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Personal profile

Research interests

Dr. Guy's research focuses on skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing, and the prediction and assessment of skin penetration and topical bioavailability. Dr. Guy has published 350+ peer-reviewed articles and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 12 patents. Specific ongoing projects include: measurement of the skin's biomechanical properties at the nanoscale using atomic force microscopy; exploring in vitro - in vivo correlations to faciltate the determination of of topical drug product bioavailability and bioequivalence; the potential of polymeric film-forming systems as sustained release platforms for topical drugs; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin using coherent Raman scattering and confocal microscopy; examination of a graphene-based biosensor for noninvasive, transdermal glucose monitoring; quantification of dermal absorption from pesticide residues from treated plant surfaces; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which come into contact with skin.

Education/Academic qualification

Medical Sciences, Doctor of Science, University of Oxford

Award Date: 15 Jan 2016

Pharmaceutical Chemistry, Doctor of Philosophy, University College London

Award Date: 1 Aug 1980

Chemistry, Master of Arts, University of Oxford

Award Date: 21 Jul 1980

Chemistry, Bachelor of Arts, University of Oxford

Award Date: 21 Jul 1977

External positions

Member, UCSF-Stanford Center of Excellence in Regulatory Science & Innovation, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco

1 Feb 2018 → …

National Expert on Secondment, European Medicines Agency

16 Jan 201815 Jan 2019

Adjunct Professor of Bioengineering and Therapeutic Sciences, University of California San Francisco

Jul 1996 → …

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Projects

Research Output

Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

Lipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 30 Jun 2018, In : Nature Nanotechnology. 13, 6, p. 504-511 8 p.

Research output: Contribution to journalArticle

Open Access
File
  • 71 Citations (Scopus)
    573 Downloads (Pure)

    Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy

    Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R., 23 Jun 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730 6 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 31 Citations (Scopus)
    165 Downloads (Pure)

    Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems

    Garvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S., 28 Aug 2015, In : Journal of Controlled Release. 212, p. 103-112 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 9 Citations (Scopus)
    157 Downloads (Pure)

    Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

    Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H., 1 Apr 2016, In : Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 29 Citations (Scopus)

    Transdermal drug delivery: 30 + years of war and still fighting!

    Wiedersberg, S. & Guy, R. H., 28 Sep 2014, In : Journal of Controlled Release. 190, p. 150-156

    Research output: Contribution to journalArticle

    Open Access
    File
  • 118 Citations (Scopus)
    278 Downloads (Pure)