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Research Output 2000 2018

2018
2 Citations (Scopus)

An intestinal paracellular pathway biased toward positively-charged macromolecules.

Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.

Research output: Contribution to journalArticle

Claudin-2
Dextrans
Permeability
Myosin Light Chains
Peptides
7 Citations (Scopus)

Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

Szabady, R., Louissaint, C., Lubben, A., Xie, B., Reeksting, S., Touhy, C., Demma, Z., Foley, S. E., Faherty, C. S., Llanos-Chea, A., Olive, A. J., Mrsny, R. & McCormick, B., 31 Aug 2018, In : Journal of Clinical Investigation. 128, 9, p. 4044-4056 13 p.

Research output: Contribution to journalArticle

Endocannabinoids
P-Glycoprotein
Neutrophils
Homeostasis
Inflammation
3 Citations (Scopus)
21 Downloads (Pure)

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Bown, H. K., Bonn, C., Yohe, S. T., Yadav, D. B., Patapoff, T. W., Daugherty, A. L. & Mrsny, R. J., 10 Mar 2018, In : Journal of Controlled Release. 273, p. 13-20 8 p.

Research output: Contribution to journalArticle

Open Access
File
Subcutaneous Injections
Biological Availability
Monoclonal Antibodies
Miniature Swine
Drug Compounding
4 Citations (Scopus)
Myosin Light Chains
Intestinal Mucosa
Phosphorylation
Tight Junctions
Peptides
2 Citations (Scopus)

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

Garcia-Castillo, M. D., Chinnapen, D. J. F., Te Welscher, Y. M., Gonzalez, R. J., Softic, S., Pacheco, M., Mrsny, R. J., Ronald Kahn, C., von Andrian, U. H., Lau, J., Pentelute, B. L. & Lencer, W. I., 31 May 2018, In : eLife. 7, p. 1-19 19 p., e34469.

Research output: Contribution to journalArticle

Open Access
Glycosphingolipids
Sorting
Glucagon-Like Peptide 1
Peptides
Ceramides
1 Citation (Scopus)

Transporters MRP1 and MRP2 regulate opposing inflammatory signals to control transepithelial neutrophil migration during Streptococcus pneumoniae lung infection

Zukauskas, A., Mrsny, R. J., Barrantes, P. C., Turner, J. R., Leong, J. M. & McCormick, B. A., 5 Jul 2018, In : mSphere. 3, 4, p. 1-15 15 p., e00303-18.

Research output: Contribution to journalArticle

Open Access
Transendothelial and Transepithelial Migration
Pneumococcal Infections
Neutrophils
Bacteremia
Lung
2017

Insights and lessons from a scientific conference on non-invasive delivery of macromolecules

Savla, R., Mrsny, R. J., Park, K., Aubert, I. & Stamoran, C., 1 Jun 2017, In : Pharmaceutical Research. 34, 6, p. 1149-1151 3 p.

Research output: Contribution to journalComment/debate

Macromolecules
Patient Compliance
Pharmaceutical Preparations
Pipelines
Safety
2016
4 Citations (Scopus)

Converting skin fibroblasts into hepatic-like cells by transient programming

Mrsny, R., Mar 2016, In : Journal of Cellular Biochemistry. 117, 3, p. 589-598

Research output: Contribution to journalArticle

Fibroblasts
Liver
Hepatocytes
Skin
End Stage Liver Disease

Increase alginate-chitosan nanoparticles transport efficiency through the epithelium by attaching nt-PE onto surface

Li, R., De Bank, P. & Mrsny, R., 2016, Proceedings of the World Congress on Recent Advances in Nanotechnology, RAN 2016. Avestia Publishing, 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
Chitosan
Exotoxins
alginate
Alginate
Pseudomonas
80 Citations (Scopus)

Intestinal permeation enhancers for oral peptide delivery

Maher, S., Mrsny, R. & Brayden, D. J., 15 Nov 2016, In : Advanced Drug Delivery Reviews. 106, Part B, p. 277-319

Research output: Contribution to journalArticle

Peptides
Dosage Forms
Intestinal Mucosa
Clinical Trials
Therapeutics
2015
21 Citations (Scopus)

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

Kinnunen, H. M., Sharma, V., Contreras-Rojas, L. R., Yu, Y., Alleman, C., Sreedhara, A., Fischer, S., Khawli, L., Yohe, S. T., Bumbaca, D., Patapoff, T. W., Daugherty, A. L. & Mrsny, R. J., 28 Sep 2015, In : Journal of Controlled Release. 214, p. 94-102 9 p.

Research output: Contribution to journalArticle

Subcutaneous Injections
Extracellular Matrix
Injections
Animal Testing Alternatives
In Vitro Techniques

DRUG DELIVERY ENHANCEMENT AGENTS

Mrsny, R., 17 Dec 2015, Patent No. WO2015189641 (A1), 21 Jun 2015, Priority date 12 Jun 2014, Priority No. 1410507.6

Research output: Patent

23 Citations (Scopus)
43 Downloads (Pure)

Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation

Taverner, A., Dondi, R., Almansour, K., Laurent, F., Owens, S-E., Eggleston, I. M., Fotaki, N. & Mrsny, R. J., 28 Jul 2015, In : Journal of Controlled Release. 210, p. 189-197 9 p.

Research output: Contribution to journalArticle

Open Access
Myosin Light Chains
Phosphoric Monoester Hydrolases
Phosphorylation
Insulin
Peptides
4 Citations (Scopus)
65 Downloads (Pure)

Hippo pathway elements co-localize with occludin: a possible sensor system in pancreatic epithelial cells

Santos Cravo, A., Carter, E., Erkan, M., Harvey, E., Furutani-Seiki, M. & Mrsny, R., 15 Jul 2015, In : Tissue Barriers. 3, 3, p. 1-35 35 p., e1037948.

Research output: Contribution to journalArticle

Open Access
File
Occludin
Epithelial Cells
Acoustic impedance
Dobutamine
Proto-Oncogene Proteins c-yes

Polymeric nanocarrier delivery of protein through the epithelial cells

Li, R., De Bank, P. & Mrsny, R., Jul 2015, (Unpublished).

Research output: Contribution to conferencePoster

Polymeric nanocarrier transport across Caco-2 cell monolayers in vitro

Li, R., De Bank, P. & Mrsny, R., Apr 2015, (Unpublished).

Research output: Contribution to conferencePoster

2014
5 Citations (Scopus)

Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer

Wang, X., Hu, J., Tan, Y., Cui, J., Wang, G., Mrsny, R. J. & Li, W., 2 May 2014, In : PLoS ONE. 9, 5, p. e95915

Research output: Contribution to journalArticle

Open Access
Neoplastic Stem Cells
lung neoplasms
Stem cells
stem cells
Lung Neoplasms
26 Citations (Scopus)

Human umbilical cord mesenchymal stromal cells rescue mice from acetaminophen-induced acute liver failure

Liu, Z., Meng, F., Li, C., Zhou, X., Zeng, X., He, Y., Mrsny, R. J., Liu, M., Hu, X., Hu, J-F. & Li, T., Sep 2014, In : Cytotherapy. 16, 9, p. 1207-1219 13 p.

Research output: Contribution to journalArticle

Acute Liver Failure
Umbilical Cord
Acetaminophen
Mesenchymal Stromal Cells
Liver
42 Citations (Scopus)
Subcutaneous Tissue
Subcutaneous Injections
Peptides
Injections
Proteins

METHODS AND APPARATUS FOR THE IN VITRO MODELLING OF DRUG ADMINISTRATION

Mrsny, R. & Kinnunen, H., 10 Apr 2014, Patent No. WO2014053840 (A1), 3 Oct 2013, Priority date 4 Oct 2012, Priority No. 1217768.9

Research output: Patent

9 Citations (Scopus)

The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs  Salmonella Typhimurium-induced neutrophil transepithelial migration

Agbor, T. A., Demma, Z., Mrsny, R. J., Castillo, A., Boll, E. J. & Mccormick, B. A., Sep 2014, In : Cellular Microbiology. 16, 9, p. 1339-1353 15 p.

Research output: Contribution to journalArticle

phospholipid-hydroperoxide glutathione peroxidase
Transendothelial and Transepithelial Migration
Salmonella typhimurium
Oxidoreductases
Arachidonate 12-Lipoxygenase
12 Citations (Scopus)
82 Downloads (Pure)

Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1

Mrsny, R., te Welscher, Y. M., Chinnapen, D. J-F., Kaoutzani, L. & Lencer, W. I., 10 Feb 2014, In : Journal of Controlled Release. 175, p. 72-8

Research output: Contribution to journalArticle

Open Access
File
Drug Carriers
Glucagon-Like Peptide 1
Ceramides
Incretins
Glycosphingolipids
2013
1 Citation (Scopus)

A time travel journey through cancer therapies

Santos Cravo, A. & Mrsny, R. J., 2013, Cancer targeted drug delivery: an elusive dream. Bae, Y. H., Mrsny, R. J. & Park, K. (eds.). New York: Springer, p. 3-35 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neoplasms
Therapeutics
Immunotoxins
Drug Therapy
Membrane Transport Proteins
18 Citations (Scopus)
Cell-Penetrating Peptides
Therapeutic Uses
Innate Immunity
Epithelial Cells
Peptides
74 Citations (Scopus)

Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming

Zhang, H., Jiao, W., Sun, L., Fan, J., Chen, M., Wang, H., Xu, X., Shen, A., Li, T., Niu, B., Ge, S., Li, W., Cui, J., Wang, G., Sun, J., Fan, X., Hu, X., Mrsny, R., Hoffman, A. R. & Hu, J-F., 3 Jul 2013, In : Cell Stem Cell. 13, 1, p. 30-35 6 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Genes
Epigenomics
Stem Cell Factor
RNA Interference
2012
1 Citation (Scopus)
78 Downloads (Pure)

A strategy to improve selectivity and targeting to epithelial-derived cancer cells

Liu, K., Hearne, K., Mrsny, A., Staka, C. & Mrsny, R. J., 10 Dec 2012, In : Journal of Controlled Release. 164, 2, p. 205-212 8 p.

Research output: Contribution to journalArticle

Open Access
File
Occludin
Neoplasms
Epithelial-Mesenchymal Transition
Gene Expression
Peptides
51 Citations (Scopus)
76 Downloads (Pure)

Oral drug delivery research in Europe

Mrsny, R. J., 20 Jul 2012, In : Journal of Controlled Release. 161, 2, p. 247-253

Research output: Contribution to journalArticle

Open Access
File
Research
Pharmaceutical Preparations
Drug Industry
European Union
Biological Availability
2011
19 Citations (Scopus)

Oral peptide delivery: Prioritizing the leading technologies

Brayden, D. J. & Mrsny, R. J., 2011, In : Therapeutic Delivery. 2, 12, p. 1567-1573 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
76 Downloads (Pure)

Sustained release formulations of rhVEGF165 produce a durable response in a murine model of peripheral angiogenesis

Daugherty, A. L., Rangell, L. K., Eckert, R., Zavala-Solorio, J., Peale, F. & Mrsny, R. J., Jun 2011, In : European Journal of Pharmaceutics and Biopharmaceutics. 78, 2, p. 289-297 9 p.

Research output: Contribution to journalArticle

Open Access
File
glycolic acid
Blood Vessels
Microspheres
Gels
Peripheral Vascular Diseases
2010
2 Citations (Scopus)

Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection

Daugherty, A. L. & Mrsny, R. J., Jan 2010, In : Journal of Drug Targeting. 18, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

Intramuscular Injections
Tissue Distribution
Vascular Endothelial Growth Factor A
Extracellular Matrix
Endothelial Cells

Seventh international nanomedicine and drug delivery symposium (NanoDDS'09)

Lipp, R., Mrsny, R. & Park, K., 1 Sep 2010, In : Journal of Controlled Release. 146, 2, p. 163 1 p.

Research output: Contribution to journalArticle

2009
18 Citations (Scopus)

Lessons from nature: "Pathogen-Mimetic" systems for mucosal Nano-medicines

Mrsny, R. J., 27 Feb 2009, In : Advanced Drug Delivery Reviews. 61, 2, p. 172-192 21 p.

Research output: Contribution to journalArticle

Nanomedicine
Urogenital System
Virulence Factors
Respiratory System
Gastrointestinal Tract
6 Citations (Scopus)

Metabolic processes at injection sites affecting pharmacokinetics, pharmacodynamics and metabolism of protein and peptide therapeutics

Mrsny, R. J., 2009, Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes. Mrsny, R. J. & Daugherty, A. L. (eds.). New York: Informa Healthcare, p. 80-105 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

New insights into mechanisms of gastrointestinal inflammation and cancer

Ward, S. G. & Mrsny, R. J., 2009, In : Current Opinion in Pharmacology. 9, 6, p. 677-679 3 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Inflammation
2 Citations (Scopus)

Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes

Mrsny, R. J. (ed.) & Daugherty, A. L. (ed.), 2009, New York: Informa Healthcare.

Research output: Book/ReportBook

Pharmacokinetics
Peptides
Drug Discovery
Industry
Proteins
7 Citations (Scopus)

The formulation and delivery of monoclonal antibodies

Sharma, V. K., Chih, H. W., Mrsny, R. J. & Daugherty, A. L., Oct 2009, Therapeutic Monoclonal Antibodies: From Bench to Clinic. An, Z. (ed.). Hoboken, NJ: Wiley, p. 671-705 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2008
73 Citations (Scopus)

A key claudin extracellular loop domain is critical for epithelial barrier integrity

Mrsny, R. J., Brown, G. T., Gerner-Smidt, K., Buret, A. G., Meddings, J. B., Quan, C., Koval, M. & Nusrat, A., Apr 2008, In : American Journal Of Pathology. 172, 4, p. 905-915 11 p.

Research output: Contribution to journalArticle

Claudin-1
Tight Junctions
Occludin
Peptides
Junctional Adhesion Molecule A
31 Citations (Scopus)

Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3

Pazos, M., Siccardi, D., Mumy, K. L., Bien, J. D., Louie, S., Shi, H. N., Gronert, K., Mrsny, R. J. & McCormick, B. A., 1 Dec 2008, In : The Journal of Immunology. 181, 11, p. 8044-8052 9 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Inflammation
Neutrophils
Intestinal Mucosa
Up-Regulation
43 Citations (Scopus)

Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro

Feighery, L. M., Cochrane, S. W., Quinn, T., Baird, A. W., O’Toole, D., Owens, S-E., O’Donoghue, D., Mrsny, R. J. & Brayden, D. J., 2008, In : Pharmaceutical Research. 25, 6, p. 1377-1386 10 p.

Research output: Contribution to journalArticle

2007
49 Citations (Scopus)

Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug

Wang, Z., Wade, P., Mandell, K. J., Akyildiz, A., Parkos, C. A., Mrsny, R. J. & Nusrat, A., 2007, In : Oncogene. 26, 8, p. 1222-1230 9 p.

Research output: Contribution to journalArticle

Occludin
Tight Junction Proteins
Zinc Fingers
Gastropoda
Epithelial-Mesenchymal Transition
2006

Active targeting strategies in cancer with a focus on potential nanotechnology applications

Mrsny, R. J., 2006, Nanotechnology in Cancer Therapeutics. Amiji, M. M. (ed.). Boca Raton, Florida: CRC Press, p. 19-42 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

192 Citations (Scopus)

Formulation and delivery issues for monoclonal antibody therapeutics

Daugherty, A. L. & Mrsny, R. J., 2006, In : Advanced Drug Delivery Reviews. 58, 5-6, p. 686-706 21 p.

Research output: Contribution to journalArticle

NF-kB-independent responses activated by bacterial-epithelial interactions: the role ofarachidonic acid metabolites

McCormick, B. A. & Mrsny, R. J., 2006, Bacterial-Epithelial Cell Cross-Talk: Molecular Mechanisms in Pathognesis. McCormick, B. A. (ed.). Cambridge, MA: Cambridge Publishing, p. 269-300 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2005
23 Citations (Scopus)

A strategy to identify stable membrane-permeant peptide inhibitors of myosin light chain kinase

Owens, S. E., Graham, W. V., Siccardi, D., Turner, J. R. & Mrsny, R. J., 2005, In : Pharmaceutical Research. 22, 5, p. 703-709 7 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure

Russo, J. M., Mrsny, R. J. & et al, N. V., 2005, In : Gastroenterology. 128, 4, p. 987-1001 15 p.

Research output: Contribution to journalArticle

260 Citations (Scopus)

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induce diarrhea in vivo

Clayburgh, D. R., Barrett, T. A., Tang, Y., Meddings, J. B., Van Eldik, L. J., Watterson, D. M., Clarke, L. L., Mrsny, R. J. & Turner, J. R., 2005, In : Journal of Clinical Investigation. 115, 10, p. 2702-2715 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Intranasal immunization strategy to impede pilin-mediated binding of Pseudomonas aeruginosa to airway epithelial cells

Hsieh, J. C., Tham, D. M., Feng, W., Huang, F., Embaie, S., Liu, K., Dean, D., Hertle, R., Fitzgerald, D. J. & Mrsny, R. J., 2005, In : Infection and immunity. 73, 11, p. 7705-7717 13 p.

Research output: Contribution to journalArticle

232 Citations (Scopus)

Mechanism of IFN- g -induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane

Utech, M., Ivanov, A. I., Samarin, S. N., Bruewer, M., Turner, J. R., Mrsny, R. J., Parkos, C. A. & Nusrat, A., 2005, In : Molecular Biology of the Cell. 16, 10, p. 5040-5052 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)