20112015

Research output per year

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Research Output

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sep 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.

Research output: Contribution to journalArticle

Open Access
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  • 15 Citations (Scopus)
    149 Downloads (Pure)
    Open Access
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  • 13 Citations (Scopus)
    126 Downloads (Pure)

    5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)

    Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. & Threadgill, M. D., 2011, In : Journal of Medicinal Chemistry. 54, 7, p. 2049-2059 11 p.

    Research output: Contribution to journalArticle

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  • 33 Citations (Scopus)
    225 Downloads (Pure)

    Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor

    Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. & Threadgill, M. D., 7 Feb 2011, In : Organic and Biomolecular Chemistry. 9, 3, p. 881-891 11 p.

    Research output: Contribution to journalArticle

    File
  • 12 Citations (Scopus)
    120 Downloads (Pure)

    Thesis

    Design and synthesis of selective inhibitors of poly(ADP-ribose)polymerase-2

    Author: Sunderland, P., 1 Jan 2010

    Supervisor: Threadgill, M. (Supervisor), Thompson, A. (Supervisor) & Martin, N. G. (External person) (Supervisor)

    Student thesis: Doctoral ThesisPhD

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