20032020

Research output per year

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Personal profile

Research interests

My research focuses on the use of biomaterial matrices for healthcare applications in two interconnected areas, tissue engineering/regenerative medicine and controlled drug delivery, both of which have the ultimate clinical goal of treating damage or disease.

Tissue engineering and regenerative medicine aim to either replace diseased or damaged tissues with a fully functional, lab-grown construct or promote the repair of tissue in situ by stimulating the body’s own cells. Within these areas, my research focuses on generating different types of 3D scaffold, such as hydrogels, nanofibres and microcarriers, from a range of biomaterials and tailoring their properties in order to promote 3D cell growth for a desired tissue target or application. We have particular interest in the development of scaffolds for musculoskeletal repair and the use of cell carriers for cell scale-up and delivery.

Controlled drug delivery approaches aim to deliver the right amount of drug to the right part of the body at the right time rather than large systemic doses, of which only a very small proportion of the drug reaches the site of disease. By encapsulating drugs in biomaterial matrices, we can control their subsequent release by altering the properties of the biomaterial and the morphology of the matrix. Using this approach, we have generated promising electrospun mats which are capable of sustained antibiotic release and have been proven to kill bacteria both in isolated colonies and within biofilms, which are currently a severe clinical problem. This approach is also compatible with tissue engineering and regenerative medicine, where controlled release of bioactive molecules can influence cell fate and promote repair.

Our research has been funded by the EPSRC, BBSRC, MRC, Royal Society, EU, FAPESP and the University of Bath.

Willing to supervise doctoral students

Happy to discuss PhD projects in tissue engineering/regenerative medicine and advanced drug delivery systems. Specific projects include:

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=49517

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=83502

 

Teaching interests

Chemical kinetics, osmotic phenomenon, routes of drug delivery, controlled and advanced drug delivery systems, protein delivery, analytical techniques for proteins and nucleic acids, stem cells and tissue engineering.

Education/Academic qualification

Organic chemistry, molecular pharmacology, biochemistry, Doctor of Philosophy, University of Nottingham

Award Date: 1 Jan 2000

Biochemistry & Biological Chemistry, Bachelor of Science, University of Nottingham

Award Date: 1 Jan 1995

Keywords

  • Tissue Engineering
  • Biomaterials
  • Regenerative medicine
  • Controlled drug delivery

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Projects

  • Research Output

    Silk fibroin/gelatin microcarriers as scaffolds for bone tissue engineering

    Luetchford, K., Chaudhuri, J. & De Bank, P., 1 Jan 2020, In : Materials Science & Engineering C. 106, p. 1-9 9 p., 110116.

    Research output: Contribution to journalArticle

    Open Access
    File
    4 Citations (Scopus)
    15 Downloads (Pure)
    Open Access
    5 Citations (Scopus)

    Microgel Matrices for Human Cancer Organoid Production

    Pinheiro De Lucena-Thomas, J., Luetchford, K. (ed.), Ellis, M. (ed.) & De Bank, P. (ed.), 1 Jul 2019.

    Research output: Contribution to conferencePoster

    Microgel Matrices for Human Cancer Organoid Production

    Pinheiro De Lucena-Thomas, J., Luetchford, K. (ed.), Ellis, M. (ed.) & De Bank, P. (ed.), 3 Nov 2019.

    Research output: Contribution to conferencePoster

    Datasets

    Data for: "Bed Expansion Properties of Tissue Engineering Particles in a Fluidised Bed Bioreactor"

    Pinheiro De Lucena-Thomas, J. (Creator), Boonprasirt, P. (Data Collector), Luetchford, K. (Supervisor), De Bank, P. (Supervisor) & Ellis, M. (Supervisor), University of Bath, 18 May 2020

    Dataset

    Thesis

    Chalcone derivatives in cancer research and tissue engineering

    Author: Ciupa, A., 28 Feb 2013

    Supervisor: Caggiano, L. (Supervisor) & De Bank, P. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Development and Characterisation of Polymeric Nano-carriers for Oral Delivery of Biopharmaceuticals

    Author: Li, M., 27 Jun 2017

    Supervisor: Mrsny, R. (Supervisor) & De Bank, P. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Development of a Novel PVA-PLGA Hollow Fibre Bioreactor for Tissue Engineering

    Author: Meneghello, G., 1 Jul 2010

    Supervisor: De Bank, P. (Supervisor) & Chaudhuri, J. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Endothelial colony forming cells (ECFCs) and biomaterials: a synergy for next-generation cardiovascular implants

    Author: Fortunato, T., 26 Apr 2017

    Supervisor: Pula, G. (Supervisor) & De Bank, P. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Molecular mechanisms of YAP signalling in the context of cancer

    Author: Xie, B., 13 Feb 2019

    Supervisor: De Bank, P. (Supervisor), Mackenzie, A. (Supervisor), Ward, S. (Supervisor) & Mrsny, R. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File