Peter Sunderland

EmailP.T.Sunderland@bath.ac.uk

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4 Article
1 Patent

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro
Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sep 2015, In: Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.
Research output: Contribution to journal › Article › peer-review

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22 Citations (Scopus)

1085 Downloads (Pure)
Use of new and known pyridine or pyrimidine compounds, for the treatment of a disease or condition associated with tankyrase, e.g. cancer selected from e.g. breast, colon, stomach, and liver
Threadgill, M., Lloyd, M., Thompson, A., Nathubhai, A., Wood, P., Paine, H., Kumpan, E., Sunderland, P. & Woon, E. C. Y., 2014, Patent No. WO2014087165-A1
Research output: Patent
One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs
Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. & Threadgill, M. D., 1 Sep 2013, In: Bioorganic and Medicinal Chemistry. 21, 17, p. 5218-5227 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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18 Citations (Scopus)

202 Downloads (Pure)
5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)
Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. & Threadgill, M. D., 2011, In: Journal of Medicinal Chemistry. 54, 7, p. 2049-2059 11 p.
Research output: Contribution to journal › Article › peer-review

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38 Citations (Scopus)

340 Downloads (Pure)
Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor
Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. & Threadgill, M. D., 7 Feb 2011, In: Organic and Biomolecular Chemistry. 9, 3, p. 881-891 11 p.
Research output: Contribution to journal › Article › peer-review

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12 Citations (Scopus)

180 Downloads (Pure)

Design and synthesis of selective inhibitors of poly(ADP-ribose)polymerase-2
Author: Sunderland, P., 1 Jan 2010
Supervisor: Threadgill, M. (Supervisor), Thompson, A. (Supervisor) & Martin, N. G. (External person) (Supervisor)
Student thesis: Doctoral Thesis › PhD

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Peter Sunderland

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Research output

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Use of new and known pyridine or pyrimidine compounds, for the treatment of a disease or condition associated with tankyrase, e.g. cancer selected from e.g. breast, colon, stomach, and liver

One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs

5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)

Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor

Thesis

Design and synthesis of selective inhibitors of poly(ADP-ribose)polymerase-2