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Research Output 1988 2019

2019
1 Citation (Scopus)
Open Access
2018
1 Citation (Scopus)

A comparative bioinformatic analysis of C9orf72

Iyer, S., Acharya, K. R. & Subramanian, V., 19 Feb 2018, In : PeerJ. 6, p. e4391

Research output: Contribution to journalArticle

Open Access
Neurodegenerative diseases
Bioinformatics
Computational Biology
bioinformatics
Introns
3 Citations (Scopus)

C9orf72, a protein associated with amyotrophic lateral sclerosis (ALS) is a guanine nucleotide exchange factor

Iyer, S., Subramanian, V. & Acharya, K. R., 17 Oct 2018, In : PeerJ. 6, 29 p., e5815.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE: a molecular basis for domain-selectivity

Cozier, G. E., Schwager, S. L., Sharma, R. K., Chibale, K., Sturrock, E. D. & Acharya, K. R., 24 Feb 2018, In : FEBS Journal.

Research output: Contribution to journalArticle

Open Access
Peptidyl-Dipeptidase A
Hydrophobic and Hydrophilic Interactions
Angiotensin-Converting Enzyme Inhibitors
Lysine
Catalytic Domain
2 Citations (Scopus)
14 Downloads (Pure)

High resolution crystal structure of substrate-free human neprilysin

Moss, S., Subramanian, V. & Acharya, K. R., 1 Oct 2018, In : Journal of Structural Biology. 204, 1, p. 19-25 7 p.

Research output: Contribution to journalArticle

Open Access
File
Neprilysin
Neurotensin
Protein Conformation
Enkephalins
Metalloproteases
2 Citations (Scopus)

High resolution crystal structures of the receptor-binding domain of neurotoxin serotypes A and FA

Davies, J. R., Hackett, G. S., Liu, S. M. & Acharya, K. R., 21 Mar 2018, In : PeerJ. 6, e4552.

Research output: Contribution to journalArticle

Open Access
neurotoxins
Neurotoxins
crystal structure
serotypes
Crystal structure

How a DNA mimic catches and cleaves NF-kB

Acharya, K-R. & Cozier, G., 28 Sep 2018, In : Journal of Biological Chemistry. 293, 39, p. 15330-15331 2 p.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme

Abrie, J. A., Moolman, W. J. A., Cozier, G. E., Schwager, S. L. U., Acharya, K. R. & Sturrock, E. D., 1 Apr 2018, In : Molecular Pharmacology. 93, 4, p. 344-354

Research output: Contribution to journalArticle

Open Access
Hominidae
Peptidyl-Dipeptidase A
Dimerization
Renin-Angiotensin System
Testis
1 Citation (Scopus)

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.

Cozier, G., Arendse, L. B., Schwager, S. L., Sturrock, E. D. & Acharya, K-R., 21 Nov 2018, In : Journal of Medicinal Chemistry. 61, 22, p. 10141-10154 14 p.

Research output: Contribution to journalArticle

Open Access
Amyotrophic Lateral Sclerosis
Mutation
Proteins
Motor Neuron Disease
Missense Mutation
6 Citations (Scopus)

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme

Fienberg, S., Cozier, G. E., Acharya, K. R., Chibale, K. & Sturrock, E. D., 11 Jan 2018, In : Journal of Medicinal Chemistry. 61, 1, p. 344-359 16 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Angioedema
Metalloproteases
Angiotensin-Converting Enzyme Inhibitors
Cough
1 Citation (Scopus)

Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics.

Davies, J. R., Liu, S. M. & Acharya, K-R., 20 Oct 2018, In : Toxins . 10, 10, 421.

Research output: Contribution to journalReview article

Open Access
2017
5 Citations (Scopus)

Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro

Bradshaw, W. J., Kirby, J. M., Roberts, A. K., Shone, C. C. & Acharya, K. R., 1 Sep 2017, In : FEBS Journal. 284, 17, p. 2886-2898 13 p.

Research output: Contribution to journalArticle

Open Access
Clostridium
Clostridium difficile
Cell adhesion
Cell Adhesion
Bacteria
5 Citations (Scopus)

High prevalence of subclass-specific binding and neutralizing antibodies against clostridium difficile toxins in adult cystic fibrosis sera: Possible mode of immunoprotection against symptomatic c. difficile infection

Monaghan, T. M., Negm, O. H., Mackenzie, B., Hamed, M. R., Shone, C. C., Humphreys, D. P., Acharya, K. R. & Wilcox, M. H., 19 Jul 2017, In : Clinical and Experimental Gastroenterology. 10, p. 169-175 7 p.

Research output: Contribution to journalArticle

Open Access
Clostridium difficile
Neutralizing Antibodies
Cystic Fibrosis
Clostridium Infections
Infection
2 Citations (Scopus)

High resolution crystal structures of Clostridium botulinum neurotoxin A3 and A4 binding domains

Davies, J. R., Rees, J., Liu, S. M. & Acharya, K. R., 26 Dec 2017, In : Journal of Structural Biology.

Research output: Contribution to journalArticle

Clostridium botulinum
Neurotoxins
Therapeutic Human Experimentation
Botulism
Type A Botulinum Toxins
8 Citations (Scopus)

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration

Negm, O. H., Mackenzie, B., Hamed, M. R., Ahmad, O. A. J., Shone, C. C., Humphreys, D. P., Ravi Acharya, K., Loscher, C. E., Marszalowska, I., Lynch, M., Wilcox, M. H. & Monaghan, T. M., Jun 2017, In : Clinical And Experimental Immunology. 188, 3, p. 437-443

Research output: Contribution to journalArticle

Clostridium difficile
Intravenous Immunoglobulins
Clostridium Infections
Antibodies
Protein Array Analysis
10 Citations (Scopus)

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis

Bradshaw, W. J., Rehman, S., Pham, T. T. K., Thiyagarajan, N., Lee, R. L., Subramanian, V. & Acharya, K. R., 8 Feb 2017, In : Scientific Reports. 7, p. 1-10 10 p., 41996.

Research output: Contribution to journalArticle

Open Access
Amyotrophic Lateral Sclerosis
Parkinson Disease
Cell Line
Pancreatic Ribonuclease
Ribonucleases
2 Citations (Scopus)

The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile

Bradshaw, W. J., Kirby, J. M., Roberts, A. K., Shone, C. C. & Acharya, K. R., 18 Dec 2017, In : FEBS Journal. 284, 24, p. 4343-4357 15 p.

Research output: Contribution to journalArticle

Open Access
Clostridium difficile
Glycoside Hydrolases
Molecular Structure
N-Acetylmuramoyl-L-alanine Amidase
Proteins
2 Citations (Scopus)

The structure of the S-layer of Clostridium difficile

Bradshaw, W. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., 23 Nov 2017, In : Journal of Cell Communication and Signaling. p. 319-331 13 p.

Research output: Contribution to journalReview article

Open Access
Clostridium
Clostridium difficile
Protein Precursors
Pathogens
Bacteria
1 Citation (Scopus)

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae

Abu Hasan, Z. I., Williams, H., Ismail, N. M., Othman, H., Cozier, G. E., Acharya, K. R. & Isaac, E. R., 27 Mar 2017, In : Scientific Reports. 7, 45409.

Research output: Contribution to journalArticle

Open Access
disease vectors
Anopheles gambiae
peptidyl-dipeptidase A
Aedes aegypti
toxicity
2016
2 Citations (Scopus)

Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor

Masuyer, G., Cozier, G. E., Kramer, G. J., Bachmann, B. O. & Acharya, K. R., 1 Dec 2016, In : FEBS Journal. 283, 23, p. 4357-4369 13 p.

Research output: Contribution to journalArticle

Open Access
Actinobacteria
Peptidyl-Dipeptidase A
Renin-Angiotensin System
Angiotensin-Converting Enzyme Inhibitors
Zinc
66 Downloads (Pure)

Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin

Davies, A. H., McGlashan, J., Posner, M. G., Roberts, A. K., Shone, C. C. & Acharya, K. R., 1 Dec 2016, In : Biochemistry and Biophysics Reports. 8, p. 55-61 7 p.

Research output: Contribution to journalArticle

Open Access
File
Clostridium
Clostridium difficile
Catalytic Domain
Cytotoxicity
ADP Ribose Transferases
7 Citations (Scopus)
29 Downloads (Pure)

Kinetic and structural characterisation of amyloid-β peptides hydrolysis by human angiotensin-1-converting enzyme

Larmuth, K. M., Masuyer, G., Douglas, R. G., Schwager, S. L., Acharya, K. R. & Sturrock, E. D., Mar 2016, In : FEBS Journal. 283, 6, p. 1060-1076

Research output: Contribution to journalArticle

Open Access
File
Amyloid beta-Peptides
Angiotensins
Hydrolysis
Kinetics
Enzymes
7 Citations (Scopus)

Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa

Schmidt, A., Hammerbacher, A. S., Bastian, M., Nieken, K. J., Klockgether, J., Merighi, M., Lapouge, K., Poschgan, C., Kölle, J., Acharya, K. R., Ulrich, M., Tümmler, B., Unden, G., Kaever, V., Lory, S., Haas, D., Schwarz, S. & Döring, G., Oct 2016, In : Environmental Microbiology. 18, 10, p. 3390–3402

Research output: Contribution to journalArticle

alginate
alginates
Pseudomonas aeruginosa
Oxygen
oxygen
2 Citations (Scopus)

Structural basis of substrate specificity in porcine RNase 4

Liang, S. & Acharya, K. R., 1 Mar 2016, In : FEBS Journal. 283, 5, p. 912-928 17 p.

Research output: Contribution to journalArticle

Pancreatic Ribonuclease
Deoxyuridine
Deoxycytidine
Ligands
Substrates
2015
1 Citation (Scopus)

A new high-resolution crystal structure of the Drosophila melanogaster angiotensin converting enzyme homologue, AnCE

Harrison, C. & Acharya, K. R., Jan 2015, In : FEBS Open Bio. 5, p. 661-667

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Drosophila melanogaster
Crystal structure
Angiotensin-Converting Enzyme Inhibitors
Glycosylation
5 Citations (Scopus)
55 Downloads (Pure)

Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: a cytosolic enzyme with a di-nuclear active site

Iyer, S., La-Borde, P. J., Payne, K. A. P., Parsons, M. R., Turner, A. J., Isaac, R. E. & Acharya, K. R., Jan 2015, In : FEBS Open Bio. 5, 1, p. 292-302 11 p.

Research output: Contribution to journalArticle

Open Access
File
Caenorhabditis elegans
Proline
Catalytic Domain
Crystal structure
Peptides
5 Citations (Scopus)
48 Downloads (Pure)

Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide

Bradshaw, W. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., 1 Mar 2015, In : Acta Crystallographica Section F:Structural Biology Communications. 71, p. 295-303 9 p.

Research output: Contribution to journalArticle

Open Access
File
Clostridium
protease
Cysteine Proteases
Clostridium difficile
cysteine
39 Citations (Scopus)

Molecular features of the sortase enzyme family

Bradshaw, W. J., Davies, A. H., Chambers, C. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., Jun 2015, In : FEBS Journal. 282, 11, p. 2097-2114 118 p.

Research output: Contribution to journalArticle

Gram-Positive Bacteria
Cell Wall
Peptidoglycan
Enzymes
Staphylococcus aureus
7 Citations (Scopus)

Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors

Masuyer, G., Davies, J. R., Moore, K., Chaddock, J. A. & Acharya, K. R., 1 Sep 2015, In : Scientific Reports. 5, 13397.

Research output: Contribution to journalArticle

Clostridium
Structural analysis
Growth Hormone-Releasing Hormone
Botulinum Toxins
Neurotoxins
7 Citations (Scopus)
48 Downloads (Pure)

Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme

Masuyer, G., Douglas, R. G., Sturrock, E. D. & Acharya, K. R., 25 Sep 2015, In : Scientific Reports. 5, 13742.

Research output: Contribution to journalArticle

Open Access
File
Peptidyl-Dipeptidase A
Hydrolysis
Dipeptides
Hematopoietic Stem Cells
Angiotensin-Converting Enzyme Inhibitors
13 Citations (Scopus)
59 Downloads (Pure)

Structure and function of a Clostridium difficile sortase enzyme

Chambers, C. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., 24 Mar 2015, In : Scientific Reports. 5, 9449.

Research output: Contribution to journalArticle

Open Access
File
Clostridium difficile
Peptidoglycan
Enzymes
Gram-Positive Bacteria
Cell Wall
2014
4 Citations (Scopus)

Absence of cell surface expression of human ACE leads to perinatal death

Michaud, A., Acharya, K. R., Masuyer, G., Quenech'du, N., Gribouval, O., Morinière, V., Gubler, M-C. & Corvol, P., Mar 2014, In : Human Molecular Genetics. 23, 6, p. 1479-1491 13 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Cell Membrane
Mutation
Perinatal Death
Renin-Angiotensin System
15 Citations (Scopus)

ACE for all: A molecular perspective

Harrison, C. & Acharya, K. R., Sep 2014, In : Journal of Cell Communication and Signaling. 8, 3, p. 195-210

Research output: Contribution to journalArticle

Insects
Enzymes
Angiotensin-Converting Enzyme Inhibitors
Genes
Pressure regulation
17 Citations (Scopus)

Angiotensin-I converting enzyme (ACE): Structure, biological roles, and molecular basis for chloride ion dependence

Masuyer, G., Yates, C. J., Sturrock, E. D. & Acharya, K. R., 1 Oct 2014, In : Biological Chemistry. 395, 10, p. 1135-1149 15 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Chlorides
Ions
Chemical activation
Substrates
14 Citations (Scopus)

Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme

Masuyer, G., Mohd, A., Czarny, B., Beau, F., Schwager, S. L. U., Sturrock, E. D., Isaac, R. E., Dive, V. & Acharya, K. R., Feb 2014, In : FEBS Journal. 281, 3, p. 943-956

Research output: Contribution to journalArticle

Enantiomers
Peptidyl-Dipeptidase A
Crystal structure
Angiotensin-Converting Enzyme Inhibitors
Isoxazoles
28 Citations (Scopus)

Engineered botulinum neurotoxins as new therapeutics

Masuyer, G., Chaddock, J. A., Foster, K. A. & Ravi Acharya, K., Jan 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 27-51 25 p.

Research output: Contribution to journalReview article

Neurotoxins
Therapeutics
Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
Proteolysis
SNARE Proteins
127 Citations (Scopus)

Eosinophil granule proteins: Form and function

Acharya, K. R. & Ackerman, S. J., 20 Jun 2014, In : Journal of Biological Chemistry. 289, 25, p. 17406-17415 10 p.

Research output: Contribution to journalArticle

Eosinophil Granule Proteins
Eosinophils
T-cells
Proteins
Tissue homeostasis
20 Citations (Scopus)

Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

Douglas, RG., Sharma, RK., Masuyer, G., Lubbe, L., Zamora, I., Acharya, K. R., Chibale, K. & Sturrock, ED., 1 Feb 2014, In : Clinical Science. 126, 4, p. 305-313

Research output: Contribution to journalArticle

7 Citations (Scopus)

Interkingdom pharmacology of angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes

Kramer, G. J., Mohd, A., Schwager, S. L. U., Masuyer, G., Acharya, K. R., Sturrock, E. D. & Bachmann, B. O., 10 Apr 2014, In : ACS Medicinal Chemistry Letters. 5, 4, p. 346-351 6 p.

Research output: Contribution to journalArticle

Open Access
Organophosphonates
Actinobacteria
Peptidyl-Dipeptidase A
Angiotensin-Converting Enzyme Inhibitors
Pharmacology
15 Citations (Scopus)

Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE)

Yates, C. J., Masuyer, G., Schwager, S. L. U., Mohd, A., Sturrock, E. D. & Acharya, K. R., 17 Jan 2014, In : Journal of Biological Chemistry. 289, 3, p. 1798-1814 17 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Thermodynamics
Chlorides
Substrates
Catalytic Domain
8 Citations (Scopus)

Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7

Ramaswamy, S., Sleiman, M. H., Masuyer, G., Arbez-Gindre, C., Micha-Screttas, M., Calogeropoulou, T., Steele, B. R. & Acharya, K. R., 24 Nov 2014, In : FEBS Journal. 282, 2, p. 372-387 16 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Structures of complexes of a metal-independent glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-acetylgalactosamine (UDP-GalNAc) and its hydrolysis products

Pham, T. T. K., Stinson, B., Thiyagarajan, N., Lizotte-Waniewskis, M., Brew, K. & Acharya, K. R., 21 Mar 2014, In : Journal of Biological Chemistry. 289, 12, p. 8041-8050 10 p.

Research output: Contribution to journalArticle

Open Access
Uridine Diphosphate N-Acetylgalactosamine
Glycosyltransferases
Bacteroides
Uridine Diphosphate
Coordination Complexes
11 Citations (Scopus)
50 Downloads (Pure)

The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile

Bradshaw, W. J., Kirby, J. M., Thiyagarajan, N., Chambers, C. J., Davies, A. H., Roberts, A. K., Shone, C. C. & Acharya, K. R., Jul 2014, In : Acta Crystallographica Section D-Biological Crystallography. 70, 7, p. 1983-1993 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cysteine Proteases
Clostridium
Lectins
Cathepsin L
Clostridium difficile
2013
5 Citations (Scopus)
57 Downloads (Pure)
Open Access
File
Crystal structure
Pancreatic Ribonuclease
Molecules
Catalytic Domain
Eosinophil-Derived Neurotoxin
4 Citations (Scopus)

Crystal structures of murine angiogenin-2 and -3 - probing ‘structure - function’ relationships amongst angiogenin homologues

Iyer, S., Holloway, D. E. & Acharya, K. R., Jan 2013, In : FEBS Journal. 280, 1, p. 302-318 17 p.

Research output: Contribution to journalArticle

Crystal structure
Pancreatic Ribonuclease
Ions
Neurodegenerative diseases
angiogenin
2012

Crystal

Sturrock, E. D. & Acharya, R., 1 Oct 2012, Patent No. DK1984008 (T3)

Research output: Patent

Patents and inventions
Crystals
Modulators
Chemical analysis
Pharmaceutical Preparations
6 Citations (Scopus)

Engineering botulinum neurotoxin domains for activation by toxin light chain

Stancombe, P. R., Masuyer, G., Birch-Machin, I., Beard, M., Foster, K. A., Chaddock, J. A. & Acharya, K. R., Feb 2012, In : FEBS Journal. 279, 3, p. 515-523 9 p.

Research output: Contribution to journalArticle

SNARE Proteins
Neurotoxins
Light
Endopeptidases
Peptides
11 Citations (Scopus)

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor

Masuyer, G., Jabeen, T., Oberg, C. T., Leffler, H., Nilsson, U. J. & Acharya, K. R., 2012, In : FEBS Journal. 279, 2, p. 193-202 10 p.

Research output: Contribution to journalArticle

Galectins
Galactose
Galactosides
Tumors
Crystal structure
70 Citations (Scopus)

Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides

Masuyer, G., Schwager, S. L. U., Sturrock, E. D., Isaac, R. E. & Acharya, K. R., 9 Oct 2012, In : Scientific Reports. 2, 10 p., 717.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Angiotensin II
Bradykinin
Peptides
Kallikrein-Kinin System