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Michael Threadgill

Prof

  • 5 WEST 3.9

Accepting PhD Students

20002018

Personal profile

Education/Academic qualification

Education, Durham University

Doctor of Science, University of Bath

Bachelor of Arts, University of Cambridge

Master of Arts, University of Cambridge

Doctor of Philosophy, University of Cambridge

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 4 Similar Profiles
Tankyrases Chemical Compounds
Poly(ADP-ribose) Polymerases Medicine & Life Sciences
Acyl Coenzyme A Chemical Compounds
Esters Chemical Compounds
Coenzyme A Medicine & Life Sciences
Phenols Chemical Compounds
Acids Chemical Compounds
Enzymes Medicine & Life Sciences

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Projects 2005 2018

Research Output 2000 2018

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 30 Apr 2018 In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journalArticle

Acyl Coenzyme A
Enzyme activity
Coenzyme A
Assays
Esters

Synthesis and solid-state conformations of 6S,8aR/S-6-alkyl-3,3-dimethyltetrahydrooxazolo[3,4-a]pyrazine-5,8-diones (pseudoproline DKPs).

Beauchard, A., Dufton, H. F., Odumah, K., Jaggers, R. H., Mahon, M. F., Wood, P. J. & Threadgill, M. 2018 In : Indian Journal of Heterocyclic Chemistry.

Research output: Contribution to journalArticle

Diketopiperazines
Pyrazines
S 6
Conformations
Dipeptides

A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 21 Apr 2017 (Unpublished)

Research output: Contribution to conferenceAbstract

File
Coenzyme A
Inhibitory Concentration 50
Acyl Coenzyme A
Prostatic Neoplasms
S 10
2 Citations

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 7 May 2017 In : Chemical Communications. 53, 37, p. 5087-5090 4 p.

Research output: Contribution to journalArticle

Open Access
Assays
Ibuprofen
Fatty acids
Fatty Acids
Degradation
9 Citations

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M. 26 Jan 2017 In : Journal of Medicinal Chemistry. 60, 2, p. 814-820

Research output: Contribution to journalArticle

Open Access
File
Tankyrases
Inhibitory Concentration 50
Protein Isoforms
Binding Sites
Glucose