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Personal profile

Research interests

My lab has interests in several different research areas, including structural biology, protein engineering, biomolecular interactions with 2D materials such as graphene, and nanopore sequencing.

Ongoing research projects include: structure and function of ubiquitin ligase HACE1 (funded by BHF); structure and function of proteins involved in organ size control, stem cell maintenance, and 3D body shape; towards a novel anti-inflammatory, vasculo-protective agent - based on our discovery of a new mode of action of Staphylococcus aureus effector protein Efb involving disruption of host blood cell complexes (funded by BHF); biofunctionalisation of graphene and other materials; nanopore sequencing applied to bacterial genome sequencing (Bordetella pertussis), and tumour infiltrating lymphocytes (part funded by Oxford Nanopore Technologies). 

Teaching interests

I teach on units in all years of the undergraduate degree programmes. This includes BB10003 Biochemistry I, BB10004 Biochemistry II, BB10213 Practical Biochemistry, BB20015 Biochemical Problems and Bioinformatics (convenor), BB20020 Protein Structure, BB30169 Concepts in Systems Biology, BB40048 Enzyme Mechanism and Evolution, BB40085 Medical Biochemistry (convenor), BB40109 Structural Biology in Biotechnology and Medicine.

I also look after the Department's Personal Tutoring System.

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Projects

Research Output

An overview of the clinical use of cabozantinib in the treatment of advanced non-clear-cell renal cell carcinoma (NCCRCC)

D'Angelo, A., Bagby, S., Di Pierro, G., Chirra, M., Nobili, S., Mini, E., Villari, D. & Roviello, G., May 2020, In : Critical Reviews in Oncology/Hematology. 149, 102921.

Research output: Contribution to journalReview article

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Cabozantinib as a second-line treatment option in hepatocellular carcinoma

D’Angelo, A., Sobhani, N., Bagby, S., Casadei-Gardini, A. & Roviello, G., 12 May 2020, In : Expert Review of Clinical Pharmacology.

Research output: Contribution to journalReview article

Immune-gene signature: a new tool for patient selection for checkpoint inhibitors?

Sobhani, N., Corona, S. P., Roviello, G., Bagby, S., D'Angelo, A., Iezzi, G. & Generali, D., 12 May 2020, In : Future oncology (London, England). 16, 19, p. 1327-1330 4 p.

Research output: Contribution to journalArticle

How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis

Ring, N., Abrahams, J., Bagby, S., Preston, A. & MacArthur, I., 19 Jul 2019, Pertussis Infection and Vaccines. Fedele, G. & Ausiello, C. (eds.). Springer, p. 1-17 17 p. (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Tumour infiltrating lymphocytes and immune-related genes as predictors of outcome in pancreatic adenocarcinoma

D'Angelo, A., Sobhani, N., Roviello, G., Bagby, S., Bonazza, D., Bottin, C., Giudici, F., Zanconati, F., De Manzini, N., Guglielmi, A. & Generali, D., 5 Aug 2019, In : PLoS ONE. 14, 8, e0219566.

Research output: Contribution to journalArticle

Open Access
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Thesis

Analysis of medaka YAP mutant affecting 3D body shape formation

Author: Wang, H., 20 May 2015

Supervisor: Furutani-Seiki, M. (Supervisor) & Bagby, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

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Structural and functional analysis of Staphylococcus aureus immune evasion proteins

Author: Clark, L., 1 Sep 2009

Supervisor: Van Den Elsen, J. (Supervisor) & Bagby, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

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Structural and functional studies of proteins from the Hippo signalling pathway

Author: Cherrett, C., 1 Sep 2011

Supervisor: Bagby, S. (Supervisor) & Van Den Elsen, J. (Supervisor)

Student thesis: Doctoral ThesisPhD

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