Shobbir Hussain

Dr

20022019
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Personal profile

Research interests

Dr Hussain was awarded a PhD in Medical and Molecular Genetics from Guy’s Hospital, King’s College London, before completing his postdoctoral training at the University of Cambridge. His current research aims to understand how aspects of transcriptome malleability can shape biological outcomes such as those associated with inherited neurodevelopmental disorders. Molecular investigations in his laboratory currently centre on developing and applying Next Generation DNA/RNA Sequencing-based methodologies, while relevant transgenic models are employed for physiological in vivo studies.

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  • 3 Similar Profiles
RNA Medicine & Life Sciences
Transcriptome Medicine & Life Sciences
Cytosine Medicine & Life Sciences
RNA Sequence Analysis Medicine & Life Sciences
Methylation Medicine & Life Sciences
DNA Sequence Analysis Medicine & Life Sciences
Nucleotides Medicine & Life Sciences
Immunoprecipitation Medicine & Life Sciences

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Projects 2015 2019

Nanopores
Methylation
Protein Isoforms
RNA
Messenger RNA
Catalysis
RNA
Research
DNA
RNA Sequence Analysis

Research Output 2002 2018

Native RNA-Sequencing Throws its Hat into the Transcriptomics Ring

Hussain, S. 1 Apr 2018 In : Trends in Biochemical Sciences. 43, 4, p. 225-227 3 p.

Research output: Contribution to journalReview article

RNA Sequence Analysis
Transcriptome
RNA
DNA
Chemical analysis
1 Citations

Illustrating the Epitranscriptome at Nucleotide Resolution Using Methylation-iCLIP (miCLIP)

George, H., Ule, J. & Hussain, S. 28 Mar 2017 In : Methods in Molecular Biology. 1562, p. 91-106 16 p.

Research output: Contribution to journalArticle

Methylation
Nucleotides
RNA
Cytosine
Transcriptome
6 Citations
Open Access
Nanopores
DNA Sequence Analysis
Technology
DNA
Throughput

Shaping and Reshaping Transcriptome Plasticity During Evolution

Hussain, S. Sep 2017 In : Trends in Biochemical Sciences. 42, 9, p. 682-684

Research output: Contribution to journalArticle

Open Access
File
Transcriptome
Plasticity
Protein Isoforms
RNA
Biodiversity
32 Citations

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

Van Haute, L., Dietmann, S., Kremer, L., Hussain, S., Pearce, S. F., Powell, C. A., Rorbach, J., Lantaff, R., Blanco, S., Sauer, S., Kotzaeridou, U., Hoffmann, G. F., Memari, Y., Kolb-Kokocinski, A., Durbin, R., Mayr, J. A., Frye, M., Prokisch, H. & Minczuk, M. 30 Jun 2016 In : Nature Communications. 7, 12039

Research output: Contribution to journalArticle

Open Access
File
RNA, Transfer, Met
ribonucleic acids
methionine
methylation
Methylation