Richard Guy – Research Output — the University of Bath's research portal

2019

Potential of iontophoresis as a drug delivery method for midazolam in pediatrics

Djabri, A., Guy, R. & Delgado-Charro, M., 1 Feb 2019, In : European Journal of Pharmaceutical Sciences. 128, p. 137-143 7 p.

Research output: Contribution to journal › Article

2018

1 Citations

Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility trial

Ridd, M. J., Gaunt, D. M., Guy, R. H., Redmond, N. M., Garfield, K., Hollinghurst, S., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C., 1 Aug 2018, In : British Journal of Dermatology. 179, 2, p. 362-370 9 p.

Research output: Contribution to journal › Article

Emollients

Eczema

Atopic Dermatitis

Outcome Assessment (Health Care)

Dermal Absorption of Pesticide Residues

Clarke, J., Cordery, S., Morgan, N. A., Knowles, P. & Guy, R., 17 Dec 2018, In : Chemical Research in Toxicology. 31, 12, p. 1356-1363

Research output: Contribution to journal › Article

File

12 Citations

Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

Lipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 1 Jun 2018, In : Nature Nanotechnology. 13, p. 501-511

Research output: Contribution to journal › Article

Open Access

File

Graphite

glucose

Graphene

Glucose

graphene

Topical bio(in)equivalence of metronidazole formulations in vivo

Pedon de Araujo, T., Moura Fittipaldi, I., Galindo Bedor, D. C., Ludna Duarte, M., Cordery, S., Guy, R., Delgado-Charro, M., Pereira de Santana, D. & Bastos Leal, L., 25 Apr 2018, In : International Journal of Pharmaceutics. 541, p. 167-172 6 p.

Research output: Contribution to journal › Article

Open Access

File

Metronidazole

Cornea

Skin

Pharmaceutical Preparations

Biological Availability

2017

4 Citations

Bioequivalence methodologies for topical drug products: in vitro and ex vivo studies with a cortiscosteroid and an anti-fungal drug

Bastos Leal, L., Cordery, S. F., Delgado-Charro, M. B., Bunge, A. L. & Guy, R. H., Apr 2017, In : Pharmaceutical Research. 34, 4, p. 730-737 8 p.

Research output: Contribution to journal › Article

Open Access

Precise laser poration to control drug delivery into and through human nail

Vanstone, S., Cordery, S., Stone, J., Gordeev, S. & Guy, R., 28 Dec 2017, In : Journal of Controlled Release. 268, p. 72-77 6 p.

Research output: Contribution to journal › Article

Open Access

File

Drug and Narcotic Control

Nails

Lasers

Pharmaceutical Preparations

Nail Diseases

1 Citations

Reverse iontophoretic extraction of metabolites from living plants and their identification by ion-chromatography coupled to high resolution mass spectrometry

Gonzalez-Sanchez, M. I., McCullagh, J., Guy, R. & Compton, R., May 2017, In : Phytochemical Analysis. 28, 3, p. 195-201 7 p.

Research output: Contribution to journal › Article

Ion chromatography

ion exchange chromatography

Metabolites

Mass spectrometry

Chromatography

6 Citations

Topical bioavailability of diclofenac from locally-acting, dermatological formulations

Cordery, S. F., Pensado, A., Chiu, W. S., Shehab, M. Z., Bunge, A. L., Delgado-Charro, M. B. & Guy, R. H., 30 Aug 2017, In : International Journal of Pharmaceutics. 529, 1-2, p. 55-64 10 p.

Research output: Contribution to journal › Article

Open Access

File

Diclofenac

Biological Availability

Skin

Pharmaceutical Preparations

Cornea

2016

15 Citations

Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H., 1 Apr 2016, In : Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.

Research output: Contribution to journal › Article

Open Access

Chemical Safety

Decision Trees

Cosmetics

Decision trees

Toxicology

9 Citations

Choice of moisturiser for eczema treatment (COMET): feasibility study of a randomised controlled parallel group trial in children recruited from primary care

Ridd, M., Garfield, K., Gaunt, D., Hollinghurst, S., Redmond, N., Powell, K., Wilson, V., Guy, R., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C., 16 Nov 2016, In : BMJ Open. 6, 11, 9 p., e012021.

Research output: Contribution to journal › Article

Open Access

Emollients

Eczema

Feasibility Studies

Primary Health Care

Therapeutics

8 Citations

Femtosecond pulsed laser ablation to enhance drug delivery across the skin

Garvie-Cook, H., Stone, J. M., Yu, F., Guy, R. H. & Gordeev, S. N., Jan 2016, In : Journal of Biophotonics. 9, 1-2, p. 144-154

Research output: Contribution to journal › Article

Laser Therapy

inks

Laser ablation

Pulsed lasers

Drug delivery

5 Citations

Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations

Celebi, D., Edler, K., Scott, J. & Guy, R., 30 Nov 2016, In : International Journal of Pharmaceutics. 514, p. 238-243 6 p.

Research output: Contribution to journal › Article

Open Access

File

oxidized cellulose

Ibuprofen

Gels

Skin

Cornea

9 Citations

Managing diabetes through the skin: Diagnostic devices

Guy, R., Jun 2016, In : Nature Nanotechnology. 11, 6, p. 493-494 2 p.

Research output: Contribution to journal › Article

Open Access

File

Medical problems

Gold

Skin

sweat

Controlled drug delivery

4 Citations

Modelling drug flux through microporated skin

Rzhevskiy, A. S., Guy, R. H. & Anissimov, Y. G., 10 Nov 2016, In : Journal of Controlled Release. 241, p. 194-199 6 p.

Research output: Contribution to journal › Article

Open Access

File

Drug Design

Skin

Pharmaceutical Preparations

Theoretical Models

Molecular Weight

6 Citations

The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs

Frederiksen, K., Guy, R. H. & Petersson, K., 2016, In : Expert Opinion on Drug Delivery. 13, 3, p. 349-360

Research output: Contribution to journal › Article

Open Access

File

Skin

Patient Compliance

Pharmaceutical Preparations

Expert Testimony

Drug Delivery Systems

2015

3 Citations

Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems

Garvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S., 28 Aug 2015, In : Journal of Controlled Release. 212, p. 103-112 10 p.

Research output: Contribution to journal › Article

Open Access

File

Betamethasone Valerate

Triglycerides

Polymers

Skin

Raman Spectrum Analysis

8 Citations

Characterization of Topical Film-Forming Systems Using Atomic Force Microscopy and Raman Microspectroscopy

Garvie-cook, H., Frederiksen, K., Petersson, K., Guy, R. H. & Gordeev, S., Mar 2015, In : Molecular Pharmaceutics. 12, 3, p. 751-757 7 p.

Research output: Contribution to journal › Article

Open Access

File

Plasticizers

Atomic Force Microscopy

Elastic Modulus

Betamethasone Valerate

Skin

10 Citations

Choice of Moisturiser for Eczema Treatment (COMET): Study protocol for a randomized controlled trial

Ridd, M. J., Redmond, N. M., Hollinghurst, S., Ball, N., Shaw, L., Guy, R., Wilson, V., Metcalfe, C. & Purdy, S., 15 Jul 2015, In : Trials. 16, 304.

Research output: Contribution to journal › Article

Open Access

File

Emollients

Eczema

Clinical Protocols

Randomized Controlled Trials

Feasibility Studies

14 Citations

Clarke, J. F., Cordery, S. F., Morgan, N. A., Knowles, P. K. & Guy, R. H., 16 Feb 2015, In : Chemical Research in Toxicology. 28, 2, p. 166-168

Research output: Contribution to journal › Article

Open Access

File

16 Citations

Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting?

Gelfuso, G. M., Barros, M. A. D. O., Delgado-Charro, M. B., Guy, R. H. & Lopez, R. F. V., Oct 2015, In : Colloids and Surfaces B: Biointerfaces. 134, p. 408-412 5 p.

Research output: Contribution to journal › Article

Open Access

File

Iontophoresis

microparticles

Drug Delivery Systems

Hair Follicle

hair

2 Citations

Iontophoretic transdermal sampling of iohexol as a noninvasive tool to assess glomerular filtration rate

Djabri, A., van’t Hoff, W., Brock, P., Wong, I. C. K., Guy, R. & Delgado-Charro, B., 1 Feb 2015, In : Pharmaceutical Research. 32, 2, p. 590-603

Research output: Contribution to journal › Article

Open Access

File

Iohexol

Iontophoresis

Glomerular Filtration Rate

Sampling

Pediatrics

21 Citations

Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy

Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R., 15 May 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730

Research output: Contribution to journal › Article

Open Access

File

Raman Spectrum Analysis

Nails

Microscopy

Nail Diseases

Propylene Glycol

5 Citations

Topical formulation and dermal delivery of active phenolic compounds in the Thai medicinal plant - Clerodendrum petasites S. Moore

Thitilertdecha, P., Rowan, M. G. & Guy, R. H., 15 Jan 2015, In : International Journal of Pharmaceutics. 478, 1, p. 39-45 7 p.

Research output: Contribution to journal › Article

Open Access

File

Petasites

Clerodendrum

Vanillic Acid

Medicinal Plants

Cornea

2014

23 Citations

A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm

Cordery, S. F., Taverner, A., Ridzwan, I. E., Guy, R. H., Delgado-Charro, M. B., Husbands, S. M. & Bailey, C. P., 1 Jul 2014, In : Addiction Biology. 19, 4, p. 575-586 12 p.

Research output: Contribution to journal › Article

Open Access

File

Buprenorphine

Naltrexone

Drug Combinations

Cocaine

Morphine

24 Citations

Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin

Thitilertdecha, P., Guy, R. H. & Rowan, M. G., 11 Jun 2014, In : Journal of Ethnopharmacology. 154, 2, p. 400-407 8 p.

Research output: Contribution to journal › Article

Open Access

File

Petasites

Clerodendrum

Vanillic Acid

Apigenin

Skin

4 Citations

Characterisation of skin barrier function using bioengineering and biophysical techniques

Yang, Q. & Guy, R. H., 5 Aug 2014, In : Pharmaceutical Research. 32, 2, p. 445-457

Research output: Contribution to journal › Article

Open Access

File

Bioengineering

Forehead

Cornea

Skin

Forearm

34 Citations

Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies

Belsey, N. A., Garrett, N. L., Contreras-Rojas, L. R., Pickup-Gerlaugh, A. J., Price, G. J., Moger, J. & Guy, R. H., 28 Jan 2014, In : Journal of Controlled Release. 174, 28, p. 37-42

Research output: Contribution to journal › Article

Open Access

File

Drug Evaluation

Raman Spectrum Analysis

Fluorescence Microscopy

Skin

Microscopy

4 Citations

Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation

Guy, R. H., Kuma, H. & Nakanishi, M., May 2014, In : European Journal of Dermatology. 24, 3, p. 365-371 7 p.

Research output: Contribution to journal › Article

Open Access

File

Photoallergic Dermatitis

Ketoprofen

Photosensitivity Disorders

Phototoxic Dermatitis

Photolysis

72 Citations

Transdermal drug delivery: 30 + years of war and still fighting!

Wiedersberg, S. & Guy, R. H., 28 Sep 2014, In : Journal of Controlled Release. 190, p. 150-156

Research output: Contribution to journal › Article

Open Access

File

Pharmaceutical Preparations

Cutaneous Administration

Skin

Technology

Research

2013

8 Citations

Effects of iontophoresis, hydration, and permeation enhancers on human nail plate: Infrared and impedance spectroscopy assessment

Benzeval, I., Bowen, C. R., Guy, R. H. & Delgado-Charro, M. B., Jun 2013, In : Pharmaceutical Research. 30, 6, p. 1652-1662 11 p.

Research output: Contribution to journal › Article

Open Access

File

Dielectric Spectroscopy

Iontophoresis

Nails

Permeation

Hydration

19 Citations

Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia

Gelfuso, G. M., Gratieri, T., Delgado-Charro, M. B., Guy, R. H. & Vianna Lopez, R. F., 1 May 2013, In : Journal of Pharmaceutical Sciences. 102, 5, p. 1488-1494

Research output: Contribution to journal › Article

Iontophoresis

Alopecia

Minoxidil

Sulfates

Hair Follicle

11 Citations

Mechanical tomography of human corneocytes with a nanoneedle

Beard, J. D., Guy, R. H. & Gordeev, S. N., Jun 2013, In : Journal Of Investigative Dermatology. 133, 6, p. 1565-1571 7 p.

Research output: Contribution to journal › Article

Open Access

File

Nanoneedles

Atomic Force Microscopy

Tomography

Atomic force microscopy

Mechanical properties

Products in "Bounty bags" potentially harm newborn skin

Ridd, M., Guy, R., Ball, N., Roberts, A. & Williams, H., 22 Jun 2013, In : BMJ . 346, 7913, f3895.

Research output: Contribution to journal › Article

5 Citations

Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs): Comparison with experimental results

Güngör, S., Delgado-Charro, M. B., Masini-Etévé, V., Potts, R. O. & Guy, R. H., 28 Dec 2013, In : Journal of Controlled Release. 172, 3, p. 601-606 6 p.

Research output: Contribution to journal › Article

Open Access

File

Selective Estrogen Receptor Modulators

Skin

Danazol

Water

Epidermis

2012

Djabri, A., Guy, R. H. & Delgado-Charro, M. B., 1 Oct 2012, In : International Journal of Pharmaceutics. 435, 1, p. 27-32

Research output: Contribution to journal › Article

Open Access

File

Iontophoresis

Ranitidine

Pediatrics

Drug Therapy

Gels

2011

1 Citations

AFM nanotools for surgery of biological Cells

Beard, J. D., Gordeev, S. N. & Guy, R. H., 2011, In : Journal of Physics: Conference Series. 286, 1, 012003.

Research output: Contribution to journal › Article

surgery

atomic force microscopy

manipulators

surface layers

electron beams

10 Citations

Assessment of dermal exposure to pesticide residues during re-entry

Belsey, N. A., Cordery, S. F., Bunge, A. L. & Guy, R. H., 15 May 2011, In : Environmental Science & Technology. 45, 10, p. 4609-4615 7 p.

Research output: Contribution to journal › Article

Open Access

File

Pesticide Residues

pesticide residue

Reentry

Pesticides

pesticide

84 Citations

Imaging drug delivery to skin with stimulated Raman scattering microscopy

Saar, B. G., Contreras-Rojas, L. R., Xie, X. S. & Guy, R. H., 6 Jun 2011, In : Molecular Pharmaceutics. 8, 3, p. 969-975 7 p.

Research output: Contribution to journal › Article

Open Access

File

Raman Spectrum Analysis

Microscopy

Skin

Pharmaceutical Preparations

Three-Dimensional Imaging

142 Citations

Mathematical models of skin permeability: An overview

Mitragotri, S., Anissimov, Y. G., Bunge, A. L., Frasch, H. F., Guy, R. H., Hadgraft, J., Kasting, G. B., Lane, M. E. & Roberts, M. S., 10 Oct 2011, In : International Journal of Pharmaceutics. 418, 1, p. 115-129 15 p.

Research output: Contribution to journal › Article

Open Access

File

Permeability

Theoretical Models

Skin

Research

Pharmaceutical Preparations

22 Citations

Optimisation of Cosolvent Concentration for Topical Drug Delivery III - Influence of Lipophilic Vehicles on Ibuprofen Permeation

Watkinson, R. M., Guy, R. H., Oliveira, G., Hadgraft, J. & Lane, M. E., 2011, In : Skin Pharmacology and Physiology. 24, 1, p. 22-26 5 p.

Research output: Contribution to journal › Article

Ibuprofen

Mineral Oil

Silicones

Skin

Membranes