Personal profile

Research interests

Dr. Guy's principal achievements have been made in the areas of skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing of blood glucose and other analytes, and the prediction and assessment of skin penetration and topical bioavailability.  In total, Dr. Guy has published 400 peer-reviewed articles (current Scopus h-index = 81 with ~25,500 citations) and over 70 book chapters.  He has co-authored one book and co-edited 7 others.  He is also co-inventor of 18 patents. 

His research has received sustained and significant public funding from the U.S. (NIH, EPA, USAF), Europe (Swiss National Science Foundation, EU, Leo Foundation) and the UK (Engineering & Physical Science and Medical Research Councils) and from the pharmaceutical and personal care industries.  Since 2013, Dr. Guy’s laboratory has been continuously funded by the U.S. FDA, Office of Generic Drugs.

Specific ongoing projects include: the development and validation of in vitro-in vivo correlations for the assessment of topical drug product bioequivalence; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin and nail using coherent Raman scattering and confocal microscopy; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which contact the skin.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 12 - Responsible Consumption and Production

Education/Academic qualification

Medical Sciences, Doctor of Science, University of Oxford

Award Date: 15 Jan 2016

Pharmaceutical Chemistry, Doctor of Philosophy, University College London

Award Date: 1 Aug 1980

Chemistry, Master of Arts, University of Oxford

Award Date: 21 Jul 1980

Chemistry, Bachelor of Arts, University of Oxford

Award Date: 21 Jul 1977

External positions

Member, UCSF-Stanford Center of Excellence in Regulatory Science & Innovation, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco

1 Feb 2018 → …

National Expert on Secondment, European Medicines Agency

16 Jan 201815 Jan 2019

Adjunct Professor of Bioengineering and Therapeutic Sciences, University of California San Francisco

Jul 1996 → …


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