Projects per year
Personal profile
Research interests
Research is concentrated in the areas of chemical biology, enzymology, enzyme kinetics, drug discovery and cancer research. Chemical Biology techniques are used to investigate enzymes as therapeutic targets, and the development of inhibitors as drugs.
Current research (with Dr Tim Woodman) is focussed on the enzyme alpha-methylacyl-CoA racemase (AMACR), a prostate cancer drug target. This enzyme is involved in the degradation of dietary and other branched-chain fatty acids. Studies have including investigations of the enzyme reaction mechanism using labelling studies and other techniques, development of activity assays, and drug development using rational design and high-throughput screening approaches.
Other projects include targeting enzymes that use NAD+ as an electrophile (such as tankyrases) with rationally designed drugs (led by Professor Mike Threadgill) and novel systems for delivery of super-potent drugs (led by Professor Threadgill, with Dr Andy Thompson). Each of these projects uses Chemical Biology as part of a multi-disciplinary approach.
Education/Academic qualification
Doctor of Philosophy, University of Oxford
Bachelor of Science, The University of Leicester
Fingerprint Dive into the research topics where Matthew Lloyd is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Tankyrases
Chemical Compounds
Acyl Coenzyme A
Chemical Compounds
Refsum Disease
Medicine & Life Sciences
Substrates
Chemical Compounds
Coenzyme A
Chemical Compounds
Enzymes
Medicine & Life Sciences
Ibuprofen
Chemical Compounds
Mixed Function Oxygenases
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2001 2018
RDDPT: Refsum’s disease: Diagnosis, pathology and Treatment
Lloyd, M., Schofield, C. J. & Wanders, R.
Project: EU Commission
Synthesis and evaluation of substrate-product hybrids as α-methylacyl-CoA racemase (AMACR) inhibitors
Lloyd, M., Woodman, T. & Jevglevskis, M.
1/08/16 → 19/09/16
Project: UK charity
Advanced Inhibitors of Tankyrases 1 and 2, Critical Pathways in Cancer
1/10/15 → 30/09/16
Project: UK charity
AMACR Targeted Drugs for Treating Advance Prostate Cancer
Lloyd, M., James, T., Jevglevskis, M., Nathubhai, A., Threadgill, M. & Woodman, T.
1/02/15 → 30/07/18
Project: UK charity
Refinement of a Polymeric System Delivering CGIs to Prostate Tumours
Threadgill, M., Lloyd, M. & Thompson, A.
1/10/14 → 30/09/17
Project: UK charity
Research Output 1990 2019
Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships
Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.Research output: Contribution to journal › Article
66
Downloads
(Pure)
Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents
Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103263.Research output: Contribution to journal › Article
Open Access
File
Pharmacology for Chemists: Drug Discovery in Context
Lloyd, M., 30 Jun 2019, The Biochemist, 41, 3, p. 71-71.Research output: Contribution to specialist publication › Book/Film/Article review
Open Access
21
Citations
(Scopus)
Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols
Sedgwick, A. C., Gardiner, J. E., Kim, G., Yevglevskis, M., Lloyd, M. D., Jenkins, A. T. A., Bull, S. D., Yoon, J. & James, T. D., 11 May 2018, In : Chemical Communications. 54, 38, p. 4786-4789 4 p.Research output: Contribution to journal › Article
Open Access
Sulfhydryl Compounds
Toxicity
Fluorescence
Drug therapy
Imaging techniques
2
Citations
(Scopus)
27
Downloads
(Pure)
Structure-activity relationships of rationally designed AMACR 1A inhibitors
Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Sep 2018, In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.Research output: Contribution to journal › Article
Open Access
File
Acyl Coenzyme A
Enzyme activity
Coenzyme A
Assays
Esters
Thesis
Approaches to new DNA-repair inhibitors for applications in cancer therapy
Author: Dhami, A., 1 Dec 2008Supervisor: Threadgill, M. (Supervisor) & Lloyd, M. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
Development of Prodrugs to Deliver Super-Potent Drugs to Prostate Tumors
Author: Twum, E., 5 Nov 2013Supervisor: Threadgill, M. (Supervisor), Thompson, A. (Supervisor) & Lloyd, M. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
Development of Selective Inhibitors of Dihydrofolate Reductase (DHFR) of Mycobacterium Tuberculosis
Author: Alfaraj, R., 31 Dec 2013Supervisor: Threadgill, M. (Supervisor), Lloyd, M. (Supervisor) & Thompson, A. (Supervisor)
Student thesis: Doctoral Thesis › MPhil
File
Feedback Regulation Mechanisms Controlling Occludin Expression And Tight Junction Function
Author: Ikem, T., 13 Jun 2016Supervisor: Mrsny, R. (Supervisor) & Lloyd, M. (Supervisor)
Student thesis: Doctoral Thesis › PhD
Inhibitors of the tankyrases, triple-function targets in the cancer cell
Author: Paine, H., 6 Jun 2014Supervisor: Threadgill, M. (Supervisor), Lloyd, M. (Supervisor) & Thompson, A. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File