• 7 WEST 2.08

20002020
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Personal profile

Research interests

Dr Nikoletta Fotaki is a UK-registered Greek Pharmacist. She graduated from the National and Kapodistrian University of Athens in Greece and she obtained a MSc in Toxicology from the University of Surrey in the UK. She completed her PhD in Biopharmaceutics-Pharmacokinetics at the School of Pharmacy of the National and Kapodistrian University of Athens in Greece. During this period she worked on various research projects. She worked as a Pharmacist in the National Organisation of Drugs in Greece (EOF) and she was a Postdoctoral Fellow in the School of Pharmacy (National and Kapodistrian University of Athens, Greece) upon completion of her Ph.D degree. After that she was offered a further postdoctoral fellowship by Roche ( New Jersey, USA).

Dr Fotaki’s research and activities are focused on the prediction of oral drug absorption, which is an area of very keen interest in the pharmaceutical world due to the increasing use of libraries to screen structures for potential activity and the need to select leads based not only on potential receptor interactions but also on the basis of ability to be absorbed orally. She is working on the development of in vitro screening tools and associated softwares for predicting oral absorption, the assessment of the impact of changes in drug substance properties and changes in the formulation process on bioavailability , animal models for predicting absorption, and in vitro-in vivo correlations/ in vitro-in vivo relations.

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Projects 2014 2020

Evaluation of In Vitro Tests to Reduce Animal Testing in Drug Toxicology Studies

Fotaki, N.

1/01/1531/12/15

Project: Central government, health and local authorities

FAPESP Bath Scheme

Fotaki, N.

1/09/141/08/16

Project: Research-related fundingInternational Relations Office Funding

Accelerating paediatric Formulation Development Through Smart Design and Predictive Science

Fotaki, N.

1/07/1431/03/18

Project: Central government, health and local authorities

Research Output 2000 2019

Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products - a PEARRL review

Guimarães, M., Statelova, M., Holm, R., Reppas, C., Symilllides, M., Vertzoni, M. & Fotaki, N., 3 Jul 2018, In : Journal of Pharmacy and Pharmacology. 40 p.

Research output: Contribution to journalArticle

Open Access
Pediatrics
Biopharmaceutics
Pharmaceutical Preparations
Gastrointestinal Tract
Drug Compounding

Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review.

Guimarães, M., Statelova, M., Holm, R., Reppas, C., Symilllides, M., Vertzoni, M. & Fotaki, N., 28 May 2018, (Accepted/In press) In : Journal of Pharmacy and Pharmacology.

Research output: Contribution to journalArticle

Biorelevant in vitro dissolution coupled with n-octanol partition assay to predict in vivo absorption of ketoprofen after oral administration

Lorier, M., Fotaki, N., Vázquez, M. & Fagiolino, P., 17 Apr 2018, In : Latin American Journal of Pharmacy. 37, 5, p. 995-999 5 p.

Research output: Contribution to journalArticle

1-Octanol
Ketoprofen
Oral Administration
Uruguay
Gastric Emptying

Dissolution highlights from the 2017 AAPS annual meeting in San Diego

Fotaki, N., Krämer, J., Lu, X., Diaz, D. & Langer, C., 1 Aug 2018, In : Dissolution Technologies. 25, 3

Research output: Contribution to journalComment/debate

Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: A PEARRL Review

Litou, C., Effinger, A., Kostewicz, E. S., Box, K. J., Fotaki, N. & Dressman, J. B., 30 Jul 2018, In : Journal of Pharmacy and Pharmacology.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Pharmacokinetics
Pharmaceutical Preparations
Microbiota
Treatment Failure

Thesis

Biopharmaceutical considerations and in vitro-in vivo correlations (IVIVCs) for orally administered amorphous formulations

Author: Long, C. M., 10 Jun 2014

Supervisor: Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

In vitro and Physiologically Based Pharmacokinetic models for pharmaceutical cocrystals Irena Tomaszewska

Author: Tomaszewska, I., 31 Dec 2013

Supervisor: Fotaki, N. (Supervisor) & Price, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Predictive models for intra-articular drug delivery

Author: Nikolettos, J., 31 Mar 2018

Supervisor: Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

Selection and analysis of predictive fed-state gastric biorelevant media

Author: Baxevanis, F., 15 Nov 2017

Supervisor: Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD