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Personal profile

Research interests

My research focuses on developing new screening assays for the selection of potent peptide inhibitors of transcription factors such as c-Myc.

Education/Academic qualification

Doctor of Philosophy, University of Cambridge

Master of Research, University of Cambridge

Master of Chemistry, University of Oxford

Keywords

  • drug discovery
  • protein-protein interactions
  • peptides
  • cancer
  • c-Myc
  • library screening

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Research Output

Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery

Madden, S. K. & Itzhaki, L. S., 28 Feb 2020, In : Biochimica Et Biophysica Acta-Proteins and Proteomics. 1868, 7, 140405.

Research output: Contribution to journalReview article

Exploring new strategies for grafting binding peptides onto protein loops using a consensus-designed tetratricopeptide repeat scaffold

Madden, S. K., Perez-Riba, A. & Itzhaki, L. S., 1 Apr 2019, In : Protein Science. 28, 4, p. 738-745 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Kawamura, A., Münzel, M., Kojima, T., Yapp, C., Bhushan, B., Goto, Y., Tumber, A., Katoh, T., King, O. N. F., Passioura, T., Walport, L. J., Hatch, S. B., Madden, S., Müller, S., Brennan, P. E., Chowdhury, R., Hopkinson, R. J., Suga, H. & Schofield, C. J., 6 Apr 2017, In : Nature Communications. 8, p. 14773

Research output: Contribution to journalArticle

Open Access
55 Citations (Scopus)

Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates

Williams, S. T., Walport, L. J., Hopkinson, R. J., Madden, S. K., Chowdhury, R., Schofield, C. J. & Kawamura, A., 27 Jan 2015, In : Epigenetics. 9, 12, p. 1596-1603 8 p.

Research output: Contribution to journalArticle

Open Access
40 Citations (Scopus)

Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase

Walport, L. J., Hopkinson, R. J., Vollmar, M., Madden, S. K., Gileadi, C., Oppermann, U., Schofield, C. J. & Johansson, C., 5 May 2014, In : The Journal of biological chemistry. 289, 26, p. 18302-13 12 p.

Research output: Contribution to journalArticle

Open Access
78 Citations (Scopus)