Rex Tyrrell

Prof

19972019
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Research Output 1997 2019

2019

Development of a peptide-based fluorescent probe for biological heme monitoring

Newton, L. D., Pascu, S. I., Tyrrell, R. M. & Eggleston, I. M., 21 Jan 2019, In : Organic and Biomolecular Chemistry. 17, 3, p. 467-471 5 p.

Research output: Contribution to journalArticle

Open Access
2018
6 Citations (Scopus)

Encapsulation of Cadmium Selenide Nanocrystals in Biocompatible Nanotubes: DFT Calculations, X-ray Diffraction Investigations, and Confocal Fluorescence Imaging

Calatayud, D. G., Ge, H., Kuganathan, N., Mirabello, V., Jacobs, R. M. J., Rees, N. H., Stoppiello, C. T., Khlobystov, A. N., Tyrrell, R. M., Como, E. D. & Pascu, S. I., 1 Feb 2018, In : ChemistryOpen. 7, 2, p. 144-158

Research output: Contribution to journalArticle

Open Access
Encapsulation
Discrete Fourier transforms
Nanocrystals
Nanotubes
Glucans
31 Citations (Scopus)
253 Downloads (Pure)

Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

Lipani, L., Dupont, B. G. R., Doungmene, F., Marken, F., Tyrrell, R. M., Guy, R. H. & Ilie, A., 30 Jun 2018, In : Nature Nanotechnology. 13, 6, p. 504-511 8 p.

Research output: Contribution to journalArticle

Open Access
File
Graphite
glucose
Graphene
Glucose
graphene
2017
8 Citations (Scopus)
11 Downloads (Pure)

Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

Ge, H., Riss, P. J., Mirabello, V., Calatayud, D. G., Flower, S. E., Arrowsmith, R. L., Fryer, T. D., Hong, Y., Sawiak, S., Jacobs, R. M. J., Botchway, S. W., Tyrrell, R. M., James, T. D., Fossey, J. S., Dilworth, J. R., Aigbirhio, F. I. & Pascu, S. I., 14 Sep 2017, In : Chem. 3, 3, p. 437-460 24 p.

Research output: Contribution to journalArticle

Open Access
Nanocapsules
Carbon Nanotubes
beta-Glucans
Carbon
Optical Imaging
2014
4 Citations (Scopus)
112 Downloads (Pure)

Development of refractoriness of ho-1 induction to a second treatment with uva radiation and the involvement of nrf2 in human skin fibroblasts

Zhong, J. L., Raval, C. M., Nisar, M. F., Bian, C., Zhang, J., Yang, L. & Tyrrell, R. M., Nov 2014, In : Photochemistry and Photobiology. 90, 6, p. 1340-1348 9 p.

Research output: Contribution to journalArticle

Open Access
File
Heme Oxygenase-1
fibroblasts
Fibroblasts
Skin
induction
21 Citations (Scopus)

Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide

Al-Qenaei, A., Yiakouvaki, A., Reelfs, O., Santambrogio, P., Levi, S., Hall, N. D., Tyrrell, R. M. & Pourzand, C., 1 Mar 2014, In : Free Radical Biology and Medicine. 68, p. 87-100

Research output: Contribution to journalArticle

2013
8 Citations (Scopus)
63 Downloads (Pure)

Effect of short-term reduced physical activity on cardiovascular risk factors in active lean and overweight middle-aged men

Dixon, N. C., Hurst, T. L., Talbot, D. C. S., Tyrrell, R. M. & Thompson, D., Mar 2013, In : Metabolism. 62, 3, p. 361-368 8 p.

Research output: Contribution to journalArticle

Open Access
File
Exercise
Area Under Curve
Alanine Transaminase
C-Reactive Protein
Glucose
17 Downloads (Pure)

Solar uv damage and skin protection:the boosting of natural defences and healing by cosmeceuticals

Tyrrell, R. M., 2013, Bulletin Technique Gattefossé N° 106 : fondation Gattefosse. France, Vol. 106. p. 70-79 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
File
Skin
Radiation
Sunburn
Electromagnetic Phenomena
Skin Neoplasms
2012
35 Citations (Scopus)

Interactions between amino acid-tagged naphthalenediimide and single walled carbon nanotubes for the design and construction of new bioimaging probes

Hu, Z., Pantoș, G. D., Kuganathan, N., Arrowsmith, R., Jacobs, R. M. J., Kociok-Köhn, G., O'Byrne, J., Jurkschat, K., Burgos, P., Tyrrell, R. M., Botchway, S. W., Sanders, J. K. M. & Pascu, S. I., 8 Feb 2012, In : Advanced Functional Materials. 22, 3, p. 503-518 16 p.

Research output: Contribution to journalArticle

Single-walled carbon nanotubes (SWCN)
Amino acids
Amino Acids
Fluorescence
High resolution transmission electron microscopy
37 Citations (Scopus)
69 Downloads (Pure)

Iron, oxidative stress and the example of solar ultraviolet A radiation

Aroun, A., Zhong, J. L., Tyrrell, R. M. & Pourzand, C., 2012, In : Photochemical & Photobiological Sciences. 11, 1, p. 118-134 17 p.

Research output: Contribution to journalArticle

Open Access
File
Oxidative stress
Iron
Radiation
iron
radiation
17 Citations (Scopus)
homeostasis
Heme Oxygenase-1
Oxidative stress
gene expression
antioxidants
22 Citations (Scopus)

The role of Bach1 in ultraviolet A mediated human heme oxygenase 1 regulation in human skin fibroblasts

Raval, C. M., Zhong, J. L., Mitchell, S. A. & Tyrrell, R. M., 1 Jan 2012, In : Free Radical Biology and Medicine. 52, 1, p. 227-236 10 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Fibroblasts
Heme
Skin
Proteins
2011
34 Citations (Scopus)

Fluorescent gallium and indium bis(thiosemicarbazonates) and their radiolabelled analogues: Synthesis, structures and cellular confocal fluorescence imaging investigations

Arrowsmith, R. L., Waghorn, P. A., Jones, M. W., Bauman, A., Brayshaw, S. K., Hu, Z. Y., Kociok-Kohn, G., Mindt, T. L., Tyrrell, R. M., Botchway, S. W., Dilworth, J. R. & Pascu, S. I., 2011, In : Dalton Transactions. 40, 23, p. 6238-6252 15 p.

Research output: Contribution to journalArticle

Gallium
Indium
Fluorescence
Molecular imaging
Imaging techniques
10 Citations (Scopus)

Markers of chronic inflammation with short-term changes in physical activity

Lund, A. J. S., Hurst, T. L., Tyrrell, R. M. & Thompson, D., Apr 2011, In : Medicine and Science in Sports and Exercise. 43, 4, p. 578-583 6 p.

Research output: Contribution to journalArticle

Exercise
Inflammation
C-Reactive Protein
Interleukin-6
Body Mass Index
2010
26 Citations (Scopus)

A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes

Zhong, J. L., Raval, C., Edwards, G. P. & Tyrrell, R. M., 15 Jan 2010, In : Free Radical Biology and Medicine. 48, 2, p. 196-206 11 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Keratinocytes
Fibroblasts
Skin
Irradiation
NF-E2-Related Factor 2
Heme Oxygenase (Decyclizing)
Heme Oxygenase-1
Fibroblasts
fibroblasts
44 Citations (Scopus)

Fluorescent copper(II) bis(thiosemicarbazonates): Fromsynthesis to radiolabelling, in vitro cytotoxicity andconfocal fluorescence microscopy

Pascu, S. I., Waghorn, P. A., Arrowsmith, R. L., Bayly, S. R., Dilworth, J. R., Christlieb, M., Tyrrell, R. M., Zhong, J. L., Kowalczyk, R. M., Collison, D., Churchill, G. C. & Aigbirhio, F. I., 15 Jun 2010, In : Journal of Labelled Compounds & Radiopharmaceuticals. 53, 7-8, p. 527-528 2 p.

Research output: Contribution to journalArticle

Light induced heme oxygenase 1 is suppressed by Bach1 in human skin keratinocytes

Xu, R., Liu, W., Zhang, J., Yang, L., Deng, L., Tyrrell, R. M. & Zhong, J. L., 2010, In : Proceedings of SPIE - The International Society for Optical Engineering. 7845, 78450Z.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Ultraviolet
Skin
Fibroblasts
fibroblasts
22 Citations (Scopus)

The heme-heme oxygenase system in wound healing: Implications for scar formation

Wagener, F., Scharstuhl, A., Tyrrell, R. M., Von den Hoff, J. W., Jozkowicz, A., Dulak, J., Russel, F. G. M. & Kuijpers-Jagtman, A. M., Dec 2010, In : Current Drug Targets. 11, 12, p. 1571-1585 15 p.

Research output: Contribution to journalArticle

Heme Oxygenase (Decyclizing)
Heme
Wound Healing
Cicatrix
Skin
48 Citations (Scopus)

The role of Nrf2 in ultraviolet A mediated heme oxygenase 1 induction in human skin fibroblasts

Zhong, J. L., Edwards, G. P., Raval, C., Li, H. B. & Tyrrell, R. M., Jan 2010, In : Photochemical & Photobiological Sciences. 9, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Heme Oxygenase-1
fibroblasts
Fibroblasts
Skin
68 Citations (Scopus)
Randomized Controlled Trials
Interleukin-6
Exercise
Alanine Transaminase
Inflammation
2009
29 Citations (Scopus)
Meals
Fasting
Exercise
Interleukin-6
Needles
8 Citations (Scopus)

Lycopene supplementation (passata sauce) reduces apoptosis but does not affect oxidant-responsive heme oxygenase-1 in human lymphocytes

Markovitch, D., Tyrrell, R. M., Tauler, P., Frystyk, J., Stokes, K. & Thompson, D., Jun 2009, In : Nutrition. 25, 6, p. 668-675 8 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Oxidants
Lymphocytes
Apoptosis
Cell Survival
18 Citations (Scopus)

The role of interleukin-6 in UVA protection against UVB-induced immunosuppression

Reeve, V. E., Tyrrell, R. M., Allanson, M., Domanski, D. & Blyth, L., Jun 2009, In : Journal Of Investigative Dermatology. 129, 6, p. 1539-1546 8 p.

Research output: Contribution to journalArticle

Immunosuppression
Interleukin-6
NSC 153174
Urocanic Acid
Skin
2008
47 Citations (Scopus)

Acute moderate-intensity exercise in middle-aged men has neither an anti- nor pro-inflammatory effect

Markovitch, D., Tyrrell, R. M. & Thompson, D., 2008, In : Journal of Applied Physiology. 105, 1, p. 260-265 6 p.

Research output: Contribution to journalArticle

Exercise
Anti-Inflammatory Agents
Lymphocytes
Walking
Monocytes
2 Citations (Scopus)
Heme Oxygenase (Decyclizing)
Lymphocytes
Exercise
Messenger RNA
Oxidative Stress
2007
3 Citations (Scopus)

The effect of prior exercise on ex vivo induction of heme oxygenase-1 in human lymphocytes

Markovitch, D., Tyrrell, R. M. & Thompson, D., 2007, In : Free Radical Research. 41, 10, p. 1125-1134 10 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Lymphocytes
Oxidants
Proteins
alpha 1-Antitrypsin

UVA and Inducible Protection

Reeve, V. E. & Tyrrell, R. M., 2007, Biophysical and Physiological Effects of Solar Radiation on Human Skin. Giacomoni, P. U. (ed.). Royal Society of Chemistry, Vol. 10. p. 293-310 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2006
40 Citations (Scopus)

Potential protection of skin by acute UVA irradiation - from cellular to animal models

Tyrrell, R. M. & Reeve, V. E., 2006, In : Progress in Biophysics and Molecular Biology. 92, p. 86-91 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Suppression of UVA-mediated release of labile iron by epicatechin - A link to lysosomal protection

Basu-Modak, S., Ali, D., Gordon, M., Polte, T., Yiakouvaki, A., Pourzand, C., Rice-Evans, C. & Tyrrell, R. M., 2006, In : Free Radical Biology and Medicine. 41, 8, p. 1197-1204 8 p.

Research output: Contribution to journalArticle

Catechin
Iron
Skin
Oxidative stress
Fibroblasts
2005
32 Citations (Scopus)

Exercise-induced expression of heme oxygenase-1 in human lymphocytes

Thompson, D., Basu-Modak, S., Gordon, M., Poore, S., Markovitch, D. & Tyrrell, R. M., 2005, In : Free Radical Research. 39, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Lymphocytes
Messenger RNA
Exercise
Polymerase chain reaction

Heme oxygenase-1 expression in human lymphocytes and resistance to oxidative stress following exercise

Markovitch, D., Tyrrell, R. M. & Thompson, D., 2005, In : FASEB Journal. 19, 4, p. A131-A131

Research output: Contribution to journalArticle

Heme oxygenase - a crucial enzyme in iron and heme homeostasis

Tyrrell, R. M., 2005, Heme Oxygenase: The Elegant Orchestration of its Products in Medicine. Otterbein, L. & Zuckerbraun, B. S. (eds.). New York: Nova Science Publishers, p. 333-349 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2004
59 Citations (Scopus)
Matrix Metalloproteinase 1
Peroxides
Lipid Peroxidation
Lipids
Skin
72 Citations (Scopus)

Regulation of the heme oxygenase 1 gene: recent advances and highlights from the international conference (Uppsala, 2003) on heme oxygenase

Alam, J., Igarashi, K., Immenshuh, S., Shibabara, S. & Tyrrell, R. M., 2004, In : Antioxidants & Redox Signaling. 6, 5, p. 924-933 10 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
Heme Oxygenase-1
Heme
Carcinogens
Skin
Genes
42 Citations (Scopus)
68 Citations (Scopus)
NF-kappa B
Fibroblasts
Modulators
Skin
Iron
2003
43 Citations (Scopus)

Beta-carotene suppresses UVA-induced HO1 gene expression in cultured FEK4

Trekli, M. C., Riss, G., Goralczyk, R. & Tyrrell, R. M., 2003, In : Free Radical Biology and Medicine. 34, 4, p. 456-464 9 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
beta Carotene
Gene expression
Genes
Gene Expression
43 Citations (Scopus)

Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts

Basu-Modak, S., Gordon, M. J., Dobson, L. H., Spencer, J. P. E., Rice-Evans, C. & Tyrrell, R. M., 2003, In : Free Radical Biology and Medicine. 35, 8, p. 910-921 12 p.

Research output: Contribution to journalArticle

Catechin
Fibroblasts
Metabolites
Skin
Sunlight

Heme oxygenase activity: current methods and applications

Ryter, S. W., Kvam, E. & Tyrrell, R. M., 2003, In : Methods in Molecular Biology. 99, p. 369-391 23 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts

Proteggente, A. R., Basu-Modak, S., Kuhnle, G., Gordon, M. J., Youdim, K., Tyrrell, R. M. & Rice-Evans, C. A., 2003, In : Photochemistry and Photobiology. 78, 3, p. 256-261 6 p.

Research output: Contribution to journalArticle

Photoprotection in skin

Tyrrell, R. M., 2003, In : Free Radical Research. 37, p. 26-26 1 p.

Research output: Contribution to journalArticle

2002
32 Citations (Scopus)

A novel iron chelator that does not induce HIF-1 activity

Creighton-Gutteridge, M. & Tyrrell, R. M., 2002, In : Free Radical Biology and Medicine. 33, 3, p. 356-363 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Inter-laboratory validation of procedures for measuring 8-oxo-7,8-dihydroguanine/8-oxo-7,8-dihydro-2 '-deoxyguanosine in DNA

Collins, A. R., Gedik, C., Wood, S., White, A., Dubois, J., Duez, P., Rees, J. F., Legall, R., Degand, L., Loft, S., Jensen, A., Poulsen, H., Weimann, A., Jensen, B. R., Cadet, J., Douki, T., Ravanat, J. L., Faure, H., Tripier, M., Morel, I. & 48 others, Sergent, O., Cillard, P., Morin, B., Epe, B., Phoa, N., Hartwig, A., Pelzer, A., Dolara, P., Casalini, C., Guglielmi, F., Luceri, C., Kasai, H., Kido, R., Olinski, R., Bialkowski, K., Durackova, Z., Hlincikova, L., Korytar, P., Dusinska, M., Mislanova, C., Vina, J., Lloret, A., Moller, L., Hofer, T., Gremaud, E., Fay, L., Stadler, R., Eakins, J., Pognan, F., O'Brien, J., Elliott, R., Astley, S., Bailley, A., Herbert, K., Chauhan, D., Kelly, F., Dunster, C., Lunec, J., Podmore, I., Patel, P., Johnson, S., Evans, M., Tyrrell, R., Gordon, M., Wild, C., Hardie, L., Smith, E. & Escodd, N. V., 2002, In : Free Radical Research. 36, 3, p. 239-245 7 p.

Research output: Contribution to journalArticle

DNA
Photosensitizing Agents
Nucleosides
Hydrolysis
8-hydroxyguanine
2001
169 Citations (Scopus)

Epicatechin and its in vivo metabolite, 3'- O -methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation

Spencer, J. P. E., Schroeter, H., Kuhnle, G., Srai, S. K. S., Tyrrell, R. M., Hahn, U. & Rice-Evans, C., 2001, In : Biochemical Journal. 354, p. 493-500 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Modulation of gene expression by solar ultraviolet radiation

Basu-Modak, S. & Tyrrell, R. M., 2001, Sun Protection in Man. Giacomoni, P. U. (ed.). Elsevier, p. 303-320 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter