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Research Output 1993 2018

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Article
2018
1 Citations

Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility trial

Ridd, M. J., Gaunt, D. M., Guy, R. H., Redmond, N. M., Garfield, K., Hollinghurst, S., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C. 1 Aug 2018 In : British Journal of Dermatology. 179, 2, p. 362-370 9 p.

Research output: Contribution to journalArticle

Emollients
Eczema
Atopic Dermatitis
Outcome Assessment (Health Care)
5 Citations

Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

Lipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A. 1 Jun 2018 In : Nature Nanotechnology. 13, p. 501-511

Research output: Contribution to journalArticle

Open Access
File
Graphite
glucose
Graphene
Glucose
graphene

Topical bio(in)equivalence of metronidazole formulations in vivo

Pedon de Araujo, T., Moura Fittipaldi, I., Galindo Bedor, D. C., Ludna Duarte, M., Cordery, S., Guy, R., Delgado-Charro, M., Pereira de Santana, D. & Bastos Leal, L. 25 Apr 2018 In : International Journal of Pharmaceutics. 541, p. 167-172 6 p.

Research output: Contribution to journalArticle

Metronidazole
Cornea
Skin
Pharmaceutical Preparations
Biological Availability
2017
4 Citations

Bioequivalence methodologies for topical drug products: in vitro and ex vivo studies with a cortiscosteroid and an anti-fungal drug

Bastos Leal, L., Cordery, S. F., Delgado-Charro, M. B., Bunge, A. L. & Guy, R. H. Apr 2017 In : Pharmaceutical Research. 34, 4, p. 730-737 8 p.

Research output: Contribution to journalArticle

Open Access

Precise laser poration to control drug delivery into and through human nail

Vanstone, S., Cordery, S., Stone, J., Gordeev, S. & Guy, R. 28 Dec 2017 In : Journal of Controlled Release. 268, p. 72-77 6 p.

Research output: Contribution to journalArticle

Open Access
File
Drug and Narcotic Control
Nails
Lasers
Pharmaceutical Preparations
Nail Diseases
1 Citations

Reverse iontophoretic extraction of metabolites from living plants and their identification by ion-chromatography coupled to high resolution mass spectrometry

Gonzalez-Sanchez, M. I., McCullagh, J., Guy, R. & Compton, R. May 2017 In : Phytochemical Analysis. 28, 3, p. 195-201 7 p.

Research output: Contribution to journalArticle

Ion chromatography
ion exchange chromatography
Metabolites
Mass spectrometry
Chromatography
4 Citations

Topical bioavailability of diclofenac from locally-acting, dermatological formulations

Cordery, S. F., Pensado, A., Chiu, W. S., Shehab, M. Z., Bunge, A. L., Delgado-Charro, M. B. & Guy, R. H. 30 Aug 2017 In : International Journal of Pharmaceutics. 529, 1-2, p. 55-64 10 p.

Research output: Contribution to journalArticle

Open Access
File
Diclofenac
Biological Availability
Skin
Pharmaceutical Preparations
Cornea
2016
12 Citations

Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H. 1 Apr 2016 In : Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.

Research output: Contribution to journalArticle

Open Access
Chemical Safety
Decision Trees
Cosmetics
Decision trees
Toxicology

Choice of moisturiser for eczema treatment (COMET): feasibility study of a randomised controlled parallel group trial in children recruited from primary care

Ridd, M., Garfield, K., Gaunt, D., Hollinghurst, S., Redmond, N., Powell, K., Wilson, V., Guy, R., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C. Nov 2016 In : BMJ Open. 6, 11, 9 p., e012021

Research output: Contribution to journalArticle

Open Access
Emollients
Eczema
Feasibility Studies
Primary Health Care
Therapeutics
8 Citations

Femtosecond pulsed laser ablation to enhance drug delivery across the skin

Garvie-Cook, H., Stone, J. M., Yu, F., Guy, R. H. & Gordeev, S. N. Jan 2016 In : Journal of Biophotonics. 9, 1-2, p. 144-154

Research output: Contribution to journalArticle

Laser Therapy
inks
Laser ablation
Pulsed lasers
Drug delivery
3 Citations
Open Access
File
oxidized cellulose
Ibuprofen
Gels
Skin
Cornea
7 Citations

Managing diabetes through the skin: Diagnostic devices

Guy, R. Jun 2016 In : Nature Nanotechnology. 11, 6, p. 493-494 2 p.

Research output: Contribution to journalArticle

Open Access
File
Medical problems
Gold
Skin
sweat
Controlled drug delivery
3 Citations

Modelling drug flux through microporated skin

Rzhevskiy, A. S., Guy, R. H. & Anissimov, Y. G. 10 Nov 2016 In : Journal of Controlled Release. 241, p. 194-199 6 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Design
Skin
Pharmaceutical Preparations
Theoretical Models
Molecular Weight
6 Citations

The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs

Frederiksen, K., Guy, R. H. & Petersson, K. 2016 In : Expert Opinion on Drug Delivery. 13, 3, p. 349-360

Research output: Contribution to journalArticle

Open Access
File
Skin
Patient Compliance
Pharmaceutical Preparations
Expert Testimony
Drug Delivery Systems
2015
3 Citations

Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems

Garvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S. 28 Aug 2015 In : Journal of Controlled Release. 212, p. 103-112 10 p.

Research output: Contribution to journalArticle

Open Access
File
Betamethasone Valerate
Triglycerides
Polymers
Skin
Raman Spectrum Analysis
8 Citations

Characterization of Topical Film-Forming Systems Using Atomic Force Microscopy and Raman Microspectroscopy

Garvie-cook, H., Frederiksen, K., Petersson, K., Guy, R. H. & Gordeev, S. Mar 2015 In : Molecular Pharmaceutics. 12, 3, p. 751-757 7 p.

Research output: Contribution to journalArticle

Open Access
File
Plasticizers
Atomic Force Microscopy
Elastic Modulus
Betamethasone Valerate
Skin
9 Citations

Choice of Moisturiser for Eczema Treatment (COMET): Study protocol for a randomized controlled trial

Ridd, M. J., Redmond, N. M., Hollinghurst, S., Ball, N., Shaw, L., Guy, R., Wilson, V., Metcalfe, C. & Purdy, S. 15 Jul 2015 In : Trials. 16, 304

Research output: Contribution to journalArticle

Open Access
File
Emollients
Eczema
Clinical Protocols
Randomized Controlled Trials
Feasibility Studies
13 Citations

Development and in vitro evaluation of lipid nanoparticle-based dressings for topical treatment of chronic wounds

Gainza, G., Chu, W. S., Guy, R. H., Pedraz, J. L., Hernandez, R. M., Delgado-Charro, B. & Igartua, M. 25 Jul 2015 In : International Journal of Pharmaceutics. 490, 1-2, p. 404-411 8 p.

Research output: Contribution to journalArticle

File
Bandages
Nanoparticles
Lipids
Wounds and Injuries
Fibrin
15 Citations

Drug delivery into microneedle-porated nails from nanoparticle reservoirs

Chiu, W. S., Belsey, N. A., Garrett, N. L., Moger, J., Price, G. J., Delgado-Charro, M. B. & Guy, R. H. 28 Dec 2015 In : Journal of Controlled Release. 220, A, p. 98-106 9 p.

Research output: Contribution to journalArticle

Open Access
File
Nails
Nanoparticles
Pharmaceutical Preparations
Raman Spectrum Analysis
Optical Imaging
21 Citations
Open Access
File
Plasticizers
Drug Delivery Systems
Betamethasone Valerate
Skin
Polymers
9 Citations

In situ detection of salicylate in Ocimum basilicum plant leaves via reverse iontophoresis

González-Sánchez, M. I., Lee, P. T., Guy, R. H. & Compton, R. G. 28 Nov 2015 In : Chemical Communications. 51, 92, p. 16534-16536 3 p.

Research output: Contribution to journalArticle

Open Access
File
Salicylates
Cyclic voltammetry
Electrodes
Chemical analysis
Iontophoresis
1 Citations

In vitro method to quantify dermal absorption of pesticide residues

Clarke, J. F., Cordery, S. F., Morgan, N. A., Knowles, P. K. & Guy, R. H. 16 Feb 2015 In : Chemical Research in Toxicology. 28, 2, p. 166-168

Research output: Contribution to journalArticle

Open Access
File
15 Citations

Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting?

Gelfuso, G. M., Barros, M. A. D. O., Delgado-Charro, M. B., Guy, R. H. & Lopez, R. F. V. Oct 2015 In : Colloids and Surfaces B: Biointerfaces. 134, p. 408-412 5 p.

Research output: Contribution to journalArticle

Open Access
File
Iontophoresis
microparticles
Drug Delivery Systems
Hair Follicle
hair
1 Citations

Iontophoretic transdermal sampling of iohexol as a noninvasive tool to assess glomerular filtration rate

Djabri, A., van’t Hoff, W., Brock, P., Wong, I. C. K., Guy, R. & Delgado-Charro, B. 1 Feb 2015 In : Pharmaceutical Research. 32, 2, p. 590-603

Research output: Contribution to journalArticle

Open Access
File
Iohexol
Iontophoresis
Glomerular Filtration Rate
Sampling
Pediatrics
20 Citations

Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy

Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R. 15 May 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730

Research output: Contribution to journalArticle

Open Access
File
Raman Spectrum Analysis
Nails
Microscopy
Nail Diseases
Propylene Glycol
5 Citations
Open Access
File
Petasites
Clerodendrum
Vanillic Acid
Medicinal Plants
Cornea
2014
23 Citations
Open Access
File
Buprenorphine
Naltrexone
Drug Combinations
Cocaine
Morphine
24 Citations
Open Access
File
Petasites
Clerodendrum
Vanillic Acid
Apigenin
Skin
3 Citations

Characterisation of skin barrier function using bioengineering and biophysical techniques

Yang, Q. & Guy, R. H. 5 Aug 2014 In : Pharmaceutical Research. 32, 2, p. 445-457

Research output: Contribution to journalArticle

Open Access
File
Bioengineering
Forehead
Cornea
Skin
Forearm
33 Citations

Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies

Belsey, N. A., Garrett, N. L., Contreras-Rojas, L. R., Pickup-Gerlaugh, A. J., Price, G. J., Moger, J. & Guy, R. H. 28 Jan 2014 In : Journal of Controlled Release. 174, 28, p. 37-42

Research output: Contribution to journalArticle

Open Access
File
Drug Evaluation
Raman Spectrum Analysis
Fluorescence Microscopy
Skin
Microscopy
3 Citations

Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation

Guy, R. H., Kuma, H. & Nakanishi, M. May 2014 In : European Journal of Dermatology. 24, 3, p. 365-371 7 p.

Research output: Contribution to journalArticle

Open Access
File
Photoallergic Dermatitis
Ketoprofen
Photosensitivity Disorders
Phototoxic Dermatitis
Photolysis
67 Citations

Transdermal drug delivery: 30 + years of war and still fighting!

Wiedersberg, S. & Guy, R. H. 28 Sep 2014 In : Journal of Controlled Release. 190, p. 150-156

Research output: Contribution to journalArticle

Open Access
File
Pharmaceutical Preparations
Cutaneous Administration
Skin
Technology
Research
2013
8 Citations
Open Access
File
Dielectric Spectroscopy
Iontophoresis
Nails
Permeation
Hydration
18 Citations

Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia

Gelfuso, G. M., Gratieri, T., Delgado-Charro, M. B., Guy, R. H. & Vianna Lopez, R. F. 1 May 2013 In : Journal of Pharmaceutical Sciences. 102, 5, p. 1488-1494

Research output: Contribution to journalArticle

Iontophoresis
Alopecia
Minoxidil
Sulfates
Hair Follicle
11 Citations

Mechanical tomography of human corneocytes with a nanoneedle

Beard, J. D., Guy, R. H. & Gordeev, S. N. Jun 2013 In : Journal Of Investigative Dermatology. 133, 6, p. 1565-1571 7 p.

Research output: Contribution to journalArticle

Open Access
File
Nanoneedles
Atomic Force Microscopy
Tomography
Atomic force microscopy
Mechanical properties

Products in "Bounty bags" potentially harm newborn skin

Ridd, M., Guy, R., Ball, N., Roberts, A. & Williams, H. 22 Jun 2013 In : BMJ . 346, 7913, f3895

Research output: Contribution to journalArticle

5 Citations

Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs): Comparison with experimental results

Güngör, S., Delgado-Charro, M. B., Masini-Etévé, V., Potts, R. O. & Guy, R. H. 28 Dec 2013 In : Journal of Controlled Release. 172, 3, p. 601-606 6 p.

Research output: Contribution to journalArticle

Open Access
File
Selective Estrogen Receptor Modulators
Skin
Danazol
Water
Epidermis
2012
26 Citations

Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping

Mohammed, D., Yang, Q., Guy, R. H., Matts, P. J., Hadgraft, J. & Lane, M. E. Sep 2012 In : European Journal of Pharmaceutics and Biopharmaceutics. 82, 1, p. 171-174

Research output: Contribution to journalArticle

Cornea
Densitometry
Surgical Tape
Volunteers
Proteins
7 Citations

Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies

Russell, L. M. & Guy, R. H. Sep 2012 In : Pharmaceutical Research. 29, 9, p. 2389-2397 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cornea
Tapes
Imaging techniques
Weighing
Therapeutic Equivalency
6 Citations

Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies: Proof-of-concept with acyclovir formulations

Russell, L. M. & Guy, R. H. Dec 2012 In : Pharmaceutical Research. 29, 12, p. 3362-3372 11 p.

Research output: Contribution to journalArticle

Open Access
File
Acyclovir
Cornea
Tapes
Imaging techniques
Weighing
67 Citations

Objective assessment of nanoparticle disposition in mammalian skin after topical exposure

Campbell, C. S. J., Contreras-Rojas, L. R., Delgado-Charro, B. & Guy, R. H. 20 Aug 2012 In : Journal of Controlled Release. 162, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

Open Access
File
Nanoparticles
Skin
Sebum
Polystyrenes
Drug Delivery Systems
16 Citations
Open Access
File
Phenobarbital
Pediatrics
Skin
Iontophoresis
Drug Compounding
30 Citations
Open Access
File
Iontophoresis
Ranitidine
Pediatrics
Drug Therapy
Gels
2011
1 Citations

AFM nanotools for surgery of biological Cells

Beard, J. D., Gordeev, S. N. & Guy, R. H. 2011 In : Journal of Physics: Conference Series. 286, 1, 012003

Research output: Contribution to journalArticle

surgery
atomic force microscopy
manipulators
surface layers
electron beams
9 Citations

Assessment of dermal exposure to pesticide residues during re-entry

Belsey, N. A., Cordery, S. F., Bunge, A. L. & Guy, R. H. 15 May 2011 In : Environmental Science & Technology. 45, 10, p. 4609-4615 7 p.

Research output: Contribution to journalArticle

Open Access
File
Pesticide Residues
pesticide residue
Reentry
Pesticides
pesticide
83 Citations

Imaging drug delivery to skin with stimulated Raman scattering microscopy

Saar, B. G., Contreras-Rojas, L. R., Xie, X. S. & Guy, R. H. 6 Jun 2011 In : Molecular Pharmaceutics. 8, 3, p. 969-975 7 p.

Research output: Contribution to journalArticle

Open Access
File
Raman Spectrum Analysis
Microscopy
Skin
Pharmaceutical Preparations
Three-Dimensional Imaging
138 Citations

Mathematical models of skin permeability: An overview

Mitragotri, S., Anissimov, Y. G., Bunge, A. L., Frasch, H. F., Guy, R. H., Hadgraft, J., Kasting, G. B., Lane, M. E. & Roberts, M. S. 10 Oct 2011 In : International Journal of Pharmaceutics. 418, 1, p. 115-129 15 p.

Research output: Contribution to journalArticle

Open Access
File
Permeability
Theoretical Models
Skin
Research
Pharmaceutical Preparations
20 Citations

Optimisation of Cosolvent Concentration for Topical Drug Delivery III - Influence of Lipophilic Vehicles on Ibuprofen Permeation

Watkinson, R. M., Guy, R. H., Oliveira, G., Hadgraft, J. & Lane, M. E. 2011 In : Skin Pharmacology and Physiology. 24, 1, p. 22-26 5 p.

Research output: Contribution to journalArticle

Ibuprofen
Mineral Oil
Silicones
Skin
Membranes
4 Citations
File
Solute transport
liquid-liquid interfaces
glycols
polyethylenes
solutes
2010

Application of biophysics and bioengineering to the assessment of barrier function

Yang, Q., Cordery, S. & Guy, R. H. Oct 2010 In : Journal of Pharmacy and Pharmacology. 62, 10, p. 1249-1250 2 p.

Research output: Contribution to journalArticle

Biophysics
Bioengineering
Forehead
Skin
Forearm