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Personal profile

Research interests

Dr. Guy's research focuses on skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing, and the prediction and assessment of skin penetration and topical bioavailability. Dr. Guy has published 350+ peer-reviewed articles and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 12 patents. Specific ongoing projects include: measurement of the skin's biomechanical properties at the nanoscale using atomic force microscopy; exploring in vitro - in vivo correlations to faciltate the determination of of topical drug product bioavailability and bioequivalence; the potential of polymeric film-forming systems as sustained release platforms for topical drugs; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin using coherent Raman scattering and confocal microscopy; examination of a graphene-based biosensor for noninvasive, transdermal glucose monitoring; quantification of dermal absorption from pesticide residues from treated plant surfaces; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which come into contact with skin.

Education/Academic qualification

Medical Sciences, Doctor of Science, University of Oxford

Pharmaceutical Chemistry, Doctor of Philosophy, University College London

Chemistry, Master of Arts, University of Oxford

Chemistry, Bachelor of Arts, University of Oxford

External positions

National Expert on Secondment, European Medicines Agency

16 Jan 201815 Jan 2019

Adjunct Professor of Bioengineering and Therapeutic Sciences, University of California San Francisco

Jul 1996 → …

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2003 2023

Research Output 1993 2018

11 Citations

Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

Lipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 1 Jun 2018, In : Nature Nanotechnology. 13, p. 501-511

Research output: Contribution to journalArticle

Open Access
File
Graphite
glucose
Graphene
Glucose
graphene
21 Citations

Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy

Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R., 15 May 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730

Research output: Contribution to journalArticle

Open Access
File
Raman Spectrum Analysis
Nails
Microscopy
Nail Diseases
Propylene Glycol
3 Citations

Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems

Garvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S., 28 Aug 2015, In : Journal of Controlled Release. 212, p. 103-112 10 p.

Research output: Contribution to journalArticle

Open Access
File
Betamethasone Valerate
Triglycerides
Polymers
Skin
Raman Spectrum Analysis
13 Citations

Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H., 1 Apr 2016, In : Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.

Research output: Contribution to journalArticle

Open Access
Chemical Safety
Decision Trees
Cosmetics
Decision trees
Toxicology
70 Citations

Transdermal drug delivery: 30 + years of war and still fighting!

Wiedersberg, S. & Guy, R. H., 28 Sep 2014, In : Journal of Controlled Release. 190, p. 150-156

Research output: Contribution to journalArticle

Open Access
File
Pharmaceutical Preparations
Cutaneous Administration
Skin
Technology
Research

Thesis

Application of biophysics and bioengineering to the assessment of skin barrier function

Author: Yang, Q., 1 Sep 2011

Supervisor: Guy, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Applications of iontophoresis in sports medicine

Author: Sylvestre, J., 1 Nov 2007

Supervisor: Guy, R. (Supervisor) & Delgado-Charro, M. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Characterization and evaluation of novel nano/meso-particulate formulations for application to the skin

Author: Wu, X., 1 Nov 2008

Supervisor: Guy, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Dermatopharmocokinetics: An approach to evaluate topical drug bioavailability

Author: Russell, L., 1 Dec 2008

Supervisor: Guy, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Formulation and Delivery of Topically Applied Drugs for the Treatment of Atopic Eczema and Other Related Diseases

Author: Tsang, M., 1 Dec 2010

Supervisor: Guy, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

File