Projects per year
Personal profile
Research interests
Research is concentrated in the areas of chemical biology, enzymology, enzyme kinetics, drug discovery and cancer research. Chemical Biology techniques are used to investigate enzymes as therapeutic targets, and the development of inhibitors as drugs.
Current research (with Dr Tim Woodman) is focussed on the enzyme alpha-methylacyl-CoA racemase (AMACR), a prostate cancer drug target. This enzyme is involved in the degradation of dietary and other branched-chain fatty acids. Studies have including investigations of the enzyme reaction mechanism using labelling studies and other techniques, development of activity assays, and drug development using rational design and high-throughput screening approaches.
Other projects include targeting enzymes that use NAD+ as an electrophile (such as tankyrases) with rationally designed drugs (led by Professor Mike Threadgill) and novel systems for delivery of super-potent drugs (led by Professor Threadgill, with Dr Andy Thompson). Each of these projects uses Chemical Biology as part of a multi-disciplinary approach.
Education/Academic qualification
Doctor of Philosophy, University of Oxford
Award Date: 1 Jan 1992
Bachelor of Science, The University of Leicester
Award Date: 1 Jan 1989
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Projects
RDDPT: Refsum’s disease: Diagnosis, pathology and Treatment
Lloyd, M., Schofield, C. J. & Wanders, R.
Project: EU Commission
Synthesis and evaluation of substrate-product hybrids as α-methylacyl-CoA racemase (AMACR) inhibitors
Lloyd, M., Woodman, T. & Jevglevskis, M.
1/08/16 → 19/09/16
Project: UK charity
Advanced Inhibitors of Tankyrases 1 and 2, Critical Pathways in Cancer
1/10/15 → 30/09/16
Project: UK charity
AMACR Targeted Drugs for Treating Advance Prostate Cancer
Lloyd, M., James, T., Jevglevskis, M., Nathubhai, A., Threadgill, M. & Woodman, T.
1/02/15 → 30/07/18
Project: UK charity
Advanced Inhibitors of Tankyrases 1 and 2, Critical Pathways in Cancer
Threadgill, M., Lloyd, M. & Nathubhai, A.
1/10/14 → 30/09/15
Project: UK charity
Research Output
Drug Target Review
Lloyd, M., 26 May 2020, Drug Target Review, 7, 2, p. 11-14.Research output: Contribution to specialist publication › Article
File
High-Throughput Screening For The Discovery Of Enzyme Inhibitors
Lloyd, M., 20 May 2020, In : Journal of Medicinal Chemistry.Research output: Contribution to journal › Article
Professor Sir Jack E. Baldwin, FRS
Lloyd, M., Apr 2020, The Biochemist, 42, 2, p. 1 1 p.Research output: Contribution to specialist publication › Letter
Open Access
Selenium status in diet affects acetaminophen-induced hepatotoxicity via interruption of redox environment
Li, J., Cheng, P., Li, S., Zhao, P., Han, B., Ren, X., Zhong, J. L., Lloyd, M., Pourzand, C., Holmgren, A. & Lu, J., 10 Jun 2020, In : Antioxidants & Redox Signaling.Research output: Contribution to journal › Article
Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships
Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.Research output: Contribution to journal › Article
2
Citations
(Scopus)