Research Output 1993 2017

2017

Bioequivalence methodologies for topical drug products: in vitro and ex vivo studies with a cortiscosteroid and an anti-fungal drug

Bastos Leal, L., Cordery, S. F., Delgado-Charro, M. B., Bunge, A. L. & Guy, R. H. Apr 2017 In : Pharmaceutical Research. 34, 4, p. 730-737 8 p.

Research output: Contribution to journalArticle

Open Access

Optical Drilling of the Human Nail Plate to Facilitate Transungual Drug Delivery

Vanstone, S. May 2017 149 p.

Research output: ThesisDoctoral Thesis

drilling
delivery
damage
porosity
temperature

Precise laser poration to control drug delivery into and through human nail

Vanstone, S., Cordery, S., Stone, J., Gordeev, S. & Guy, R. 28 Dec 2017 In : Journal of Controlled Release. 268, p. 72-77 6 p.

Research output: Contribution to journalArticle

Drug and Narcotic Control
Nails
Lasers
Nail Diseases
Pharmaceutical Chemistry
Skin
Drug Monitoring
Patient Compliance
Research Design
Lipids

Reverse iontophoretic extraction of metabolites from living plants and their identification by ion-chromatography coupled to high resolution mass spectrometry

Gonzalez-Sanchez, M. I., McCullagh, J., Guy, R. & Compton, R. May 2017 In : Phytochemical Analysis. 28, 3, p. 195-201 7 p.

Research output: Contribution to journalArticle

Chromatography
Mass Spectrometry
Ions
Iontophoresis
Ocimum basilicum

Topical bioavailability of diclofenac from locally-acting, dermatological formulations

Cordery, S. F., Pensado, A., Chiu, W. S., Shehab, M. Z., Bunge, A. L., Delgado-Charro, M. B. & Guy, R. H. 30 Aug 2017 In : International Journal of Pharmaceutics. 529, 1-2, p. 55-64 10 p.

Research output: Contribution to journalArticle

Diclofenac
Biological Availability
Skin
Cornea
In Vitro Techniques
2016
8 Citations

Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H. 1 Apr 2016 In : Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.

Research output: Contribution to journalArticle

Open Access
Chemical Safety
Cosmetics
Toxicology
Skin
Skin Absorption

Choice of moisturiser for eczema treatment (COMET): feasibility study of a randomised controlled parallel group trial in children recruited from primary care

Ridd, M., Garfield, K., Gaunt, D., Hollinghurst, S., Redmond, N., Powell, K., Wilson, V., Guy, R., Ball, N., Shaw, L., Purdy, S. & Metcalfe, C. Nov 2016 In : BMJ Open. 6, 11, 9 p., e012021

Research output: Contribution to journalArticle

Open Access
Emollients
Eczema
Feasibility Studies
Primary Health Care
Referral and Consultation

Femtosecond pulsed laser ablation to enhance drug delivery across the skin

Garvie-Cook, H., Stone, J. M., Yu, F., Guy, R. H. & Gordeev, S. N. Jan 2016 In : Journal of Biophotonics. 9, 1-2, p. 144-154

Research output: Contribution to journalArticle

Laser Therapy
Lasers
Skin
Ink
Hot Temperature
1 Citations
Open Access
File
oxidized cellulose
Ibuprofen
Gels
Skin
In Vitro Techniques
5 Citations

Managing diabetes through the skin: Diagnostic devices

Guy, R. Jun 2016 In : Nature Nanotechnology. 11, 6, p. 493-494 2 p.

Research output: Contribution to journalArticle

Open Access
File
Gold
gold
Controlled drug delivery
Medical problems
Graphene
1 Citations

Modelling drug flux through microporated skin

Rzhevskiy, A. S., Guy, R. H. & Anissimov, Y. G. 10 Nov 2016 In : Journal of Controlled Release. 241, p. 194-199 6 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Design
Skin
Molecular Weight
Water
Phenylalanine
Amino Acids
Skin
Serum
Hematologic Tests

The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs

Frederiksen, K., Guy, R. H. & Petersson, K. 2016 In : Expert Opinion on Drug Delivery. 13, 3, p. 349-360

Research output: Contribution to journalArticle

Open Access
File
Skin
Patient Compliance
Expert Testimony
Drug Delivery Systems
Esthetics
2015
2 Citations

Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems

Garvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S. 28 Aug 2015 In : Journal of Controlled Release. 212, p. 103-112 10 p.

Research output: Contribution to journalArticle

Open Access
File
Triglycerides
Drug Liberation
Betamethasone Valerate
Polymers
Skin
7 Citations

Characterization of Topical Film-Forming Systems Using Atomic Force Microscopy and Raman Microspectroscopy

Garvie-cook, H., Frederiksen, K., Petersson, K., Guy, R. H. & Gordeev, S. Mar 2015 In : Molecular Pharmaceutics. 12, 3, p. 751-757 7 p.

Research output: Contribution to journalArticle

Open Access
File
Plasticizers
Atomic Force Microscopy
Elastic Modulus
Skin
Betamethasone Valerate

Choice of Moisturiser for Eczema Treatment (COMET): Study protocol for a randomized controlled trial

Ridd, M. J., Redmond, N. M., Hollinghurst, S., Ball, N., Shaw, L., Guy, R., Wilson, V., Metcalfe, C. & Purdy, S. 15 Jul 2015 In : Trials. 16, 304

Research output: Contribution to journalArticle

Open Access
File
Emollients
Eczema
Clinical Protocols
Randomized Controlled Trials
Feasibility Studies
11 Citations

Development and in vitro evaluation of lipid nanoparticle-based dressings for topical treatment of chronic wounds

Gainza, G., Chu, W. S., Guy, R. H., Pedraz, J. L., Hernandez, R. M., Delgado-Charro, B. & Igartua, M. 25 Jul 2015 In : International Journal of Pharmaceutics. 490, 1-2, p. 404-411 8 p.

Research output: Contribution to journalArticle

File
Bandages
Nanoparticles
Lipids
Wounds and Injuries
In Vitro Techniques
10 Citations

Drug delivery into microneedle-porated nails from nanoparticle reservoirs

Chiu, W. S., Belsey, N. A., Garrett, N. L., Moger, J., Price, G. J., Delgado-Charro, M. B. & Guy, R. H. 28 Dec 2015 In : Journal of Controlled Release. 220, A, p. 98-106 9 p.

Research output: Contribution to journalArticle

Open Access
File
Nails
Nanoparticles
Raman Spectrum Analysis
Optical Imaging
Photons
17 Citations
Open Access
File
Plasticizers
Drug Delivery Systems
Skin
Betamethasone Valerate
Citric Acid
6 Citations

In situ detection of salicylate in Ocimum basilicum plant leaves via reverse iontophoresis

González-Sánchez, M. I., Lee, P. T., Guy, R. H. & Compton, R. G. 28 Nov 2015 In : Chemical Communications. 51, 92, p. 16534-16536 3 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclic voltammetry
Electrodes
Chemical analysis
1 Citations

In vitro method to quantify dermal absorption of pesticide residues

Clarke, J. F., Cordery, S. F., Morgan, N. A., Knowles, P. K. & Guy, R. H. 16 Feb 2015 In : Chemical Research in Toxicology. 28, 2, p. 166-168

Research output: Contribution to journalArticle

Open Access
File
11 Citations

Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting?

Gelfuso, G. M., Barros, M. A. D. O., Delgado-Charro, M. B., Guy, R. H. & Lopez, R. F. V. Oct 2015 In : Colloids and Surfaces B: Biointerfaces. 134, p. 408-412 5 p.

Research output: Contribution to journalArticle

Open Access
File
Minoxidil
Iontophoresis
Drug Delivery Systems
Sulfates
Hair Follicle
1 Citations

Iontophoretic transdermal sampling of iohexol as a noninvasive tool to assess glomerular filtration rate

Djabri, A., van’t Hoff, W., Brock, P., Wong, I. C. K., Guy, R. & Delgado-Charro, B. 1 Feb 2015 In : Pharmaceutical Research. 32, 2, p. 590-603

Research output: Contribution to journalArticle

Open Access
File
Iohexol
Glomerular Filtration Rate
Iontophoresis
In Vitro Techniques
Pediatrics
16 Citations

Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy

Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R. 15 May 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730

Research output: Contribution to journalArticle

Open Access
File
Raman Spectrum Analysis
Nails
Microscopy
Nail Diseases
Propylene Glycol

Non-invasive, transdermal, path-selective and highly specific glucose monitoring on a graphene platform

Dupont, B. Sep 2015 200 p.

Research output: ThesisDoctoral Thesis

Oxidised Cellulose Gels and Films for Encapsulation and Release

Celebi, D. May 2015

Research output: ThesisDoctoral Thesis

File
4 Citations
Open Access
File
Petasites
Clerodendrum
Vanillic Acid
Medicinal Plants
Skin
2014
2 Citations
Open Access
File
Buprenorphine
Naltrexone
Drug Combinations
Cocaine
Morphine
19 Citations
Open Access
File
Petasites
Clerodendrum
Skin
Vanillic Acid
Apigenin

Characterisation of skin barrier function using bioengineering and biophysical techniques

Yang, Q. & Guy, R. H. 5 Aug 2014 In : Pharmaceutical Research. 32, 2, p. 445-457

Research output: Contribution to journalArticle

Open Access
File
Bioengineering
Cornea
Skin
Forehead
Forearm

Effective use of transdermal drug delivery in children

Delgado-Charro, M. B. & Guy, R. H. 30 Jun 2014 In : Advanced Drug Delivery Reviews. 73, p. 63-82

Research output: Contribution to journalReview article

File
Pediatrics
Skin
Cutaneous Administration
Transdermal Patch
Buprenorphine
30 Citations

Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies

Belsey, N. A., Garrett, N. L., Contreras-Rojas, L. R., Pickup-Gerlaugh, A. J., Price, G. J., Moger, J. & Guy, R. H. 28 Jan 2014 In : Journal of Controlled Release. 174, 28, p. 37-42

Research output: Contribution to journalArticle

Open Access
File
Drug Evaluation
Raman Spectrum Analysis
Fluorescence Microscopy
Skin
Microscopy
3 Citations

Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation

Guy, R. H., Kuma, H. & Nakanishi, M. May 2014 In : European Journal of Dermatology. 24, 3, p. 365-371 7 p.

Research output: Contribution to journalArticle

Open Access
File
Photoallergic Dermatitis
Ketoprofen
Photosensitivity Disorders
Skin
Phototoxic Dermatitis

Transdermal drug delivery: 30 + years of war and still fighting!

Wiedersberg, S. & Guy, R. H. 28 Sep 2014 In : Journal of Controlled Release. 190, p. 150-156

Research output: Contribution to journalArticle

Open Access
File
Skin
Cutaneous Administration
Technology

Visualization of the mechanism(s) of drug transport and delivery into and through the nail

Chiu, W-S. Oct 2014 235 p.

Research output: ThesisDoctoral Thesis

Open Access
File
2013
Open Access
File
Dielectric Spectroscopy
Iontophoresis
Nails
Acetylcysteine
Keratins

Formulation Optimization for the Topical Delivery of Active Agents in Traditional Medicines

Thitilertdecha, P. Apr 2013 229 p.

Research output: ThesisDoctoral Thesis

File
Vanillic Acid
Traditional Medicine
Petasites
Skin
In Vitro Techniques
18 Citations

Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia

Gelfuso, G. M., Gratieri, T., Delgado-Charro, M. B., Guy, R. H. & Vianna Lopez, R. F. 1 May 2013 In : Journal of Pharmaceutical Sciences. 102, 5, p. 1488-1494

Research output: Contribution to journalArticle

Minoxidil
Iontophoresis
Alopecia
Sulfates
Hair Follicle

Mechanical tomography of human corneocytes with a nanoneedle

Beard, J. D., Guy, R. H. & Gordeev, S. N. Jun 2013 In : Journal Of Investigative Dermatology. 133, 6, p. 1565-1571 7 p.

Research output: Contribution to journalArticle

Open Access
File
Atomic Force Microscopy
Tomography
Surface Properties
Volunteers
Pathology

Products in "Bounty bags" potentially harm newborn skin

Ridd, M., Guy, R., Ball, N., Roberts, A. & Williams, H. 22 Jun 2013 In : BMJ . 346, 7913, f3895

Research output: Contribution to journalArticle

5 Citations

Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs): Comparison with experimental results

Güngör, S., Delgado-Charro, M. B., Masini-Etévé, V., Potts, R. O. & Guy, R. H. 28 Dec 2013 In : Journal of Controlled Release. 172, 3, p. 601-606 6 p.

Research output: Contribution to journalArticle

Open Access
File
Selective Estrogen Receptor Modulators
Skin
Water
Danazol
Epidermis
2012
21 Citations

Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping

Mohammed, D., Yang, Q., Guy, R. H., Matts, P. J., Hadgraft, J. & Lane, M. E. Sep 2012 In : European Journal of Pharmaceutics and Biopharmaceutics. 82, 1, p. 171-174

Research output: Contribution to journalArticle

Cornea
Densitometry
Proteins
Surgical Tape
Volunteers
7 Citations

Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies

Russell, L. M. & Guy, R. H. Sep 2012 In : Pharmaceutical Research. 29, 9, p. 2389-2397 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cornea
Therapeutic Equivalency
5 Citations

Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies: Proof-of-concept with acyclovir formulations

Russell, L. M. & Guy, R. H. Dec 2012 In : Pharmaceutical Research. 29, 12, p. 3362-3372 11 p.

Research output: Contribution to journalArticle

Open Access
File
Gold Alloys
Acyclovir
Cornea
Adenofibroma
Common Bile Duct Diseases
62 Citations

Objective assessment of nanoparticle disposition in mammalian skin after topical exposure

Campbell, C. S. J., Contreras-Rojas, L. R., Delgado-Charro, B. & Guy, R. H. 20 Aug 2012 In : Journal of Controlled Release. 162, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

Open Access
File
Nanoparticles
Skin
Sebum
Polystyrenes
Drug Delivery Systems
16 Citations
Open Access
File
Phenobarbital
Pediatrics
Skin
Iontophoresis
Pharmaceutical Chemistry
29 Citations
Open Access
File
Iontophoresis
Ranitidine
Pediatrics
Drug Therapy
Gels