• 4 SOUTH 1.09

Accepting PhD Students

20112020
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Research Output 2011 2019

2019
1 Citation (Scopus)

Cigarette smoke exposure redirects Staphylococcus aureus to a virulence profile associated with persistent infection

Lacoma, A., Edwards, A. M., Young, B. C., Dominguez, J., Prat, C. & Laabei, M., 1 Dec 2019, In : Scientific Reports. 9, 1, 10798.

Research output: Contribution to journalArticle

Open Access

Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent

Steinig, E. J., Duchene, S., Ashley-Robinson, D., Monecke, S., Yokoyama, M., Laabei, M., Slickers, P., Andersson, P., Williamson, D., Kearns, A., Goering, R. V., Dickson, E., Ehricht, R., Ip, M., O'Sullivan, M. V. N., Coombs, G. W., Petersen, A., Brennan, G., Shore, A. C., Coleman, D. C. & 18 others, Pantosti, A., De Lencastre, H., Westh, H., Kobayashi, N., Heffernan, H., Strommenger, B., Layer, F., Weber, S., Vangstein Aamot, H., Skakni, L., Peacock, S. J., Sarovich, D., Harris, S., Parkhill, J., Massey, R. C., Holden, M. T. G., Bentley, S. D. & Tong, S. Y. C., 26 Nov 2019, In : mBio. 10, 6, 20 p., e01105-19.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Molecular analysis of accessory gene regulator functionality and virulence genes in Staphylococcus aureus derived from pediatric wound infections

Taghizadeh Maleki, D., Ghalavand, Z., Laabei, M., Nikmanesh, B., Houri, H., Kodori, M., Hashemi, A., Kadkhoda, H. & Eslami, G., 30 Sep 2019, In : Infection, Genetics and Evolution. 73, p. 255-260 6 p.

Research output: Contribution to journalArticle

The hijackers guide to escaping complement: Lessons learned from pathogens

Ermert, D., Ram, S. & Laabei, M., 1 Oct 2019, In : Molecular Immunology. 114, p. 49-61 13 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.

Ermert, D., Laabei, M., Weckel, A., Morgelin, M., Lundqvist, M., Bjorck, L., Ram, S., Linse, S. & Blom, A. M., 4 Jun 2019, In : Frontiers in Immunology. 10, JUN, 1230.

Research output: Contribution to journalArticle

Open Access
2018
6 Citations (Scopus)

Catch Me if You Can: Streptococcus pyogenes Complement Evasion Strategies

Ermert, D. & Laabei, M., 1 Dec 2018, In : Journal of Innate Immunity. 11, 1, p. 3-12 10 p.

Research output: Contribution to journalReview article

Open Access
8 Citations (Scopus)

Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis

Méric, G., Mageiros, L., Pensar, J., Laabei, M., Yahara, K., Pascoe, B., Kittiwan, N., Tadee, P., Post, V., Lamble, S., Bowden, R., Bray, J. E., Morgenstern, M., Jolley, K. A., Maiden, M. C. J., Feil, E. J., Didelot, X., Miragaia, M., de Lencastre, H., Moriarty, T. F. & 5 others, Rohde, H., Massey, R., Mack, D., Corander, J. & Sheppard, S. K., 1 Dec 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 5034.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Yokoyama, M., Stevens, E., Laabei, M., Bacon, L., Heesom, K., Bayliss, S., Ooi, N., O'Neill, A. J., Murray, E., Williams, P., Lubben, A., Reeksting, S., Meric, G., Pascoe, B., Sheppard, S. K., Recker, M., Hurst, L. D. & Massey, R. C., 18 Jul 2018, In : Genome Biology. 19, 1, p. 1-12 12 p., 94.

Research output: Contribution to journalArticle

Open Access
epistasis
antibiotic resistance
Methicillin-Resistant Staphylococcus aureus
Microbial Drug Resistance
Mupirocin
2 Citations (Scopus)
24 Downloads (Pure)

Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen Moraxella catarrhalis

Laabei, M., Liu, G., Ermert, D., Lambris, J. D., Riesbeck, K. & Blom, A. M., 1 Nov 2018, In : The Journal of Immunology. 201, 9, p. 2721-2730 10 p.

Research output: Contribution to journalArticle

Open Access
File
2017
7 Citations (Scopus)

Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections

Gomes-Fernandes, M., Laabei, M., Pagan, N., Hidalgo, J., Molinos, S., Villar Hernandez, R., Domínguez-Villanueva, D., Jenkins, A. T. A., Lacoma, A. & Prat, C., 1 Apr 2017, In : PLoS ONE. 12, 4, e0175552.

Research output: Contribution to journalArticle

Open Access
Accessories
Regulator Genes
regulator genes
Respiratory Tract Infections
respiratory tract diseases
8 Citations (Scopus)

Assessment of the influence of direct tobacco smoke on infection and active TB management

PII Smoking SEPAR Working Group, 24 Aug 2017, In : PLoS ONE. 12, 8, p. 1-17 17 p., e0182998.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

Clonal differences in Staphylococcus aureus bacteraemia-associated mortality

Recker, M., Laabei, M., Toleman, M. S., Reuter, S., Saunderson, R. B., Blane, B., Estee Török, M., Ouadi, K., Stevens, E., Yokoyama, M., Steventon, J., Thompson, L., Milne, G., Bayliss, S., Bacon, L., Peacock, S. J. & Massey, R. C., 1 Oct 2017, In : Nature Microbiology. 2, 10, p. 1381-1388 8 p.

Research output: Contribution to journalArticle

Open Access
Bacteremia
Staphylococcus aureus
Mortality
Infection
Biofilms
2 Citations (Scopus)

Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase

Stevens, E., Laabei, M., Gardner, S., Somerville, G. A. & Massey, R. C., 1 Dec 2017, In : Scientific Reports. 7, 1, 13744.

Research output: Contribution to journalArticle

Open Access
Farnesyltranstransferase
Quorum Sensing
Electron Transport
Heme
Staphylococcus aureus
14 Citations (Scopus)

Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line

Lacoma, A., Cano, V., Moranta, D., Regueiro, V., Domínguez-Villanueva, D., Laabei, M., González-Nicolau, M., Ausina, V., Prat, C. & Bengoechea, J. A., 12 Sep 2017, In : Virulence. 8, 8, p. 1761-1775 15 p.

Research output: Contribution to journalArticle

Open Access
2016
8 Citations (Scopus)
108 Downloads (Pure)

Inexpensive and fast pathogenic bacteria screening using field-effect transistors

Formisano, N., Bhalla, N., Heeran, M., Reyes Martinez, J., Sarkar, A., Laabei, M., Jolly, P., Bowen, C. R., Taylor, J. T., Flitsch, S. & Estrela, P., 15 Nov 2016, In : Biosensors and Bioelectronics. 85, p. 103-109 7 p.

Research output: Contribution to journalArticle

Open Access
File
Semiconductors
MOSFET devices
Field effect transistors
Oxides
Bacteria
9 Citations (Scopus)

Using functional genomics to decipher the complexity of microbial pathogenicity

Laabei, M. & Massey, R., 1 Aug 2016, In : Current Genetics. 62, 3, p. 523-525 3 p.

Research output: Contribution to journalReview article

Open Access
Genomics
Virulence
Bacteria
Infection
Staphylococcus aureus
2015
10 Citations (Scopus)

Autonomously sensing hydrogels for the rapid and selective detection of pathogenic bacteria

Ebrahimi, M-M. S., Laabei, M., Jenkins, A. T. A. & Schönherr, H., Dec 2015, In : Macromolecular Rapid Communications. 36, 24, p. 2123-2128

Research output: Contribution to journalArticle

Hydrogels
Bacteria
Enzymes
Chromogenics
alpha-Glucosidases
46 Citations (Scopus)
40 Downloads (Pure)

Evolutionary trade-offs underlie the multi-faceted virulence of staphylococcus aureus

Laabei, M., Uhlemann, A-C., Lowy, F. D., Austin, E. D., Yokoyama, M., Ouadi, K., Feil, E., Thorpe, H. A., Williams, B. G., Perkins, M., Peacock, S. J., Clarke, S. R., Dordel, J., Holden, M., Votintseva, A. A., Bowden, R., Crook, D. W., Young, B. C., Wilson, D. J., Recker, M. & 1 others, Massey, R. C., 2 Sep 2015, In : PLoS Biology. 13, 9, p. 1-21 21 p., e1002229.

Research output: Contribution to journalArticle

Open Access
Toxicity
Virulence
Staphylococcus aureus
virulence
Poisons
30 Citations (Scopus)
103 Downloads (Pure)

Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection

O'Keefe, K. M., Wilk, M. M., Leech, J. M., Murphy, A. G., Laabei, M., Monk, I. R., Massey, R. C., Lindsay, J. A., Foster, T. J., Geoghegan, J. A. & McLoughlin, R. M., Sep 2015, In : Infection and immunity. 83, 9, p. 3445-3457

Research output: Contribution to journalArticle

Open Access
File
Autophagy
Phagocytes
Staphylococcus aureus
Dendritic Cells
Infection
2014
14 Citations (Scopus)
113 Downloads (Pure)

A new assay for rhamnolipid detection-important virulence factors of Pseudomonas aeruginosa

Laabei, M., Jamieson, W. D., Lewis, S. E., Diggle, S. P. & Jenkins, A. T. A., Aug 2014, In : Applied Microbiology and Biotechnology. 98, 16, p. 7199-7209 11 p.

Research output: Contribution to journalArticle

Open Access
File
Virulence Factors
Pseudomonas aeruginosa
Infection
rhamnolipid
Professional Competence
27 Citations (Scopus)
64 Downloads (Pure)
Open Access
Staphylococcus aureus
Structural properties
Peptides
Arsenals
T-cells
26 Citations (Scopus)

Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus

Rudkin, J. K., Laabei, M., Edwards, A. M., Joo, H-S., Otto, M., Lennon, K. L., O'Gara, J. P., Waterfield, N. R. & Massey, R. C., Feb 2014, In : Antimicrobial Agents and Chemotherapy. 58, 2, p. 1100-1107 8 p.

Research output: Contribution to journalArticle

Oxacillin
Methicillin-Resistant Staphylococcus aureus
Chromosomes
Penicillin-Binding Proteins
Quorum Sensing
13 Citations (Scopus)
106 Downloads (Pure)

Photopolymerization of polydiacetylene in hybrid liposomes: Effect of polymerization on stability and response to pathogenic bacterial toxins

Thet, N. T., Jamieson, W. D., Laabei, M., Mercer-Chalmers, J. D. & Jenkins, A. T. A., 22 May 2014, In : Journal of Physical Chemistry B. 118, 20, p. 5418-5427 10 p.

Research output: Contribution to journalArticle

File
Photopolymerization
Liposomes
Lipids
Polymerization
Chain length
75 Citations (Scopus)
59 Downloads (Pure)

Predicting the virulence of MRSA from its genome sequence

Laabei, M., Recker, M., Rudkin, J. K., Aldeljawi, M., Gulay, Z., Sloan, T. J., Williams, P., Endres, J. L., Bayles, K. W., Fey, P. D., Yajjala, V. K., Widhelm, T., Hawkins, E., Lewis, K., Parfett, S., Scowen, L., Peacock, S. J., Holden, M., Wilson, D., Read, T. D. & 6 others, Van Den Elsen, J., Priest, N. K., Feil, E. J., Hurst, L. D., Josefsson, E. & Massey, R. C., 1 May 2014, In : Genome Research. 24, 5, p. 839-849 11 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)
99 Downloads (Pure)

Staphylococcus aureus Interaction with Phospholipid Vesicles – A New Method to Accurately Determine Accessory Gene Regulator (agr) Activity

Laabei, M., Jamieson, W. D., Massey, R. C. & Jenkins, A. T. A., 30 Jan 2014, In : PLoS ONE. 9, 1, e87270.

Research output: Contribution to journalArticle

Open Access
File
Accessories
Regulator Genes
regulator genes
Staphylococcus aureus
Assays
33 Citations (Scopus)
81 Downloads (Pure)

Triggered Release of Bacteriophage K from Agarose/Hyaluronan Hydrogel Matrixes by Staphylococcus aureus Virulence Factors

Bean, J. E., Alves, D. R., Laabei, M., Pérez Esteban, P., Thet, N. T., Enright, M. C. & Jenkins, A. T. A., 23 Dec 2014, In : Chemistry of Materials. 26, 24, p. 7201-7208 8 p.

Research output: Contribution to journalArticle

File
2013
18 Citations (Scopus)
Fluorescent Dyes
Pseudomonas aeruginosa
Lipids
Staphylococcus aureus
Dyes
2012
39 Citations (Scopus)

From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

Priest, N. K., Rudkin, J. K., Feil, E. J., Van Den Elsen, J. M. H., Cheung, A., Peacock, S. J., Laabei, M., Lucks, D. A., Recker, M. & Massey, R. C., Nov 2012, In : Nature Reviews Microbiology. 10, 11, p. 791-797 7 p.

Research output: Contribution to journalReview article

Systems Biology
Virulence
Staphylococcus aureus
Genotype
Phenotype
7 Citations (Scopus)
Child Care
Exotoxins
Staphylococcus aureus
Septic Shock
T-Lymphocytes
30 Citations (Scopus)

Staphylococcus aureus extracellular adherence protein triggers TNFα release, promoting attachment to endothelial cells via protein A

Edwards, A. M., Bowden, M. G., Brown, E. L., Laabei, M. & Massey, R. C., 15 Aug 2012, In : PLoS ONE. 7, 8, e43046.

Research output: Contribution to journalArticle

Endothelial cells
Staphylococcal Protein A
endothelial cells
Staphylococcus aureus
Adhesion
2011
24 Citations (Scopus)
122 Downloads (Pure)

Development of a prototype wound dressing technology which can detect and report colonization by pathogenic bacteria

Zhou, J., Tun, T. N., Hong, S-H., Mercer-Chalmers, J. D., Laabei, M., Young, A. E. R. & Jenkins, A. T. A., 15 Dec 2011, In : Biosensors and Bioelectronics. 30, 1, p. 67-72 6 p.

Research output: Contribution to journalArticle

Open Access
File
Bandages
Pseudomonas aeruginosa
Escherichia coli
Staphylococcus aureus
Bacteria