Personal profile

Research interests

Upon completion of the human genome project, the biggest surprise was that humans have far fewer genes than previously expected (~ 21,000). Additionally, less than 2% of the available DNA directly codes for these genes. To address this paradox, recent studies have suggested that much of the remaining 98% of DNA is turned into 'non-coding RNA' and that these regulate the expression of gene expression at the level of transcription and translation. For convenience, we commonly divide this non-coding RNA into small non-coding RNAs and long non-coding RNAs. At the present time, we have little idea about the role of the majority of this non-coding RNA.

My research group is interested in using oligonucleotide-based therapeutics (siRNA and antisense) to target the down-regulation or inhibition of protein coding mRNAs and non-coding RNAs. In the last few years, the emphasis has been upon using next generation sequencing to identify mRNAs, miRNAs and long non-coding RNAs (lncRNAs) that underlying biological responses/diseases.

Current project include:

  • The role of long non-coding RNAs and the innate immune response (James Heward and Dr Benoir Roux)
  • Transcriptome analysis in re-current squamous cell lung cancer (Dr Andre Koper - Manchester)
  • Transcriptome analysis in muscle myositis (Dr Philip Hamann)
  • Age Related Changes in miRNAs expression (Jasmine Malchrist)
  • Models of rhinovirus infection in human lungs (Anna Pomerenke - Manchester)
  • Identification of genetic and serum biomarkers of psoriatic arthritis (Dr Deepak Jadon)

Collaborations include:

Professor Fan Chung (Imperial College) – Transcriptome analysis in airway smooth muscle in normal, mild and severe asthma

Dr Simon Jones (University of Birmingham) - Examination of the transcriptome in the synovial fibroblasts of patients with osteoarthritis (normal weight versus obese individuals)

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


Dive into the research topics where Mark Lindsay is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years

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