Projects per year
Personal profile
Research interests
Dr Hussain is an Associate Professor in Human Genetics, and was awarded a PhD in Medical and Molecular Genetics from King’s College London before completing his postdoctoral training at the University of Cambridge. His current research aims to understand how aspects of transcriptome malleability can shape biological outcomes such as those associated with inherited neurodevelopmental disorders. Molecular investigations in his laboratory currently centre on developing and applying next generation DNA/RNA sequencing-based methodologies, while relevant transgenic models are employed for physiological in vivo studies.
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Projects
- 4 Finished
Long-read Nanopore Sequencing to Identify Isoform-Specific Patterns of mRNA Methylation
Biotechnology and Biological Sciences Research Council
15/01/18 → 14/01/19
Project: Research council
Characterising the Epitanscriptome Using Catalysis-Dependent RIPseq Approaches
Biotechnology and Biological Sciences Research Council
1/04/16 → 31/08/19
Project: Research council
Characterizing the Landscape and Function of the Epitranscriptome using Catalysis-Dependent RIP-seq Approaches
23/03/15 → 22/03/16
Project: Research council
Research Output
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Hussain, S., 1 May 2020, In : Trends in Cancer. 6, 5, p. 365-368 4 p.Research output: Contribution to journal › Review article
FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA
Carter, J-M., Emmett, W., Rdl Mozos, I., Kotter, A., Helm, M., Ule, J. & Hussain, S., 4 Nov 2019, In : Nucleic Acids Research. 47, 19, p. e113-e124 12 p., gkz658.Research output: Contribution to journal › Article
Open Access
4
Citations
(Scopus)
A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes
Soneson, C., Yao, Y., Bratus-Neuenschwander, A., Patrignani, A., Robinson, M. D. & Hussain, S., 31 Jul 2019, In : Nature Communications. 10, 1, p. 1-14 14 p., 3359.Research output: Contribution to journal › Article
Open Access
9
Citations
(Scopus)
Robust long-read native DNA sequencing using the ONT CsgG Nanopore system
Carter, J-M. & Hussain, S., 2017, In : Wellcome Open Research. 2, 23.Research output: Contribution to journal › Article
Open Access
14
Citations
(Scopus)
Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
Van Haute, L., Dietmann, S., Kremer, L., Hussain, S., Pearce, S. F., Powell, C. A., Rorbach, J., Lantaff, R., Blanco, S., Sauer, S., Kotzaeridou, U., Hoffmann, G. F., Memari, Y., Kolb-Kokocinski, A., Durbin, R., Mayr, J. A., Frye, M., Prokisch, H. & Minczuk, M., 30 Jun 2016, In : Nature Communications. 7, p. 1-10 10 p., 12039.Research output: Contribution to journal › Article
Open Access
63
Citations
(Scopus)
74
Downloads
(Pure)
Thesis
Investigation into the role of the RNA methyltransferase NSun2 in neuroplasticity regulation
Author: George, H., 2 Oct 2019Supervisor: Williams, R. J. (Supervisor) & Hussain, M. S. (Supervisor)
Student thesis: Doctoral Thesis › PhD
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