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Personal profile

Research interests

Our research is aimed at elucidating the structure-function relationship of molecules involved in normal and disease processes with a more recent focus on angiogenic molecules(angiogenin and VEGF family members) and molecules involved in inflammatory processes (toxins), functions in the vascular system such as Angiotensin-I converting enzyme (ACE) and glycosyltransferases.

We have complemented our structural studies using X-ray crystallography in understanding protein-protein/carbohydrate interactions with high-throughput compound library screening, structure based design of inhibitors, computational and biophysical techniques as well as protein engineering, enzyme kinetics, cell and developmental biology approaches.

To achieve this goal we have been ably supported by a number of very active collaborators (including clinicians and biologists) who are international experts. The long term objective of our research is directed towards the design of new pharmacological agents to treat human diseases.

  • PhD, Bangalore University, India (1982)
  • Scientist at the National Chemical Laboratory, Pune, India (1982-1983)
  • Post-doctoral Research Scientist, Laboratory of Molecular Biophysics, Oxford (1984-1990)
  • Sir E.P.Abraham Junior Research Fellow, Linacre College, Oxford University (1988-1990)
  • Lecturer (1990-1994), Reader (1994-1998), University of Bath
  • Leverhulme Trust Research Fellow, University of Bath (1993-1994)
  • Nuffield Foundation Science Research Fellow, University of Bath (1994-1995)
  • Royal Society - Leverhulme Trust Senior Research Fellow, University of Bath (2001-2002)
  • Wellcome Trust Research Leave Fellow, University of Bath (2004-2007)
  • Royal Society Industry Research Fellow, University of Bath (2007-2011)
  • Elected Fellow of Royal Society of Biology (2011)
  • Excellence in Doctoral Supervision Award - University of Bath (2012)
  • Syntaxin/Ipsen Bioinnovation Ltd (UK) Research Fellow (2011-2016)
  • Professor of Structural Biology, University of Bath (since May 1998)

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Structural Chemistry, Doctor of Philosophy, X-ray crystallographic studies on some important antibiotic molecules, Bangalore University

Award Date: 1 May 1982

Physics-X-ray crystallography, Master in Science, -, Bangalore University

Award Date: 1 May 1976

Physics, Chemistry and Mathematics, Bachelor of Science, -, Mahatma Gandhi Memorial College

Award Date: 1 May 1974

External positions

Honorary Research Professor, University of Cape Town



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