Projects per year
Personal profile
Research interests
Our research is aimed at elucidating the structure-function relationship of molecules involved in normal and disease processes with a more recent focus on angiogenic molecules(angiogenin and VEGF family members) and molecules involved in inflammatory processes (toxins), functions in the vascular system such as Angiotensin-I converting enzyme (ACE) and glycosyltransferases.
We have complemented our structural studies using X-ray crystallography in understanding protein-protein/carbohydrate interactions with high-throughput compound library screening, structure based design of inhibitors, computational and biophysical techniques as well as protein engineering, enzyme kinetics, cell and developmental biology approaches.
To achieve this goal we have been ably supported by a number of very active collaborators (including clinicians and biologists) who are international experts. The long term objective of our research is directed towards the design of new pharmacological agents to treat human diseases.
- PhD, Bangalore University, India (1982)
- Scientist at the National Chemical Laboratory, Pune, India (1982-1983)
- Post-doctoral Research Scientist, Laboratory of Molecular Biophysics, Oxford (1984-1990)
- Sir E.P.Abraham Junior Research Fellow, Linacre College, Oxford University (1988-1990)
- Lecturer (1990-1994), Reader (1994-1998), University of Bath
- Leverhulme Trust Research Fellow, University of Bath (1993-1994)
- Nuffield Foundation Science Research Fellow, University of Bath (1994-1995)
- Royal Society - Leverhulme Trust Senior Research Fellow, University of Bath (2001-2002)
- Wellcome Trust Research Leave Fellow, University of Bath (2004-2007)
- Royal Society Industry Research Fellow, University of Bath (2007-2011)
- Elected Fellow of Royal Society of Biology (2011)
- Excellence in Doctoral Supervision Award - University of Bath (2012)
- Syntaxin/Ipsen Bioinnovation Ltd (UK) Research Fellow (2011-2016)
- Professor of Structural Biology, University of Bath (since May 1998)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Structural Chemistry, Doctor of Philosophy, Bangalore University
Award Date: 1 May 1982
Physics-X-ray crystallography, Master in Science, Bangalore University
Award Date: 1 May 1976
Physics, Chemistry and Mathematics, Bachelor of Science, Mahatma Gandhi Memorial College
Award Date: 1 May 1974
External positions
Honorary Research Professor, University of Cape Town
2014 → 2019
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Network
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Understanding the molecular basis of Aß peptide interacting proteins in Alzheimer's disease.
1/10/21 → 30/09/24
Project: UK charity
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Structural studies on Clostridial difficile surface proteins
1/10/21 → 30/09/23
Project: Central government, health and local authorities
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Predicting effective targets for novel antimicrobials: Probing an essential signalling network
Porter, S., Titball, R. & Acharya, R.
1/10/18 → 30/03/23
Project: Research council
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Structure-function studies on Clostridium botulinum neurotoxins
1/10/18 → 31/12/22
Project: UK industry
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Crystal structures of botulinum neurotoxin subtypes A4 and A5 cell binding domains in complex with receptor ganglioside
Gregory, K., Mojanaga, O., Man Liu, S. & Acharya, R., 8 Feb 2022, In: Toxins . 14, 2, 129.Research output: Contribution to journal › Article › peer-review
Open Access -
Probing the requirements for dual angiotensin-converting enzyme C-domain selective/neprilysin inhibition
Arendse, L. B., Cozier, G., Eyermann, C., Basarab, G., Schwager, S. L. U., Chibale, K., Acharya, R. & Sturrock, E. D., 24 Feb 2022, In: Journal of Medicinal Chemistry. 65, 4, p. 3371-3387 17 p.Research output: Contribution to journal › Article › peer-review
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Structural basis for the inhibition of human angiotensin-1 converting enzyme by fosinoprilat
Cozier, G., Newby, E., Schwager, S., Isaac, E., Sturrock, E. & Acharya, R., 1 Jun 2022, (Acceptance date) In: FEBS Journal.Research output: Contribution to journal › Article › peer-review
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Structural features of Clostridium botulinum neurotoxin subtype A2 cell binding domain
Gregory, K., Mahadeva, T., Liu, S. M. & Acharya, R., 19 May 2022, In: Toxins . 14, 5, 356.Research output: Contribution to journal › Article › peer-review
Open Access -
Angiotensin-converting enzyme open for business: structural insights into the subdomain dynamics
Cozier, G., Lubbe, L., Sturrock, E. & Acharya, R., 30 Apr 2021, In: FEBS Journal. 288, 7, p. 2238-2256 19 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (SciVal)