Maria Niklison Chirou

Search results

• 2024

  Are lipid droplets the picnic basket of brain tumours?

  Bingi, T., Cotton, K., Comer, C. & Niklison-Chirou, M. V., 16 Jan 2024, In: Cell Death Discovery. 10, 1, 31.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Fat Droplet 100%
  • Intracranial Tumor 100%
  • Lipid Droplet 100%
  • Malignant Neoplasm 50%
  • Neoplasm 33%
  2 Citations (SciVal)

• The Proteasome Inhibitor CEP-18770 Induces Cell Death in Medulloblastoma

  Varma, S. N., Ye, S., Ferlin, S., Comer, C., Cotton, K. & Niklison Chirou, M., 31 May 2024, In: Pharmaceutics. 16, 5, 672.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Death 100%
  • Proteasome Inhibitor 100%
  • Medulloblastoma 100%
  • Proteasome 100%
  • Anticancer 50%
  1 Citation (SciVal)
• 2023

  Apoptotic cell death in disease-Current understanding of the NCCD 2023

  Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J. & Bazan, N. G. & 208 others, Becker, C., Bernassola, F., Bertrand, M. J. M., Bianchi, M. E., Blagosklonny, M. V., Blander, J. M., Blandino, G., Blomgren, K., Borner, C., Bortner, C. D., Bove, P., Boya, P., Brenner, C., Broz, P., Brunner, T., Damgaard, R. B., Calin, G. A., Campanella, M., Candi, E., Carbone, M., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chen, G. Q., Chen, Q., Chen, Y. H., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Ciliberto, G., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, V., Daugaard, M., Dawson, T. M., Dawson, V. L., De Maria, R., De Strooper, B., Debatin, K. M., Deberardinis, R. J., Degterev, A., Del Sal, G., Deshmukh, M., Di Virgilio, F., Diederich, M., Dixon, S. J., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Engeland, K., Fimia, G. M., Galassi, C., Ganini, C., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Gerlic, M., Ghosh, S., Green, D. R., Greene, L. A., Gronemeyer, H., Häcker, G., Hajnóczky, G., Hardwick, J. M., Haupt, Y., He, S., Heery, D. M., Hengartner, M. O., Hetz, C., Hildeman, D. A., Ichijo, H., Inoue, S., Jäättelä, M., Janic, A., Joseph, B., Jost, P. J., Kanneganti, T. D., Karin, M., Kashkar, H., Kaufmann, T., Kelly, G. L., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Kluck, R., Krysko, D. V., Kulms, D., Kumar, S., Lavandero, S., Lavrik, I. N., Lemasters, J. J., Liccardi, G., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Luedde, T., MacFarlane, M., Madeo, F., Malorni, W., Manic, G., Mantovani, R., Marchi, S., Marine, J. C., Martin, S. J., Martinou, J. C., Mastroberardino, P. G., Medema, J. P., Mehlen, P., Meier, P., Melino, G., Melino, S., Miao, E. A., Moll, U. M., Muñoz-Pinedo, C., Murphy, D. J., Niklison-Chirou, M. V., Novelli, F., Núñez, G., Oberst, A., Ofengeim, D., Opferman, J. T., Oren, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pentimalli, F., Pereira, D. M., Pervaiz, S., Peter, M. E., Pinton, P., Porta, G., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rajalingam, K., Ravichandran, K. S., Rehm, M., Ricci, J. E., Rizzuto, R., Robinson, N., Rodrigues, C. M. P., Rotblat, B., Rothlin, C. V., Rubinsztein, D. C., Rudel, T., Rufini, A., Ryan, K. M., Sarosiek, K. A., Sawa, A., Sayan, E., Schroder, K., Scorrano, L., Sesti, F., Shao, F., Shi, Y., Sica, G. S., Silke, J., Simon, H. U., Sistigu, A., Stephanou, A., Stockwell, B. R., Strapazzon, F., Strasser, A., Sun, L., Sun, E., Sun, Q., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Troy, C. M., Turk, B., Urbano, N., Vandenabeele, P., Vanden Berghe, T., Vander Heiden, M. G., Vanderluit, J. L., Verkhratsky, A., Villunger, A., von Karstedt, S., Voss, A. K., Vousden, K. H., Vucic, D., Vuri, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, R., Wang, Y., Weber, A., Wood, W., Yamazaki, T., Yang, H. T., Zakeri, Z., Zawacka-Pankau, J. E., Zhang, L., Zhang, H., Zhivotovsky, B., Zhou, W., Piacentini, M., Kroemer, G. & Galluzzi, L., 30 May 2023, In: Cell Death and Differentiation. 30, 5, p. 1097-1154 58 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cell Death 100%
  • Apoptosis 100%
  • Disease 100%
  • Homeostasis 66%
  • Genetics 33%
  163 Citations (SciVal)

  106 Downloads (Pure)
• 2022

  The role of immunomodulators in treatment-resistant depression: case studies

  Beckett, C. W. & Niklison-Chirou, M. V., 31 Dec 2022, In: Cell Death Discovery. 8, 1, 367.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunomodulating Agent 100%
  • Treatment Resistant Depression 100%
  • Antidepressant 50%
  • Ketamine 50%
  • Celecoxib 50%
  24 Citations (SciVal)
• 2021

  Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

  Meier, S., Cantilena, S., Niklison Chirou, M. V., Anderson, J., Hargrave, D., Salomoni, P., de Boer, J. & Michod, D., 11 Aug 2021, In: Cell Death and Disease. 12, 8, 785.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pediatrics 100%
  • Disulfiram 100%
  • Ganglioglioma 100%
  • Low-Grade Glioma 28%
  • Gene Expression 14%
  11 Citations (SciVal)

• Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?

  Mcnamee, M., Michod, D. & Niklison Chirou, M., Jun 2021, In: Cell Death Discovery. 7, 1, 87.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cancer Therapy 100%
  • Serine 100%
  • Phosphoglycerate Dehydrogenase 100%
  • Malignant Neoplasm 100%
  • Neoplasm 66%
  12 Citations (SciVal)

  39 Downloads (Pure)

• Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma

  Freire-Benéitez, V., Pomella, N., Milner, T. O., Dumas, A., Niklison Chirou, M., Maniati, E., Wang, J., Rajeeve, V., Cutillas, P. & Marino, S., 31 Mar 2021, In: NAR Cancer. 3, 1, zcab009.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interactome 100%
  • BMI1 100%
  • BMI1 Protein 100%
  • Chromatin Immunoprecipitation 50%
  • Mass Spectrometry 50%
  6 Citations (SciVal)

• Erratum: Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma (NAR Cancer (2021) 3:1 (zcab009) DOI: 10.1093/narcan/zcab009)

  Freire-Benéitez, V., Pomella, N., Millner, T. O., Dumas, A. A., Niklison-Chirou, M. V., Maniati, E., Wang, J., Rajeeve, V., Cutillas, P. & Marino, S., 30 Jun 2021, In: NAR Cancer. 3, 2, p. 1 1 p., zcab020.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Intracranial Tumor 100%
  1 Citation (SciVal)

• Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

  Badodi, S., Pomella, N., Zhang, X., Rosser, G., Whittingham, J., Niklison Chirou, M., Lim, Y. M., Brandner, S., Morrison, G., Pollard, S. M., Bennett, C. D., Clifford, S. C., Peet, A., Basson, A. & Marino, S., 12 Apr 2021, In: Nature Communications. 12, 1, 16 p., 2148.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epigenetics 100%
  • Inositol 100%
  • Metabolic Pathway 50%
  • Cytotoxicity 50%
  • Cisplatin 50%
  21 Citations (SciVal)

• Role of microRNAs in the development and progression of the four Medulloblastoma subgroups

  Bevacqua, E., Farshchi, J., Niklison Chirou, M. & Tucci, P., 16 Dec 2021, In: Cancers. 13, 24, 6323.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • microRNA 100%
  • Medulloblastoma 100%
  • MicroRNA 100%
  • Disease 33%
  • Neoplasm 33%
  4 Citations (SciVal)
• 2020

  Regulation of Adult Neurogenesis in Mammalian Brain

  Niklison-Chirou, M. V., Agostini, M., Amelio, I. & Melino, G., 9 Jul 2020, In: International Journal of Molecular Sciences. 21, 14, p. 1-21 21 p., 4869.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Neurogenesis 100%
  • Transcription Factors 25%
  • Neurodegenerative Disorder 12%
  • Metabolic Pathway 12%
  • Hippocampus 12%
  97 Citations (SciVal)

• The C terminus of p73 is essential for hippocampal development

  Amelio, I., Panatta, E., Niklison Chirou, M., Steinert, J. R., Agostini, M., Morone, N., Knight, R. A. & Melino, G., 7 Jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 117, 27, p. 15694-15701 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • C-Terminus 100%
  • Alternative Splicing 100%
  • P73 100%
  • Hippocampus 33%
  • Promoter Region 33%
  19 Citations (SciVal)

  6 Downloads (Pure)
• 2019

  FASN activity is important for the initial stages of the induction of senescence

  Fafián-Labora, J., Carpintero-Fernández, P., Jordan, S. J. D., Shikh-Bahaei, T., Abdullah, S. M., Mahenthiran, M., Rodríguez-Navarro, J. A., Niklison-Chirou, M. V. & O’Loghlen, A., 1 Apr 2019, In: Cell Death and Disease. 10, 4, 318.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fatty Acid Synthase 100%
  • Interleukin 1 28%
  • Interleukin-1 28%
  • Secretion (Process) 14%
  • Malignant Neoplasm 14%
  63 Citations (SciVal)

• NPI-0052 and γ-radiation induce a synergistic apoptotic effect in medulloblastoma

  Frisira, E., Rashid, F., Varma, S. N., Badodi, S., Benjamin-Ombo, V. A., Michod, D. & Niklison-Chirou, M. V., 16 Oct 2019, In: Cell Death and Disease. 10, 11, 785.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Medulloblastoma 100%
  • Proteasome 100%
  • Antineoplastic Activity 50%
  • Neoplasm 36%
  • Cell Death 25%
  19 Citations (SciVal)

• Proteasome inhibition—a new target for brain tumours

  Rashid, F. & Niklison-Chirou, M. V., 4 Dec 2019, In: Cell Death Discovery. 5, 1, 147.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  11 Citations (SciVal)

• TET2 Regulates the Neuroinflammatory Response in Microglia

  Carrillo-Jimenez, A., Deniz, O., Niklison Chirou, M., Ruiz, R., Bezerra-Salomao, K., Stratoulias, V., Amouroux, R., Yip, P. K., Vilalta, A., Cheray, M., Scott-Egerton, A. M., Rivas, E., Tayara, K., Garcia-Dominguez, I., Garcia-Revilla, J., Fernandez-Martin, J. C., Espinosa-Oliva, A. M., Shen, X., St George-Hyslop, P. & Charles Brown, G. & 5 others, Hajkova, P., Joseph, B., Venero, J. L., Ramos Branco, M. & Burguillos, M. A., 15 Oct 2019, In: Cell Reports. 29, 3, p. 697-713.e8 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  79 Citations (SciVal)
• 2018

  Glutamine metabolism, the Achilles heel for medulloblastoma tumor comment

  Niklison-Chirou, M. V., 22 Jan 2018, (E-pub ahead of print) In: Cell Death and Disease. 9, 2, 74.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  3 Citations (SciVal)

• p73 Regulates Primary Cortical Neuron Metabolism: a Global Metabolic Profile

  Agostini, M., Niklison-Chirou, M. V., Annicchiarico-Petruzzelli, M. M., Grelli, S., Di Daniele, N., Pestlikis, I., Knight, R. A., Melino, G. & Rufini, A., 1 Apr 2018, In: Molecular Neurobiology. 55, 4, p. 3237-3250 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolic Pathway 100%
  • P73 100%
  • Isoform 44%
  • Cell Signaling 25%
  • Transcription Factors 25%
  9 Citations (SciVal)

• Sustained protein synthesis and reduced eEF2K levels in TAp73^-\- mice brain: a possible compensatory mechanism

  Rotblat, B., Agostini, M., Niklison-Chirou, M. V., Amelio, I., Willis, A. E. & Melino, G., 2 Dec 2018, In: Cell Cycle. 17, 23, p. 2637-2643 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Biosynthesis 100%
  • RNA Translation 66%
  • Homeostasis 33%
  • Transcription Factors 33%
  • Transcription 33%
  4 Citations (SciVal)

• TAp73 contributes to the oxidative stress response by regulating protein synthesis

  Marini, A., Rotblat, B., Sbarrato, T., Niklison-Chirou, M. V., Knight, J. R. P., Dudek, K., Jones, C., Bushell, M., Knight, R. A., Amelio, I., Willis, A. E. & Melino, G., 12 Jun 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 24, p. 6219-6224 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidative Stress 100%
  • Protein Biosynthesis 100%
  • Homeostasis 66%
  • RNA Processing 33%
  • Ribosomal RNA 33%
  30 Citations (SciVal)
• 2017

  Enhanced Energetic State and Protection from Oxidative Stress in Human Myoblasts Overexpressing BMI1

  Dibenedetto, S., Niklison-Chirou, M., Cabrera, C. P., Ellis, M., Robson, L. G., Knopp, P., Tedesco, F. S., Ragazzi, M., Di Foggia, V., Barnes, M. R., Radunovic, A. & Marino, S., 8 Aug 2017, In: Stem Cell Reports. 9, 2, p. 528-542 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Energy Transfer 100%
  • Oxidative Stress 100%
  • BMI1 100%
  • Mouse Model 80%
  • Skeletal Muscle 40%
  7 Citations (SciVal)

• TAp73 is a marker of glutamine addiction in medulloblastoma

  Niklison-Chirou, M. V., Erngren, I., Engskog, M., Haglöf, J., Picard, D., Remke, M., McPolin, P. H. R., Selby, M., Williamson, D., Clifford, S. C., Michod, D., Hadjiandreou, M., Arvidsson, T., Pettersson, C., Melino, G. & Marino, S., 1 Sept 2017, In: Genes and Development. 31, 17, p. 1738-1753 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glutamine 100%
  • Medulloblastoma 100%
  • P73 80%
  • Genetics 20%
  • Metabolic Pathway 20%
  50 Citations (SciVal)
• 2016

  How Does p73 Cause Neuronal Defects?

  Niklison-Chirou, M. V., Killick, R., Knight, R. A., Nicotera, P., Melino, G. & Agostini, M., 1 Sept 2016, In: Molecular Neurobiology. 53, 7, p. 4509-4520 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Notch 100%
  • Metabolic Pathway 100%
  • Central Nervous System 100%
  • Carcinogenesis 100%
  • Neural Stem Cell 100%
  24 Citations (SciVal)

• Metabolic reprogramming during neuronal differentiation

  Agostini, M., Romeo, F., Inoue, S., Niklison-Chirou, M. V., Elia, A. J., Dinsdale, D., Morone, N., Knight, R. A., Mak, T. W. & Melino, G., 1 Sept 2016, In: Cell Death and Differentiation. 23, 9, p. 1502-1514 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Reprogramming 100%
  • Nerve Cell Differentiation 100%
  • Mitochondrial Biogenesis 100%
  • Metabolic Pathway 100%
  • Upregulation 33%
  195 Citations (SciVal)
• 2015

  Erratum to GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation (Cell Cycle, 12, 22, 3564-3573, 10.4161/cc.26771)

  Velletri, T., Romeo, F., Tucci, P., Peschiaroli, A., Annicchiarico-Petruzzelli, M., Niklison-Chirou, M., Amelio, I., Knight, R., Mak, T., Melino, G. & Agostini, M., 31 Dec 2015, In: Cell Cycle. 14, 10, p. 1611-1612 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  5 Citations (SciVal)
• 2014

  TAp73 promotes anti-senescence-anabolism not proliferation

  Agostini, M., Niklison-Chirou, M. V., Catani, M. V., Knight, R. A., Melino, G. & Rufini, A., 13 Nov 2014, In: Aging. 6, 11, p. 921-930 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Anabolism 100%
  • Biosynthesis 100%
  • Protein P53 100%
  • Tumor Suppressor Protein 100%
  • Pentose Phosphate 100%
  18 Citations (SciVal)
• 2013

  GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

  Velletri, T., Romeo, F., Tucci, P., Peschiaroli, A., Annicchiarico-Petruzzelli, M., Niklison-Chirou, M. V., Amelio, I., Knight, R. A., Mak, T. W., Melino, G. & Agostini, M., 15 Nov 2013, In: Cell Cycle. 12, 22, p. 3564-3573 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Nerve Cell Differentiation 100%
  • P73 100%
  • Enzyme 50%
  • Isoform 50%
  • Glutamine 50%
  80 Citations (SciVal)

• TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor

  Niklison-Chirou, M. V., Steinert, J. R., Agostini, M., Knight, R. A., Dinsdale, D., Cattaneo, A., Mak, T. W. & Melino, G., 19 Nov 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 18952-18957 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nervous System 100%
  • Neurotrophin Receptor P75 100%
  • Central Nervous System 40%
  • Peripheral Nervous System 40%
  • Amino Terminal Sequence 20%
  49 Citations (SciVal)
• 2012

  Relative expression of TAp73 and ΔNp73 isoforms

  Conforti, F., Yang, A. L., Agostini, M., Rufini, A., Tucci, P., Nicklison-Chirou, M. V., Grespi, F., Velletri, T., Knight, R. A., Melino, G. & Sayan, B. S., 31 Mar 2012, In: Aging. 4, 3, p. 202-205 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Isoform 100%
  • P73 75%
  • P53 25%
  • Transcription Factors 12%
  • N-Terminus 12%
  33 Citations (SciVal)

• TAp73 depletion accelerates aging through metabolic dysregulation

  Rufini, A., Niklison-Chirou, M. V., Inoue, S., Tomasini, R., Harris, I. S., Marino, A., Federici, M., Dinsdale, D., Knight, R. A., Melino, G. & Mak, T. W., 15 Sept 2012, In: Genes and Development. 26, 18, p. 2009-2014 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Homeostasis 100%
  • Adenosine Triphosphate 100%
  • Oxidative Stress 100%
  • Mitochondrial Respiration 100%
  • Cytochrome C Oxidase 100%
  114 Citations (SciVal)
• 2011

  Microcin J25-Ga induces apoptosis in mammalian cells by inhibiting mitochondrial RNA-polymerase

  Niklison-Chirou, M. V., Dupuy, F., Saavedra, L., Hebert, E., Banchio, C., Minahk, C. & Morero, R. D., Apr 2011, In: Peptides. 32, 4, p. 832-834 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Mammalian Cell 100%
  • RNA Polymerase 100%
  • Mitochondrial RNA 100%
  • Microcin 100%
  • Microcin J25 100%
  10 Citations (SciVal)

• P63 in tooth development

  Rufini, A., Barlattani, A., Docimo, R., Velletri, T., Niklison-Chirou, M. V., Agostini, M. & Melino, G., 15 Nov 2011, In: Biochemical Pharmacology. 82, 10, p. 1256-1261 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Promoter Region 100%
  • P53 100%
  • Alternative Splicing 100%
  • Primary Transcript 100%
  • Teeth 100%
  12 Citations (SciVal)

• p73: A multifunctional protein in neurobiology

  Killick, R., Niklison-Chirou, M., Tomasini, R., Bano, D., Rufini, A., Grespi, F., Velletri, T., Tucci, P., Sayan, B. S., Conforti, F., Gallagher, E., Nicotera, P., Mak, T. W., Melino, G., Knight, R. A. & Agostini, M., Apr 2011, In: Molecular Neurobiology. 43, 2, p. 139-146 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neural Development 100%
  • Neurobiology 100%
  • P73 100%
  • Multifunctional Protein 100%
  • Alzheimer's Disease 50%
  66 Citations (SciVal)

• P73 in cancer

  Rufini, A., Agostini, M., Grespi, F., Tomasini, R., Sayan, B. S., Niklison-Chirou, M. V., Conforti, F., Velletri, T., Mastino, A., Mak, T. W., Melino, G. & Knight, R. A., 1 Apr 2011, In: Genes and Cancer. 2, 4, p. 491-502 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Isoform 100%
  • P73 100%
  • N-Terminus 42%
  • Tumor Suppressor Protein 42%
  • P53 42%
  131 Citations (SciVal)
• 2010

  Microcin J25 triggers cytochrome c release through irreversible damage of mitochondrial proteins and lipids

  Niklison-Chirou, M. V., Dupuy, F., Pena, L. B., Gallego, S. M., Barreiro-Arcos, M. L., Avila, C., Torres-Bugeau, C., Arcuri, B. E., Bellomio, A., Minahk, C. & Morero, R. D., 1 Feb 2010, In: International Journal of Biochemistry and Cell Biology. 42, 2, p. 273-281 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginine 100%
  • Cytochrome C 100%
  • Mitochondrial Protein 100%
  • Microcin J25 100%
  • Nitric Oxide 33%
  17 Citations (SciVal)
• 2009

  Proton motive force dissipation precludes interaction of microcin J25 with RNA polymerase, but enhances reactive oxygen species overproduction

  Dupuy, F. G., Chirou, M. V. N., de Arcuri, B. F., Minahk, C. J. & Morero, R. D., 1 Oct 2009, In: Biochimica et Biophysica Acta - General Subjects. 1790, 10, p. 1307-1313 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Proton Motive Force 100%
  • Bacterial Membrane 100%
  • RNA Polymerase 100%
  • Microcin 100%
  • Oxygen Consumption 66%
  6 Citations (SciVal)
• 2008

  Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generation

  Niklison Chirou, M., Bellomio, A., Dupuy, F., Arcuri, B., Minahk, C. & Morero, R., 1 Aug 2008, In: FEBS Journal. 275, 16, p. 4088-4096 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Superoxide 100%
  • Cytochrome C 100%
  • Microcin J25 100%
  • Microcin 100%
  • Protein 100%
  23 Citations (SciVal)
• 2004

  Antimitochondrial activity displayed by the antimicrobial peptide microcin J25

  Niklison Chirou, M. V., Minahk, C. J. & Morero, R. D., 7 May 2004, In: Biochemical and Biophysical Research Communications. 317, 3, p. 882-886 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenosine Triphosphate 100%
  • Antimicrobial Peptides 100%
  • Microcin 100%
  • Polypeptide Antibiotic Agent 100%
  • Microcin J25 100%
  16 Citations (SciVal)