1990 …2022

Research output per year

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Personal profile

Willing to supervise PhD

Inhibiting tau, amyloid-β and α-synuclein toxicity: protecting neuronal network function in Dementias

Understanding microglial migration to pathogenic synapses

Assessing the neuroprotective potential and risk reducing capability of dietary polyphenolics in Alzheimer's Disease

 

Research interests

My laboratory is interested in the molecular mechanisms underlying synaptic dysfunction and neuronal loss in Alzheimer's Disease and other forms of neurodegeneration.  We are focused on cell signalling abnormalities that underpin the early stages of disease with the aim of identifying new targets for therapeutic intervention. 

 

 

 

Other responsibilities

Member of Alzheimer's Research UK Grant Review Board: 2013 - 2019

Editorial Board of Neurochemistry International: 2015 - 

Editorial Board of Nutrition and Aging: 2012 -

Editorial Advisory Board of Journal of Alzheimer's Disease: 2018 - 2019

Education/Academic qualification

Doctor of Science, University of Leeds

Bachelor of Science, University of Leeds

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Projects

Research Output

Excitation-energy-dependent molecular beacon detects early stage neurotoxic aβ aggregates in the presence of cortical neurons

Gulácsy, C. E., Meade, R., Catici, D. A. M., Soeller, C., Pantos, G. D., Jones, D. D., Alibhai, D., Jepson, M., Valev, V. K., Mason, J. M., Williams, R. J. & Pudney, C. R., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
35 Downloads (Pure)

Advanced glycation end products modulate amyloidogenic APP processing and Tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer’s disease

Batkulwar, K., Godbole, R., Banarjee, R., Kassaar, O., Williams, R. J. & Kulkarni, M., 16 May 2018, In : ACS Chemical Neuroscience. 9, 5, p. 988-1000 13 p.

Research output: Contribution to journalArticle

Open Access
File
  • 18 Citations (Scopus)
    35 Downloads (Pure)

    Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis

    Pereira Morais, M., Munir, O. K., Flower, S., Williams, R. J., James, T. & Van Den Elsen, J., 14 Nov 2018, Electrophoretic Separation of Proteins: Methods and Protocols. T. Kurien, B. & Hal Scofield, R. (eds.). New York, U. S. A.: Humana Press, p. 161-175 (Methods in Molecular Biology; vol. 1855).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Open Access
    File
  • 2 Citations (Scopus)
    65 Downloads (Pure)

    Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

    Kassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. & Van Den Elsen, J., 23 Feb 2017, In : Scientific Reports. 7, p. 1-12 12 p., 42874.

    Research output: Contribution to journalArticle

    Open Access
  • 14 Citations (Scopus)

    Thesis

    Alpha-Synuclein Expression Influences the Processing of the Amyloid Precursor Protein

    Author: Roberts, H., 23 Nov 2016

    Supervisor: Brown, D. R. (External person) (Supervisor) & Williams, R. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Flavonoids as regulators of amyloid precursor protein processing

    Author: Cox, C., 14 May 2014

    Supervisor: Williams, R. (Supervisor) & Wonnacott, S. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Inducing Age Related Changes in Microglia as a Model for Neurodegenerative Disease

    Author: Angelova, D., 13 Feb 2019

    Supervisor: Williams, R. J. (Supervisor) & Brown, D. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Investigation into the role of the RNA methyltransferase NSun2 in neuroplasticity regulation

    Author: George, H., 2 Oct 2019

    Supervisor: Williams, R. J. (Supervisor) & Hussain, M. S. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Regulation and subcellular localisation of a novel E3 ubiquitin ligase in mouse primary cortical neurons

    Author: Jasem, S., 19 Feb 2020

    Supervisor: Licchesi, J. (Supervisor) & Williams, R. (Supervisor)

    Student thesis: Doctoral ThesisPhD