1990 …2022

Research output per year

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Research Output

2019

Excitation-energy-dependent molecular beacon detects early stage neurotoxic aβ aggregates in the presence of cortical neurons

Gulácsy, C. E., Meade, R., Catici, D. A. M., Soeller, C., Pantos, G. D., Jones, D. D., Alibhai, D., Jepson, M., Valev, V. K., Mason, J. M., Williams, R. J. & Pudney, C. R., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
40 Downloads (Pure)
2018

Advanced glycation end products modulate amyloidogenic APP processing and Tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer’s disease

Batkulwar, K., Godbole, R., Banarjee, R., Kassaar, O., Williams, R. J. & Kulkarni, M., 16 May 2018, In : ACS Chemical Neuroscience. 9, 5, p. 988-1000 13 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
39 Downloads (Pure)

Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis

Pereira Morais, M., Munir, O. K., Flower, S., Williams, R. J., James, T. & Van Den Elsen, J., 14 Nov 2018, Electrophoretic Separation of Proteins: Methods and Protocols. T. Kurien, B. & Hal Scofield, R. (eds.). New York, U. S. A.: Humana Press, p. 161-175 (Methods in Molecular Biology; vol. 1855).

Research output: Chapter in Book/Report/Conference proceedingChapter

2017
Open Access
File
3 Citations (Scopus)
78 Downloads (Pure)

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

Kassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. & Van Den Elsen, J., 23 Feb 2017, In : Scientific Reports. 7, p. 1-12 12 p., 42874.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Nutrition for the ageing brain: towards evidence for an optimal diet

Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Banati, D., Barberger-Gateau, P., Bowman, G., Carbelotto, L., Clarke, R., Hogervorst, E., Kiliaan, A., Lucca, U., Manach, C., Minihane, A-M., Mitchell, E. S., Perneczky, R., Perry, H., Roussel, A-M., Schuermans, J., Sijben, J. & 8 others, Spencer, J. PE., Thuret, S., van de Rest, O., Vandewoude, M., Wesnes, K., Williams, R. J., Williams, R. SB. & Ramirez, M., 1 May 2017, In : Ageing Research Reviews. 35, p. 222-240

Research output: Contribution to journalArticle

Open Access
55 Citations (Scopus)

Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy

Carvalho, D., Paulino, M., Polticelli, F., Arredondo, F., Williams, R. J. & Abin-Carriquiry, J. A., 19 Jun 2017, In : European Journal of Pharmaceutical Sciences. 106, p. 393-403 11 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
169 Downloads (Pure)
2016

Neuro-nutraceuticals: Further insights into their promise for brain health

Williams, R. J., Mohanakumar, K. P. & Beart, P. M., 1 May 2016, In : Neurochemistry International. 95, p. 1-3 3 p.

Research output: Contribution to journalEditorial

Open Access
File
3 Citations (Scopus)
112 Downloads (Pure)
2015

Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing

Cox, C. J., Choudhry, F., Peacey, E., Perkinton, M. S., Richardson, J. C., Howlett, D. R., Lichtenthaler, S. F., Francis, P. T. & Williams, R. J., 1 Jan 2015, In : Neurobiology of Aging. 36, 1, p. 178-187 10 p.

Research output: Contribution to journalArticle

Open Access
48 Citations (Scopus)
93 Downloads (Pure)

Neuro-nutraceuticals: the path to brain health via nourishment is not so distant

Williams, R. J., Mohanakumar, K. & Beart, P. M., Oct 2015, In : Neurochemistry International. 89, p. 1-6

Research output: Contribution to journalArticle

File
9 Citations (Scopus)
177 Downloads (Pure)
2014

Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden

Tan, M. G. K., Lee, C., Lee, J. H., Francis, P. T., Williams, R. J., Ramírez, M. J., Chen, C. P., Wong, P. T-H. & Lai, M. K. P., Jan 2014, In : Neurochemistry International. 64, p. 29-36 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2013

AMPA receptor activation promotes non-amyloidogenic amyloid precursor protein processing and suppresses neuronal amyloid-β production

Hoey, S. E., Buonocore, F., Cox, C. J., Hammond, V. J., Perkinton, M. S. & Williams, R. J., 24 Oct 2013, In : PLoS ONE. 8, 10, e78155.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
123 Downloads (Pure)

Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis

Pereira Morais, M. P., Marshall, D., Flower, S. E., Caunt, C. J., James, T. D., Williams, R. J., Waterfield, N. R. & Van Den Elsen, J. M. H., 27 Mar 2013, In : Scientific Reports. 3, p. 1-7 7 p., 1437.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Potential neuroprotective actions of dietary flavonoids

Vazour, D., Rattray, M., Williams, R. J. & Spencer, J., 1 Jan 2013, Handbook of Natural Products: Natural Products. Ramawat, K. G. & Merillion, J-M. (eds.). Springer, p. 2617-2640

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)
2012

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

Williams, R. J. & Spencer, J. P. E., 1 Jan 2012, In : Free Radical Biology & Medicine. 52, 1, p. 35-45 11 p.

Research output: Contribution to journalArticle

260 Citations (Scopus)

Neuroinflammation: Modulation by flavonoids and mechanisms of action

Spencer, J. P. E., Vafeiadou, K., Williams, R. J. & Vauzour, D., Feb 2012, In : Molecular Aspects of Medicine. 33, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity

Bahia, P. K., Pugh, V., Hoyland, K., Hensley, V., Rattray, M. & Williams, R. J., Oct 2012, In : Journal of Neurochemistry. 123, 1, p. 182-191

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
132 Downloads (Pure)

Prion protein expression alters APP cleavage without interaction with BACE-1

McHugh, P. C., Wright, J. A., Williams, R. J. & Brown, D. R., Oct 2012, In : Neurochemistry International. 61, 5, p. 672-680

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
120 Downloads (Pure)

Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice.

Choudhry, F., Howlett, D. R., Richardson, J. C., Francis, P. T. & Williams, R. J., May 2012, In : Neurobiology of Aging. 33, 5, p. 960-968 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia

Guadagna, S., Esiri, M. M., Williams, R. J. & Francis, P. T., Dec 2012, In : Neurobiology of Aging. 33, 12, p. 2798-2806

Research output: Contribution to journalArticle

28 Citations (Scopus)
2011

Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease

Gaeta, A., Molina-Holgado, F., Kong, X. L., Salvage, S., Fakih, S., Francis, P. T., Williams, R. J. & Hider, R. C., 1 Feb 2011, In : Bioorganic & Medicinal Chemistry. 19, 3, p. 1285-97 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2010

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L-O., Westman, E., Guntert, A., Kinsey, A., Proitsi, P., Powell, J., Causevic, M., Killick, R., Lunnon, K., Lynham, S., Broadstock, M., Choudhry, F., Howlett, D., Williams, R. J. & 27 others, Sharp, S., Mitchlemore, C., Tunnard, C., Leung, R., Foy, C., O'Brien, D., Breen, G., Furney, S., Ward, M., Kloszewska, I., Mecocco, P., Soininen, H., Tsolaki, M., Vellas, B., Hodges, A., Murphy, D., Parkins, S., Richardson, J., Resnik, S., Ferrucci, L., Wong, D., Zhou, Y., Muehlboeck, S., Evans, A., Francis, P., Spenger, C. & Lovestone, S., Jul 2010, In : Archives of General Psychiatry. 67, 7, p. 739-748 10 p.

Research output: Contribution to journalArticle

260 Citations (Scopus)
22 Citations (Scopus)
2009
139 Citations (Scopus)

The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury

Vafeiadou, K., Vauzour, D., Lee, H. Y., Rodriguez-Mateos, A., Williams, R. J. & Spencer, J. P. E., 1 Apr 2009, In : Archives of Biochemistry and Biophysics. 484, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)
2008

1-42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors

Abbott, J. J., Howlett, D. R., Francis, P. T. & Williams, R. J., Jul 2008, In : Neurobiology of Aging. 29, 7, p. 992-1001 10 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
60 Citations (Scopus)

Glial metabolism of quercetin reduces its neurotoxic potential

Vafeiadou, K., Vauzour, D., Rodriguez-Mateos, A., Whiteman, M., Williams, R. & Spencer, J., 15 Oct 2008, In : Archives of Biochemistry and Biophysics. 478, 2, p. 195-200 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells

Molina-Holgado, F., Gaeta, A., Francis, P. T., Williams, R. J. & Hider, R. C., 8 Apr 2008, In : Journal of Neurochemistry. 105, 6, p. 2466-2476 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.

Rainey-Smith, S., Schroetke, L-W., Bahia, P., Fahmi, A., Skilton, R., Spencer, J. P. E., Rice-Evans, C., Rattray, M. & Williams, R. J., 13 Jun 2008, In : Neuroscience Letters. 438, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

File
41 Citations (Scopus)
133 Downloads (Pure)

Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions

Pezet, S., Marchand, F., D'Mello, R., Grist, J., Clark, A. K., Malcangio, M., Dickenson, A. H., Williams, R. J. & McMahon, S. B., 16 Apr 2008, In : The Journal of Neuroscience: The Official Journal of the Society for Neuroscience. 28, 16, p. 4261-4270 10 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)
2007

(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons

Schroeter, H., Bahia, P., Spencer, J. P. E., Sheppard, O., Rattray, M., Cadenas, E., Rice-Evans, C. & Williams, R. J., Jun 2007, In : Journal of Neurochemistry. 101, 6, p. 1596-1606 11 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons

Vauzour, D., Vafeiadou, K., Rice-Evans, C., Williams, R. J. & Spencer, J. P. E., 2007, In : Journal of Neurochemistry. 103, 4, p. 1355-67 13 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)

CB2 cannabinoid receptors promote mouse neural stem cell proliferation

Molina-Holgado, F., Rubio-Araiz, A., García-Ovejero, D., Williams, R. J., Moore, J. D., Arévalo-Martín, A., Gómez-Torres, O. & Molina-Holgado, E., 2007, In : European Journal of Neuroscience. 25, 3, p. 629-34 6 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Metals ions and neurodegeneration

Molina-Holgado, F., Hider, R. C., Gaeta, A., Williams, R. & Francis, P., 2007, In : Biometals. 20, 3-4, p. 639-54 16 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)
2006

Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease

Jacobs, E. H., Williams, R. & Francis, P. T., 2006, In : Neuroscience. 138, 2, p. 511-22 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
5 Citations (Scopus)
2005

Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons

Pezet, S., Spyropoulos, A., Williams, R. J. & McMahon, S. B., 2005, In : European Journal of Neuroscience. 21, 7, p. 1785-97 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2004

Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress

Tortarolo, M., Crossthwaite, A. J., Conforti, L., Spencer, J. P., Williams, R. J., Bendotti, C. & Rattray, M., 2004, In : Journal of Neurochemistry. 88, 2, p. 481-93 13 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Flavonoids: antioxidants or signalling molecules?

Williams, R. J., Spencer, J. P. E. & Rice-Evans, C., 1 Apr 2004, In : Free Radical Biology and Medicine. 36, 7, p. 838-849 12 p.

Research output: Contribution to journalArticle

1418 Citations (Scopus)

Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1/2 and Akt/PKB but not JNK in cultured striatal neurones

Crossthwaite, A. J., Valli, H. & Williams, R. J., 2004, In : Journal of Neurochemistry. 88, 5, p. 1127-39 13 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage

Williams, R. J., Spencer, J. P. E., Goni, F. M. & Rice-Evans, C. A., 2004, In : Neuroscience Letters. 371, 2-3, p. 106-10 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2003

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites

Spencer, J. P. E., Kuhnle, G. G. C., Williams, R. J. & Rice-Evans, C., 2003, In : Biochemical Journal. 372, 1, p. 173-81 9 p.

Research output: Contribution to journalArticle

203 Citations (Scopus)
285 Citations (Scopus)

The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings

Suchak, S. K., Baloyianni, N. V., Perkinton, M. S., Williams, R. J., Meldrum, B. S. & Rattray, M., 2003, In : Journal of Neurochemistry. 84, 3, p. 522-32 11 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)
2002

Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase

Crossthwaite, A. J., Hasan, S. & Williams, R. J., 2002, In : Journal of Neurochemistry. 80, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter, H., Boyd, C., Spencer, J. P. E., Williams, R. J., Cadenas, E. & Rice-Evans, C., 2002, In : Neurobiology of Aging. 23, 5, p. 861-80 20 p.

Research output: Contribution to journalArticle

253 Citations (Scopus)

Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn

Pezet, S., Malcangio, M., Lever, I. J., Perkinton, M. S., Thompson, S. W. N., Williams, R. J. & McMahon, S. B., 2002, In : Molecular and Cellular Neuroscience. 21, 4, p. 684-95 12 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones

Perkinton, M. S., Ip, J. K., Wood, G. L., Crossthwaite, A. J. & Williams, R. J., 2002, In : Journal of Neurochemistry. 80, 2, p. 239-54 16 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)
2001

Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

Spencer, J. P., Schroeter, H., Crossthwaithe, A. J., Kuhnle, G., Williams, R. J. & Rice-Evans, C., 2001, In : Free Radical Biology and Medicine. 31, 9, p. 1139-46 8 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)