1990 …2022
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Personal profile

Willing to supervise PhD

Inhibiting tau, amyloid-β and α-synuclein toxicity: protecting neuronal network function in Dementias

Understanding microglial migration to pathogenic synapses

Assessing the neuroprotective potential and risk reducing capability of dietary polyphenolics in Alzheimer's Disease


Research interests

My laboratory is interested in the molecular mechanisms underlying synaptic dysfunction and neuronal loss in Alzheimer's Disease and other forms of neurodegeneration.  We are focused on cell signalling abnormalities that underpin the early stages of disease with the aim of identifying new targets for therapeutic intervention. 




Other responsibilities

Member of Alzheimer's Research UK Grant Review Board: 2013 - 2019

Editorial Board of Neurochemistry International: 2015 - 

Editorial Board of Nutrition and Aging: 2012 -

Editorial Advisory Board of Journal of Alzheimer's Disease: 2018 - 2019

Education/Academic qualification

Doctor of Science, University of Leeds

Bachelor of Science, University of Leeds

Fingerprint Dive into the research topics where Robert Williams is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Neurons Medicine & Life Sciences
Flavonoids Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Phosphatidylinositol 3-Kinase Medicine & Life Sciences
Amyloid beta-Protein Precursor Medicine & Life Sciences
Catechin Medicine & Life Sciences
Amyloid Precursor Protein Secretases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2022

Research Output 1990 2019

1 Citation (Scopus)
34 Downloads (Pure)

Excitation-energy-dependent molecular beacon detects early stage neurotoxic aβ aggregates in the presence of cortical neurons

Gulácsy, C. E., Meade, R., Catici, D. A. M., Soeller, C., Pantos, G. D., Jones, D. D., Alibhai, D., Jepson, M., Valev, V. K., Mason, J. M., Williams, R. J. & Pudney, C. R., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
33 Downloads (Pure)

Advanced glycation end products modulate amyloidogenic APP processing and Tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer’s disease

Batkulwar, K., Godbole, R., Banarjee, R., Kassaar, O., Williams, R. J. & Kulkarni, M., 16 May 2018, In : ACS Chemical Neuroscience. 9, 5, p. 988-1000 13 p.

Research output: Contribution to journalArticle

Open Access
Advanced Glycosylation End Products
Alzheimer Disease
Cathepsin B

Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis

Pereira Morais, M., Munir, O. K., Flower, S., Williams, R. J., James, T. & Van Den Elsen, J., 14 Nov 2018, Electrophoretic Separation of Proteins: Methods and Protocols. T. Kurien, B. & Hal Scofield, R. (eds.). New York, U. S. A.: Humana Press, p. 161-175 (Methods in Molecular Biology; vol. 1855).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)
59 Downloads (Pure)
Open Access
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Alzheimer Disease
13 Citations (Scopus)

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

Kassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. & Van Den Elsen, J., 23 Feb 2017, In : Scientific Reports. 7, p. 1-12 12 p., 42874.

Research output: Contribution to journalArticle

Open Access
Macrophage Migration-Inhibitory Factors
Alzheimer Disease


Alpha-Synuclein Expression Influences the Processing of the Amyloid Precursor Protein

Author: Roberts, H., 23 Nov 2016

Supervisor: Brown, D. R. (External person) (Supervisor) & Williams, R. (Supervisor)

Student thesis: Doctoral ThesisPhD


Flavonoids as regulators of amyloid precursor protein processing

Author: Cox, C., 14 May 2014

Supervisor: Williams, R. (Supervisor) & Wonnacott, S. (Supervisor)

Student thesis: Doctoral ThesisPhD


Inducing Age Related Changes in Microglia as a Model for Neurodegenerative Disease

Author: Angelova, D., 13 Feb 2019

Supervisor: Williams, R. J. (Supervisor) & Brown, D. (Supervisor)

Student thesis: Doctoral ThesisPhD


Investigation into the role of the RNA methyltransferase NSun2 in neuroplasticity regulation

Author: George, H., 2 Oct 2019

Supervisor: Williams, R. J. (Supervisor) & Hussain, M. S. (Supervisor)

Student thesis: Doctoral ThesisPhD


α7 nicotinic acetylcholine receptors at the glutamatergic synapse

Author: Hammond, V., 4 Nov 2014

Supervisor: Williams, R. (Supervisor) & Wonnacott, S. (Supervisor)

Student thesis: Doctoral ThesisPhD