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Accepting PhD Students

20032017
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Personal profile

Research interests

My research focuses on the use of biomaterial matrices for healthcare applications in two interconnected areas, tissue engineering/regenerative medicine and controlled drug delivery, both of which have the ultimate clinical goal of treating damage or disease.

Tissue engineering and regenerative medicine aim to either replace diseased or damaged tissues with a fully functional, lab-grown construct or promote the repair of tissue in situ by stimulating the body’s own cells. Within these areas, my research focuses on generating different types of 3D scaffold, such as hydrogels, nanofibres and microcarriers, from a range of biomaterials and tailoring their properties in order to promote 3D cell growth for a desired tissue target or application. We have particular interest in the development of scaffolds for musculoskeletal repair and the use of cell carriers for cell scale-up and delivery.

Controlled drug delivery approaches aim to deliver the right amount of drug to the right part of the body at the right time rather than large systemic doses, of which only a very small proportion of the drug reaches the site of disease. By encapsulating drugs in biomaterial matrices, we can control their subsequent release by altering the properties of the biomaterial and the morphology of the matrix. Using this approach, we have generated promising electrospun mats which are capable of sustained antibiotic release and have been proven to kill bacteria both in isolated colonies and within biofilms, which are currently a severe clinical problem. This approach is also compatible with tissue engineering and regenerative medicine, where controlled release of bioactive molecules can influence cell fate and promote repair.

Our research has been funded by the EPSRC, BBSRC, MRC, Royal Society, EU, FAPESP and the University of Bath.

Willing to supervise PhD

Happy to discuss PhD projects in tissue engineering/regenerative medicine and advanced drug delivery systems. Specific projects include:

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=49517

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=83502

 

Teaching interests

Chemical kinetics, osmotic phenomenon, routes of drug delivery, controlled and advanced drug delivery systems, protein delivery, analytical techniques for proteins and nucleic acids, stem cells and tissue engineering.

Education/Academic qualification

Biochemistry & Biological Chemistry, Bachelor of Science, University of Nottingham

Organic chemistry, molecular pharmacology, biochemistry, Doctor of Philosophy, University of Nottingham

Keywords

  • Tissue Engineering
  • Biomaterials
  • Regenerative medicine
  • Controlled drug delivery

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2006 2014

Global Research Scholarship Scheme - Biodegradable nanofibres, tissue engineering

De Bank, P.

1/04/141/12/14

Project: Research-related fundingInternational Relations Office Funding

Photopatterned Dendrons for Tissue Engineering

De Bank, P.

1/10/0930/09/12

Project: Research council

Dendrimers
Tissue engineering
Adhesives
Tissue
Polymers

SELF-ASSEMBLED CELL AGGREGATES FOR TISSUE ENGINEERING

De Bank, P.

5/06/074/06/10

Project: Research council

Tissue Engineering
Polymers
Intercellular Signaling Peptides and Proteins
Research
Bone and Bones

Electrospun Silk Nanofibers for Neuronal Regeneration

De Bank, P.

1/10/0630/09/07

Project: UK charityIndividual grant

Research Output 2003 2017

Open Access
File
3 Citations

Dual crosslinked pectin–alginate network as sustained release hydrophilic matrix for repaglinide

Awasthi, R., Kulkarni, G., Ramana, M. V., Pinto, T., Kikuchi, I. S., Ghisleni, D., de Souza Braga, M., De Bank, P. & Dua, K. Apr 2017 In : International Journal of Biological Macromolecules. 97, p. 721-732

Research output: Contribution to journalArticle

Open Access
File
repaglinide
Pharmaceutical Preparations
Tablets
Polymers
Excipients
1 Citations

The effect of ozone gas sterilization on the properties and cell compatibility of electrospun polycaprolactone scaffolds

Rediguieri, C., De Bank, P., Zanin, M. H. A., Leo, P., Cerize, N. N. P., de Oliveira, A. M. & Pinto, T. 30 Jul 2017 In : Journal of Biomaterials Science, Polymer Edition. 28, 16, p. 1918-1934 17 p.

Research output: Contribution to journalArticle

Polycaprolactone
Ozone
Scaffolds (biology)
Scaffolds
Gases

Vascular Regenerative Surgery: Promised Land for Tissue Engineers?

Fortunato, T., De Bank, P. & Pula, G. 3 Jun 2017 In : International Journal of Stem Cell Research and Transplantation. 5, 2, p. 268-276

Research output: Contribution to journalArticle

Open Access
File
Cell- and Tissue-Based Therapy
Blood Vessels
Biocompatible Materials
Cardiovascular Diseases
Induced Pluripotent Stem Cells
11 Citations
Zein
Biofilms
Tetracycline
Staphylococcus aureus
Skin