Randy Mrsny

Personal profile

Research interests

Randall Mrsny obtained a BS degree in Biochemistry and Biophysics and a PhD degree in Anatomy and Cell Biology from the University of California at Davis undergraduate and medical school campuses, respectively. As an NIH post-doctoral fellowship he studies membrane lipid-protein interactions at the Institute of Molecular Biology located in the University of Oregon Eugene campus. Prior to taking Professors’ post in Cardiff University and now the University of Bath, Randy led research groups in two companies: ALZA and Genentech. He has been involved in starting two new biotech companies through the acquisition of venture capital funding. Randy has been elected president of an international society and organized international meeting. He currently serves as a reviewer or advisor for multiple international agencies and companies.

Research Interests

The current research interest of the Mrsny Laboratory focuses on a variety of aspects of epithelial cell structure/function in health and disease. This work is supported through grants from governmental agencies and private foundations as well as through collaborative partnership with pharmaceutical companies.

Identification of molecules secreted by intestinal and airway epithelial cells which can control neutrophil and eosinophil transmigration
Identification of molecules that allow epithelial cells regulation to lymphocyte activation
Examine the role played by tight junction elements in controlling epithelial cells oncogenesis
Examine endogenous mechanisms that dynamically control tight junction opening and closing for drug delivery
Examine epithelial transcytosis mechanisms used by bacterial toxins for the delivery of biotherapeutics such as proteins, peptides, and siRNA.

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Projects

1 Active
5 Finished

Bringing Light Sheet Fluorescence Microscopy to the University of Bath

De Bank, P. & Mrsny, R.

BBSRC

1/07/19 → 30/06/20

Project: Research council

BioProNET

Mrsny, R.

BBSRC

1/04/15 → 31/07/15

Project: Research council

KTP with Qualasept Limited

Watts, A. & Mrsny, R.

Innovate UK

1/12/14 → 30/11/17

Project: Central government, health and local authorities

Enhanced Oral Delivery of Biopharmaceuticals

Mrsny, R.

MRC

15/05/14 → 14/11/14

Project: Research council

In Vitro System of Subcutaneous Injection

Mrsny, R.

Innovate UK

1/08/13 → 31/01/15

Project: Central government, health and local authorities

Research Output

63 Article
9 Chapter
3 Book
2 Poster
5 More

Accelerating the development of novel technologies and tools for the subcutaneous delivery of biotherapeutics

Collins, D. S., Sanchez-Felix, M., Badkar, A. V. & Mrsny, R., 24 Feb 2020, In : Journal of Controlled Release. 321, p. 475-482

Research output: Contribution to journal › Review article

Open Access

Cholix Protein Domain I Functions as a Carrier Element for Efficient Apical to Basal Epithelial Transcytosis

Taverner, A., Mackay, J., Laurent, F., Hunter, T., Liu, K., Mangat, K., Song, L., Seto, E., Postlethwaite, S., Alam, A., Chandalia, A., Seung, M., Saberi, M., Feng, W. & Mrsny, R., 13 Jan 2020, In : Tissue Barriers. 1710429.

Research output: Contribution to journal › Article

Open Access

An intestinal paracellular pathway biased toward positively-charged macromolecules.

Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

Szabady, R., Louissaint, C., Lubben, A., Xie, B., Reeksting, S., Touhy, C., Demma, Z., Foley, S. E., Faherty, C. S., Llanos-Chea, A., Olive, A. J., Mrsny, R. & McCormick, B., 31 Aug 2018, In : Journal of Clinical Investigation. 128, 9, p. 4044-4056 13 p.

Research output: Contribution to journal › Article

Open Access

9 Citations (Scopus)

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Bown, H. K., Bonn, C., Yohe, S. T., Yadav, D. B., Patapoff, T. W., Daugherty, A. L. & Mrsny, R. J., 10 Mar 2018, In : Journal of Controlled Release. 273, p. 13-20 8 p.

Research output: Contribution to journal › Article

Open Access

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