Shobbir Hussain


  • 4 SOUTH 1.32

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Personal profile

Research interests

Dr Hussain was awarded a PhD in Medical and Molecular Genetics from Guy’s Hospital, King’s College London, before completing his postdoctoral training at the University of Cambridge. His current research aims to understand how aspects of transcriptome malleability can shape biological outcomes such as those associated with inherited neurodevelopmental disorders. Molecular investigations in his laboratory currently centre on developing and applying Next Generation DNA/RNA Sequencing-based methodologies, while relevant transgenic models are employed for physiological in vivo studies.

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RNA Medicine & Life Sciences
Transcriptome Medicine & Life Sciences
Cytosine Medicine & Life Sciences
RNA Sequence Analysis Medicine & Life Sciences
Methylation Medicine & Life Sciences
DNA Sequence Analysis Medicine & Life Sciences
Nucleotides Medicine & Life Sciences
Immunoprecipitation Medicine & Life Sciences

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Projects 2015 2019

Protein Isoforms
Messenger RNA
RNA Sequence Analysis

Research Output 2002 2019

A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes

Soneson, C., Yao, Y., Bratus-Neuenschwander, A., Patrignani, A., Robinson, M. D. & Hussain, M. S., 31 Jul 2019, In : Nature Communications. 10, 1, p. 1-14 14 p., 3359.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs

Soneson, C., Love, M. I., Patro, R., Hussain, M. S., Malhotra, D. & Robinson, M. D., 1 Feb 2019, In : Life Science Alliance. 2, 1, e201800175.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
3 Downloads (Pure)

Catalytic crosslinking-based methods for enzyme-specified profiling of RNA ribonucleotide modifications

Hussain, M. S., 1 Mar 2019, In : Methods. 156, p. 60-65 6 p.

Research output: Contribution to journalArticle

Open Access

FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA

Carter, J-M., Emmett, W., Rdl Mozos, I., Kotter, A., Helm, M., Ule, J. & Hussain, M. S., 4 Nov 2019, In : Nucleic Acids Research. 47, 19, p. 1-12 12 p., gkz658.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
13 Downloads (Pure)

Native RNA-Sequencing Throws its Hat into the Transcriptomics Ring

Hussain, S., 1 Apr 2018, In : Trends in Biochemical Sciences. 43, 4, p. 225-227 3 p.

Research output: Contribution to journalReview article

Open Access
RNA Sequence Analysis
Chemical analysis


Investigation into the role of the RNA methyltransferase NSun2 in neuroplasticity regulation

Author: George, H., 2 Oct 2019

Supervisor: Williams, R. J. (Supervisor) & Hussain, M. S. (Supervisor)

Student thesis: Doctoral ThesisPhD