1983 …2020

Research output per year

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Personal profile

Research interests

Our research is aimed at elucidating the structure-function relationship of molecules involved in normal and disease processes with a more recent focus on angiogenic molecules(angiogenin and VEGF family members) and molecules involved in inflammatory processes (toxins), functions in the vascular system such as Angiotensin-I converting enzyme (ACE) and glycosyltransferases.

We have complemented our structural studies using X-ray crystallography in understanding protein-protein/carbohydrate interactions with high-throughput compound library screening, structure based design of inhibitors, computational and biophysical techniques as well as protein engineering, enzyme kinetics, cell and developmental biology approaches.

To achieve this goal we have been ably supported by a number of very active collaborators (including clinicians and biologists) who are international experts. The long term objective of our research is directed towards the design of new pharmacological agents to treat human diseases.

  • PhD, Bangalore University, India (1982)
  • Scientist at the National Chemical Laboratory, Pune, India (1982-1983)
  • Post-doctoral Research Scientist, Laboratory of Molecular Biophysics, Oxford (1984-1990)
  • Sir E.P.Abraham Junior Research Fellow, Linacre College, Oxford University (1988-1990)
  • Lecturer (1990-1994), Reader (1994-1998), University of Bath
  • Leverhulme Trust Research Fellow, University of Bath (1993-1994)
  • Nuffield Foundation Science Research Fellow, University of Bath (1994-1995)
  • Royal Society - Leverhulme Trust Senior Research Fellow, University of Bath (2001-2002)
  • Wellcome Trust Research Leave Fellow, University of Bath (2004-2007)
  • Royal Society Industry Research Fellow, University of Bath (2007-2011)
  • Elected Fellow of Royal Society of Biology (2011)
  • Excellence in Doctoral Supervision Award - University of Bath (2012)
  • Syntaxin/Ipsen Bioinnovation Ltd (UK) Research Fellow (2011-2016)
  • Professor of Structural Biology, University of Bath (since May 1998)

Education/Academic qualification

Structural Chemistry, Doctor of Philosophy, Bangalore University

Physics-X-ray crystallography, Master in Science, Bangalore University

Physics, Chemistry and Mathematics, Bachelor of Science, Mahatma Gandhi Memorial College

External positions

Honorary Research Professor, University of Cape Town

20142019

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Projects

  • Research Output

    ACE-domain selectivity extends beyond direct interacting residues at the active site

    Cozier, G., Lubbe, L., Sturrock, E. & Acharya, R., 17 Apr 2020, In : Biochemical Journal. 477, 7, p. 1241-1259 19 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    3 Downloads (Pure)

    Charcot-Leyden Crystal Protein/Galectin-10 Interacts with Cationic Ribonucleases and is Required for Eosinophil Granulogenesis.

    Grozdanovic, M., Doyle, C., Lu, L., Maybruck, B., Kwatia, M., Thiyagarajan, N., Acharya, R. & Ackerman, S., 23 Jan 2020, In : Journal of Allergy and Clinical Immunology.

    Research output: Contribution to journalArticle

    Open Access

    Thesis

    An investigation into the roles of Talpid3 and primary cilia in the developing brain

    Author: Bashford, A., 25 Nov 2015

    Supervisor: Subramanian, V. (Supervisor) & Acharya, K. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    A Study of the Interaction between Botulinum Neurotoxin and Cellular Membranes

    Author: Harris, I., 1 Sep 2014

    Supervisor: Acharya, K. (Supervisor), Harper, E. (External person) (Supervisor) & Beard, M. (External person) (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Investigation of the Clostridium difficile Sortase by Gene Knockout, X-ray Crystallography and Biochemical Characterisation

    Author: Chambers, C., 28 Jan 2014

    Supervisor: Acharya, K. (Supervisor) & Shone, C. C. (External person) (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Structural basis of porcine RNase 4 recognition

    Author: Liang, S., 3 May 2015

    Supervisor: Acharya, K. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Structural Studies on Actin-ADP Ribosylating Binary Toxin From C. Difficile

    Author: Sundriyal, A., 1 Feb 2010

    Supervisor: Acharya, K. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File