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Peter Sunderland

Dr

20112015

Research output per year

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Research Output

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sep 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.

Research output: Contribution to journal › Article

Open Access
File
    • 15 Citations (Scopus)
    712 Downloads (Pure)

    Use of new and known pyridine or pyrimidine compounds, for the treatment of a disease or condition associated with tankyrase, e.g. cancer selected from e.g. breast, colon, stomach, and liver

    Threadgill, M., Lloyd, M., Thompson, A., Nathubhai, A., Wood, P., Paine, H., Kumpan, E., Sunderland, P. & Woon, E. C. Y., 2014, Patent No. WO2014087165-A1

    Research output: Patent

    One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs

    Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. & Threadgill, M. D., 1 Sep 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5218-5227 10 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 13 Citations (Scopus)
    140 Downloads (Pure)

    5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)

    Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. & Threadgill, M. D., 2011, In : Journal of Medicinal Chemistry. 54, 7, p. 2049-2059 11 p.

    Research output: Contribution to journal › Article

    File
    • 33 Citations (Scopus)
    242 Downloads (Pure)

    Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor

    Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. & Threadgill, M. D., 7 Feb 2011, In : Organic and Biomolecular Chemistry. 9, 3, p. 881-891 11 p.

    Research output: Contribution to journal › Article

    File
    • 12 Citations (Scopus)
    131 Downloads (Pure)

    Thesis

    Design and synthesis of selective inhibitors of poly(ADP-ribose)polymerase-2

    Author: Sunderland, P., 1 Jan 2010

    Supervisor: Threadgill, M. (Supervisor), Thompson, A. (Supervisor) & Martin, N. G. (External person) (Supervisor)

    Student thesis: Doctoral Thesis › PhD

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