Projects per year
Personal profile
Research interests
Dr. Guy's principal achievements have been made in the areas of skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing of blood glucose and other analytes, and the prediction and assessment of skin penetration and topical bioavailability. In total, Dr. Guy has published 400 peer-reviewed articles (current Scopus h-index = 81 with ~25,500 citations) and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 18 patents.
His research has received sustained and significant public funding from the U.S. (NIH, EPA, USAF), Europe (Swiss National Science Foundation, EU, Leo Foundation) and the UK (Engineering & Physical Science and Medical Research Councils) and from the pharmaceutical and personal care industries. Since 2013, Dr. Guy’s laboratory has been continuously funded by the U.S. FDA, Office of Generic Drugs.
Specific ongoing projects include: the development and validation of in vitro-in vivo correlations for the assessment of topical drug product bioequivalence; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin and nail using coherent Raman scattering and confocal microscopy; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which contact the skin.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medical Sciences, Doctor of Science, University of Oxford
Award Date: 15 Jan 2016
Pharmaceutical Chemistry, Doctor of Philosophy, University College London
Award Date: 1 Aug 1980
Chemistry, Master of Arts, University of Oxford
Award Date: 21 Jul 1980
Chemistry, Bachelor of Arts, University of Oxford
Award Date: 21 Jul 1977
External positions
Member, UCSF-Stanford Center of Excellence in Regulatory Science & Innovation, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco
1 Feb 2018 → …
National Expert on Secondment, European Medicines Agency
16 Jan 2018 → 15 Jan 2019
Adjunct Professor of Bioengineering and Therapeutic Sciences, University of California San Francisco
Jul 1996 → …
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Collaborations and top research areas from the last five years
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Assessing the skin pharmacokinetics of topical drugs, and the bio(in)equivalence of topical drug products, using non-invasive techniques
Guy, R. (PI), Delgado-Charro, B. (CoI) & Woodman, T. (CoI)
1/09/18 → 31/08/25
Project: Other
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Bioequivalence of Topical Drug Products: In Vitro - In Vivo Correlations
Guy, R. (PI) & Delgado-Charro, B. (CoI)
U.S Food and Drug Administration
1/09/13 → 30/06/20
Project: Other
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Development and Validation of a Physiologically-Based Pharmacokinetic Model for Dermal Absorption
Delgado-Charro, B. (PI), Guy, R. (CoI) & White, J. (CoI)
1/09/16 → 31/08/20
Project: Other
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Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform
Lipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 30 Jun 2018, In: Nature Nanotechnology. 13, 6, p. 504-511 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile287 Citations (SciVal)1331 Downloads (Pure) -
Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy
Chiu, W.-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R., 23 Jun 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (SciVal)281 Downloads (Pure) -
Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems
Garvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S., 28 Aug 2015, In: Journal of Controlled Release. 212, p. 103-112 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (SciVal)417 Downloads (Pure) -
Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)
Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H., 1 Apr 2016, In: Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Citations (SciVal) -
Transdermal drug delivery: 30 + years of war and still fighting!
Wiedersberg, S. & Guy, R. H., 28 Sept 2014, In: Journal of Controlled Release. 190, p. 150-156Research output: Contribution to journal › Article › peer-review
Open AccessFile244 Citations (SciVal)965 Downloads (Pure)
Prizes
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Prix d’honneur de l’Académie nationale de Pharmacie, France
Guy, R. (Recipient), 2023
Prize: Prize (including medals and awards)