• 5 WEST 2.13

Accepting Doctoral Students

1990 …2020

Research output per year

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Personal profile

Research interests

Research is concentrated in the areas of chemical biology, enzymology, enzyme kinetics, drug discovery and cancer research. Chemical Biology techniques are used to investigate enzymes as therapeutic targets, and the development of inhibitors as drugs.

Current research (with Dr Tim Woodman) is focussed on the enzyme alpha-methylacyl-CoA racemase (AMACR), a prostate cancer drug target. This enzyme is involved in the degradation of dietary and other branched-chain fatty acids. Studies have including investigations of the enzyme reaction mechanism using labelling studies and other techniques, development of activity assays, and drug development using rational design and high-throughput screening approaches. 

Other projects include targeting enzymes that use NAD+ as an electrophile (such as tankyrases) with rationally designed drugs (led by Professor Mike Threadgill) and novel systems for delivery of super-potent drugs (led by Professor Threadgill, with Dr Andy Thompson). Each of these projects uses Chemical Biology as part of a multi-disciplinary approach.

Education/Academic qualification

Doctor of Philosophy, University of Oxford

Award Date: 1 Jan 1992

Bachelor of Science, The University of Leicester

Award Date: 1 Jan 1989

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Projects

Research Output

Drug Target Review

Lloyd, M., 26 May 2020, Drug Target Review, 7, 2, p. 11-14.

Research output: Contribution to specialist publicationArticle

File

High-Throughput Screening For The Discovery Of Enzyme Inhibitors

Lloyd, M., 20 May 2020, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Professor Sir Jack E. Baldwin, FRS

Lloyd, M., Apr 2020, The Biochemist, 42, 2, p. 1 1 p.

Research output: Contribution to specialist publicationLetter

Open Access

Selenium status in diet affects acetaminophen-induced hepatotoxicity via interruption of redox environment

Li, J., Cheng, P., Li, S., Zhao, P., Han, B., Ren, X., Zhong, J. L., Lloyd, M., Pourzand, C., Holmgren, A. & Lu, J., 10 Jun 2020, In : Antioxidants & Redox Signaling.

Research output: Contribution to journalArticle

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships

Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.

Research output: Contribution to journalArticle

2 Citations (Scopus)