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Peter Sunderland

Dr

20112015
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Poly(ADP-ribose) Polymerases Medicine & Life Sciences
Tankyrases Chemical Compounds
Molecular modeling Chemical Compounds
Benzamides Chemical Compounds
Deprotonation Chemical Compounds
Niacinamide Chemical Compounds
Cyclization Chemical Compounds
beta Catenin Chemical Compounds

Research Output 2011 2015

15 Citations (Scopus)
121 Downloads (Pure)

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sep 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.

Research output: Contribution to journal › Article

Open Access
File
Tankyrases
Benzamides
Deprotonation
Molecular modeling
Niacinamide

Use of new and known pyridine or pyrimidine compounds, for the treatment of a disease or condition associated with tankyrase, e.g. cancer selected from e.g. breast, colon, stomach, and liver

Threadgill, M., Lloyd, M., Thompson, A., Nathubhai, A., Wood, P., Paine, H., Kumpan, E., Sunderland, P. & Woon, E. C. Y., 2014, Patent No. WO2014087165-A1

Research output: Patent

12 Citations (Scopus)
107 Downloads (Pure)

One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs

Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. & Threadgill, M. D., 1 Sep 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5218-5227 10 p.

Research output: Contribution to journal › Article

Open Access
File
Cyclization
3-nitrobenzoic acid
Poly(ADP-ribose) Polymerases
Water
Lead compounds
32 Citations (Scopus)
195 Downloads (Pure)

5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. & Threadgill, M. D., 2011, In : Journal of Medicinal Chemistry. 54, 7, p. 2049-2059 11 p.

Research output: Contribution to journal › Article

File
Poly(ADP-ribose) Polymerases
Protein Isoforms
Acylation
Alkylation
Chlorides
12 Citations (Scopus)
102 Downloads (Pure)

Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor

Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. & Threadgill, M. D., 7 Feb 2011, In : Organic and Biomolecular Chemistry. 9, 3, p. 881-891 11 p.

Research output: Contribution to journal › Article

File
ribose
adenosine diphosphate
Poly(ADP-ribose) Polymerases
inhibitors
bicycle

Thesis

Design and synthesis of selective inhibitors of poly(ADP-ribose)polymerase-2

Author: Sunderland, P., 1 Jan 2010

Supervisor: Threadgill, M. (Supervisor), Thompson, A. (Supervisor) & Martin, N. G. (External person) (Supervisor)

Student thesis: Doctoral Thesis › PhD

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