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Personal profile

Research interests

My laboratory is interested in the molecular mechanisms underlying synaptic dysfunction and neuronal loss in Alzheimer's Disease and other forms of neurodegeneration.  We are focused primarily on understanding cell signalling abnormalities that underpin the early prodromal stages of disease with the aim of identifying new targets for therapeutic intervention.  Part of our strategy is to identify dietary factors that could be harnessed to slow onset or reduce the risk of dementia and we have worked extensively on plant polyphenols most notably flavonoids. 

Specific Project Areas:

  • Inhibiting tau, amyloid-β and α-synuclein toxicity: protecting synapses and neuronal network function in Dementias 
  • Understanding microglial migration to pathogenic synapses, phagocytosis and the innate immune response
  • Assessing the neuroprotective potential and risk reducing capability of dietary polyphenolics in Alzheimer's Disease
  • Using human stem cell models and microelectrode arrays as a replacement for rodent models of network dysfunction under the NC3Rs




Other responsibilities

Member of the University of Bath Healthy Living Longer Network https://www.bath.ac.uk/research-groups/healthy-later-living-network/

Member of European Science Foundation College of Experts: 2022 -

Member of Alzheimer's Research UK Grant Review Board: 2013 - 2019

Member of MJFF Review Board 2013

Member of Bath and Bristol Alzheimer's Research UK Network: 2009 - 

Editorial Board of Neurochemistry International: 2015 - 

Editorial Board of Nutrition and Aging: 2012 -

Editorial Board of Journal of Neurochemistry: 1998 - 2010

Editorial Advisory Board of Journal of Alzheimer's Disease: 2018 - 2019

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Science, University of Leeds

Award Date: 1 Jan 1990

Bachelor of Science, University of Leeds

Award Date: 1 Jan 1986


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