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Personal profile

Research interests

Upon completion of the human genome project, the biggest surprise was that humans have far fewer genes than previously expected (~ 21,000). Additionally, less than 2% of the available DNA directly codes for these genes. To address this paradox, recent studies have suggested that much of the remaining 98% of DNA is turned into 'non-coding RNA' and that these regulate the expression of gene expression at the level of transcription and translation. For convenience, we commonly divide this non-coding RNA into small non-coding RNAs and long non-coding RNAs. At the present time, we have little idea about the role of the majority of this non-coding RNA.

My research group is interested in using oligonucleotide-based therapeutics (siRNA and antisense) to target the down-regulation or inhibition of protein coding mRNAs and non-coding RNAs. In the last few years, the emphasis has been upon using next generation sequencing to identify mRNAs, miRNAs and long non-coding RNAs (lncRNAs) that underlying biological responses/diseases.

Current project include:

  • The role of long non-coding RNAs and the innate immune response (James Heward and Dr Benoir Roux)
  • Transcriptome analysis in re-current squamous cell lung cancer (Dr Andre Koper - Manchester)
  • Transcriptome analysis in muscle myositis (Dr Philip Hamann)
  • Age Related Changes in miRNAs expression (Jasmine Malchrist)
  • Models of rhinovirus infection in human lungs (Anna Pomerenke - Manchester)
  • Identification of genetic and serum biomarkers of psoriatic arthritis (Dr Deepak Jadon)

Collaborations include:

Professor Fan Chung (Imperial College) – Transcriptome analysis in airway smooth muscle in normal, mild and severe asthma

Dr Simon Jones (University of Birmingham) - Examination of the transcriptome in the synovial fibroblasts of patients with osteoarthritis (normal weight versus obese individuals)

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Long Noncoding RNA Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Untranslated RNA Medicine & Life Sciences
Innate Immunity Medicine & Life Sciences
Psoriatic Arthritis Medicine & Life Sciences
Lung Medicine & Life Sciences
Gene Expression Profiling Medicine & Life Sciences
Alveolar Epithelial Cells Medicine & Life Sciences

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Projects 2013 2020

Elucidating the Role of Long Non-coding RNAs

Lindsay, M.

1/07/1630/06/19

Project: Research council

Long Noncoding RNA
Untranslated RNA
Small Untranslated RNA
Inflammation
Human Genome Project
Baths
Oxygen
Wales
Electron Spin Resonance Spectroscopy
Brain
Long Noncoding RNA
Untranslated RNA
Innate Immunity
RNA
Inflammation

Research Output 2008 2017

6 Citations

Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis

Jadon, D. R., Sengupta, R., Nightingale, A., Lindsay, M., Korendowych, E., Robinson, G., Jobling, A., Shaddick, G., Bi, J., Winchester, R., Giles, J. T. & McHugh, N. J. 1 Apr 2017 In : Annals of the Rheumatic Diseases. 76, 4, p. 701-707

Research output: Contribution to journalArticle

Open Access
File
Psoriatic Arthritis
Ankylosing Spondylitis
Phenotype
HLA-B Antigens
Psoriasis
2 Citations

Catalog of Differentially Expressed Long Non-Coding RNA following Activation of Human and Mouse Innate Immune Response

Roux, B., Heward, J., Donnelly, L., Jones, S. & Lindsay, M. 29 Aug 2017 In : Frontiers in Immunology. 8, 20 p., 1038

Research output: Contribution to journalArticle

Open Access
File
Long Noncoding RNA
Innate Immunity
Macrophages
Interleukin-7
Peritoneal Macrophages
6 Citations

Clinical potential of oligonucleotide-based therapeutics in the respiratory system

Moschos, S. A., Usher, L. & Lindsay, M. A. Jan 2017 In : Pharmacology and Therapeutics. 169, p. 83-103

Research output: Contribution to journalArticle

Open Access
File
Oligonucleotides
Respiratory System
Nucleic Acids
Lung Diseases
Untranslated RNA
1 Citations

Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study

Jadon, D. R., Sengupta, R., Nightingale, A., Lu, H., Dunphy, J., Green, A., Elder, J. T., Nair, R. P., Korendowych, E., Lindsay, M. A. & McHugh, N. J. 21 Sep 2017 In : Arthritis Research & Therapy. 19, 1, 210

Research output: Contribution to journalArticle

Open Access
File
Psoriatic Arthritis
Bone Remodeling
Cross-Sectional Studies
Biomarkers
Arthritis
1 Citations

Transcriptional profiling identifies differential expression of long non-coding RNAs in Jo-1 associated and inclusion body myositis

Hamann, P. D., Roux, B. T., Heward, J. A., Love, S., McHugh, N. J., Jones, S. W. & Lindsay, M. A. 14 Aug 2017 In : Scientific Reports. 7, 1, 8024

Research output: Contribution to journalArticle

Open Access
Inclusion Body Myositis
Long Noncoding RNA
Myositis
Muscles
Biopsy