Projects per year
Dr. Guy's research focuses on skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing, and the prediction and assessment of skin penetration and topical bioavailability. Dr. Guy has published 350+ peer-reviewed articles and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 12 patents. Specific ongoing projects include: measurement of the skin's biomechanical properties at the nanoscale using atomic force microscopy; exploring in vitro - in vivo correlations to faciltate the determination of of topical drug product bioavailability and bioequivalence; the potential of polymeric film-forming systems as sustained release platforms for topical drugs; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin using coherent Raman scattering and confocal microscopy; examination of a graphene-based biosensor for noninvasive, transdermal glucose monitoring; quantification of dermal absorption from pesticide residues from treated plant surfaces; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which come into contact with skin.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Medical Sciences, Doctor of Science, University of Oxford
Award Date: 15 Jan 2016
Pharmaceutical Chemistry, Doctor of Philosophy, University College London
Award Date: 1 Aug 1980
Chemistry, Master of Arts, University of Oxford
Award Date: 21 Jul 1980
Chemistry, Bachelor of Arts, University of Oxford
Award Date: 21 Jul 1977
Member, UCSF-Stanford Center of Excellence in Regulatory Science & Innovation, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco
1 Feb 2018 → …
National Expert on Secondment, European Medicines Agency
16 Jan 2018 → 15 Jan 2019
Adjunct Professor of Bioengineering and Therapeutic Sciences, University of California San Francisco
Jul 1996 → …
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1/09/13 → 30/06/20
1/03/17 → 31/12/20
Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platformLipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 30 Jun 2018, In: Nature Nanotechnology. 13, 6, p. 504-511 8 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile144 Citations (SciVal)855 Downloads (Pure)
Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R., 23 Jun 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730 6 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile35 Citations (SciVal)180 Downloads (Pure)
Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systemsGarvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S., 28 Aug 2015, In: Journal of Controlled Release. 212, p. 103-112 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile16 Citations (SciVal)241 Downloads (Pure)
Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H., 1 Apr 2016, In: Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access37 Citations (SciVal)
Wiedersberg, S. & Guy, R. H., 28 Sep 2014, In: Journal of Controlled Release. 190, p. 150-156
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile171 Citations (SciVal)469 Downloads (Pure)