Projects per year
Upon completion of the human genome project, the biggest surprise was that humans have far fewer genes than previously expected (~ 21,000). Additionally, less than 2% of the available DNA directly codes for these genes. To address this paradox, recent studies have suggested that much of the remaining 98% of DNA is turned into 'non-coding RNA' and that these regulate the expression of gene expression at the level of transcription and translation. For convenience, we commonly divide this non-coding RNA into small non-coding RNAs and long non-coding RNAs. At the present time, we have little idea about the role of the majority of this non-coding RNA.
My research group is interested in using oligonucleotide-based therapeutics (siRNA and antisense) to target the down-regulation or inhibition of protein coding mRNAs and non-coding RNAs. In the last few years, the emphasis has been upon using next generation sequencing to identify mRNAs, miRNAs and long non-coding RNAs (lncRNAs) that underlying biological responses/diseases.
Current project include:
- The role of long non-coding RNAs and the innate immune response (James Heward and Dr Benoir Roux)
- Transcriptome analysis in re-current squamous cell lung cancer (Dr Andre Koper - Manchester)
- Transcriptome analysis in muscle myositis (Dr Philip Hamann)
- Age Related Changes in miRNAs expression (Jasmine Malchrist)
- Models of rhinovirus infection in human lungs (Anna Pomerenke - Manchester)
- Identification of genetic and serum biomarkers of psoriatic arthritis (Dr Deepak Jadon)
Professor Fan Chung (Imperial College) – Transcriptome analysis in airway smooth muscle in normal, mild and severe asthma
Dr Simon Jones (University of Birmingham) - Examination of the transcriptome in the synovial fibroblasts of patients with osteoarthritis (normal weight versus obese individuals)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Select a country/territory to view shared publications and projects
27/03/17 → 26/09/18
Project: UK charity
1/10/16 → 31/03/21
Project: UK charity
Divergent immunometabolic changes in adipose tissue and skeletal muscle with ageing in healthy humansTrim, W., Walhin, J-P., Koumanov, F., Bouloumie, A., Lindsay, M., Chen, Y. C., Travers, R., Turner, J. & Thompson, D., 15 Feb 2022, In: The Journal of Physiology. 600, 4, p. 921-947 27 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access6 Citations (SciVal)
Wijesinghe, S. N., Lindsay, M. A. & Jones, S. W., 27 Feb 2022, Long Noncoding RNA. Carpenter, S. (ed.). Cham, Switzerland: Springer, p. 35-70 36 p. (Advances in Experimental Medicine and Biology; vol. 1363).
Research output: Chapter or section in a book/report/conference proceeding › Chapter or section1 Citation (SciVal)
Trim, W., Walhin, J-P., Koumanov, F., Bouloumie, A., Lindsay, M., Travers, R., Turner, J. & Thompson, D., 1 Jan 2022, In: The Journal of Clinical Endocrinology & Metabolism. 107, 1, p. 177-191 15 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access1 Citation (SciVal)
Pre-concentration of microRNAs by LNA-modified magnetic beads for enhancement of electrochemical detectionUstuner, S., Lindsay, M. & Estrela, P., 4 Oct 2021, In: Scientific Reports. 11, 10 p., 19650.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (SciVal)14 Downloads (Pure)
Wijesinghe, S. N., Lindsay, M. A. & Jones, S. W., 31 Aug 2021, In: Biomedicines. 9, 8, 902.
Research output: Contribution to journal › Review article › peer-reviewOpen Access5 Citations (SciVal)
Trim, W. (Creator), Walhin, J. (Creator), Koumanov, F. (Creator), Bouloumié, A. (Creator), Lindsay, M. (Creator), Travers, R. (Creator), Turner, J. (Creator) & Thompson, D. (Creator), University of Bath, 6 Sep 2021
Dataset for "Divergent immunometabolic changes in adipose tissue and skeletal muscle with ageing in healthy humans"
Trim, W. (Creator), Walhin, J. (Creator), Koumanov, F. (Creator), Bouloumié, A. (Creator), Lindsay, M. (Creator), Chen, Y. (Creator), Travers, R. (Creator), Turner, J. (Creator) & Thompson, D. (Creator), University of Bath, 24 Apr 2021