Shobbir Hussain


  • 4 SOUTH 1.32


Research output per year

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Personal profile

Research interests

Dr Hussain is an Associate Professor in Human Genetics, and was awarded a PhD in Medical and Molecular Genetics from King’s College London before completing his postdoctoral training at the University of Cambridge. His current research aims to understand how aspects of transcriptome malleability can shape biological outcomes such as those associated with inherited neurodevelopmental disorders. Molecular investigations in his laboratory currently centre on developing and applying next generation DNA/RNA sequencing-based methodologies, while relevant transgenic models are employed for physiological in vivo studies.

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Research Output

On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity

Hussain, S., 1 May 2020, In : Trends in Cancer. 6, 5, p. 365-368 4 p.

Research output: Contribution to journalReview article

FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA

Carter, J-M., Emmett, W., Rdl Mozos, I., Kotter, A., Helm, M., Ule, J. & Hussain, S., 4 Nov 2019, In : Nucleic Acids Research. 47, 19, p. e113-e124 12 p., gkz658.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes

Soneson, C., Yao, Y., Bratus-Neuenschwander, A., Patrignani, A., Robinson, M. D. & Hussain, S., 31 Jul 2019, In : Nature Communications. 10, 1, p. 1-14 14 p., 3359.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Robust long-read native DNA sequencing using the ONT CsgG Nanopore system

Carter, J-M. & Hussain, S., 2017, In : Wellcome Open Research. 2, 23.

Research output: Contribution to journalArticle

Open Access
  • 14 Citations (Scopus)

    Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

    Van Haute, L., Dietmann, S., Kremer, L., Hussain, S., Pearce, S. F., Powell, C. A., Rorbach, J., Lantaff, R., Blanco, S., Sauer, S., Kotzaeridou, U., Hoffmann, G. F., Memari, Y., Kolb-Kokocinski, A., Durbin, R., Mayr, J. A., Frye, M., Prokisch, H. & Minczuk, M., 30 Jun 2016, In : Nature Communications. 7, p. 1-10 10 p., 12039.

    Research output: Contribution to journalArticle

    Open Access
  • 63 Citations (Scopus)
    74 Downloads (Pure)


    Investigation into the role of the RNA methyltransferase NSun2 in neuroplasticity regulation

    Author: George, H., 2 Oct 2019

    Supervisor: Williams, R. J. (Supervisor) & Hussain, M. S. (Supervisor)

    Student thesis: Doctoral ThesisPhD