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Research interests

Dr Nikoletta Fotaki is a UK-registered Greek Pharmacist. She graduated from the National and Kapodistrian University of Athens in Greece and she obtained a MSc in Toxicology from the University of Surrey in the UK. She completed her PhD in Biopharmaceutics-Pharmacokinetics at the School of Pharmacy of the National and Kapodistrian University of Athens in Greece. During this period she worked on various research projects. She worked as a Pharmacist in the National Organisation of Drugs in Greece (EOF) and she was a Postdoctoral Fellow in the School of Pharmacy (National and Kapodistrian University of Athens, Greece) upon completion of her Ph.D degree. After that she was offered a further postdoctoral fellowship by Roche ( New Jersey, USA).

Dr Fotaki’s research and activities are focused on the prediction of oral drug absorption, which is an area of very keen interest in the pharmaceutical world due to the increasing use of libraries to screen structures for potential activity and the need to select leads based not only on potential receptor interactions but also on the basis of ability to be absorbed orally. She is working on the development of in vitro screening tools and associated softwares for predicting oral absorption, the assessment of the impact of changes in drug substance properties and changes in the formulation process on bioavailability , animal models for predicting absorption, and in vitro-in vivo correlations/ in vitro-in vivo relations.

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Projects 2014 2020

Evaluation of In Vitro Tests to Reduce Animal Testing in Drug Toxicology Studies

Fotaki, N.

Innovate UK

1/01/1531/12/15

Project: Central government, health and local authorities

FAPESP Bath Scheme

Fotaki, N.

1/09/141/08/16

Project: Research-related funding

Accelerating paediatric Formulation Development Through Smart Design and Predictive Science

Fotaki, N.

Innovate UK

1/07/1431/03/18

Project: Central government, health and local authorities

Research Output 2000 2019

Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL review

Loisios-Konstantinidis, I., Paraiso, R. L. M., Fotaki, N., McAllister, M., Cristofoletti, R. & Dressman, J., 1 Apr 2019, In : Journal of Pharmacy and Pharmacology. 71, 4, p. 699-723 25 p.

Research output: Contribution to journalReview article

Biorelevant release testing of biodegradable microspheres intended for intra-articular administration

Magri, G., Selmin, F., Cilurzo, F. & Fotaki, N., 1 Jun 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 139, p. 115-122 8 p.

Research output: Contribution to journalArticle

Co-delivery of buparvaquone and polymyxin B in a nanostructured lipid carrier for leishmaniasis treatment

Monteiro, L. M., Löbenberg, R., Fotaki, N., Barros de Araujo, G. L., Cotrim, P. C. & Bou-Chacra, N. A., 1 Sep 2019, In : Journal of Global Antimicrobial Resistance. 18, p. 279-283 5 p.

Research output: Contribution to journalArticle

Highly Water-Soluble Orotic Acid Nanocrystals Produced by High-Energy Milling

de Cássia Zaghi Compri, J., Andres Felli, V. M., Lourenço, F. R., Takatsuka, T., Fotaki, N., Löbenberg, R., Bou-Chacra, N. A. & Barros de Araujo, G. L., 1 May 2019, In : Journal of Pharmaceutical Sciences. p. 1848-1856

Research output: Contribution to journalArticle

In vitro–in vivo correlations based on in vitro dissolution of parent drug diltiazem and pharmacokinetics of its metabolite

Mircioiu, C., Anuta, V., Mircioiu, I., Nicolescu, A. & Fotaki, N., 16 Jul 2019, In : Pharmaceutics. 11, 7, 344.

Research output: Contribution to journalArticle

Open Access

Thesis

Biopharmaceutical considerations and in vitro-in vivo correlations (IVIVCs) for orally administered amorphous formulations

Author: Long, C. M., 10 Jun 2014

Supervisor: Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

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Clinically relevant in vitro dissolution/release testing for parenteral formulations

Author: Diaz De Leon Ortega, R., 3 Apr 2019

Supervisor: Pourzand, C. (Supervisor) & Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

In vitro and Physiologically Based Pharmacokinetic models for pharmaceutical cocrystals Irena Tomaszewska

Author: Tomaszewska, I., 31 Dec 2013

Supervisor: Fotaki, N. (Supervisor) & Price, R. (Supervisor)

Student thesis: Doctoral ThesisPhD

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Predictive models for intra-articular drug delivery

Author: Nikolettos, J., 31 Mar 2018

Supervisor: Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Selection and analysis of predictive fed-state gastric biorelevant media

Author: Baxevanis, F., 15 Nov 2017

Supervisor: Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

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