Michael Danson

Prof

19972019
If you made any changes in Pure these will be visible here soon.

Research Output 1997 2019

2019

Inhibition of extracellular proteases improves the production of a xylanase in Parageobacillus thermoglucosidasius

Holland, A. T. N., Danson, M. J. & Bolhuis, A., 20 Mar 2019, In : BMC Biotechnology. 19, 1, 17.

Research output: Contribution to journalArticle

Open Access
2018
2 Citations (Scopus)

Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase

Buddrus, L., Andrews, E. S. V., Leak, D., Danson, M., Arcus, V. L. & Crennell, S., 1 Mar 2018, In : Acta Crystallographica Section F:Structural Biology Communications. 74, 3, p. 179-186 8 p.

Research output: Contribution to journalArticle

Open Access
Pyruvate Decarboxylase
pyruvates
enzymes
Crystal structure
Bins
8 Downloads (Pure)
Open Access
File
phospho-2-keto-3-deoxy-gluconate aldolase
Thermoplasmales
Aldehyde-Lyases
Sulfolobus solfataricus
Fructose-Bisphosphate Aldolase
2 Citations (Scopus)
23 Downloads (Pure)

Uncovering the relationship between the change in heat capacity for enzyme catalysis and vibrational frequency through isotope effect studies

Jones, H. B. L., Crean, R. M., Matthews, C., Troya, A. B., Danson, M. J., Bull, S. D., Arcus, V. L., Van Der Kamp, M. W. & Pudney, C. R., 1 Jun 2018, In : ACS Catalysis. 8, 6, p. 5340-5349 10 p.

Research output: Contribution to journalArticle

Open Access
File
Vibrational spectra
Isotopes
Catalysis
Specific heat
Substitution reactions
2017
1 Citation (Scopus)

Development of an efficient technique for gene deletion and allelic exchange in Geobacillus spp.

Bacon, L. F., Hamley-Bennett, C., Danson, M. J. & Leak, D. J., 5 Apr 2017, In : Microbial Cell Factories. 16, 1, 8 p., 58.

Research output: Contribution to journalArticle

Open Access
Geobacillus
Gene Deletion
Genes
Homologous Recombination
Ethanol
2016
4 Citations (Scopus)
54 Downloads (Pure)

Crystal structure of pyruvate decarboxylase from Zymobacter palmae

Buddrus, L., Andrews, E. S. V., Leak, D. J., Danson, M. J., Arcus, V. L. & Crennell, S. J., 1 Sep 2016, In : Acta Crystallographica Section F:Structural Biology Communications. 72, 9, p. 700-706

Research output: Contribution to journalArticle

Open Access
File
Pyruvate Decarboxylase
Thiamine Pyrophosphate
pyruvates
Bins
Pyruvic Acid

Investigating bottlenecks during protein secretion in Geobacillus thermoglucosidasisius

Holland, A., Danson, M. & Bolhuis, A., Nov 2016.

Research output: Contribution to conferencePoster

2 Citations (Scopus)
84 Downloads (Pure)

Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius

Extance, J., Danson, M. J. & Crennell, S. J., 29 Aug 2016, In : Protein Science. 25, 11, p. 2045-2053

Research output: Contribution to journalArticle

Open Access
File
acetaldehyde dehydrogenase (acylating)
Geobacillus
Dimers
Alcohol Dehydrogenase
Coenzymes
2014
9 Citations (Scopus)
104 Downloads (Pure)
Open Access
File
Geobacillus
Glycoside Hydrolases
Enzymes
Xylosidases
Xylans
2 Citations (Scopus)
90 Downloads (Pure)

Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea

Borziak, K., Posner, M., Upadhyay, A., Danson, M., Bagby, S. & Dorus, S., 28 Jan 2014, In : PLoS ONE. 9, p. 1 - 9 9 p., e87063.

Research output: Contribution to journalArticle

Open Access
File
Aerobiosis
Lipoylation
Keto Acids
aerobiosis
Archaea
3 Citations (Scopus)

Draft genome sequences of Geobacillus sp. strains CAMR5420 and CAMR12739

De Maayer, P., Williamson, C. E., Vennard, C. T., Danson, M. J. & Cowan, D. A., 2014, In : Genome announcements. 2, 3, e00567-14.

Research output: Contribution to journalArticle

Open Access
Geobacillus
Genome
Polymers
19 Citations (Scopus)
83 Downloads (Pure)
File
Citrate (si)-Synthase
Rigidity
Crystallography
Citric Acid Cycle
Carbon
10 Citations (Scopus)
84 Downloads (Pure)

Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex

Marrott, N., Marshall, J. J. T., Svergun, DI., Crennell, S., Hough, D. W., Van Den Elsen, J. & Danson, M., 1 Nov 2014, In : Biochemical Journal. 463, 3, p. 405-412 8 p.

Research output: Contribution to journalArticle

Open Access
File
Keto Acids
Oxidoreductases
Multienzyme Complexes
Thermoplasma
Dihydrolipoamide Dehydrogenase
2013
8 Citations (Scopus)
84 Downloads (Pure)

Post-translational modification in the archaea: structural characterization of multi-enzyme complex lipoylation

Posner, M. G., Upadhyay, A., Crennell, S., Watson, A. J. A., Dorus, S., Danson, M. J. & Bagby, S., 15 Jan 2013, In : Biochemical Journal. 449, 2, p. 415-425 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lipoylation
Archaea
Post Translational Protein Processing
Enzymes
Protein C
16 Citations (Scopus)
70 Downloads (Pure)

Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius

Extance, J., Crennell, S. J., Eley, K., Cripps, R., Hough, D. W. & Danson, M. J., Oct 2013, In : Acta Crystallographica Section D-Biological Crystallography. 69, 10, p. 2104-2115 12 p.

Research output: Contribution to journalArticle

Open Access
File
Geobacillus
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
NAD
Acyl Coenzyme A
16 Citations (Scopus)
Fructose-Bisphosphate Aldolase
Arabinose
Xylose
Enantiomers
Pyruvic Acid
39 Citations (Scopus)

Temperature and the catalytic activity of enzymes: a fresh understanding

Daniel, R. M. & Danson, M. J., 2013, In : FEBS Letters. 17, 2, p. 2738-2743

Research output: Contribution to journalArticle

Catalyst activity
Temperature
Enzymes
Kinetics
2012
9 Citations (Scopus)

The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly

Marrott, N. L., Marshall, J. J. T., Svergun, D. I., Crennell, S. J., Hough, D. W., Danson, M. J. & van den Elsen, J. M. H., Mar 2012, In : FEBS Journal. 279, 5, p. 713-723 11 p.

Research output: Contribution to journalArticle

Multienzyme Complexes
Keto Acids
Oxidoreductases
Proteins
Point groups
2011
4 Citations (Scopus)
80 Downloads (Pure)

Contribution of inter-subunit interactions to the thermostability of Pyrococcus furiosus citrate synthase

Moore, V., Kanu, A., Byron, O., Campbell, G., Danson, M. J., Hough, D. W. & Crennell, S. J., May 2011, In : Extremophiles. 15, 3, p. 327-336 10 p.

Research output: Contribution to journalArticle

Open Access
File
Pyrococcus furiosus
Citrate (si)-Synthase
Guanidine
Dimerization
Mutant Proteins
2010
63 Citations (Scopus)

A new understanding of how temperature affects the catalytic activity of enzymes

Daniel, R. M. & Danson, M. J., Oct 2010, In : Trends in Biochemical Sciences. 35, 10, p. 584-591 8 p.

Research output: Contribution to journalArticle

Catalyst activity
Hot Temperature
Temperature
Enzymes
Enzyme Activation
6 Citations (Scopus)

Discovery of a putative acetoin dehydrogenase complex in the hyperthermophilic archaeon Sulfolobus solfataricus

Payne, K. A. P., Hough, D. W. & Danson, M. J., 19 Mar 2010, In : FEBS Letters. 584, 6, p. 1231-1234 4 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Metabolism of pentose sugars in the hyperthermophilic archaea sulfolobus solfataricus and sulfolobus acidocaldarius

Nunn, C. E. M., Johnsen, U., Schonheit, P., Fuhrer, T., Sauer, U., Hough, D. W. & Danson, M. J., 29 Oct 2010, In : Journal of Biological Chemistry. 285, 44, p. 33701-33709 9 p.

Research output: Contribution to journalArticle

Sulfolobus acidocaldarius
Sulfolobus solfataricus
Pentoses
Archaea
Metabolism
28 Citations (Scopus)
Mutagenesis
Fructose-Bisphosphate Aldolase
Biocatalysts
Site-Directed Mutagenesis
Carbon
59 Citations (Scopus)

The molecular basis of the effect of temperature on enzyme activity

Daniel, R. M., Peterson, M. E., Danson, M. J., Price, N. C., Kelly, S. M., Monk, C. R., Weinberg, C. S., Oudshoorn, M. L. & Lee, C. K., 15 Jan 2010, In : Biochemical Journal. 425, 2, p. 353-360 8 p.

Research output: Contribution to journalArticle

Enzyme activity
Denaturation
Temperature
Enzymes
Catalytic Domain
2009
14 Citations (Scopus)

A unique lipoylation system in the Archaea: lipoylation in Thermoplasma acidophilum requires two proteins

Posner, M. G., Upadhyay, A., Bagby, S., Hough, D. W. & Danson, M. J., Aug 2009, In : FEBS Journal. 276, 15, p. 4012-4022 11 p.

Research output: Contribution to journalArticle

Thermoplasma
Lipoylation
Archaea
Multienzyme Complexes
Keto Acids

Engineering stereocontrol into aldolase catalyzed reactions

Bull, S. D., Danson, M. J., Hough, D. W. & Royer, S., 2009, In : Abstracts of Papers of the American Chemical Society. 238, 23-ORGN.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Nitroreductase from Bacillus licheniformis:a stable enzyme for prodrug activation

Emptage, C. D., Knox, R. J., Danson, M. J. & Hough, D. W., 1 Jan 2009, In : Biochemical Pharmacology. 77, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Nitroreductases
Enzyme Activation
Prodrugs
Bacilli
Chemical activation
1 Citation (Scopus)

Where to land on Mars

Cockell, C., Bridges, J., Dannatt, L., Burchell, M., Patel, M. & Danson, M., Dec 2009, In : Astronomy & Geophysics. 50, 6, p. 18-26 9 p.

Research output: Contribution to journalArticle

Site selection
Landing
mars
Mars
site selection
2008
2 Citations (Scopus)

Enzyme stability and activity at high temperatures

Daniel, R. M., Danson, M. J., Hough, D. W., Lee, C. K., Peterson, M. E. & Cowan, D. A., 2008, Protein adaptation in extremophiles. Siddiqui, K. S. & Thomas, T. (eds.). New York, U. S. A.: Nova Science Publishers, p. 1-34 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

The 2-oxoacid dehydrogenase multienzyme complex of Haloferax volcanii

Al-Mailem, D. M., Hough, D. W. & Danson, M. J., 2008, In : Extremophiles. 12, 1, p. 89-96 8 p.

Research output: Contribution to journalArticle

Multienzyme Complexes
Haloferax volcanii
Dihydrolipoamide Dehydrogenase
Keto Acids
Archaea
44 Citations (Scopus)

The effect of temperature on enzyme activity: new insights and their implications

Daniel, R. M., Danson, M. J., Eisenthal, R., Lee, C. K. & Peterson, M. E., 2008, In : Extremophiles. 12, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Hot Temperature
Temperature
Enzymes
Enzyme Activation
Biotechnology

The Equilibrium Model for the effect of temperature on enzymes - Insights and implications

Weinberg, C. S., Daniel, R. M., Monk, C. R., Danson, M. J. & Lee, C. K., 2008, In : Chimica Oggi-Chemistry Today. 26, 4, p. 14-15 2 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase

Potter, J. A., Kerou, M., Lamble, H. J., Bull, S. D., Hough, D. W., Danson, M. J. & Taylor, G. L., 2008, In : Acta Crystallographica Section D-Biological Crystallography. 64, p. 1283-1287 5 p.

Research output: Contribution to journalArticle

Sulfolobus solfataricus
Galactose
Glucose
Sodium Acetate
Archaea
2007
15 Citations (Scopus)

A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids

Lamble, H. J., Royer, S. F., Hough, D. W., Danson, M. J., Taylor, G. L. & Bull, S. D., 2007, In : Advanced Synthesis & Catalysis. 349, 6, p. 817-821 5 p.

Research output: Contribution to journalArticle

Fructose-Bisphosphate Aldolase
Biocatalysts
Acids
Bioreactors
Pyruvic Acid
150 Citations (Scopus)

Catalytic efficiency and k(cat)/K-M: a useful comparator?

Eisenthal, R., Danson, M. J. & Hough, D. W., 2007, In : Trends in Biotechnology. 25, 6, p. 247-249 3 p.

Research output: Contribution to journalArticle

Enzymes
Substrates

Central metabolism

Danson, M. J., Lamble, H. J. & Hough, D. W., 2007, Archaea: Molecular and Cellular Biology. Cavicchioli, R. (ed.). Washington DC: ASM Press, p. 260-287 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

21 Citations (Scopus)

Eurythermalism and the temperature dependence of enzyme activity

Lee, C. K., Daniel, R. M., Shepherd, C., Saul, D., Cary, S. C., Danson, M. J., Eisenthal, R. & Peterson, M. E., 2007, In : FASEB Journal. 21, 8, p. 1934-1941 8 p.

Research output: Contribution to journalArticle

Enzyme activity
Temperature
Enzymes
Growth temperature
Enzyme Stability
9 Citations (Scopus)

New parameters controlling the effect of temperature on enzyme activity

Daniel, R. M., Danson, M. J., Eisenthal, R., Lee, C. K. & Peterson, M. E., 2007, In : Biochemical Society Transactions. 35, p. 1543-1546 4 p.

Research output: Contribution to journalArticle

Enzyme activity
Temperature
Enzymes
Hot Temperature
Biotechnology
22 Citations (Scopus)

The 2-oxoacid dehydrogenase multi-enzyme complex of the archaeon Thermoplasma acidophilum - recombinant expression, assembly and characterization

Heath, C., Posner, M. G., Aass, H. C., Upadhyay, A., Scott, D. J., Hough, D. W. & Danson, M. J., 2007, In : FEBS Journal. 274, 20, p. 5406-5415 10 p.

Research output: Contribution to journalArticle

Keto Acids
Oxidoreductases
2-oxoglutarate synthase
Enzymes
Genes
92 Citations (Scopus)

The dependence of enzyme activity on temperature: determination and validation of parameters

Peterson, M. E., Daniel, R. M., Danson, M. J. & Eisenthal, R., 2007, In : Biochemical Journal. 402, p. 331-337 7 p.

Research output: Contribution to journalArticle

Enzyme activity
Temperature
Enzymes
Hot Temperature
Biotechnology
2006
36 Citations (Scopus)

The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus

Milburn, C. C., Lamble, H. J., Theodossis, A., Bull, S. D., Hough, D. W., Danson, M. J. & Taylor, G. L., 23 Mar 2006, In : Journal of Biological Chemistry. 281, 21, p. 14796-14804 9 p.

Research output: Contribution to journalArticle

Glucose 1-Dehydrogenase
Sulfolobus solfataricus
Archaea
Xylose
Glucose
41 Citations (Scopus)

The thermal behaviour of enzyme activity: implications for biotechnology

Eisenthal, R., Peterson, M. E., Daniel, R. M. & Danson, M. J., 1 Jul 2006, In : Trends in Biotechnology. 24, 7, p. 289-292 4 p.

Research output: Contribution to journalArticle

Enzyme activity
Biotechnology
Enzymes
Hot Temperature
Temperature
2005
34 Citations (Scopus)

Engineering stereocontrol into an aldolase-catalysed reaction

Lamble, H. J., Danson, M. J., Hough, D. W. & Bull, S. D., 2005, In : Chemical Communications. 2005, 1, p. 124-126 3 p.

Research output: Contribution to journalArticle

Fructose-Bisphosphate Aldolase
Enzymes
Substrates
3-hydroxybutanal
4 Citations (Scopus)

Promiscuity in the Archaea. The enzymology of metabolic pathways

Danson, M. J. & Hough, D. W., 2005, In : The Biochemist. 27, p. 17-21 5 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus

Lamble, H. J., Theodossis, A., Milburn, C. C., Taylor, G. L., Bull, S., Hough, D. W. & Danson, M. J., 19 Dec 2005, In : FEBS Letters. 579, 30, p. 6865-6869 5 p.

Research output: Contribution to journalArticle

Sulfolobus solfataricus
Archaea
Metabolism
Galactose
Glucose
2004
63 Citations (Scopus)

A new intrinsic thermal parameter for enzymes reveals true temperature optima

Peterson, M. E., Eisenthal, R., Danson, M. J., Spence, A. & Daniel, R. M., May 2004, In : Journal of Biological Chemistry. 279, 20, p. 20717-20722 6 p.

Research output: Contribution to journalArticle

Hot Temperature
Temperature
Enzymes
Thermodynamic properties
Enzyme activity
17 Citations (Scopus)
Thermoplasma
Multienzyme Complexes
Keto Acids
Archaea
Oxidoreductases
57 Citations (Scopus)

Gluconate dehydratase from the promiscuous Entner-Doudoroff pathway in Sulfolobus solfataricus

Lamble, F. J., Milburn, C. C., Taylor, G. L., Hough, D. W. & Danson, M. J., 2004, In : FEBS Letters. 576, 1-2, p. 133-136 4 p.

Research output: Contribution to journalArticle

gluconate dehydratase
Sulfolobus solfataricus
galactonate dehydratase
Glucose 1-Dehydrogenase
Archaea

Multienzyme complexes in the Archaea: predictions from genome sequences

Danson, M. J., Morgan, D. J., Jeffries, A. C., Hough, D. W. & Dyall-Smith, M. L., 2004, Halophilic Microorganisms. Ventosa, A. (ed.). Springer, p. 177-191 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter