Projects per year
Personal profile
Research interests
Randall Mrsny obtained a BS degree in Biochemistry and Biophysics and a PhD degree in Anatomy and Cell Biology from the University of California at Davis undergraduate and medical school campuses, respectively. As an NIH post-doctoral fellowship he studies membrane lipid-protein interactions at the Institute of Molecular Biology located in the University of Oregon Eugene campus. Prior to taking Professors’ post in Cardiff University and now the University of Bath, Randy led research groups in two companies: ALZA and Genentech. He has been involved in starting two new biotech companies through the acquisition of venture capital funding. Randy has been elected president of an international society and organized international meeting. He currently serves as a reviewer or advisor for multiple international agencies and companies.
Research Interests
The current research interest of the Mrsny Laboratory focuses on a variety of aspects of epithelial cell structure/function in health and disease. This work is supported through grants from governmental agencies and private foundations as well as through collaborative partnership with pharmaceutical companies.
- Identification of molecules secreted by intestinal and airway epithelial cells which can control neutrophil and eosinophil transmigration
- Identification of molecules that allow epithelial cells regulation to lymphocyte activation
- Examine the role played by tight junction elements in controlling epithelial cells oncogenesis
- Examine endogenous mechanisms that dynamically control tight junction opening and closing for drug delivery
- Examine epithelial transcytosis mechanisms used by bacterial toxins for the delivery of biotherapeutics such as proteins, peptides, and siRNA.
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Projects 2012 2020
Bringing Light Sheet Fluorescence Microscopy to the University of Bath
1/07/19 → 30/06/20
Project: Research council
KTP with Qualasept Limited
1/12/14 → 30/11/17
Project: Central government, health and local authorities
In Vitro System of Subcutaneous Injection
1/08/13 → 31/01/15
Project: Central government, health and local authorities
Research Output 2000 2018
An intestinal paracellular pathway biased toward positively-charged macromolecules.
Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.Research output: Contribution to journal › Article
Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis
Szabady, R., Louissaint, C., Lubben, A., Xie, B., Reeksting, S., Touhy, C., Demma, Z., Foley, S. E., Faherty, C. S., Llanos-Chea, A., Olive, A. J., Mrsny, R. & McCormick, B., 31 Aug 2018, In : Journal of Clinical Investigation. 128, 9, p. 4044-4056 13 p.Research output: Contribution to journal › Article
In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Bown, H. K., Bonn, C., Yohe, S. T., Yadav, D. B., Patapoff, T. W., Daugherty, A. L. & Mrsny, R. J., 10 Mar 2018, In : Journal of Controlled Release. 273, p. 13-20 8 p.Research output: Contribution to journal › Article
Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia
Almansour, K., Taverner, A., Eggleston, I. M. & Mrsny, R. J., 10 Jun 2018, In : Journal of Controlled Release. 279, p. 208-219 12 p.Research output: Contribution to journal › Article
Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
Garcia-Castillo, M. D., Chinnapen, D. J. F., Te Welscher, Y. M., Gonzalez, R. J., Softic, S., Pacheco, M., Mrsny, R. J., Ronald Kahn, C., von Andrian, U. H., Lau, J., Pentelute, B. L. & Lencer, W. I., 31 May 2018, In : eLife. 7, p. 1-19 19 p., e34469.Research output: Contribution to journal › Article
Thesis
Characterization of the trafficking pathway used by Pseudomonas aeruginosa Exotoxin A and application to oral drug delivery
Author: Laurent, F., 12 Feb 2016Supervisor: Mrsny, R. (Supervisor)
Student thesis: Doctoral Thesis › PhD
Development and Characterisation of Polymeric Nano-carriers for Oral Delivery of Biopharmaceuticals
Author: Li, M., 27 Jun 2017Supervisor: Mrsny, R. (Supervisor) & De Bank, P. (Supervisor)
Student thesis: Doctoral Thesis › PhD
Development of methods for in vitro characterisation of antibody-drug conjugates
Author: Chapman, T., 19 Jun 2019Supervisor: Watts, A. (Supervisor), Mrsny, R. (Supervisor) & Watson, M. L. (Supervisor)
Student thesis: Doctoral Thesis › PhD
Feedback Regulation Mechanisms Controlling Occludin Expression And Tight Junction Function
Author: Ikem, T., 13 Jun 2016Supervisor: Mrsny, R. (Supervisor) & Lloyd, M. (Supervisor)
Student thesis: Doctoral Thesis › PhD
Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation
Author: Almansour, K., 1 Sep 2017Supervisor: Mrsny, R. (Supervisor) & Eggleston, I. (Supervisor)
Student thesis: Doctoral Thesis › PhD