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Accepting PhD Students

1990 …2018
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Personal profile

Research interests

Research is concentrated in the areas of chemical biology, enzymology, enzyme kinetics, drug discovery and cancer research. Chemical Biology techniques are used to investigate enzymes as therapeutic targets, and the development of inhibitors as drugs.

Current research (with Dr Tim Woodman) is focussed on the enzyme alpha-methylacyl-CoA racemase (AMACR), a prostate cancer drug target. This enzyme is involved in the degradation of dietary and other branched-chain fatty acids. Studies have including investigations of the enzyme reaction mechanism using labelling studies and other techniques, development of activity assays, and drug development using rational design and high-throughput screening approaches. 

Other projects include targeting enzymes that use NAD+ as an electrophile (such as tankyrases) with rationally designed drugs (led by Professor Mike Threadgill) and novel systems for delivery of super-potent drugs (led by Professor Threadgill, with Dr Andy Thompson). Each of these projects uses Chemical Biology as part of a multi-disciplinary approach.

Education/Academic qualification

Bachelor of Science, The University of Leicester

Doctor of Philosophy, University of Oxford

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Esters Chemical Compounds

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Projects 2001 2018

Research Output 1990 2018

Open Access
Sulfhydryl Compounds
Toxicity
Fluorescence
Drug therapy
Imaging techniques

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 30 Apr 2018 In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journalArticle

Acyl Coenzyme A
Enzyme activity
Coenzyme A
Assays
Esters

A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 21 Apr 2017 (Unpublished)

Research output: Contribution to conferenceAbstract

File
Coenzyme A
Inhibitory Concentration 50
Acyl Coenzyme A
Prostatic Neoplasms
S 10
2 Citations

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M. 7 May 2017 In : Chemical Communications. 53, 37, p. 5087-5090 4 p.

Research output: Contribution to journalArticle

Open Access
Assays
Ibuprofen
Fatty acids
Fatty Acids
Degradation
9 Citations

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M. 26 Jan 2017 In : Journal of Medicinal Chemistry. 60, 2, p. 814-820

Research output: Contribution to journalArticle

Open Access
File
Tankyrases
Inhibitory Concentration 50
Protein Isoforms
Binding Sites
Glucose