1990 …2022
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Personal profile

Willing to supervise PhD

Inhibiting tau, amyloid-β and α-synuclein toxicity: protecting neuronal network function in Dementias

Understanding microglial migration to pathogenic synapses

 

Research interests

My laboratory is interested in the molecular mechanisms underlying synaptic dysfunction and neuronal loss in Alzheimer's Disease and other forms of neurodegeneration.  We are focused on cell signalling abnormalities the underpin the early stages of disease with the aim of identifying new targets for therapeutic intervention. 

 

 

 

Other responsibilities

Member of Alzheimer's Research UK Grant Review Board: 2013 - 2019

Editorial Board of Neurochemistry International: 2015 - 

Editorial Board of Nutrition and Aging: 2012 -

Editorial Advisory Board of Journal of Alzheimer's Disease: 2018 -

Education/Academic qualification

Doctor of Science, University of Leeds

Bachelor of Science, University of Leeds

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Neurons Medicine & Life Sciences
Flavonoids Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Phosphatidylinositol 3-Kinase Medicine & Life Sciences
Amyloid beta-Protein Precursor Medicine & Life Sciences
Catechin Medicine & Life Sciences
Amyloid Precursor Protein Secretases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2022

Research Output 1990 2018

3 Citations

Advanced glycation end products modulate amyloidogenic APP processing and Tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer’s disease

Batkulwar, K., Godbole, R., Banarjee, R., Kassaar, O., Williams, R. J. & Kulkarni, M., 16 May 2018, In : ACS Chemical Neuroscience. 9, 5, p. 1-37

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Phosphorylation
Alzheimer Disease
Endopeptidases
Cathepsin B

Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis

Pereira Morais, M., Munir, O. K., Flower, S., Williams, R. J., James, T. & Van Den Elsen, J., 14 Nov 2018, Electrophoretic Separation of Proteins: Methods and Protocols. T. Kurien, B. & Hal Scofield, R. (eds.). New York, U. S. A.: Humana Press, p. 161-175 (Methods in Molecular Biology; vol. 1855).

Research output: Chapter in Book/Report/Conference proceedingChapter

An excitation-energy-dependent molecular beacon detects early-stage neurotoxic Aβ aggregates in the presence of cortical neurons

Gulácsy, C., Meade, R., Catici, A. M. D., Soeller, C., Pantoș, G. D., Jones, D. D., Alibhai, D., Jepson, M., Valev, V., Mason, J., Williams, R. J. & Pudney, C., 16 Oct 2018, In : ACS Chemical Neuroscience. 13 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations
Open Access
File
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Proteins
Alzheimer Disease
Luciferases
6 Citations

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

Kassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. & Van Den Elsen, J., 23 Feb 2017, In : Scientific Reports. 7, 42874.

Research output: Contribution to journalArticle

Open Access
Macrophage Migration-Inhibitory Factors
Alzheimer Disease
Glucose
Hyperglycemia
Aptitude

Thesis

Alpha-Synuclein Expression Influences the Processing of the Amyloid Precursor Protein

Author: Roberts, H., 23 Nov 2016

Supervisor: Brown, D. R. (External person) (Supervisor) & Williams, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

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Flavonoids as regulators of amyloid precursor protein processing

Author: Cox, C., 14 May 2014

Supervisor: Williams, R. (Supervisor) & Wonnacott, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

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α7 nicotinic acetylcholine receptors at the glutamatergic synapse

Author: Hammond, V., 4 Nov 2014

Supervisor: Williams, R. (Supervisor) & Wonnacott, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

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