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Personal profile

Research interests

Randall Mrsny obtained a BS degree in Biochemistry and Biophysics and a PhD degree in Anatomy and Cell Biology from the University of California at Davis undergraduate and medical school campuses, respectively. As an NIH post-doctoral fellowship he studies membrane lipid-protein interactions at the Institute of Molecular Biology located in the University of Oregon Eugene campus. Prior to taking Professors’ post in Cardiff University and now the University of Bath, Randy led research groups in two companies: ALZA and Genentech. He has been involved in starting two new biotech companies through the acquisition of venture capital funding. Randy has been elected president of an international society and organized international meeting. He currently serves as a reviewer or advisor for multiple international agencies and companies.

Research Interests

The current research interest of the Mrsny Laboratory focuses on a variety of aspects of epithelial cell structure/function in health and disease. This work is supported through grants from governmental agencies and private foundations as well as through collaborative partnership with pharmaceutical companies.

  • Identification of molecules secreted by intestinal and airway epithelial cells which can control neutrophil and eosinophil transmigration
  • Identification of molecules that allow epithelial cells regulation to lymphocyte activation
  • Examine the role played by tight junction elements in controlling epithelial cells oncogenesis
  • Examine endogenous mechanisms that dynamically control tight junction opening and closing for drug delivery
  • Examine epithelial transcytosis mechanisms used by bacterial toxins for the delivery of biotherapeutics such as proteins, peptides, and siRNA.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 8 Similar Profiles
Tight Junctions Medicine & Life Sciences
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Peptides Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Subcutaneous Injections Medicine & Life Sciences
Neutrophils Medicine & Life Sciences
Myosin Light Chains Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2017

BioProNET

Mrsny, R.

1/04/1531/07/15

Project: Research council

Economics
Molecules
Screening
Insulin
Cost effectiveness

KTP with Qualasept Limited

Watts, A. & Mrsny, R.

1/12/1430/11/17

Project: Central government, health and local authorities

Enhanced Oral Delivery of Biopharmaceuticals

Mrsny, R.

15/05/1414/11/14

Project: Research council

In Vitro System of Subcutaneous Injection

Mrsny, R.

1/08/1331/01/15

Project: Central government, health and local authorities

Research Output 2000 2018

An intestinal paracellular pathway biased toward positively-charged macromolecules.

Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.

Research output: Contribution to journalArticle

Claudin-2
Dextrans
Permeability
Myosin Light Chains
Peptides
2 Citations

Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

Szabady, R., Louissaint, C., Lubben, A., Xie, B., Reeksting, S., Touhy, C., Demma, Z., Foley, S. E., Faherty, C. S., Llanos-Chea, A., Olive, A. J., Mrsny, R. & McCormick, B., 31 Aug 2018, In : Journal of Clinical Investigation. 128, 9, p. 4044-4056 13 p.

Research output: Contribution to journalArticle

Endocannabinoids
P-Glycoprotein
Neutrophils
Homeostasis
Inflammation
1 Citations

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Bown, H. K., Bonn, C., Yohe, S. T., Yadav, D. B., Patapoff, T. W., Daugherty, A. L. & Mrsny, R. J., 1 Mar 2018, In : Journal of Controlled Release. 273, p. 13-20 8 p.

Research output: Contribution to journalArticle

Subcutaneous Injections
Biological Availability
Monoclonal Antibodies
Miniature Swine
Drug Compounding
1 Citations
Myosin Light Chains
Intestinal Mucosa
Phosphorylation
Tight Junctions
Peptides
1 Citations

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

Garcia-Castillo, M. D., Chinnapen, D. J. F., Te Welscher, Y. M., Gonzalez, R. J., Softic, S., Pacheco, M., Mrsny, R. J., Ronald Kahn, C., von Andrian, U. H., Lau, J., Pentelute, B. L. & Lencer, W. I., 31 May 2018, In : eLife. 7, e34469.

Research output: Contribution to journalArticle

Open Access
Glycosphingolipids
Sorting
Glucagon-Like Peptide 1
Peptides
Ceramides

Thesis

Characterization of the trafficking pathway used by Pseudomonas aeruginosa Exotoxin A and application to oral drug delivery

Author: Laurent, F., 12 Feb 2016

Supervisor: Mrsny, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Development and Characterisation of Polymeric Nano-carriers for Oral Delivery of Biopharmaceuticals

Author: Li, M., 27 Jun 2017

Supervisor: Mrsny, R. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Feedback Regulation Mechanisms Controlling Occludin Expression And Tight Junction Function

Author: Ikem, T., 13 Jun 2016

Supervisor: Mrsny, R. (Supervisor) & Lloyd, M. (Supervisor)

Student thesis: Doctoral ThesisPhD

Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation

Author: Almansour, K., 1 Sep 2017

Supervisor: Mrsny, R. (Supervisor) & Eggleston, I. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

The Role of Epithelial Cell De Differentiation in the Context of Improved Chemotherapy Applied to Pancreatic Cancer

Author: Santos Cravo, A., 16 Jan 2015

Supervisor: Mrsny, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

File