20002020

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Personal profile

Research interests

Dr Nikoletta Fotaki is a UK-registered Greek Pharmacist. She graduated from the National and Kapodistrian University of Athens in Greece and she obtained a MSc in Toxicology from the University of Surrey in the UK. She completed her PhD in Biopharmaceutics-Pharmacokinetics at the School of Pharmacy of the National and Kapodistrian University of Athens in Greece. During this period she worked on various research projects. She worked as a Pharmacist in the National Organisation of Drugs in Greece (EOF) and she was a Postdoctoral Fellow in the School of Pharmacy (National and Kapodistrian University of Athens, Greece) upon completion of her Ph.D degree. After that she was offered a further postdoctoral fellowship by Roche ( New Jersey, USA).

Dr Fotaki’s research and activities are focused on the prediction of oral drug absorption, which is an area of very keen interest in the pharmaceutical world due to the increasing use of libraries to screen structures for potential activity and the need to select leads based not only on potential receptor interactions but also on the basis of ability to be absorbed orally. She is working on the development of in vitro screening tools and associated softwares for predicting oral absorption, the assessment of the impact of changes in drug substance properties and changes in the formulation process on bioavailability , animal models for predicting absorption, and in vitro-in vivo correlations/ in vitro-in vivo relations.

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Projects

FAPESP - Bath Scheme 2018

Fotaki, N. & Bou-Chacra, N. A.

1/03/191/03/20

Project: Research-related funding

Evaluation of In Vitro Tests to Reduce Animal Testing in Drug Toxicology Studies

Fotaki, N.

Innovate UK

1/01/1531/12/15

Project: Central government, health and local authorities

FAPESP Bath Scheme

Fotaki, N.

1/09/141/08/16

Project: Research-related funding

Research Output

American association of pharmaceutical scientists (AAPS) and Chinese national institutes for food and drug control (NIFDC) joint workshop on dissolution, bioequivalence, product performance, and quality

Lu, X., Ning, B., Fotaki, N., Sharp, S. S., Burgess, D. & Haddouchi, S., 1 Jan 2020, In : Dissolution Technologies. 27, 2, p. 42-50 9 p.

Research output: Contribution to journalBook/Film/Article review

Open Access

A new medium-throughput screening design approach for the development of hydroxymethylnitrofurazone (NFOH) nanostructured lipid carrier for treating leishmaniasis

de Souza, A., Yukuyama, M. N., Barbosa, E. J., Monteiro, L. M., Faloppa, A. C. B., Calixto, L. A., de Barros Araújo, G. L., Fotaki, N., Löbenberg, R. & Bou-Chacra, N. A., 1 May 2020, In : Colloids and Surfaces B: Biointerfaces. 193, 111097.

Research output: Contribution to journalArticle

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Hypromellose (HPMC)

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 2020, In : AAPS Journal. 22, 49.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Superdisintegrants

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 31 Mar 2020, In : AAPS Journal. 22, 2, 46.

Research output: Contribution to journalArticle

Open Access
Open Access

Thesis

Biopharmaceutical considerations and in vitro-in vivo correlations (IVIVCs) for orally administered amorphous formulations

Author: Long, C. M., 10 Jun 2014

Supervisor: Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Biopharmaceutical understanding of excipient variability in drug product performance

Author: Zarmpi, P., 4 Sep 2019

Supervisor: Fotaki, N. (Supervisor) & Bolhuis, A. (Supervisor)

Student thesis: Doctoral ThesisPhD

Clinically relevant in vitro dissolution/release testing for parenteral formulations

Author: Diaz De Leon Ortega, R., 3 Apr 2019

Supervisor: Pourzand, C. (Supervisor) & Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Developing in vitro and in silico tools to predict the impact of gastrointestinal disease states on drug product performance

Author: Effinger, A., 19 Feb 2020

Supervisor: Fotaki, N. (Supervisor), O'Driscoll, C. M. O. (External person) (Supervisor), McAllister, M. (External person) (Supervisor) & Caggiano, L. (Supervisor)

Student thesis: Doctoral ThesisPhD

Formulation performance in paediatric patients - in vitro predictive models and biowaivers

Author: Martir, J., 4 Sep 2019

Supervisor: Fotaki, N. (Supervisor) & Husbands, S. (Supervisor)

Student thesis: Doctoral ThesisPhD