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Accepting PhD Students

1990 …2019
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Personal profile

Research interests

Research is concentrated in the areas of chemical biology, enzymology, enzyme kinetics, drug discovery and cancer research. Chemical Biology techniques are used to investigate enzymes as therapeutic targets, and the development of inhibitors as drugs.

Current research (with Dr Tim Woodman) is focussed on the enzyme alpha-methylacyl-CoA racemase (AMACR), a prostate cancer drug target. This enzyme is involved in the degradation of dietary and other branched-chain fatty acids. Studies have including investigations of the enzyme reaction mechanism using labelling studies and other techniques, development of activity assays, and drug development using rational design and high-throughput screening approaches. 

Other projects include targeting enzymes that use NAD+ as an electrophile (such as tankyrases) with rationally designed drugs (led by Professor Mike Threadgill) and novel systems for delivery of super-potent drugs (led by Professor Threadgill, with Dr Andy Thompson). Each of these projects uses Chemical Biology as part of a multi-disciplinary approach.

Education/Academic qualification

Doctor of Philosophy, University of Oxford

Bachelor of Science, The University of Leicester

Fingerprint Dive into the research topics where Matthew Lloyd is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Tankyrases Chemical Compounds
Acyl Coenzyme A Chemical Compounds
Refsum Disease Medicine & Life Sciences
Substrates Chemical Compounds
Coenzyme A Chemical Compounds
Enzymes Medicine & Life Sciences
Ibuprofen Chemical Compounds
Mixed Function Oxygenases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2001 2018

Research Output 1990 2019

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships

Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.

Research output: Contribution to journalArticle

10 Downloads (Pure)

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103263.

Research output: Contribution to journalArticle

Open Access
File

Pharmacology for Chemists: Drug Discovery in Context

Lloyd, M., 30 Jun 2019, The Biochemist, 41, 3, p. 71-71.

Research output: Contribution to specialist publicationBook/Film/Article review

Open Access
16 Citations (Scopus)

Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols

Sedgwick, A. C., Gardiner, J. E., Kim, G., Yevglevskis, M., Lloyd, M. D., Jenkins, A. T. A., Bull, S. D., Yoon, J. & James, T. D., 11 May 2018, In : Chemical Communications. 54, 38, p. 4786-4789 4 p.

Research output: Contribution to journalArticle

Open Access
Sulfhydryl Compounds
Toxicity
Fluorescence
Drug therapy
Imaging techniques
2 Citations (Scopus)
6 Downloads (Pure)

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Sep 2018, In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journalArticle

Open Access
File
Acyl Coenzyme A
Enzyme activity
Coenzyme A
Assays
Esters

Thesis

Approaches to new DNA-repair inhibitors for applications in cancer therapy

Author: Dhami, A., 1 Dec 2008

Supervisor: Threadgill, M. (Supervisor) & Lloyd, M. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Development of Prodrugs to Deliver Super-Potent Drugs to Prostate Tumors

Author: Twum, E., 5 Nov 2013

Supervisor: Threadgill, M. (Supervisor), Thompson, A. (Supervisor) & Lloyd, M. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Development of Selective Inhibitors of Dihydrofolate Reductase (DHFR) of Mycobacterium Tuberculosis

Author: Alfaraj, R., 31 Dec 2013

Supervisor: Threadgill, M. (Supervisor), Lloyd, M. (Supervisor) & Thompson, A. (Supervisor)

Student thesis: Doctoral ThesisMPhil

File

Feedback Regulation Mechanisms Controlling Occludin Expression And Tight Junction Function

Author: Ikem, T., 13 Jun 2016

Supervisor: Mrsny, R. (Supervisor) & Lloyd, M. (Supervisor)

Student thesis: Doctoral ThesisPhD

Inhibitors of the tankyrases, triple-function targets in the cancer cell

Author: Paine, H., 6 Jun 2014

Supervisor: Threadgill, M. (Supervisor), Lloyd, M. (Supervisor) & Thompson, A. (Supervisor)

Student thesis: Doctoral ThesisPhD

File