Matthew Lloyd

2024

Functional implications of unusual NOS and SONOS covalent linkages found in proteins

Lloyd, M. D., Gregory, K. S. & Acharya, K. R., 14 Sept 2024, In: Chemical communications (Cambridge, England). 60, p. 9463-9471 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

α-Methylacyl-CoA racemase from Mycobacterium tuberculosis - Detailed Kinetic and Structural Characterization of the Active site

Mojanaga, O., Woodman, T., Lloyd, M. & Acharya, R., 31 Mar 2024, In: Biomolecules. 14, 3, 15 p., 299.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Analysis of enzyme reactions using NMR techniques: A case study with α-methylacyl-CoA racemase (AMACR)

Woodman, T. & Lloyd, M., 19 Oct 2023, Modern Methods of Drug Design and Development. Lloyd, M. (ed.). New York, U. S. A.: Elsevier Academic Press Inc, p. 159-209 51 p. (Methods in Enzymology; vol. 690).

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

2 Citations (SciVal)

Assay performance and the Z’-factor in HTS

Lloyd, M., 30 Mar 2023, Drug Target Review, p. 36-38 3 p.

Research output: Contribution to specialist publication › Article

Recombinant protein production for structural and kinetic studies: A case study using M. tuberculosis α-methylacyl-CoA racemase (MCR)

Mojanaga, O., Ravi Acharya, K. & Lloyd, M. D., 21 Oct 2023, Modern Methods of Drug Design and Development. Lloyd, M. (ed.). New York, U. S. A.: Elsevier Academic Press Inc, p. 1-37 37 p. (Methods in Enzymology; vol. 690).

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

2 Citations (SciVal)

Steady-state kinetic analysis of reversible enzyme inhibitors: A case study on calf intestine alkaline phosphatase

Brooke, H., Ghoshray, M., Ibrahim, A. & Lloyd, M. D., 19 Oct 2023, Modern Methods of Drug Design and Development. Lloyd, M. (ed.). New York, U. S. A.: Elsevier Academic Press Inc, p. 39-84 46 p. (Methods in Enzymology; vol. 690).

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

1 Citation (SciVal)

2021

Racemases and epimerases operating through a 1,1-proton transfer mechanism: Reactivity, mechanism and inhibition

Lloyd, M., Jevglevskis, M., Nathubhai, A., James, T., Threadgill, M. & Woodman, T., 1 May 2021, In: Chemical Society Reviews. 50, 10, p. 5952–5984 33 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Citations (SciVal)

Selenium status in diet affects acetaminophen-induced hepatotoxicity via interruption of redox environment

Li, J., Cheng, P., Li, S., Zhao, P., Han, B., Ren, X., Zhong, J. L., Lloyd, M. D., Pourzand, C., Holmgren, A. & Lu, J., 10 Jun 2021, In: Antioxidants & Redox Signaling. 34, 17, p. 1355-1368 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

15 Citations (SciVal)

142 Downloads (Pure)

Steady-State Enzyme Kinetics

Lloyd, M., 30 Jun 2021, The Biochemist, 43, 3, p. 40-45 6 p.

Research output: Contribution to specialist publication › Article

Open Access

File

3 Citations (SciVal)

202 Downloads (Pure)

UVA-Triggered Drug Release and Photo-Protection of Skin

Karisma, V. W., Wu, W., Lei, M., Liu, H., Nisar, M. F., Lloyd, M., Pourzand, C. & Li Zhong, J., 11 Feb 2021, In: Frontiers in Cell and Developmental Biology. 9, 598717.

Research output: Contribution to journal › Review article › peer-review

Open Access

20 Citations (SciVal)

Why some screening hits are a PAIN

Lloyd, M., 7 Jun 2021, Drug Target Review, 8, 2, p. 42-44 3 p.

Research output: Contribution to specialist publication › Article

Open Access

2020

High-throughput screening as a method for discovering new drugs

Lloyd, M., 26 May 2020, Drug Target Review, 7, 2, p. 11-14.

Research output: Contribution to specialist publication › Article

File

18 Downloads (Pure)

High-Throughput Screening For The Discovery Of Enzyme Inhibitors

Lloyd, M., 8 Oct 2020, In: Journal of Medicinal Chemistry. 63, 19, p. 10742–10772 31 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

51 Citations (SciVal)

137 Downloads (Pure)

Professor Sir Jack E. Baldwin, FRS

Lloyd, M., Apr 2020, The Biochemist, 42, 2, p. 1 1 p.

Research output: Contribution to specialist publication › Other

Open Access

2019

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships

Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In: Bioorganic Chemistry. 92, 103264.

Research output: Contribution to journal › Article › peer-review

Open Access

File

12 Citations (SciVal)

127 Downloads (Pure)

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In: Bioorganic Chemistry. 92, 103263.

Research output: Contribution to journal › Article › peer-review

Open Access

File

10 Citations (SciVal)

246 Downloads (Pure)

Pharmacology for Chemists: Drug Discovery in Context

Lloyd, M., 30 Jun 2019, The Biochemist, 41, 3, p. 71-71.

Research output: Contribution to specialist publication › Other

Open Access

2018

Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols

Sedgwick, A. C., Gardiner, J. E., Kim, G., Yevglevskis, M., Lloyd, M. D., Jenkins, A. T. A., Bull, S. D., Yoon, J. & James, T. D., 11 May 2018, In: Chemical Communications. 54, 38, p. 4786-4789 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Citations (SciVal)

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Sept 2018, In: Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (SciVal)

95 Downloads (Pure)

2017

A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 21 Apr 2017, (Unpublished).

Research output: Contribution to conference › Abstract › peer-review

File

75 Downloads (Pure)

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 7 May 2017, In: Chemical Communications. 53, 37, p. 5087-5090 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (SciVal)

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M., 26 Jan 2017, In: Journal of Medicinal Chemistry. 60, 2, p. 814-820 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

47 Citations (SciVal)

359 Downloads (Pure)

High-Throughput Screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Petrova, Y., Mattan, H., Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 21 Apr 2017.

Research output: Contribution to conference › Poster › peer-review

File

57 Downloads (Pure)

Methods (amacr)

Lloyd, M. (Inventor), Jevglevskis, M. (Inventor), Lee, G. L. (Inventor), Woodman, T. (Inventor) & Threadgill, M. (Inventor), 22 Jun 2017, Patent No. US20170176436 A1, Priority date 3 Feb 2014

Research output: Patent

2016

A convenient colorimetric assay for alpha-methylacyl-CoA racemase (AMACR; P504S) and testing for inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 21 May 2016, (Unpublished).

Research output: Contribution to conference › Poster

File

39 Downloads (Pure)

A Convenient Colorimetric Assay For Alpha-Methylacyl-CoA Racemase (AMACR; P504S) And Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., Threadgill, M., James, T., Woodman, T. & Lloyd, M., Jun 2016.

Research output: Contribution to conference › Poster

Open Access

File

58 Downloads (Pure)

A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 27 Apr 2016, (Unpublished).

Research output: Contribution to conference › Poster

File

65 Downloads (Pure)

A study on the AMACR catalysed elimination reaction and its application to inhibitor testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T. D., Woodman, T. J. & Lloyd, M. D., Jan 2016, In: Organic and Biomolecular Chemistry. 14, 2, p. 612-622

Research output: Contribution to journal › Article › peer-review

Open Access

File

11 Citations (SciVal)

143 Downloads (Pure)

A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. & Lloyd, M., 27 Apr 2016, (Unpublished).

Research output: Contribution to conference › Poster

File

85 Downloads (Pure)

Electro-engineered polymeric films for the development of sensitive aptasensors for prostate cancer marker detection

Jolly, P., Miodek, A., Yang, D. K., Chen, L. C., Lloyd, M. & Estrela, P., 23 Nov 2016, In: ACS Sensors. 1, 11, p. 1308-1314 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

34 Citations (SciVal)

368 Downloads (Pure)

High-throughput screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Petrova, Y., Matan, H., Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 27 Apr 2016, (Unpublished).

Research output: Contribution to conference › Poster

Methods (AMACR)

Lloyd, M. (Inventor), Jevglevskis, M. (Inventor), Lee, G. L. (Inventor), Woodman, T. (Inventor) & Threadgill, M. (Inventor), 14 Dec 2016, Patent No. EP3102694 A1, Priority date 3 Feb 2014

Research output: Patent

Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases

Nathubhai, A., Haikarainen, T., Hayward, P. C., Munoz-Descalzo, S., Thompson, A. S., Lloyd, M. D., Lehtio, L. & Threadgill, M., 8 Aug 2016, In: European Journal of Medicinal Chemistry. 118, p. 316-327 12 p.

Research output: Contribution to journal › Article

Open Access

File

25 Citations (SciVal)

345 Downloads (Pure)

The different catalytic roles of the metal- binding ligands in human 4-hydroxyphenylpyruvate dioxygenase

Huang, C.-W., Liu, H.-C., Shen, C.-P., Chen, Y.-T., Lee, S.-J., Lloyd, M. D. & Lee, H.-J., 1 May 2016, In: Biochemical Journal. 473, 9, p. 1179-1189 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

12 Citations (SciVal)

408 Downloads (Pure)

2015

A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 11 Nov 2015, (Unpublished).

Research output: Contribution to conference › Poster

File

72 Downloads (Pure)

A novel AMACR aptasensor based on chitosan-SWCNT film integrated OEG to enhance anti-fouling characteristics

Jolly, P., Miodek, A., Yang, D. K., Chen, L. C., Lloyd, M. & Estrela, P., 2015, (Unpublished).

Research output: Contribution to conference › Poster

A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. & Lloyd, M., 11 Nov 2015, (Unpublished).

Research output: Contribution to conference › Poster

File

61 Downloads (Pure)

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sept 2015, In: Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

27 Citations (SciVal)

1154 Downloads (Pure)

High-throughput screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Petrova, Y., Matan, H., Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 11 Nov 2015, (Unpublished).

Research output: Contribution to conference › Poster

Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems

Twum, E. A., Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. & Threadgill, M. D., 1 Jul 2015, In: Bioorganic and Medicinal Chemistry. 23, 13, p. 3481-3489

Research output: Contribution to journal › Article › peer-review

File

3 Citations (SciVal)

395 Downloads (Pure)

Methods (AMACR).

Lloyd, M. (Inventor), Woodman, T. (Inventor), Jevglevskis, M. (Inventor), Threadgill, M. (Inventor) & Lee, G. L. (Inventor), 6 Aug 2015, IPC No. C12Q1/533, G01N33/574, Patent No. WO2015114383A1, 2 Feb 2015, Priority date 3 Feb 2014, Priority No. GB201401817A

Research output: Patent

File

52 Downloads (Pure)

Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases

Kumpan, K., Nathubhai, A., Zhang, C., Wood, P. J., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Lehtio, L. & Threadgill, M. D., 1 Jul 2015, In: Bioorganic and Medicinal Chemistry. 23, p. 3013-3032

Research output: Contribution to journal › Article › peer-review

File