Matthew Lloyd — the University of Bath's research portal

Personal profile

Research interests

Research is concentrated in the areas of chemical biology, enzymology, enzyme kinetics, drug discovery and cancer research. Chemical Biology techniques are used to investigate enzymes as therapeutic targets, and the development of inhibitors as drugs.

Current research (with Dr Tim Woodman) is focussed on the enzyme alpha-methylacyl-CoA racemase (AMACR), a prostate cancer drug target. This enzyme is involved in the degradation of dietary and other branched-chain fatty acids. Studies have including investigations of the enzyme reaction mechanism using labelling studies and other techniques, development of activity assays, and drug development using rational design and high-throughput screening approaches.

Other projects include targeting enzymes that use NAD+ as an electrophile (such as tankyrases) with rationally designed drugs (led by Professor Mike Threadgill) and novel systems for delivery of super-potent drugs (led by Professor Threadgill, with Dr Andy Thompson). Each of these projects uses Chemical Biology as part of a multi-disciplinary approach.

Education/Academic qualification

Doctor of Philosophy, University of Oxford

Bachelor of Science, The University of Leicester

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6 Similar Profiles

Tankyrases Chemical Compounds

Acyl Coenzyme A Chemical Compounds

Refsum Disease Medicine & Life Sciences

Substrates Chemical Compounds

Coenzyme A Chemical Compounds

Enzymes Medicine & Life Sciences

Ibuprofen Chemical Compounds

Mixed Function Oxygenases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2001 2018

1 Not started
21 Finished

RDDPT: Refsum’s disease: Diagnosis, pathology and Treatment

Lloyd, M., Schofield, C. J. & Wanders, R.

Project: EU Commission › Individual grant

Synthesis and evaluation of substrate-product hybrids as α-methylacyl-CoA racemase (AMACR) inhibitors

Lloyd, M., Woodman, T. & Jevglevskis, M.

1/08/16 → 19/09/16

Project: UK charity

Advanced Inhibitors of Tankyrases 1 and 2, Critical Pathways in Cancer

Threadgill, M. & Lloyd, M.

1/10/15 → 30/09/16

Project: UK charity

AMACR Targeted Drugs for Treating Advance Prostate Cancer

Lloyd, M., James, T., Jevglevskis, M., Nathubhai, A., Threadgill, M. & Woodman, T.

1/02/15 → 30/07/18

Project: UK charity

Refinement of a Polymeric System Delivering CGIs to Prostate Tumours

Threadgill, M., Lloyd, M. & Thompson, A.

1/10/14 → 30/09/17

Project: UK charity

Research Output 1990 2019

Pharmacology for Chemists: Drug Discovery in Context

Lloyd, M., 30 Jun 2019, The Biochemist, 41, 3, p. 71-71.

Research output: Contribution to specialist publication › Book/Film/Article review

Open Access

11 Citations (Scopus)

Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols

Sedgwick, A. C., Gardiner, J. E., Kim, G., Yevglevskis, M., Lloyd, M. D., Jenkins, A. T. A., Bull, S. D., Yoon, J. & James, T. D., 2018, In : Chemical Communications. 54, 38, p. 4786-4789 4 p.

Research output: Contribution to journal › Article

Open Access

Sulfhydryl Compounds

Toxicity

Fluorescence

Drug therapy

Imaging techniques

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Sep 2018, In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journal › Article

Acyl Coenzyme A

Enzyme activity

Coenzyme A

Assays

Esters

A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 21 Apr 2017, (Unpublished).

Research output: Contribution to conference › Abstract

File

Coenzyme A

Inhibitory Concentration 50

Acyl Coenzyme A

Prostatic Neoplasms

S 10

3 Citations (Scopus)

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 7 May 2017, In : Chemical Communications. 53, 37, p. 5087-5090 4 p.

Research output: Contribution to journal › Article

Open Access

Assays

Ibuprofen

Fatty acids

Fatty Acids

Degradation