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Personal profile

Research interests

Our research is aimed at elucidating the structure-function relationship of molecules involved in normal and disease processes with a more recent focus on angiogenic molecules(angiogenin and VEGF family members) and molecules involved in inflammatory processes (toxins), functions in the vascular system such as Angiotensin-I converting enzyme (ACE) and glycosyltransferases.

We have complemented our structural studies using X-ray crystallography in understanding protein-protein/carbohydrate interactions with high-throughput compound library screening, structure based design of inhibitors, computational and biophysical techniques as well as protein engineering, enzyme kinetics, cell and developmental biology approaches.

To achieve this goal we have been ably supported by a number of very active collaborators (including clinicians and biologists) who are international experts. The long term objective of our research is directed towards the design of new pharmacological agents to treat human diseases.

  • PhD, Bangalore University, India (1982)
  • Scientist at the National Chemical Laboratory, Pune, India (1982-1983)
  • Post-doctoral Research Scientist, Laboratory of Molecular Biophysics, Oxford (1984-1990)
  • Sir E.P.Abraham Junior Research Fellow, Linacre College, Oxford University (1988-1990)
  • Lecturer (1990-1994), Reader (1994-1998), University of Bath
  • Leverhulme Trust Research Fellow, University of Bath (1993-1994)
  • Nuffield Foundation Science Research Fellow, University of Bath (1994-1995)
  • Royal Society - Leverhulme Trust Senior Research Fellow, University of Bath (2001-2002)
  • Wellcome Trust Research Leave Fellow, University of Bath (2004-2007)
  • Royal Society Industry Research Fellow, University of Bath (2007-2011)
  • Elected Fellow of Royal Society of Biology (2011)
  • Excellence in Doctoral Supervision Award - University of Bath (2012)
  • Syntaxin/Ipsen Bioinnovation Ltd (UK) Research Fellow (2011-2016)
  • Professor of Structural Biology, University of Bath (since May 1998)

Education/Academic qualification

Structural Chemistry, Doctor of Philosophy, Bangalore University

Physics-X-ray crystallography, Master in Science, Bangalore University

Physics, Chemistry and Mathematics, Bachelor of Science, Mahatma Gandhi Memorial College

External positions

Honorary Research Professor, University of Cape Town


Fingerprint Dive into the research topics where Ravi Acharya is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Peptidyl-Dipeptidase A Medicine & Life Sciences
Clostridium difficile Medicine & Life Sciences
Clostridium Chemical Compounds
Crystal structure Chemical Compounds
Catalytic Domain Medicine & Life Sciences
Neurotoxins Medicine & Life Sciences
Proteins Chemical Compounds
Angiotensin-Converting Enzyme Inhibitors Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2002 2020

Angiotensin-Converting Enzyme Inhibitors
Crystal structure
Blood pressure
Clostridium difficile
Clostridium Infections
Anti-Bacterial Agents

Research Output 1983 2020

Charcot-Leyden Crystal Protein/Galectin-10 Interacts with Cationic Ribonucleases and is Required for Eosinophil Granulogenesis.

Grozdanovic, M., Doyle, C., Lu, L., Maybruck, B., Kwatia, M., Thiyagarajan, N., Acharya, R. & Ackerman, S., 23 Jan 2020, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Crystal structures of angiotensin-converting enzyme from Anopheles gambiae in its native form and with a bound inhibitor

Cashman, J. S., Cozier, G. E., Harrison, C., Isaac, R. E. & Acharya, K. R., 4 Nov 2019, In : Biochemical Journal. 476, 22, p. 3505-3520 16 p.

Research output: Contribution to journalArticle

Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile

Bradshaw, W. J., Bruxelle, J. F., Kovacs-Simon, A., Harmer, N. J., Janoir, C., Péchiné, S., Acharya, K. R. & Michell, S. L., 25 Oct 2019, In : The Journal of biological chemistry. 294, 43, p. 15850-15861 12 p.

Research output: Contribution to journalArticle

Open Access


An investigation into the roles of Talpid3 and primary cilia in the developing brain

Author: Bashford, A., 25 Nov 2015

Supervisor: Subramanian, V. (Supervisor) & Acharya, K. (Supervisor)

Student thesis: Doctoral ThesisPhD


A Study of the Interaction between Botulinum Neurotoxin and Cellular Membranes

Author: Harris, I., 1 Sep 2014

Supervisor: Acharya, K. (Supervisor), Harper, E. (External person) (Supervisor) & Beard, M. (External person) (Supervisor)

Student thesis: Doctoral ThesisPhD


Investigation of the Clostridium difficile Sortase by Gene Knockout, X-ray Crystallography and Biochemical Characterisation

Author: Chambers, C., 28 Jan 2014

Supervisor: Acharya, K. (Supervisor) & Shone, C. C. (External person) (Supervisor)

Student thesis: Doctoral ThesisPhD


Structural basis of porcine RNase 4 recognition

Author: Liang, S., 3 May 2015

Supervisor: Acharya, K. (Supervisor)

Student thesis: Doctoral ThesisPhD


Structural Studies on Actin-ADP Ribosylating Binary Toxin From C. Difficile

Author: Sundriyal, A., 1 Feb 2010

Supervisor: Acharya, K. (Supervisor)

Student thesis: Doctoral ThesisPhD