Shobbir Hussain

Dr

  • 4 SOUTH 1.32

20022019
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Research Output 2002 2019

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Article
2019

A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes

Soneson, C., Yao, Y., Bratus-Neuenschwander, A., Patrignani, A., Robinson, M. D. & Hussain, M. S., 31 Jul 2019, In : Nature Communications. 10, 1, p. 1-14 14 p., 3359.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs

Soneson, C., Love, M. I., Patro, R., Hussain, M. S., Malhotra, D. & Robinson, M. D., 1 Feb 2019, In : Life Science Alliance. 2, 1, e201800175.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
1 Downloads (Pure)

Catalytic crosslinking-based methods for enzyme-specified profiling of RNA ribonucleotide modifications

Hussain, M. S., 1 Mar 2019, In : Methods. 156, p. 60-65 6 p.

Research output: Contribution to journalArticle

Open Access
File

FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA

Carter, J-M., Emmett, W., Rdl Mozos, I., Kotter, A., Helm, M., Ule, J. & Hussain, M. S., 4 Nov 2019, In : Nucleic Acids Research. 47, 19, p. 1-12 12 p., gkz658.

Research output: Contribution to journalArticle

Open Access
2017
4 Citations (Scopus)

Illustrating the Epitranscriptome at Nucleotide Resolution Using Methylation-iCLIP (miCLIP)

George, H., Ule, J. & Hussain, S., 28 Mar 2017, In : Methods in Molecular Biology. 1562, p. 91-106 16 p.

Research output: Contribution to journalArticle

Methylation
Nucleotides
RNA
Cytosine
Transcriptome
11 Citations (Scopus)

Robust long-read native DNA sequencing using the ONT CsgG Nanopore system

Carter, J-M. & Hussain, S., 2017, In : Wellcome Open Research. 2, 23.

Research output: Contribution to journalArticle

Open Access
Nanopores
DNA Sequence Analysis
Technology
DNA
Throughput
1 Citation (Scopus)
25 Downloads (Pure)

Shaping and Reshaping Transcriptome Plasticity During Evolution

Hussain, S., Sep 2017, In : Trends in Biochemical Sciences. 42, 9, p. 682-684

Research output: Contribution to journalArticle

Open Access
File
Transcriptome
Plasticity
Protein Isoforms
RNA
Biodiversity
2016
55 Citations (Scopus)
67 Downloads (Pure)

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

Van Haute, L., Dietmann, S., Kremer, L., Hussain, S., Pearce, S. F., Powell, C. A., Rorbach, J., Lantaff, R., Blanco, S., Sauer, S., Kotzaeridou, U., Hoffmann, G. F., Memari, Y., Kolb-Kokocinski, A., Durbin, R., Mayr, J. A., Frye, M., Prokisch, H. & Minczuk, M., 30 Jun 2016, In : Nature Communications. 7, p. 1-10 10 p., 12039.

Research output: Contribution to journalArticle

Open Access
File
RNA, Transfer, Met
ribonucleic acids
methionine
methylation
Methylation
76 Citations (Scopus)

Stem cell function and stress response are controlled by protein synthesis

Blanco, S., Bandiera, R., Popis, M., Hussain, S., Lombard, P., Aleksic, J., Sajini, A., Tanna, H., Cortés-Garrido, R., Gkatza, N., Dietmann, S. & Frye, M., Jun 2016, In : Nature. 534, 7607, p. 335-340 6 p.

Research output: Contribution to journalArticle

Open Access
Stem Cells
Proteins
Activation Analysis
Neoplastic Stem Cells
Cytosine
2015
1 Citation (Scopus)

A new conceptual framework for investigating complex genetic disease

Hussain, S., 4 Nov 2015, In : Frontiers in Genetics. 6, 327.

Research output: Contribution to journalArticle

Open Access
Inborn Genetic Diseases
Inheritance Patterns
Mosaicism
Incidence
Population
9 Citations (Scopus)
2014
159 Citations (Scopus)
44 Downloads (Pure)

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

Blanco, S., Dietmann, S., Flores, J. V., Hussain, S., Kutter, C., Humphreys, P., Lukk, M., Lombard, P., Treps, L., Popis, M., Kellner, S., Holter, S. M., Garrett, L., Wurst, W., Becker, L., Klopstock, T., Fuchs, H., Gailus-Durner, V., Hrabe De Angelis, M., Karadottir, R. T. & 5 others, Helm, M., Ule, J., Gleeson, J. G., Odom, D. T. & Frye, M., 17 Sep 2014, In : The EMBO Journal. 33, 18, p. 2020-2039

Research output: Contribution to journalArticle

Open Access
2013
90 Citations (Scopus)

Characterizing 5-methylcytosine in the mammalian epitranscriptome

Hussain, S., Aleksic, J., Blanco, S., Dietmann, S. & Frye, M., 29 Nov 2013, In : Genome Biology. 14, 11, p. 215

Research output: Contribution to journalArticle

177 Citations (Scopus)

NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs

Hussain, S., Sajini, AA., Blanco, S., Dietmann, S., Lombard, P., Sugimoto, Y., Paramor, M., Gleeson, JG., Odom, D. T., Ule, J. & Frye, M., 1 Jul 2013, In : Cell Reports. 4, 2, p. 255-261

Research output: Contribution to journalArticle

Untranslated RNA
Methylation
Cytosine
RNA
Processing
63 Citations (Scopus)

The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation

Hussain, S., Tuorto, F., Menon, S., Blanco, S., Cox, C., Flores, J. V., Watt, S., Kudo, N. R., Lyko, F. & Frye, M., 15 Apr 2013, In : Molecular and Cellular Biology. 33, 8, p. 1561-1570

Research output: Contribution to journalArticle

2012
122 Citations (Scopus)
79 Downloads (Pure)

Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions

Sugimoto, Y., König, J., Hussain, S., Zupan, B., Curk, T., Frye, M. & Ule, J., 2012, In : Genome Biology. 13, 8, p. R67

Research output: Contribution to journalArticle

Open Access
File
crosslinking
Immunoprecipitation
RNA
Nucleotides
nucleotides
95 Citations (Scopus)

Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability

Khan, MA., Rafiq, MA., Noor, A., Hussain, S., Flores, JV., Rupp, V., Vincent, AK., Malli, R., Ali, G., Khan, FS., Ishak, GE., Doherty, D., Weksberg, R., Ayub, M., Windpassinger, C., Ibrahim, S., Frye, M., Ansar, M. & Vincent, JB., 4 May 2012, In : American Journal of Human Genetics. 90, 5, p. 856-863

Research output: Contribution to journalArticle

2011
38 Citations (Scopus)

The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis

Nascimento, E. M., Cox, C. L., Macarthur, S., Hussain, S., Trotter, M., Blanco, S., Suraj, M., Nichols, J., Kübler, B., Benitah, S. A., Hendrich, B., Odom, D. T. & Frye, M., 2011, In : Nature cell biology. 13, 12, p. 1395-1405

Research output: Contribution to journalArticle

2009
75 Citations (Scopus)

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability

Hussain, S., Blanco Benavente, S., Nascimento, E., Dragoni, I., Kurowski, A., Gillich, A., Humphreys, P. & Frye, M., 13 Jul 2009, In : The Journal of Cell Biology (JCB). 186, 1, p. 27-40

Research output: Contribution to journalArticle

Spindle Apparatus
Methyltransferases
RNA
Proteins
18S Ribosomal RNA
2008
66 Citations (Scopus)

FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3

Wilson, J. B., Yamamoto, K., Marriott, A. S., Hussain, S., Sung, P., Hoatlin, M. E., Mathew, C. G., Takata, M., Thompson, L. H., Kupfer, G. M. & Jones, N. J., 12 Jun 2008, In : Oncogene. 27, 26, p. 3641-3652

Research output: Contribution to journalArticle

2007
21 Citations (Scopus)
75 Downloads (Pure)

Insights into Fanconi Anaemia from the structure of human FANCE

Nookala, R. K., Hussain, S. & Pellegrini, L., 2007, In : Nucleic Acids Research. 35, 5, p. 1638-1648

Research output: Contribution to journalArticle

Open Access
File
Fanconi Anemia
Fanconi Anemia Complementation Group Proteins
Fanconi Anemia Complementation Group E Protein
Fanconi Anemia Complementation Group D2 Protein
Chromosome Breakage
2006
38 Citations (Scopus)

Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2

Hussain, S., Wilson, J. B., Blom, E., Thompson, L. H., Sung, P., Gordon, S. M., Kupfer, G. M., Joenje, H., Mathew, C. G. & Jones, N. J., 10 May 2006, In : DNA Repair. 5, 5, p. 629-640

Research output: Contribution to journalArticle

2005
338 Citations (Scopus)

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

Levitus, M., Waisfisz, Q., Godthelp, B. C., Vries, Y. D., Hussain, S., Wiegant, W. W., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, M. A., Pals, G., Arwert, F., Mathew, C. G., Zdzienicka, M. Z., Hiom, K., De Winter, J. P. & Joenje, H., 1 Sep 2005, In : Nature Genetics. 37, 9, p. 934-935

Research output: Contribution to journalArticle

2004
164 Citations (Scopus)

Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways

Hussain, S., Wilson, J. B., Medhurst, A. L., Hejna, J., Witt, E., Ananth, S., Davies, A., Masson, J-Y., Moses, R., West, S. C., De Winter, J. P., Ashworth, A., Jones, N. J. & Mathew, C. G., 2004, In : Human Molecular Genetics. 13, 12, p. 1241-1248

Research output: Contribution to journalArticle

2003
93 Citations (Scopus)

Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1

Hussain, S., Witt, E., Huber, P. A. J., Medhurst, A. L., Ashworth, A. & Mathew, C. G., 2003, In : Human Molecular Genetics. 12, 19, p. 2503-2510

Research output: Contribution to journalArticle

120 Citations (Scopus)

Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour

McCabe, C. J., Khaira, J. S., Boelaert, K., Heaney, A. P., Tannahill, L. A., Hussain, S., Mitchell, R., Olliff, J., Sheppard, M. C., Franklyn, J. A. & Gittoes, N. J. L., 5 Feb 2003, In : Clinical Endocrinology. 58, 2, p. 141-150

Research output: Contribution to journalArticle

2002
163 Citations (Scopus)

Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors

Mccabe, C. J., Boelaert, K., Tannahill, L. A., Heaney, A. P., Stratford, A. L., Khaira, J. S., Hussain, S., Sheppard, M. C., Franklyn, J. A. & Gittoes, N. J. L., 1 Sep 2002, In : The Journal of Clinical Endocrinology & Metabolism. 87, 9, p. 4238-4244

Research output: Contribution to journalArticle