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Accepting PhD Students

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Personal profile

Research interests

My research focuses on the use of biomaterial matrices for healthcare applications in two interconnected areas, tissue engineering/regenerative medicine and controlled drug delivery, both of which have the ultimate clinical goal of treating damage or disease.

Tissue engineering and regenerative medicine aim to either replace diseased or damaged tissues with a fully functional, lab-grown construct or promote the repair of tissue in situ by stimulating the body’s own cells. Within these areas, my research focuses on generating different types of 3D scaffold, such as hydrogels, nanofibres and microcarriers, from a range of biomaterials and tailoring their properties in order to promote 3D cell growth for a desired tissue target or application. We have particular interest in the development of scaffolds for musculoskeletal repair and the use of cell carriers for cell scale-up and delivery.

Controlled drug delivery approaches aim to deliver the right amount of drug to the right part of the body at the right time rather than large systemic doses, of which only a very small proportion of the drug reaches the site of disease. By encapsulating drugs in biomaterial matrices, we can control their subsequent release by altering the properties of the biomaterial and the morphology of the matrix. Using this approach, we have generated promising electrospun mats which are capable of sustained antibiotic release and have been proven to kill bacteria both in isolated colonies and within biofilms, which are currently a severe clinical problem. This approach is also compatible with tissue engineering and regenerative medicine, where controlled release of bioactive molecules can influence cell fate and promote repair.

Our research has been funded by the EPSRC, BBSRC, MRC, Royal Society, EU, FAPESP and the University of Bath.

Willing to supervise PhD

Happy to discuss PhD projects in tissue engineering/regenerative medicine and advanced drug delivery systems. Specific projects include:




Teaching interests

Chemical kinetics, osmotic phenomenon, routes of drug delivery, controlled and advanced drug delivery systems, protein delivery, analytical techniques for proteins and nucleic acids, stem cells and tissue engineering.

Education/Academic qualification

Organic chemistry, molecular pharmacology, biochemistry, Doctor of Philosophy, University of Nottingham

Biochemistry & Biological Chemistry, Bachelor of Science, University of Nottingham


  • Tissue Engineering
  • Biomaterials
  • Regenerative medicine
  • Controlled drug delivery

Fingerprint Dive into the research topics where Paul De Bank is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2006 2020

Tissue engineering
Tissue Engineering
Intercellular Signaling Peptides and Proteins
Bone and Bones

Research Output 2003 2020

9 Downloads (Pure)

Silk fibroin/gelatin microcarriers as scaffolds for bone tissue engineering

Luetchford, K., Chaudhuri, J. & De Bank, P., 1 Jan 2020, In : Materials Science & Engineering C. 106, p. 1-9 9 p., 110116.

Research output: Contribution to journalArticle

Open Access
Open Access

Modelling biofilms on infected chronic wounds

Cheng, Y., De Bank, P. & Bolhuis, A., 8 Apr 2019, In : Access Microbiology. 1, 1A

Research output: Contribution to journalMeeting abstract

Open Access

Microgel Matrices for Human Cancer Organoid Production

Pinheiro De Lucena-Thomas, J., Luetchford, K., Ellis, M. & De Bank, P., 2 Feb 2018.

Research output: Contribution to conferencePoster

Scaffolds (biology)

Microgel Matrices for Human Cancer Organoid Production

Pinheiro De Lucena-Thomas, J., Luetchford, K. (ed.), Ellis, M. (ed.) & De Bank, P. (ed.), 6 Dec 2018.

Research output: Contribution to conferencePoster


Chalcone derivatives in cancer research and tissue engineering

Author: Ciupa, A., 28 Feb 2013

Supervisor: Caggiano, L. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD


Development and Characterisation of Polymeric Nano-carriers for Oral Delivery of Biopharmaceuticals

Author: Li, M., 27 Jun 2017

Supervisor: Mrsny, R. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD


Development of a Novel PVA-PLGA Hollow Fibre Bioreactor for Tissue Engineering

Author: Meneghello, G., 1 Jul 2010

Supervisor: De Bank, P. (Supervisor) & Chaudhuri, J. (Supervisor)

Student thesis: Doctoral ThesisPhD


Endothelial colony forming cells (ECFCs) and biomaterials: a synergy for next-generation cardiovascular implants

Author: Fortunato, T., 26 Apr 2017

Supervisor: Pula, G. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD


Molecular mechanisms of YAP signalling in the context of cancer

Author: Xie, B., 13 Feb 2019

Supervisor: De Bank, P. (Supervisor), Mackenzie, A. (Supervisor), Ward, S. (Supervisor) & Mrsny, R. (Supervisor)

Student thesis: Doctoral ThesisPhD