Projects per year
Personal profile
Education/Academic qualification
Education, Durham University
Doctor of Science, University of Bath
Bachelor of Arts, University of Cambridge
Master of Arts, University of Cambridge
Doctor of Philosophy, University of Cambridge
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Tankyrases
Chemical Compounds
Poly(ADP-ribose) Polymerases
Medicine & Life Sciences
Acyl Coenzyme A
Chemical Compounds
Esters
Chemical Compounds
Coenzyme A
Medicine & Life Sciences
Phenols
Chemical Compounds
Acids
Chemical Compounds
Enzymes
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2005 2018
AMACR Targeted Drugs for Treating Advance Prostate Cancer
Lloyd, M., James, T., Jevglevskis, M., Nathubhai, A., Threadgill, M. & Woodman, T.
1/02/15 → 30/07/18
Project: UK charity
Advanced Inhibitors of Tankyrases 1 and 2, Critical Pathways in Cancer
1/10/15 → 30/09/16
Project: UK charity
Advanced Inhibitors of Tankyrases 1 and 2, Critical Pathways in Cancer
Threadgill, M., Lloyd, M. & Nathubhai, A.
1/10/14 → 30/09/15
Project: UK charity
Refinement of a Polymeric System Delivering CGIs to Prostate Tumours
Threadgill, M., Lloyd, M. & Thompson, A.
1/10/14 → 30/09/17
Project: UK charity
Advanced Inhibitors of Tankyrases 1 and 2, Critical Pathways in Cancer
Threadgill, M., Lloyd, M. & Nathubhai, A.
1/10/13 → 30/09/14
Project: UK charity
Research Output 2000 2018
Structure-activity relationships of rationally designed AMACR 1A inhibitors
Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 30 Apr 2018 In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.Research output: Contribution to journal › Article
Acyl Coenzyme A
Enzyme activity
Coenzyme A
Assays
Esters
Synthesis and solid-state conformations of 6S,8aR/S-6-alkyl-3,3-dimethyltetrahydrooxazolo[3,4-a]pyrazine-5,8-diones (pseudoproline DKPs).
Beauchard, A., Dufton, H. F., Odumah, K., Jaggers, R. H., Mahon, M. F., Wood, P. J. & Threadgill, M. 2018 In : Indian Journal of Heterocyclic Chemistry.Research output: Contribution to journal › Article
Diketopiperazines
Pyrazines
S 6
Conformations
Dipeptides
A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors
Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 21 Apr 2017 (Unpublished)Research output: Contribution to conference › Abstract
File
Coenzyme A
Inhibitory Concentration 50
Acyl Coenzyme A
Prostatic Neoplasms
S 10
2
Citations
A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate
Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 7 May 2017 In : Chemical Communications. 53, 37, p. 5087-5090 4 p.Research output: Contribution to journal › Article
Open Access
Assays
Ibuprofen
Fatty acids
Fatty Acids
Degradation
9
Citations
Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity
Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M. 26 Jan 2017 In : Journal of Medicinal Chemistry. 60, 2, p. 814-820Research output: Contribution to journal › Article
Open Access
File
Tankyrases
Inhibitory Concentration 50
Protein Isoforms
Binding Sites
Glucose