Personal profile

Willing to supervise PhD

Inhibiting tau, amyloid-β and α-synuclein toxicity: protecting neuronal network function in Dementias

Understanding microglial migration to pathogenic synapses

 

Research interests

My laboratory is interested in the molecular mechanisms underlying synaptic dysfunction and neuronal loss in Alzheimer's Disease and other forms of neurodegeneration.  We are focused on cell signalling abnormalities the underpin the early stages of disease with the aim of identifying new targets for therapeutic intervention. 

 

 

 

Other responsibilities

Member of Alzheimer's Research UK Grant Review Board: 2013 - 2019

Editorial Board of Neurochemistry International: 2015 - 

Editorial Board of Nutrition and Aging: 2012 -

Editorial Advisory Board of Journal of Alzheimer's Disease: 2018 -

Education/Academic qualification

Doctor of Science, University of Leeds

Bachelor of Science, University of Leeds

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Neurons Medicine & Life Sciences
Flavonoids Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Phosphatidylinositol 3-Kinase Medicine & Life Sciences
Amyloid beta-Protein Precursor Medicine & Life Sciences
Catechin Medicine & Life Sciences
Amyloid Precursor Protein Secretases Medicine & Life Sciences

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Projects 2010 2021

Research Output 1990 2018

Advanced glycation end products modulate amyloidogenic APP processing and Tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer’s disease

Batkulwar, K., Godbole, R., Banarjee, R., Kassaar, O., Williams, R. J. & Kulkarni, M. 31 Jan 2018 In : ACS Chemical Neuroscience. p. 1-37

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Phosphorylation
Alzheimer Disease
Endopeptidases
Cathepsin B
1 Citations
Open Access
File
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Proteins
Alzheimer Disease
Luciferases
5 Citations

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

Kassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. & Van Den Elsen, J. 23 Feb 2017 In : Scientific Reports. 7, 42874

Research output: Contribution to journalArticle

Open Access
Macrophage Migration-Inhibitory Factors
Alzheimer Disease
Glucose
Hyperglycemia
Aptitude
13 Citations

Nutrition for the ageing brain: towards evidence for an optimal diet

Vauzour, D. , Camprubi-Robles, M. , Miquel-Kergoat, S. , Andres-Lacueva, C. , Banati, D. , Barberger-Gateau, P. , Bowman, G. , Carbelotto, L. , Clarke, R. , Hogervorst, E. , Kiliaan, A. , Lucca, U. , Manach, C. , Minihane, A-M. , Mitchell, E. S. , Perneczky, R. , Perry, H. , Roussel, A-M. , Schuermans, J. , Sijben, J. & 8 others Spencer, J. P. E., Thuret, S., van de Rest, O., Vandewoude, M., Wesnes, K., Williams, R. J., Williams, R. S. B. & Ramirez, M. 1 May 2017 In : Ageing Research Reviews. 35, p. 222-240

Research output: Contribution to journalArticle

Open Access
Nutrition
Brain
Aging of materials
Diet
Cognition
2 Citations

Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy

Carvalho, D., Paulino, M., Polticelli, F., Arredondo, F., Williams, R. J. & Abin-Carriquiry, J. A. 19 Jun 2017 In : European Journal of Pharmaceutical Sciences. 106, p. 393-403 11 p.

Research output: Contribution to journalArticle

Quercetin
Proteins
Phosphatidylinositol 3-Kinase
Poly(ADP-ribose) Polymerases
Xanthine Oxidase