Projects per year
Personal profile
Research interests
Our research is aimed at elucidating the structure-function relationship of molecules involved in normal and disease processes with a more recent focus on angiogenic molecules(angiogenin and VEGF family members) and molecules involved in inflammatory processes (toxins), functions in the vascular system such as Angiotensin-I converting enzyme (ACE) and glycosyltransferases.
We have complemented our structural studies using X-ray crystallography in understanding protein-protein/carbohydrate interactions with high-throughput compound library screening, structure based design of inhibitors, computational and biophysical techniques as well as protein engineering, enzyme kinetics, cell and developmental biology approaches.
To achieve this goal we have been ably supported by a number of very active collaborators (including clinicians and biologists) who are international experts. The long term objective of our research is directed towards the design of new pharmacological agents to treat human diseases.
- PhD, Bangalore University, India (1982)
- Scientist at the National Chemical Laboratory, Pune, India (1982-1983)
- Post-doctoral Research Scientist, Laboratory of Molecular Biophysics, Oxford (1984-1990)
- Sir E.P.Abraham Junior Research Fellow, Linacre College, Oxford University (1988-1990)
- Lecturer (1990-1994), Reader (1994-1998), University of Bath
- Leverhulme Trust Research Fellow, University of Bath (1993-1994)
- Nuffield Foundation Science Research Fellow, University of Bath (1994-1995)
- Royal Society - Leverhulme Trust Senior Research Fellow, University of Bath (2001-2002)
- Wellcome Trust Research Leave Fellow, University of Bath (2004-2007)
- Royal Society Industry Research Fellow, University of Bath (2007-2011)
- Elected Fellow of Royal Society of Biology (2011)
- Excellence in Doctoral Supervision Award - University of Bath (2012)
- Syntaxin/Ipsen Bioinnovation Ltd (UK) Research Fellow (2011-2016)
- Professor of Structural Biology, University of Bath (since May 1998)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Structural Chemistry, Doctor of Philosophy, X-ray crystallographic studies on some important antibiotic molecules, Bangalore University
Award Date: 1 May 1982
Physics-X-ray crystallography, Master in Science, -, Bangalore University
Award Date: 1 May 1976
Physics, Chemistry and Mathematics, Bachelor of Science, -, Mahatma Gandhi Memorial College
Award Date: 1 May 1974
External positions
Honorary Research Professor, University of Cape Town
2014 → 2019
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Collaborations and top research areas from the last five years
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The structural and thermodynamic dissection of the interdomain cooperativity of human ACE
Biotechnology and Biological Sciences Research Council
1/04/23 → 31/03/26
Project: Research council
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Targeting intracellular Aß-peptide by Neprilysin in a human iPS cell organoid model.
1/09/22 → 31/08/25
Project: UK charity
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Structural studies on Clostridial difficile surface proteins
1/10/21 → 30/09/23
Project: Central government, health and local authorities
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Understanding the molecular basis of Aß peptide interacting proteins in Alzheimer's disease.
1/10/21 → 30/09/24
Project: UK charity
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A Comprehensive Structural Analysis of Clostridium botulinum Neurotoxin A Cell-Binding Domain from Different Subtypes
Gregory, K. & Acharya, R., 18 Jan 2023, In: Toxins . 15, 2, 23 p., 92.Research output: Contribution to journal › Review article › peer-review
Open Access2 Citations (SciVal) -
A Molecular Analysis of the Aminopeptidase P-Related Domain of PID-5 from Caenorhabditis elegans
Lloyd, A., Gregory, K., Isaac, E. & Acharya, K. R., 14 Jul 2023, In: Biomolecules. 13, 7, 23 p., 1132.Research output: Contribution to journal › Article › peer-review
Open Access -
Crystal Structure of the Catalytic Domain of a Botulinum Neurotoxin Homologue from Enterococcus faecium: Potential Insights into Substrate Recognition
Gregory, K., Hall, P-R., Onuh, J. P., Mojanaga, O., Liu, S. M. & Acharya, R., 12 Aug 2023, In: International Journal of Molecular Sciences. 24Research output: Contribution to journal › Article › peer-review
Open Access -
Molecular basis of selective amyloid-β degrading enzymes in Alzheimer’s disease
Zukowska, J., Moss, S., Subramanian, V. & Acharya, K. R., 25 Aug 2023, (E-pub ahead of print) In: FEBS Journal.Research output: Contribution to journal › Review article › peer-review
Open Access -
Crystal structures of botulinum neurotoxin subtypes A4 and A5 cell binding domains in complex with receptor ganglioside
Gregory, K., Mojanaga, O., Man Liu, S. & Acharya, R., 8 Feb 2022, In: Toxins . 14, 2, 129.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (SciVal)