Shobbir Hussain

Dr

  • 4 SOUTH 1.32

20022020

Research output per year

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Research Output

2020

On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity

Hussain, S., 1 May 2020, In : Trends in Cancer. 6, 5, p. 365-368 4 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2019

A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes

Soneson, C., Yao, Y., Bratus-Neuenschwander, A., Patrignani, A., Robinson, M. D. & Hussain, S., 31 Jul 2019, In : Nature Communications. 10, 1, p. 1-14 14 p., 3359.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs

Soneson, C., Love, M. I., Patro, R., Hussain, S., Malhotra, D. & Robinson, M. D., 1 Feb 2019, In : Life Science Alliance. 2, 1, e201800175.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Catalytic crosslinking-based methods for enzyme-specified profiling of RNA ribonucleotide modifications

Hussain, S., 1 Mar 2019, In : Methods. 156, p. 60-65 6 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
21 Downloads (Pure)

FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA

Carter, J-M., Emmett, W., Rdl Mozos, I., Kotter, A., Helm, M., Ule, J. & Hussain, S., 4 Nov 2019, In : Nucleic Acids Research. 47, 19, p. e113-e124 12 p., gkz658.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Native RNA-Sequencing Throws its Hat into the Transcriptomics Ring

Hussain, S., 1 Apr 2018, In : Trends in Biochemical Sciences. 43, 4, p. 225-227 3 p.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
35 Downloads (Pure)
2017

Illustrating the Epitranscriptome at Nucleotide Resolution Using Methylation-iCLIP (miCLIP)

George, H., Ule, J. & Hussain, S., 28 Mar 2017, In : Methods in Molecular Biology. 1562, p. 91-106 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Robust long-read native DNA sequencing using the ONT CsgG Nanopore system

Carter, J-M. & Hussain, S., 2017, In : Wellcome Open Research. 2, 23.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Shaping and Reshaping Transcriptome Plasticity During Evolution

Hussain, S., Sep 2017, In : Trends in Biochemical Sciences. 42, 9, p. 682-684

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
42 Downloads (Pure)
2016

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

Van Haute, L., Dietmann, S., Kremer, L., Hussain, S., Pearce, S. F., Powell, C. A., Rorbach, J., Lantaff, R., Blanco, S., Sauer, S., Kotzaeridou, U., Hoffmann, G. F., Memari, Y., Kolb-Kokocinski, A., Durbin, R., Mayr, J. A., Frye, M., Prokisch, H. & Minczuk, M., 30 Jun 2016, In : Nature Communications. 7, p. 1-10 10 p., 12039.

Research output: Contribution to journalArticle

Open Access
66 Citations (Scopus)
74 Downloads (Pure)

Stem cell function and stress response are controlled by protein synthesis

Blanco, S., Bandiera, R., Popis, M., Hussain, S., Lombard, P., Aleksic, J., Sajini, A., Tanna, H., Cortés-Garrido, R., Gkatza, N., Dietmann, S. & Frye, M., 16 Jun 2016, In : Nature. 534, 7607, p. 335-340 6 p.

Research output: Contribution to journalArticle

Open Access
122 Citations (Scopus)
2015

A new conceptual framework for investigating complex genetic disease

Hussain, S., 4 Nov 2015, In : Frontiers in Genetics. 6, 327.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
13 Citations (Scopus)
2014

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

Blanco, S., Dietmann, S., Flores, J. V., Hussain, S., Kutter, C., Humphreys, P., Lukk, M., Lombard, P., Treps, L., Popis, M., Kellner, S., Holter, S. M., Garrett, L., Wurst, W., Becker, L., Klopstock, T., Fuchs, H., Gailus-Durner, V., Hrabe De Angelis, M., Karadottir, R. T. & 5 others, Helm, M., Ule, J., Gleeson, J. G., Odom, D. T. & Frye, M., 17 Sep 2014, In : The EMBO Journal. 33, 18, p. 2020-2039 20 p.

Research output: Contribution to journalArticle

Open Access
197 Citations (Scopus)
44 Downloads (Pure)
2013

Characterizing 5-methylcytosine in the mammalian epitranscriptome

Hussain, S., Aleksic, J., Blanco, S., Dietmann, S. & Frye, M., 29 Nov 2013, In : Genome Biology. 14, 11, p. 215

Research output: Contribution to journalArticle

105 Citations (Scopus)

NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs

Hussain, S., Sajini, AA., Blanco, S., Dietmann, S., Lombard, P., Sugimoto, Y., Paramor, M., Gleeson, JG., Odom, D. T., Ule, J. & Frye, M., 1 Jul 2013, In : Cell Reports. 4, 2, p. 255-261

Research output: Contribution to journalArticle

221 Citations (Scopus)

The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation

Hussain, S., Tuorto, F., Menon, S., Blanco, S., Cox, C., Flores, J. V., Watt, S., Kudo, N. R., Lyko, F. & Frye, M., 15 Apr 2013, In : Molecular and Cellular Biology. 33, 8, p. 1561-1570

Research output: Contribution to journalArticle

76 Citations (Scopus)
2012

Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions

Sugimoto, Y., König, J., Hussain, S., Zupan, B., Curk, T., Frye, M. & Ule, J., 2012, In : Genome Biology. 13, 8, p. R67

Research output: Contribution to journalArticle

Open Access
File
129 Citations (Scopus)
133 Downloads (Pure)

Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability

Khan, MA., Rafiq, MA., Noor, A., Hussain, S., Flores, JV., Rupp, V., Vincent, AK., Malli, R., Ali, G., Khan, FS., Ishak, GE., Doherty, D., Weksberg, R., Ayub, M., Windpassinger, C., Ibrahim, S., Frye, M., Ansar, M. & Vincent, JB., 4 May 2012, In : American Journal of Human Genetics. 90, 5, p. 856-863

Research output: Contribution to journalArticle

107 Citations (Scopus)
2011

The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis

Nascimento, E. M., Cox, C. L., Macarthur, S., Hussain, S., Trotter, M., Blanco, S., Suraj, M., Nichols, J., Kübler, B., Benitah, S. A., Hendrich, B., Odom, D. T. & Frye, M., 2011, In : Nature cell biology. 13, 12, p. 1395-1405

Research output: Contribution to journalArticle

41 Citations (Scopus)
2009

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability

Hussain, S., Blanco Benavente, S., Nascimento, E., Dragoni, I., Kurowski, A., Gillich, A., Humphreys, P. & Frye, M., 13 Jul 2009, In : The Journal of Cell Biology (JCB). 186, 1, p. 27-40

Research output: Contribution to journalArticle

84 Citations (Scopus)
2008

FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3

Wilson, J. B., Yamamoto, K., Marriott, A. S., Hussain, S., Sung, P., Hoatlin, M. E., Mathew, C. G., Takata, M., Thompson, L. H., Kupfer, G. M. & Jones, N. J., 12 Jun 2008, In : Oncogene. 27, 26, p. 3641-3652

Research output: Contribution to journalArticle

67 Citations (Scopus)
2007

Insights into Fanconi Anaemia from the structure of human FANCE

Nookala, R. K., Hussain, S. & Pellegrini, L., 2007, In : Nucleic Acids Research. 35, 5, p. 1638-1648

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
136 Downloads (Pure)
2006

Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2

Hussain, S., Wilson, J. B., Blom, E., Thompson, L. H., Sung, P., Gordon, S. M., Kupfer, G. M., Joenje, H., Mathew, C. G. & Jones, N. J., 10 May 2006, In : DNA Repair. 5, 5, p. 629-640

Research output: Contribution to journalArticle

39 Citations (Scopus)
2005

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

Levitus, M., Waisfisz, Q., Godthelp, B. C., Vries, Y. D., Hussain, S., Wiegant, W. W., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, M. A., Pals, G., Arwert, F., Mathew, C. G., Zdzienicka, M. Z., Hiom, K., De Winter, J. P. & Joenje, H., 1 Sep 2005, In : Nature Genetics. 37, 9, p. 934-935

Research output: Contribution to journalArticle

348 Citations (Scopus)
2004

Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways

Hussain, S., Wilson, J. B., Medhurst, A. L., Hejna, J., Witt, E., Ananth, S., Davies, A., Masson, J-Y., Moses, R., West, S. C., De Winter, J. P., Ashworth, A., Jones, N. J. & Mathew, C. G., 2004, In : Human Molecular Genetics. 13, 12, p. 1241-1248

Research output: Contribution to journalArticle

165 Citations (Scopus)
2003

Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1

Hussain, S., Witt, E., Huber, P. A. J., Medhurst, A. L., Ashworth, A. & Mathew, C. G., 2003, In : Human Molecular Genetics. 12, 19, p. 2503-2510

Research output: Contribution to journalArticle

93 Citations (Scopus)

Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour

McCabe, C. J., Khaira, J. S., Boelaert, K., Heaney, A. P., Tannahill, L. A., Hussain, S., Mitchell, R., Olliff, J., Sheppard, M. C., Franklyn, J. A. & Gittoes, N. J. L., 5 Feb 2003, In : Clinical Endocrinology. 58, 2, p. 141-150

Research output: Contribution to journalArticle

123 Citations (Scopus)
2002

Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors

Mccabe, C. J., Boelaert, K., Tannahill, L. A., Heaney, A. P., Stratford, A. L., Khaira, J. S., Hussain, S., Sheppard, M. C., Franklyn, J. A. & Gittoes, N. J. L., 1 Sep 2002, In : The Journal of Clinical Endocrinology & Metabolism. 87, 9, p. 4238-4244

Research output: Contribution to journalArticle

168 Citations (Scopus)