Projects per year
Dr. Guy's principal achievements have been made in the areas of skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing of blood glucose and other analytes, and the prediction and assessment of skin penetration and topical bioavailability. In total, Dr. Guy has published 400 peer-reviewed articles (current Scopus h-index = 81 with ~25,500 citations) and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 18 patents.
His research has received sustained and significant public funding from the U.S. (NIH, EPA, USAF), Europe (Swiss National Science Foundation, EU, Leo Foundation) and the UK (Engineering & Physical Science and Medical Research Councils) and from the pharmaceutical and personal care industries. Since 2013, Dr. Guy’s laboratory has been continuously funded by the U.S. FDA, Office of Generic Drugs.
Specific ongoing projects include: the development and validation of in vitro-in vivo correlations for the assessment of topical drug product bioequivalence; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin and nail using coherent Raman scattering and confocal microscopy; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which contact the skin.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Medical Sciences, Doctor of Science, University of Oxford
Award Date: 15 Jan 2016
Pharmaceutical Chemistry, Doctor of Philosophy, University College London
Award Date: 1 Aug 1980
Chemistry, Master of Arts, University of Oxford
Award Date: 21 Jul 1980
Chemistry, Bachelor of Arts, University of Oxford
Award Date: 21 Jul 1977
Member, UCSF-Stanford Center of Excellence in Regulatory Science & Innovation, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco
1 Feb 2018 → …
National Expert on Secondment, European Medicines Agency
16 Jan 2018 → 15 Jan 2019
Adjunct Professor of Bioengineering and Therapeutic Sciences, University of California San Francisco
Jul 1996 → …
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Collaborations and top research areas from the last five years
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1/09/13 → 30/06/20
1/03/17 → 31/12/20
Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platformLipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 30 Jun 2018, In: Nature Nanotechnology. 13, 6, p. 504-511 8 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile218 Citations (SciVal)1029 Downloads (Pure)
Chiu, W-S., Belsey, N., Garrett, N. L., Moger, J., Delgado-Charro, M. & Guy, R., 23 Jun 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. 7725-7730 6 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile42 Citations (SciVal)206 Downloads (Pure)
Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systemsGarvie-Cook, H., Frederiksen, K., Petersson, K., Guy, R. & Gordeev, S., 28 Aug 2015, In: Journal of Controlled Release. 212, p. 103-112 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile21 Citations (SciVal)289 Downloads (Pure)
Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)Williams, F. M., Rothe, H., Barrett, G., Chiodini, A., Whyte, J., Cronin, M. T. D., Monteiro-Riviere, N. A., Plautz, J., Roper, C., Westerhout, J., Yang, C. & Guy, R. H., 1 Apr 2016, In: Regulatory Toxicology and Pharmacology. 76, p. 174-186 13 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access45 Citations (SciVal)
Wiedersberg, S. & Guy, R. H., 28 Sept 2014, In: Journal of Controlled Release. 190, p. 150-156
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile211 Citations (SciVal)668 Downloads (Pure)