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Personal profile

Research interests

Randall Mrsny obtained a BS degree in Biochemistry and Biophysics and a PhD degree in Anatomy and Cell Biology from the University of California at Davis undergraduate and medical school campuses, respectively. As an NIH post-doctoral fellowship he studies membrane lipid-protein interactions at the Institute of Molecular Biology located in the University of Oregon Eugene campus. Prior to taking Professors’ post in Cardiff University and now the University of Bath, Randy led research groups in two companies: ALZA and Genentech. He has been involved in starting two new biotech companies through the acquisition of venture capital funding. Randy has been elected president of an international society and organized international meeting. He currently serves as a reviewer or advisor for multiple international agencies and companies.

Research Interests

The current research interest of the Mrsny Laboratory focuses on a variety of aspects of epithelial cell structure/function in health and disease. This work is supported through grants from governmental agencies and private foundations as well as through collaborative partnership with pharmaceutical companies.

  • Identification of molecules secreted by intestinal and airway epithelial cells which can control neutrophil and eosinophil transmigration
  • Identification of molecules that allow epithelial cells regulation to lymphocyte activation
  • Examine the role played by tight junction elements in controlling epithelial cells oncogenesis
  • Examine endogenous mechanisms that dynamically control tight junction opening and closing for drug delivery
  • Examine epithelial transcytosis mechanisms used by bacterial toxins for the delivery of biotherapeutics such as proteins, peptides, and siRNA.

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Projects

  • KTP with Qualasept Limited

    Watts, A. & Mrsny, R.

    Innovate UK

    1/12/1430/11/17

    Project: Central government, health and local authorities

    In Vitro System of Subcutaneous Injection

    Mrsny, R.

    Innovate UK

    1/08/1331/01/15

    Project: Central government, health and local authorities

    Research Output

    Accelerating the development of novel technologies and tools for the subcutaneous delivery of biotherapeutics

    Collins, D. S., Sanchez-Felix, M., Badkar, A. V. & Mrsny, R., 10 May 2020, In : Journal of Controlled Release. 321, p. 475-482

    Research output: Contribution to journalReview article

    Open Access
    2 Citations (Scopus)

    Cholix Protein Domain I Functions as a Carrier Element for Efficient Apical to Basal Epithelial Transcytosis

    Taverner, A., Mackay, J., Laurent, F., Hunter, T., Liu, K., Mangat, K., Song, L., Seto, E., Postlethwaite, S., Alam, A., Chandalia, A., Seung, M., Saberi, M., Feng, W. & Mrsny, R., 13 Jan 2020, In : Tissue Barriers. 1710429.

    Research output: Contribution to journalArticle

    Open Access

    Pseudopterosin and O-methyltylophorinidine suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma

    Xie, B., Haensel, J., Mundorf, V., Betz, J., Reimche, I., Erkan, M., Buedeyri, I., Gessell, A., Kerr, R., Ariantari, N. P., Yu, H., Proksch, P., Teusch, N. & Mrsny, R., 13 Jun 2020, (Acceptance date) In : Bioengineering.

    Research output: Contribution to journalArticle

    Systemic Delivery of Peptides by the Oral Route: Formulation and Medicinal Chemistry Approaches

    Brayden, D. J., Hill, T. A., Fairlie, D. P., Maher, S. & Mrsny, R., 30 May 2020, (Acceptance date) In : Advanced Drug Delivery Reviews.

    Research output: Contribution to journalArticle

    An intestinal paracellular pathway biased toward positively-charged macromolecules.

    Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.

    Research output: Contribution to journalArticle

  • 5 Citations (Scopus)

    Thesis

    Characterization of the trafficking pathway used by Pseudomonas aeruginosa Exotoxin A and application to oral drug delivery

    Author: Laurent, F., 12 Feb 2016

    Supervisor: Mrsny, R. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Development and Characterisation of Polymeric Nano-carriers for Oral Delivery of Biopharmaceuticals

    Author: Li, M., 27 Jun 2017

    Supervisor: Mrsny, R. (Supervisor) & De Bank, P. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Development of methods for in vitro characterisation of antibody-drug conjugates

    Author: Chapman, T., 19 Jun 2019

    Supervisor: Watts, A. (Supervisor), Mrsny, R. (Supervisor) & Watson, M. L. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Feedback Regulation Mechanisms Controlling Occludin Expression And Tight Junction Function

    Author: Ikem, T., 13 Jun 2016

    Supervisor: Mrsny, R. (Supervisor) & Lloyd, M. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation

    Author: Almansour, K., 1 Sep 2017

    Supervisor: Mrsny, R. (Supervisor) & Eggleston, I. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File