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Personal profile

Research interests

Our research is aimed at elucidating the structure-function relationship of molecules involved in normal and disease processes with a more recent focus on angiogenic molecules(angiogenin and VEGF family members) and molecules involved in inflammatory processes (toxins), functions in the vascular system such as Angiotensin-I converting enzyme (ACE) and glycosyltransferases.

We have complemented our structural studies using X-ray crystallography in understanding protein-protein/carbohydrate interactions with high-throughput compound library screening, structure based design of inhibitors, computational and biophysical techniques as well as protein engineering, enzyme kinetics, cell and developmental biology approaches.

To achieve this goal we have been ably supported by a number of very active collaborators (including clinicians and biologists) who are international experts. The long term objective of our research is directed towards the design of new pharmacological agents to treat human diseases.

  • PhD, Bangalore University, India (1982)
  • Scientist at the National Chemical Laboratory, Pune, India (1982-1983)
  • Post-doctoral Research Scientist, Laboratory of Molecular Biophysics, Oxford (1984-1990)
  • Sir E.P.Abraham Junior Research Fellow, Linacre College, Oxford University (1988-1990)
  • Lecturer (1990-1994), Reader (1994-1998), University of Bath
  • Leverhulme Trust Research Fellow, University of Bath (1993-1994)
  • Nuffield Foundation Science Research Fellow, University of Bath (1994-1995)
  • Royal Society - Leverhulme Trust Senior Research Fellow, University of Bath (2001-2002)
  • Wellcome Trust Research Leave Fellow, University of Bath (2004-2007)
  • Royal Society Industry Research Fellow, University of Bath (2007-2011)
  • Elected Fellow of Society of Biology (2011)
  • Excellence in Doctoral Supervision Award - University of Bath (2012)
  • Syntaxin Ltd (UK) Research Fellow (since October 2011)
  • Professor of Structural Biology, University of Bath (since May 1998)

Education/Academic qualification

Structural Chemistry, Doctor of Philosophy, Bangalore University

Physics-X-ray crystallography, Master in Science, Bangalore University

Physics, Chemistry and Mathematics, Bachelor of Science, Mahatma Gandhi Memorial College

External positions

Honorary Research Professor, University of Cape Town

1 Jul 2014 → …

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Peptidyl-Dipeptidase A Medicine & Life Sciences
Clostridium difficile Medicine & Life Sciences
Clostridium Chemical Compounds
Crystal structure Chemical Compounds
Catalytic Domain Medicine & Life Sciences
Neurotoxins Medicine & Life Sciences
Proteins Chemical Compounds
Angiotensin-Converting Enzyme Inhibitors Medicine & Life Sciences

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Projects 2002 2020

Angiotensins
Angiotensin-Converting Enzyme Inhibitors
Enzymes
Crystal structure
Blood pressure
Clostridium difficile
Clostridium Infections
Bacteria
Anti-Bacterial Agents
Spores

Complementary Approaches in Structural Molecular Biology

Acharya, K.

1/01/1431/01/14

Project: Research council

Research Output 1992 2018

A comparative bioinformatic analysis of C9orf72

Iyer, S., Acharya, K. R. & Subramanian, V., 19 Feb 2018, In : PeerJ. 6, p. e4391

Research output: Contribution to journalArticle

Open Access
Neurodegenerative diseases
Bioinformatics
Computational Biology
bioinformatics
Introns

C9orf72, a protein associated with amyotrophic lateral sclerosis (ALS) is a guanine nucleotide exchange factor

Iyer, S., Subramanian, V. & Acharya, K. R., 17 Oct 2018, In : PeerJ. 6, 29 p., e5815.

Research output: Contribution to journalArticle

Open Access

Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE: a molecular basis for domain-selectivity

Cozier, G. E., Schwager, S. L., Sharma, R. K., Chibale, K., Sturrock, E. D. & Acharya, K. R., 24 Feb 2018, In : FEBS Journal.

Research output: Contribution to journalArticle

Open Access
Peptidyl-Dipeptidase A
Hydrophobic and Hydrophilic Interactions
Angiotensin-Converting Enzyme Inhibitors
Lysine
Catalytic Domain
Neprilysin
Neurotensin
Protein Conformation
Enkephalins
Metalloproteases
1 Citations

High resolution crystal structures of the receptor-binding domain of neurotoxin serotypes A and FA

Davies, J. R., Hackett, G. S., Liu, S. M. & Acharya, K. R., 21 Mar 2018, In : PeerJ. 6, e4552.

Research output: Contribution to journalArticle

Open Access
neurotoxins
Neurotoxins
crystal structure
serotypes
Crystal structure