Projects per year
Personal profile
Research interests
Our research is aimed at elucidating the structure-function relationship of molecules involved in normal and disease processes with a more recent focus on angiogenic molecules(angiogenin and VEGF family members) and molecules involved in inflammatory processes (toxins), functions in the vascular system such as Angiotensin-I converting enzyme (ACE) and glycosyltransferases.
We have complemented our structural studies using X-ray crystallography in understanding protein-protein/carbohydrate interactions with high-throughput compound library screening, structure based design of inhibitors, computational and biophysical techniques as well as protein engineering, enzyme kinetics, cell and developmental biology approaches.
To achieve this goal we have been ably supported by a number of very active collaborators (including clinicians and biologists) who are international experts. The long term objective of our research is directed towards the design of new pharmacological agents to treat human diseases.
- PhD, Bangalore University, India (1982)
- Scientist at the National Chemical Laboratory, Pune, India (1982-1983)
- Post-doctoral Research Scientist, Laboratory of Molecular Biophysics, Oxford (1984-1990)
- Sir E.P.Abraham Junior Research Fellow, Linacre College, Oxford University (1988-1990)
- Lecturer (1990-1994), Reader (1994-1998), University of Bath
- Leverhulme Trust Research Fellow, University of Bath (1993-1994)
- Nuffield Foundation Science Research Fellow, University of Bath (1994-1995)
- Royal Society - Leverhulme Trust Senior Research Fellow, University of Bath (2001-2002)
- Wellcome Trust Research Leave Fellow, University of Bath (2004-2007)
- Royal Society Industry Research Fellow, University of Bath (2007-2011)
- Elected Fellow of Royal Society of Biology (2011)
- Excellence in Doctoral Supervision Award - University of Bath (2012)
- Syntaxin/Ipsen Bioinnovation Ltd (UK) Research Fellow (2011-2016)
- Professor of Structural Biology, University of Bath (since May 1998)
Education/Academic qualification
Structural Chemistry, Doctor of Philosophy, Bangalore University
Physics-X-ray crystallography, Master in Science, Bangalore University
Physics, Chemistry and Mathematics, Bachelor of Science, Mahatma Gandhi Memorial College
External positions
Honorary Research Professor, University of Cape Town
2014 → 2019Fingerprint Dive into the research topics where Ravi Acharya is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Projects
- 20 Finished
Structure-function Studies on Human Angiotensin-l Concervting Enzyme (Human ACE)
1/02/16 → 30/04/20
Project: Research council
Structure-Function Studies on Clostridium Difficile Large Toxins
1/04/14 → 31/03/17
Project: Research council
Structure-function studies on ALS associated C9orf72 Protein
Motor Neurone Disease Association
1/12/13 → 30/11/16
Project: UK charity
Research Output
ACE-domain selectivity extends beyond direct interacting residues at the active site
Cozier, G., Lubbe, L., Sturrock, E. & Acharya, R., 17 Apr 2020, In : Biochemical Journal. 477, 7, p. 1241-1259 19 p.Research output: Contribution to journal › Article
Open Access
File
3
Downloads
(Pure)
Charcot-Leyden Crystal Protein/Galectin-10 Interacts with Cationic Ribonucleases and is Required for Eosinophil Granulogenesis.
Grozdanovic, M., Doyle, C., Lu, L., Maybruck, B., Kwatia, M., Thiyagarajan, N., Acharya, R. & Ackerman, S., 23 Jan 2020, In : Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article
Crystal structure of botulinum neurotoxin subtype A3 cell binding domain in complex with GD1a co-receptor ganglioside.
Gregory, K., Liu, S. M. & Acharya, R., Mar 2020, In : FEBS Open Bio. 10, 3, p. 298-305Research output: Contribution to journal › Article
Open Access
Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.
Sharma, U., Cozier, G., Sturrock, E. & Acharya, R., 2020, In : Journal of Medicinal Chemistry.Research output: Contribution to journal › Article
Open Access
Crystal structure of peptide-bound neprilysin reveals key binding interactions
Moss, S., Subramanian, V. & Acharya, K. R., 12 Sep 2019, In : FEBS Letters. 10 p.Research output: Contribution to journal › Article
Thesis
An investigation into the roles of Talpid3 and primary cilia in the developing brain
Author: Bashford, A., 25 Nov 2015Supervisor: Subramanian, V. (Supervisor) & Acharya, K. (Supervisor)
Student thesis: Doctoral Thesis › PhD
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A Study of the Interaction between Botulinum Neurotoxin and Cellular Membranes
Author: Harris, I., 1 Sep 2014Supervisor: Acharya, K. (Supervisor), Harper, E. (External person) (Supervisor) & Beard, M. (External person) (Supervisor)
Student thesis: Doctoral Thesis › PhD
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Investigation of the Clostridium difficile Sortase by Gene Knockout, X-ray Crystallography and Biochemical Characterisation
Author: Chambers, C., 28 Jan 2014Supervisor: Acharya, K. (Supervisor) & Shone, C. C. (External person) (Supervisor)
Student thesis: Doctoral Thesis › PhD
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Structural basis of porcine RNase 4 recognition
Author: Liang, S., 3 May 2015Supervisor: Acharya, K. (Supervisor)
Student thesis: Doctoral Thesis › PhD
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Structural Studies on Actin-ADP Ribosylating Binary Toxin From C. Difficile
Author: Sundriyal, A., 1 Feb 2010Supervisor: Acharya, K. (Supervisor)
Student thesis: Doctoral Thesis › PhD
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