• 4 SOUTH 1.09

Accepting Doctoral Students

20112020

Research output per year

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Personal profile

Research interests

My main research interests involve Staphylococcus aureus pathogenicity, specifically mechanisms that contribute to its ability to evade and manipulate host immunity. S aureusis a major human pathogen and has one of the most sophisticated arsenals of virulence factors in prokaryotes. It is a clonal pathogen whereby certain clones circulate at higher frequencies in certain geographical regions. One aim is phenotypically investigate the immune evasive capacity of a broad range of clinical isolates from different clonal groups and combine this data with their genetic information to unravel their immune evasiveness. This functional genomics approach will allow us to understand, on a global level, genetic loci involved in immune evasion and to highlighted clonal specific virulent signatures which will aid in the development of novel immune therapeutics. 

My second research objective is centred on two Gram-negative human pathogens (Pseudomonas aeruginosa and Acinetobacter baumannii). In this project we will evaluate how these organisms restrict immune activation, evade/resist phagocytosis and invade and persist intracellularly. 

In both projects we will use start-of-the-art molecular microbiological techniques including but not limited to cloning, gene expression, protein-protein interactions, flow cytometry, serum bactericidal and ex vivo blood killing assays, cell culture, complement deposition studies and bioinformatics.

Willing to supervise doctoral students

Experience working in a microbiology/ immunobiology or molecular biology is preferred but not essential. We are seeking candidates with a strong interest in host-pathogen interactions with motivation to explore and better understand the molecular basis of pathogen immune evasion. 

Education/Academic qualification

Natural Sciences, Bachelor of Science, Trinity College Dublin

1 Oct 20051 Jun 2009

Award Date: 1 Jul 2009

Molecular Medical Microbiology, Master in Science, University of Nottingham

1 Oct 200930 Sep 2010

External positions

Postdoctoral Research Fellow, Lund University

1 Jun 201730 Nov 2018

Research Fellow, Fundació Institut Investigació Germans (IGTP) Trias i Pujol, Barcelona, Spain

1 Mar 201631 May 2017

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Projects

Research Output

Interaction of Streptococcus pyogenes with extracellular matrix components resulting in immunomodulation and bacterial eradication

Colineau, L., Laabei, M., Liu, G., Ermert, D., Lambris, J. D., Riesbeck, K. & Blom, A. M., 13 Jan 2020, In : Matrix Biology Plus . 10020.

Research output: Contribution to journalArticle

Open Access

Cigarette smoke exposure redirects Staphylococcus aureus to a virulence profile associated with persistent infection

Lacoma, A., Edwards, A. M., Young, B. C., Dominguez, J., Prat, C. & Laabei, M., 1 Dec 2019, In : Scientific Reports. 9, 1, 10798.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent

Steinig, E. J., Duchene, S., Ashley-Robinson, D., Monecke, S., Yokoyama, M., Laabei, M., Slickers, P., Andersson, P., Williamson, D., Kearns, A., Goering, R. V., Dickson, E., Ehricht, R., Ip, M., O'Sullivan, M. V. N., Coombs, G. W., Petersen, A., Brennan, G., Shore, A. C., Coleman, D. C. & 18 others, Pantosti, A., De Lencastre, H., Westh, H., Kobayashi, N., Heffernan, H., Strommenger, B., Layer, F., Weber, S., Vangstein Aamot, H., Skakni, L., Peacock, S. J., Sarovich, D., Harris, S., Parkhill, J., Massey, R. C., Holden, M. T. G., Bentley, S. D. & Tong, S. Y. C., 26 Nov 2019, In : mBio. 10, 6, 20 p., e01105-19.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Molecular analysis of accessory gene regulator functionality and virulence genes in Staphylococcus aureus derived from pediatric wound infections

Taghizadeh Maleki, D., Ghalavand, Z., Laabei, M., Nikmanesh, B., Houri, H., Kodori, M., Hashemi, A., Kadkhoda, H. & Eslami, G., 30 Sep 2019, In : Infection, Genetics and Evolution. 73, p. 255-260 6 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
1 Downloads (Pure)

The hijackers guide to escaping complement: Lessons learned from pathogens

Ermert, D., Ram, S. & Laabei, M., 1 Oct 2019, In : Molecular Immunology. 114, p. 49-61 13 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Thesis