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Personal profile

Research interests

Randall Mrsny obtained a BS degree in Biochemistry and Biophysics and a PhD degree in Anatomy and Cell Biology from the University of California at Davis undergraduate and medical school campuses, respectively. As an NIH post-doctoral fellowship he studies membrane lipid-protein interactions at the Institute of Molecular Biology located in the University of Oregon Eugene campus. Prior to taking Professors’ post in Cardiff University and now the University of Bath, Randy led research groups in two companies: ALZA and Genentech. He has been involved in starting two new biotech companies through the acquisition of venture capital funding. Randy has been elected president of an international society and organized international meeting. He currently serves as a reviewer or advisor for multiple international agencies and companies.

Research Interests

The current research interest of the Mrsny Laboratory focuses on a variety of aspects of epithelial cell structure/function in health and disease. This work is supported through grants from governmental agencies and private foundations as well as through collaborative partnership with pharmaceutical companies.

  • Identification of molecules secreted by intestinal and airway epithelial cells which can control neutrophil and eosinophil transmigration
  • Identification of molecules that allow epithelial cells regulation to lymphocyte activation
  • Examine the role played by tight junction elements in controlling epithelial cells oncogenesis
  • Examine endogenous mechanisms that dynamically control tight junction opening and closing for drug delivery
  • Examine epithelial transcytosis mechanisms used by bacterial toxins for the delivery of biotherapeutics such as proteins, peptides, and siRNA.

Fingerprint Dive into the research topics where Randy Mrsny is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Tight Junctions Medicine & Life Sciences
Occludin Medicine & Life Sciences
Peptides Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Subcutaneous Injections Medicine & Life Sciences
Neutrophils Medicine & Life Sciences
Myosin Light Chains Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences

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Projects 2012 2020


Mrsny, R.



Project: Research council

Cost effectiveness

KTP with Qualasept Limited

Watts, A. & Mrsny, R.

Innovate UK


Project: Central government, health and local authorities

Enhanced Oral Delivery of Biopharmaceuticals

Mrsny, R.



Project: Research council

In Vitro System of Subcutaneous Injection

Mrsny, R.

Innovate UK


Project: Central government, health and local authorities

Research Output 2000 2020

Cholix Protein Domain I Functions as a Carrier Element for Efficient Apical to Basal Epithelial Transcytosis

Taverner, A., Mackay, J., Laurent, F., Hunter, T., Liu, K., Mangat, K., Song, L., Seto, E., Postlethwaite, S., Alam, A., Chandalia, A., Seung, M., Saberi, M., Feng, W. & Mrsny, R., 13 Jan 2020, In : Tissue Barriers. 1710429.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

An intestinal paracellular pathway biased toward positively-charged macromolecules.

Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.

Research output: Contribution to journalArticle

Myosin Light Chains
8 Citations (Scopus)

Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

Szabady, R., Louissaint, C., Lubben, A., Xie, B., Reeksting, S., Touhy, C., Demma, Z., Foley, S. E., Faherty, C. S., Llanos-Chea, A., Olive, A. J., Mrsny, R. & McCormick, B., 31 Aug 2018, In : Journal of Clinical Investigation. 128, 9, p. 4044-4056 13 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
35 Downloads (Pure)

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Bown, H. K., Bonn, C., Yohe, S. T., Yadav, D. B., Patapoff, T. W., Daugherty, A. L. & Mrsny, R. J., 10 Mar 2018, In : Journal of Controlled Release. 273, p. 13-20 8 p.

Research output: Contribution to journalArticle

Open Access
Subcutaneous Injections
Biological Availability
Monoclonal Antibodies
Miniature Swine
Drug Compounding
4 Citations (Scopus)
Myosin Light Chains
Intestinal Mucosa
Tight Junctions


Characterization of the trafficking pathway used by Pseudomonas aeruginosa Exotoxin A and application to oral drug delivery

Author: Laurent, F., 12 Feb 2016

Supervisor: Mrsny, R. (Supervisor)

Student thesis: Doctoral ThesisPhD


Development and Characterisation of Polymeric Nano-carriers for Oral Delivery of Biopharmaceuticals

Author: Li, M., 27 Jun 2017

Supervisor: Mrsny, R. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD


Development of methods for in vitro characterisation of antibody-drug conjugates

Author: Chapman, T., 19 Jun 2019

Supervisor: Watts, A. (Supervisor), Mrsny, R. (Supervisor) & Watson, M. L. (Supervisor)

Student thesis: Doctoral ThesisPhD

Feedback Regulation Mechanisms Controlling Occludin Expression And Tight Junction Function

Author: Ikem, T., 13 Jun 2016

Supervisor: Mrsny, R. (Supervisor) & Lloyd, M. (Supervisor)

Student thesis: Doctoral ThesisPhD

Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation

Author: Almansour, K., 1 Sep 2017

Supervisor: Mrsny, R. (Supervisor) & Eggleston, I. (Supervisor)

Student thesis: Doctoral ThesisPhD