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Accepting PhD Students

20032018
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Personal profile

Research interests

My research focuses on the use of biomaterial matrices for healthcare applications in two interconnected areas, tissue engineering/regenerative medicine and controlled drug delivery, both of which have the ultimate clinical goal of treating damage or disease.

Tissue engineering and regenerative medicine aim to either replace diseased or damaged tissues with a fully functional, lab-grown construct or promote the repair of tissue in situ by stimulating the body’s own cells. Within these areas, my research focuses on generating different types of 3D scaffold, such as hydrogels, nanofibres and microcarriers, from a range of biomaterials and tailoring their properties in order to promote 3D cell growth for a desired tissue target or application. We have particular interest in the development of scaffolds for musculoskeletal repair and the use of cell carriers for cell scale-up and delivery.

Controlled drug delivery approaches aim to deliver the right amount of drug to the right part of the body at the right time rather than large systemic doses, of which only a very small proportion of the drug reaches the site of disease. By encapsulating drugs in biomaterial matrices, we can control their subsequent release by altering the properties of the biomaterial and the morphology of the matrix. Using this approach, we have generated promising electrospun mats which are capable of sustained antibiotic release and have been proven to kill bacteria both in isolated colonies and within biofilms, which are currently a severe clinical problem. This approach is also compatible with tissue engineering and regenerative medicine, where controlled release of bioactive molecules can influence cell fate and promote repair.

Our research has been funded by the EPSRC, BBSRC, MRC, Royal Society, EU, FAPESP and the University of Bath.

Willing to supervise PhD

Happy to discuss PhD projects in tissue engineering/regenerative medicine and advanced drug delivery systems. Specific projects include:

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=49517

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=83502

 

Teaching interests

Chemical kinetics, osmotic phenomenon, routes of drug delivery, controlled and advanced drug delivery systems, protein delivery, analytical techniques for proteins and nucleic acids, stem cells and tissue engineering.

Education/Academic qualification

Organic chemistry, molecular pharmacology, biochemistry, Doctor of Philosophy, University of Nottingham

Biochemistry & Biological Chemistry, Bachelor of Science, University of Nottingham

Keywords

  • Tissue Engineering
  • Biomaterials
  • Regenerative medicine
  • Controlled drug delivery

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2006 2014

Global Research Scholarship Scheme - Biodegradable nanofibres, tissue engineering

De Bank, P.

1/04/141/12/14

Project: Research-related fundingInternational Relations Office Funding

Photopatterned Dendrons for Tissue Engineering

De Bank, P.

1/10/0930/09/12

Project: Research council

Dendrimers
Tissue engineering
Adhesives
Tissue
Polymers

SELF-ASSEMBLED CELL AGGREGATES FOR TISSUE ENGINEERING

De Bank, P.

5/06/074/06/10

Project: Research council

Tissue Engineering
Polymers
Intercellular Signaling Peptides and Proteins
Research
Bone and Bones

Electrospun Silk Nanofibers for Neuronal Regeneration

De Bank, P.

1/10/0630/09/07

Project: UK charityIndividual grant

Research Output 2003 2018

Microgel Matrices for Human Cancer Organoid Production

Pinheiro De Lucena-Thomas, J., Luetchford, K., Ellis, M. & De Bank, P., 22 Feb 2018, (Unpublished).

Research output: Contribution to conferencePaper

Hydrogels
Screening
Scaffolds (biology)
Bioreactors
Encapsulation

Microgel Matrices for Human Cancer Organoid Production

Pinheiro De Lucena-Thomas, J., Luetchford, K., Ellis, M. & De Bank, P., 2018.

Research output: Contribution to conferencePoster

Microgel Matrices for Human Cancer Organoid Production

Pinheiro De Lucena-Thomas, J., Luetchford, K., Ellis, M. & De Bank, P., 21 May 2018.

Research output: Contribution to conferencePoster

Hydrogels
Screening
Scaffolds (biology)
Bioreactors
Encapsulation

Microgel Matrices for Human Cancer Organoid Production

Pinheiro De Lucena-Thomas, J., Luetchford, K. (ed.), Ellis, M. (ed.) & De Bank, P. (ed.), 25 Jun 2018.

Research output: Contribution to conferencePoster

Hydrogels
Screening
Scaffolds (biology)
Bioreactors
Encapsulation

Organoid Expansion Bioreactor Development

Pinheiro De Lucena-Thomas, J., Luetchford, K., De Bank, P. & Ellis, M., 25 Jun 2018, (Unpublished).

Research output: Contribution to conferencePaper

Organoids
Bioreactors

Thesis

Chalcone derivatives in cancer research and tissue engineering

Author: Ciupa, A., 28 Feb 2013

Supervisor: Caggiano, L. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Development and Characterisation of Polymeric Nano-carriers for Oral Delivery of Biopharmaceuticals

Author: Li, M., 27 Jun 2017

Supervisor: Mrsny, R. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Development of a Novel PVA-PLGA Hollow Fibre Bioreactor for Tissue Engineering

Author: Meneghello, G., 1 Jul 2010

Supervisor: De Bank, P. (Supervisor) & Chaudhuri, J. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Endothelial colony forming cells (ECFCs) and biomaterials: a synergy for next-generation cardiovascular implants

Author: Fortunato, T., 26 Apr 2017

Supervisor: Pula, G. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Novel Scaffolds for Musculoskeletal Tissue Engineering

Author: Wells, J., 26 Apr 2017

Supervisor: De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisMPhil

File