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Research Output 1992 2018

2018

A comparative bioinformatic analysis of C9orf72

Iyer, S., Acharya, K. R. & Subramanian, V., 19 Feb 2018, In : PeerJ. 6, p. e4391

Research output: Contribution to journalArticle

Open Access
Neurodegenerative diseases
Bioinformatics
Computational Biology
bioinformatics
Introns

C9orf72, a protein associated with amyotrophic lateral sclerosis (ALS) is a guanine nucleotide exchange factor

Iyer, S., Subramanian, V. & Acharya, K. R., 17 Oct 2018, In : PeerJ. 6, 29 p., e5815.

Research output: Contribution to journalArticle

Open Access

Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE: a molecular basis for domain-selectivity

Cozier, G. E., Schwager, S. L., Sharma, R. K., Chibale, K., Sturrock, E. D. & Acharya, K. R., 24 Feb 2018, In : FEBS Journal.

Research output: Contribution to journalArticle

Open Access
Peptidyl-Dipeptidase A
Hydrophobic and Hydrophilic Interactions
Angiotensin-Converting Enzyme Inhibitors
Lysine
Catalytic Domain
Neprilysin
Neurotensin
Protein Conformation
Enkephalins
Metalloproteases
1 Citations

High resolution crystal structures of the receptor-binding domain of neurotoxin serotypes A and FA

Davies, J. R., Hackett, G. S., Liu, S. M. & Acharya, K. R., 21 Mar 2018, In : PeerJ. 6, e4552.

Research output: Contribution to journalArticle

Open Access
neurotoxins
Neurotoxins
crystal structure
serotypes
Crystal structure
1 Citations

Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme

Abrie, J. A., Moolman, W. J. A., Cozier, G. E., Schwager, S. L. U., Acharya, K. R. & Sturrock, E. D., 1 Apr 2018, In : Molecular Pharmacology. 93, 4, p. 344-354

Research output: Contribution to journalArticle

Open Access
Hominidae
Peptidyl-Dipeptidase A
Dimerization
Renin-Angiotensin System
Testis

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.

Cozier, G., Arendse, L. B., Schwager, S. L., Sturrock, E. D. & Acharya, K-R., 29 Oct 2018, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Mutation
Proteins
Motor Neuron Disease
Missense Mutation

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme

Fienberg, S., Cozier, G. E., Acharya, K. R., Chibale, K. & Sturrock, E. D., 11 Jan 2018, In : Journal of Medicinal Chemistry. 61, 1, p. 344-359 16 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Angioedema
Metalloproteases
Angiotensin-Converting Enzyme Inhibitors
Cough

Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics.

Davies, J. R., Liu, S. M. & Acharya, K-R., 20 Oct 2018, In : Toxins . 10, 10, 421.

Research output: Contribution to journalReview article

Open Access
2017
3 Citations

Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro

Bradshaw, W. J., Kirby, J. M., Roberts, A. K., Shone, C. C. & Acharya, K. R., 1 Sep 2017, In : FEBS Journal. 284, 17, p. 2886-2898 13 p.

Research output: Contribution to journalArticle

Open Access
Clostridium
Clostridium difficile
Cell adhesion
Cell Adhesion
Bacteria
4 Citations

High prevalence of subclass-specific binding and neutralizing antibodies against clostridium difficile toxins in adult cystic fibrosis sera: Possible mode of immunoprotection against symptomatic c. difficile infection

Monaghan, T. M., Negm, O. H., Mackenzie, B., Hamed, M. R., Shone, C. C., Humphreys, D. P., Acharya, K. R. & Wilcox, M. H., 19 Jul 2017, In : Clinical and Experimental Gastroenterology. 10, p. 169-175 7 p.

Research output: Contribution to journalArticle

Open Access
Clostridium difficile
Neutralizing Antibodies
Cystic Fibrosis
Clostridium Infections
Infection
1 Citations
Clostridium botulinum
Neurotoxins
Therapeutic Human Experimentation
Botulism
Type A Botulinum Toxins
6 Citations

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration

Negm, O. H., Mackenzie, B., Hamed, M. R., Ahmad, O. A. J., Shone, C. C., Humphreys, D. P., Ravi Acharya, K., Loscher, C. E., Marszalowska, I., Lynch, M., Wilcox, M. H. & Monaghan, T. M., Jun 2017, In : Clinical And Experimental Immunology. 188, 3, p. 437-443

Research output: Contribution to journalArticle

Clostridium difficile
Intravenous Immunoglobulins
Clostridium Infections
Antibodies
Protein Array Analysis
2 Citations

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis

Bradshaw, W. J., Rehman, S., Pham, T. T. K., Thiyagarajan, N., Lee, R. L., Subramanian, V. & Acharya, K. R., 8 Feb 2017, In : Scientific Reports. 7, 41996.

Research output: Contribution to journalArticle

Open Access
Amyotrophic Lateral Sclerosis
Parkinson Disease
Cell Line
Pancreatic Ribonuclease
Ribonucleases

Structure and Function Studies of Clostridium difficile Surface-Associated Proteins

Bradshaw, W., Sep 2017, 214 p.

Research output: ThesisDoctoral Thesis

Clostridium difficile
Membrane Proteins
Proteins
Bacteria
Cell Wall
2 Citations

The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile

Bradshaw, W. J., Kirby, J. M., Roberts, A. K., Shone, C. C. & Acharya, K. R., 18 Dec 2017, In : FEBS Journal. 284, 24, p. 4343-4357 15 p.

Research output: Contribution to journalArticle

Open Access
Clostridium difficile
Glycoside Hydrolases
Molecular Structure
N-Acetylmuramoyl-L-alanine Amidase
Proteins

The structure of the S-layer of Clostridium difficile

Bradshaw, W. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., 23 Nov 2017, In : Journal of Cell Communication and Signaling. p. 319-331 13 p.

Research output: Contribution to journalReview article

Open Access
Clostridium
Clostridium difficile
Protein Precursors
Pathogens
Bacteria

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae

Abu Hasan, Z. I., Williams, H., Ismail, N. M., Othman, H., Cozier, G. E., Acharya, K. R. & Isaac, E. R., 27 Mar 2017, In : Scientific Reports. 7, 45409.

Research output: Contribution to journalArticle

Open Access
disease vectors
Anopheles gambiae
peptidyl-dipeptidase A
Aedes aegypti
toxicity
2016

Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor

Masuyer, G., Cozier, G. E., Kramer, G. J., Bachmann, B. O. & Acharya, K. R., 1 Dec 2016, In : FEBS Journal. 283, 23, p. 4357-4369 13 p.

Research output: Contribution to journalArticle

Open Access
Actinobacteria
Peptidyl-Dipeptidase A
Renin-Angiotensin System
Angiotensin-Converting Enzyme Inhibitors
Zinc

Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin

Davies, A. H., McGlashan, J., Posner, M. G., Roberts, A. K., Shone, C. C. & Acharya, K. R., 1 Dec 2016, In : Biochemistry and Biophysics Reports. 8, p. 55-61 7 p.

Research output: Contribution to journalArticle

Open Access
File
Clostridium
Clostridium difficile
Catalytic Domain
Cytotoxicity
ADP Ribose Transferases
2 Citations

Kinetic and structural characterisation of amyloid-β peptides hydrolysis by human angiotensin-1-converting enzyme

Larmuth, K. M., Masuyer, G., Douglas, R. G., Schwager, S. L., Acharya, K. R. & Sturrock, E. D., Mar 2016, In : FEBS Journal. 283, 6, p. 1060-1076

Research output: Contribution to journalArticle

Open Access
File
Amyloid beta-Peptides
Angiotensins
Hydrolysis
Kinetics
Enzymes
7 Citations

Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa

Schmidt, A., Hammerbacher, A. S., Bastian, M., Nieken, K. J., Klockgether, J., Merighi, M., Lapouge, K., Poschgan, C., Kölle, J., Acharya, K. R., Ulrich, M., Tümmler, B., Unden, G., Kaever, V., Lory, S., Haas, D., Schwarz, S. & Döring, G., Oct 2016, In : Environmental Microbiology. 18, 10, p. 3390–3402

Research output: Contribution to journalArticle

alginate
alginates
Pseudomonas aeruginosa
Oxygen
oxygen
1 Citations

Structural basis of substrate specificity in porcine RNase 4

Liang, S. & Acharya, K. R., 1 Mar 2016, In : FEBS Journal. 283, 5, p. 912-928 17 p.

Research output: Contribution to journalArticle

Pancreatic Ribonuclease
Deoxyuridine
Deoxycytidine
Ligands
Substrates
2015

A new high-resolution crystal structure of the Drosophila melanogaster angiotensin converting enzyme homologue, AnCE

Harrison, C. & Acharya, K. R., Jan 2015, In : FEBS Open Bio. 5, p. 661-667

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Drosophila melanogaster
Crystal structure
Angiotensin-Converting Enzyme Inhibitors
Glycosylation

An investigation into the roles of Talpid3 and primary cilia in the developing brain

Bashford, A., May 2015, (Unpublished) 293 p.

Research output: ThesisDoctoral Thesis

File
Cilia
Brain
Hedgehogs
Phenotype
Centrioles
3 Citations

Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: a cytosolic enzyme with a di-nuclear active site

Iyer, S., La-Borde, P. J., Payne, K. A. P., Parsons, M. R., Turner, A. J., Isaac, R. E. & Acharya, K. R., Jan 2015, In : FEBS Open Bio. 5, 1, p. 292-302 11 p.

Research output: Contribution to journalArticle

Open Access
File
Caenorhabditis elegans
Proline
Catalytic Domain
Crystal structure
Peptides
5 Citations

Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide

Bradshaw, W. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., 1 Mar 2015, In : Acta Crystallographica Section F:Structural Biology Communications. 71, p. 295-303 9 p.

Research output: Contribution to journalArticle

Open Access
File
Clostridium
protease
Cysteine Proteases
Clostridium difficile
cysteine
30 Citations

Molecular features of the sortase enzyme family

Bradshaw, W. J., Davies, A. H., Chambers, C. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., Jun 2015, In : FEBS Journal. 282, 11, p. 2097-2114 118 p.

Research output: Contribution to journalArticle

Gram-Positive Bacteria
Cell Wall
Peptidoglycan
Enzymes
Staphylococcus aureus
7 Citations

Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors

Masuyer, G., Davies, J. R., Moore, K., Chaddock, J. A. & Acharya, K. R., 2015, In : Scientific Reports. 5, 13397.

Research output: Contribution to journalArticle

Clostridium
Structural analysis
Growth Hormone-Releasing Hormone
Botulinum Toxins
Neurotoxins
2 Citations

Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme

Masuyer, G., Douglas, R. G., Sturrock, E. D. & Acharya, K. R., 25 Sep 2015, In : Scientific Reports. 5, 13742.

Research output: Contribution to journalArticle

Open Access
File
Peptidyl-Dipeptidase A
Hydrolysis
Dipeptides
Hematopoietic Stem Cells
Angiotensin-Converting Enzyme Inhibitors

Structural studied on Galectin-7 and Sirtuins

Ramaswamy, S., Oct 2015, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Sirtuins
Galectins
Aging of materials
Crystallization
Proteins
13 Citations

Structure and function of a Clostridium difficile sortase enzyme

Chambers, C. J., Roberts, A. K., Shone, C. C. & Acharya, K. R., 24 Mar 2015, In : Scientific Reports. 5, 9449.

Research output: Contribution to journalArticle

Open Access
File
Clostridium difficile
Peptidoglycan
Enzymes
Gram-Positive Bacteria
Cell Wall

Structure Based Inhibitor Design Studies on Angiotensin Converting Enzyme Homologues

Harrison, C., 30 Sep 2015, 264 p.

Research output: ThesisDoctoral Thesis

Open Access
File
Peptidyl-Dipeptidase A
Anopheles gambiae
Blood Pressure
Angiotensin-Converting Enzyme Inhibitors
Catalytic Domain
2014
4 Citations

Absence of cell surface expression of human ACE leads to perinatal death

Michaud, A., Acharya, K. R., Masuyer, G., Quenech'du, N., Gribouval, O., Morinière, V., Gubler, M-C. & Corvol, P., Mar 2014, In : Human Molecular Genetics. 23, 6, p. 1479-1491 13 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Cell Membrane
Mutation
Perinatal Death
Renin-Angiotensin System
14 Citations

ACE for all: A molecular perspective

Harrison, C. & Acharya, K. R., Sep 2014, In : Journal of Cell Communication and Signaling. 8, 3, p. 195-210

Research output: Contribution to journalArticle

Insects
Enzymes
Angiotensin-Converting Enzyme Inhibitors
Genes
Pressure regulation
14 Citations

Angiotensin-I converting enzyme (ACE): Structure, biological roles, and molecular basis for chloride ion dependence

Masuyer, G., Yates, C. J., Sturrock, E. D. & Acharya, K. R., 1 Oct 2014, In : Biological Chemistry. 395, 10, p. 1135-1149 15 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Chlorides
Ions
Chemical activation
Substrates
11 Citations

Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme

Masuyer, G., Mohd, A., Czarny, B., Beau, F., Schwager, S. L. U., Sturrock, E. D., Isaac, R. E., Dive, V. & Acharya, K. R., Feb 2014, In : FEBS Journal. 281, 3, p. 943-956

Research output: Contribution to journalArticle

Enantiomers
Peptidyl-Dipeptidase A
Crystal structure
Angiotensin-Converting Enzyme Inhibitors
Isoxazoles
28 Citations

Engineered botulinum neurotoxins as new therapeutics

Masuyer, G., Chaddock, J. A., Foster, K. A. & Ravi Acharya, K., Jan 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 27-51 25 p.

Research output: Contribution to journalReview article

Neurotoxins
Therapeutics
Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
Proteolysis
SNARE Proteins
93 Citations

Eosinophil granule proteins: Form and function

Acharya, K. R. & Ackerman, S. J., 20 Jun 2014, In : Journal of Biological Chemistry. 289, 25, p. 17406-17415 10 p.

Research output: Contribution to journalArticle

Eosinophil Granule Proteins
Eosinophils
T-cells
Proteins
Tissue homeostasis
14 Citations

Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

Douglas, RG., Sharma, RK., Masuyer, G., Lubbe, L., Zamora, I., Acharya, K. R., Chibale, K. & Sturrock, ED., 1 Feb 2014, In : Clinical Science. 126, 4, p. 305-313

Research output: Contribution to journalArticle

6 Citations

Interkingdom pharmacology of angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes

Kramer, G. J., Mohd, A., Schwager, S. L. U., Masuyer, G., Acharya, K. R., Sturrock, E. D. & Bachmann, B. O., 10 Apr 2014, In : ACS Medicinal Chemistry Letters. 5, 4, p. 346-351 6 p.

Research output: Contribution to journalArticle

Open Access
Organophosphonates
Actinobacteria
Peptidyl-Dipeptidase A
Angiotensin-Converting Enzyme Inhibitors
Pharmacology
13 Citations

Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE)

Yates, C. J., Masuyer, G., Schwager, S. L. U., Mohd, A., Sturrock, E. D. & Acharya, K. R., 17 Jan 2014, In : Journal of Biological Chemistry. 289, 3, p. 1798-1814 17 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Thermodynamics
Chlorides
Substrates
Catalytic Domain

Structural basis of porcine RNase 4 recognition

Liang, S., Oct 2014, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Ribonucleases
Pancreatic Ribonuclease
Ligands
Hydrogen bonds
Proteins

Structure And Biochemical Analysis Of Toxins From The Superbug Clostridium Difficile

Davies, A., 2014, (Unpublished) 261 p.

Research output: ThesisDoctoral Thesis

File
Clostridium difficile
Pseudomembranous Enterocolitis
Spores
Catalytic Domain
X-Rays

Structure and function of metal-independent CAZy family 6 glycosyltransferase from Bacteroides ovatus

Pham, T., Jun 2014, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Glycosyltransferases
Metals
Carbohydrates
Enzymes
Uridine Diphosphate
8 Citations

Structures of complexes of a metal-independent glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-acetylgalactosamine (UDP-GalNAc) and its hydrolysis products

Pham, T. T. K., Stinson, B., Thiyagarajan, N., Lizotte-Waniewskis, M., Brew, K. & Acharya, K. R., 21 Mar 2014, In : Journal of Biological Chemistry. 289, 12, p. 8041-8050 10 p.

Research output: Contribution to journalArticle

Open Access
Uridine Diphosphate N-Acetylgalactosamine
Glycosyltransferases
Bacteroides
Uridine Diphosphate
Coordination Complexes
10 Citations

The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile

Bradshaw, W. J., Kirby, J. M., Thiyagarajan, N., Chambers, C. J., Davies, A. H., Roberts, A. K., Shone, C. C. & Acharya, K. R., Jul 2014, In : Acta Crystallographica Section D-Biological Crystallography. 70, 7, p. 1983-1993 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cysteine Proteases
Clostridium
Lectins
Cathepsin L
Clostridium difficile
2013

A Study of the Interaction between Botulinum Neurotoxin and Cellular Membranes

Harris, I., 1 Sep 2013

Research output: ThesisDoctoral Thesis

Open Access
File
5 Citations
Open Access
File
Crystal structure
Pancreatic Ribonuclease
Molecules
Catalytic Domain
Eosinophil-Derived Neurotoxin