• MILNER CENTRE 1.26

20022020
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Personal profile

Research interests

I am Professor and director of Bioinformatics (Milner Centre for Evolution) at the University of Bath and Co-PI of MRC CLIMB (Cloud Infrastructure for Microbial Bioinformatics)–the UKs largest cloud-based system for the analysis of microbial genomes.

Research in my group centres on the use of genetics/genomics and phenotypic studies to address complex questions in the ecology, epidemiology and evolution of microbes.

Our most recent interests focus upon comparative genome analyses to describe the core and flexible genome of pathogenic bacteria (Campylobacter, Staphylococcus, Helicobacter and Escherichia coli) and how this is related to population genetic structuring, the maintenance of species, and the evolution of host/niche adaptation and virulence.

Group website

CLIMB website

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Bacteria Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2016 2020

Medical Microbial Bioinformatics

Sheppard, S. & Pascoe, B.

1/07/1631/08/20

Project: Research council

Research Output 2002 2019

Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students

Royden, A., Ormandy, E., Pinchbeck, G., Pascoe, B., Hitchings, M. D., Sheppard, S. K. & Williams, N. J., 1 Jan 2019, In : Veterinary Record Open. 6, 1, e000307.

Research output: Contribution to journalArticle

Open Access

A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk

Berthenet, E., Yahara, K., Thorell, K., Pascoe, B., Meric, G., Mikhail, J. M., Engstrand, L., Enroth, H., Burette, A., Megraud, F., Varon, C., Atherton, J. C., Smith, S., Wilkinson, T. S., Hitchings, M. D., Falush, D. & Sheppard, S. K., 2 Aug 2018, In : BMC Biology. 16, 11 p., 84.

Research output: Contribution to journalArticle

Open Access
stomach neoplasms
Helicobacter pylori
Genome-Wide Association Study
Stomach Neoplasms
cancer
1 Citations

Comparative genomic survey of Bacillus cereus sensu stricto isolates from the dairy production chain in Brazil

Marques Rossi, G. A., Silva, H. O., Gamero Aguilar, C. E., Rochetti, A. L., Pascoe, B., Méric, G., Mourkas, E., Hitchings, M. D., Mathias, L. A., De Azevedo Ruiz, V. L., Fukumasu, H., Sheppard, S. K. & Centola Vidal, A. M., 1 Feb 2018, In : FEMS Microbiology Letters. 365, 3, p. 1 - 9 9 p., fnx283.

Research output: Contribution to journalArticle

Open Access
File
Bacillus cereus
Brazil
Dairy Products
Milk
Equipment and Supplies

Convergent amino acid signatures in polyphyletic Campylobacter jejuni sub-populations suggest human niche tropism

Méric, G., McNally, A., Pessia, A., Mourkas, E., Pascoe, B., Mageiros, L., Vehkala, M., Corander, J. & Sheppard, S. K., 14 Feb 2018, In : Genome biology and evolution. p. 763-774

Research output: Contribution to journalArticle

Open Access
tropisms
Campylobacter jejuni
Tropism
subpopulation
human population

Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis

Méric, G., Mageiros, L., Pensar, J., Laabei, M., Yahara, K., Pascoe, B., Kittiwan, N., Tadee, P., Post, V., Lamble, S., Bowden, R., Bray, J. E., Morgenstern, M., Jolley, K. A., Maiden, M. C. J., Feil, E. J., Didelot, X., Miragaia, M., de Lencastre, H., Moriarty, T. F. & 5 othersRohde, H., Massey, R., Mack, D., Corander, J. & Sheppard, S. K., 28 Nov 2018, In : Nature Communications. 9, 1, 11 p., 5034.

Research output: Contribution to journalArticle

Open Access