review
File1 Citation (Scopus)4 Downloads (Pure) -
Cabozantinib as a second-line treatment option in hepatocellular carcinoma
D’Angelo, A., Sobhani, N., Bagby, S., Casadei-Gardini, A. & Roviello, G., 2020, In: Expert Review of Clinical Pharmacology. 13, 6, p. 623-629Research output: Contribution to journal › Review article › peer-review
2 Citations (Scopus) -
Focus on ROS1-Positive Non-Small Cell Lung Cancer (NSCLC): Crizotinib, Resistance Mechanisms and the Newer Generation of Targeted Therapies
D'Angelo, A., Sobhani, N., Chapman, R., Bagby, S., Bortoletti, C., Traversini, M., Ferrari, K., Voltolini, L., Darlow, J. & Roviello, G., 6 Nov 2020, In: Cancers. 12, 11, 3293.Research output: Contribution to journal › Review article › peer-review
Open Access -
Immune-gene signature: a new tool for patient selection for checkpoint inhibitors?
Sobhani, N., Corona, S. P., Roviello, G., Bagby, S., D'Angelo, A., Iezzi, G. & Generali, D., 31 Jul 2020, In: Future oncology (London, England). 16, 19, p. 1327-1330 4 p.Research output: Contribution to journal › Article › peer-review
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Myositis autoantibodies: recent perspectives
Riddell, V., Bagby, S. & McHugh, N., 2 Sep 2020, In: Current Opinion in Rheumatology.Research output: Contribution to journal › Article › peer-review