Lorenzo Caggiano

Search results

• 2020

  NADPH oxidase 1 is a novel pharmacological target for the development of an antiplatelet drug without bleeding side effects

  Vara, D., Tarafdar, A., Celikag, M., Patinha, D., Gulacsy, C. E., Hounslea, E., Warren, Z., Ferreira, B., Koeners, M. P., Caggiano, L. & Pula, G., 29 Sep 2020, In: FASEB Journal. 34, 10, p. 13969-13977 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2-acetylphenothiazine
  • NADPH Oxidase 1
  • Platelet Aggregation Inhibitors
  • Platelets
  • Pharmacology

• Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells

  Alexander, B. E., Sun, S., Palframan, M. J., Kociok-Köhn, G., Dibwe, D. F., Watanabe, S., Caggiano, L., Awale, S. & Lewis, S. E., 7 Jan 2020, In: ChemMedChem. 15, 1, p. 125-135 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human Activities
  • Cells
  • Pancreatic Neoplasms
  • Biological Products
  • Chemotherapy
  50 Downloads (Pure)

• Stuart Warren (24 Dec 1938-22 Mar 2020)

  Aggarwal, V. K., Armstrong, S. K., Caggiano, L., Chibale, K., Clayden, J., Coldham, I., Greeves, N., Hartley, R. C., Knight, J. G., Kuhnert, N., Mitchell, H. J., Nelson, A., O'Brien, P., Thomas, S. P. & Wyatt, P., 30 Sep 2020, In: Organic & biomolecular chemistry. 18, 37, p. 7236-7237 2 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity

  Ali Khan, M., Wood, P. J., Lamb-Guhren, N. M., Caggiano, L., Kociok-Köhn, G., Tosh, D. & Lewis, S. E., 1 Jul 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 13, p. 2815-2819 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biological Products
  • Functional groups
  • HT29 Cells
  • grandifloracin
  8 Citations (Scopus)

  149 Downloads (Pure)
• 2013

  Book Review: An introduction to medicinal chemistry (5th edition)

  Caggiano, L., 15 Aug 2013, Chemistry World.

  Research output: Contribution to specialist publication › Book/Film/Article review

• Design, synthesis and antiproliferative activity of indole analogues of indanocine.

  Tunbridge, G. A., Oram, J. & Caggiano, L., 2013, In: MedChemComm. 4, 11, p. 1452-1456

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • indanocine
  • indole
  • Cells
  • Cell Line
  • Neoplasms
  20 Citations (Scopus)

  148 Downloads (Pure)

• Mild and efficient capture and functionalisation of CO₂ using silver(I) oxide and application to ¹³C-labelled dialkyl carbonates

  Tunbridge, G. A., Baruchello, R. & Caggiano, L., 14 Apr 2013, In: RSC Advances. 3, 14, p. 4613-4621 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Carbonates
  • Oxides
  • Silver
  • ethylamine
  • Iodides
  2 Citations (Scopus)

  283 Downloads (Pure)

• Multicellular aggregation of maltol-modified cells triggered by Fe³⁺ ions

  Ciupa, A., De Bank, P. A. & Caggiano, L., 7 Nov 2013, In: Chemical Communications. 49, 86, p. 10148-10150 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • maltol
  • Ions
  • Agglomeration
  4 Citations (Scopus)

  147 Downloads (Pure)

• Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

  Ciupa, A., De Bank, P. A., Mahon, M. F., Wood, P. J. & Caggiano, L., 1 Jun 2013, In: MedChemComm. 4, 6, p. 956-961 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Lead compounds
  • Cells
  • Lead
  • X ray crystallography
  • Tubulin
  20 Citations (Scopus)
• 2012

  Simple pyrazoline and pyrazole “turn on” fluorescent sensors selective for Cd²⁺ and Zn²⁺ in MeCN

  Ciupa, A., Mahon, M., De Bank, P. & Caggiano, L., 28 Nov 2012, In: Organic and Biomolecular Chemistry. 10, 44, p. 8753-8757 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • pyrazole
  • ligands
  • Ligands
  • sensors
  • Sensors
  52 Citations (Scopus)

  313 Downloads (Pure)
• 2011

  Bi(OTf)₃-catalysed prenylation of electron-rich aryl ethers and phenols with isoprene: a direct route to prenylated derivatives

  Judd, K. E. & Caggiano, L., 21 Jul 2011, In: Organic and Biomolecular Chemistry. 9, 14, p. 5201-5210 10 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • isoprene
  • Ethers
  • Prenylation
  • Phenols
  • phenols
  13 Citations (Scopus)

  334 Downloads (Pure)

• Design, synthesis and antiproliferative activity of urocanic-chalcone hybrid derivatives

  Ciupa, A., Griffiths, N. J., Light, S. K., Wood, P. J. & Caggiano, L., 1 Oct 2011, In: MedChemComm. 2, 10, p. 1011-1015 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chalcone
  • Cells
  • Derivatives
  • Inhibitory Concentration 50
  • Cell Line
  13 Citations (Scopus)

  311 Downloads (Pure)
• 2009

  Application of Negishi Cross-Coupling to the Synthesis of the Cyclic Tripeptides OF4949-III and K-13

  Nolasco, L., Perez Gonzalez, M., Caggiano, L. & Jackson, R. F. W., 2009, In: Journal of Organic Chemistry. 74, 21, p. 8280-8289 10 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• Efficient synthesis of tetrahydro-β-carbolin-1-one and dihydroisoquinolin-1-one derivatives as versatile intermediates

  Judd, K. E., Mahon, M. F. & Caggiano, L., Aug 2009, In: Synthesis. 2009, 16, p. 2809-2817 9 p.

  Research output: Contribution to journal › Article › peer-review

  • G 1617
  • Lactams
  • Isocyanates
  • Carboxylic acids
  • Carboxylic Acids
  20 Citations (Scopus)

• Enantioselective oxidation of an alkyl aryl sulfide: Synthesis of (S)-(-)-methyl p-Bromophenyl sulfoxide

  Drago, C., Walker, E. J., Caggiano, L. & Jackson, R. F. W., 2009, In: Organic Syntheses. 86, p. 121-129 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  Ionisation of the zinc/iodine bond of alkylzinc iodides in dimethylformamide from theory and experiment

  Caggiano, L., Jackson, R. F. W., Meijer, A. J. H. M., Pickup, B. T. & Wilkinson, K. A., 2008, In: Chemistry - A European Journal. 14, 29, p. 8798 1 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Negishi cross-coupling reactions of alpha-amino acid-derived organozinc reagents and aromatic bromides

  Oswald, C. L., Carrillo-Marquez, T., Caggiano, L. & Jackson, R. F. W., 2008, In: Tetrahedron. 64, 4, p. 681-687 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Bromides
  • Iodides
  • palladium(II) acetate
  • Cross Reactions
  • Catalysts
  21 Citations (Scopus)

• Synthesis of β²-homophenylalanine derivatives by Negishi cross-coupling reactions

  Bartrum, H. E., Adams, H., Caggiano, L. & Jackson, R. F. W., 2008, In: Tetrahedron. 64, 17, p. 3701-3712 12 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-amino-4-phenylbutyric acid
  • Cross Reactions
  • Crystal structure
  • Derivatives
  • X rays
  11 Citations (Scopus)

• α-Fluorination of β-ketosulfones by Selectfluor™ F–TEDA–BF4

  Loghmani-Khouzani, H., Poorheravi, M. R., Sadeghi, M. M. M., Caggiano, L. & Jackson, R. F. W., 2008, In: Tetrahedron. 64, 30-31, p. 7419-7425 7 p.

  Research output: Contribution to journal › Article › peer-review

  • selectfluor
  • Fluorination
  • Halogenation
  • Disulfides
  • Decomposition
  39 Citations (Scopus)
• 2007

  Stereoselective synthesis of 2,3-difunctionalised thioesters using nucleophilic epoxidation of 1-arylthio-1-nitroalkenes

  Evans, L. A., Adams, H., Barber, C. G., Caggiano, L. & Jackson, R. F. W., 2007, In: Organic and Biomolecular Chemistry. 5, p. 31356-3163 1808 p.

  Research output: Contribution to journal › Article › peer-review

  13 Citations (Scopus)
• 2006

  A formal total synthesis of eleutherobin using the ring-closing metathesis (RCM) reaction of a densely functionalized diene as the key step: investigation of the unusual kinetically controlled RCM stereochemistry

  Castoldi, D., Caggiano, L., Panigada, L., Sharon, O., Costa, A. M. & Gennari, C., 2006, In: Chemistry. 12, p. 51-62 12 p.

  Research output: Contribution to journal › Article › peer-review

• Effective asymmetric oxidation of enones and alkyl aryl sulfides

  Hinch, M., Jacques, O., Drago, C., Caggiano, L., Jackson, R. F. W., Dexter, C., Anson, M. S. & MacDonald, S. J. F., 2006, In: Journal of Molecular Catalysis A: Chemical. 251, 1-2, p. 123-128 6 p.

  Research output: Contribution to journal › Article › peer-review

  28 Citations (Scopus)

• Oxidative kinetic resolution of alky aryl sulfoxides

  Mohammadpoor-Baltork, I., Hill, M., Caggiano, L. & Jackson, R. F. W., 2006, In: Synlett. 20, p. 3540-3544 5 p.

  Research output: Contribution to journal › Article › peer-review

  30 Citations (Scopus)

• Synthesis of orthogonally protected biaryl amino acid derivatives

  Moreno, E., Nolasco, L. A., Caggiano, L. & Jackson, R. F. W., 2006, In: Organic and Biomolecular Chemistry. 4, p. 3639-3647 9 p.

  Research output: Contribution to journal › Article › peer-review

  13 Citations (Scopus)
• 2005

  A formal total synthesis of eleutherobin through an unprecedented kinetically controlled ring-closing-metathesis reaction of a densely functionalized diene

  Castoldi, D., Caggiano, L., Panigada, L., Sharon, O., Costa, A. M. & Gennari, C., 2005, In: Angewandte Chemie-International Edition. 44, p. 588-591 4 p.

  Research output: Contribution to journal › Article › peer-review
  51 Citations (Scopus)

• Development and applications of amino ccid derived organometallics

  Rilatt, I., Caggiano, L. & Jackson, R. F., 2005, In: Synlett. 18, p. 2701-2719 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Organometallics
  • Amino Acids
  • Palladium
  • Iodides
  • Aspartic Acid
  73 Citations (Scopus)

• New routes to b-cycloalkylalanine derivatives using serine-derived organozinc reagents

  Carrillo-Marquez, T., Caggiano, L., Jackson, R. F. W., Graboswka, U., Rae, A. & Tozer, M. J., 2005, In: Organic and Biomolecular Chemistry. 3, p. 4117-4123 7 p.

  Research output: Contribution to journal › Article › peer-review

  17 Citations (Scopus)

• Silicon-mediated transformations of functional groups (Book review)

  Caggiano, L., 2005, In: Applied Organometallic Chemistry. 19, 5, p. 699 1 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of novel, simplified, C-7 substituted eleutheside analogues with potent microtubule-stabilizing activity

  Castoldi, D., Caggiano, L., Bayon, P., Costa, A. M., Cappella, P., Sharon, O. & Gennari, C., 2005, In: Tetrahedron. 61, p. 2123-2139 17 p.

  Research output: Contribution to journal › Article › peer-review

  30 Citations (Scopus)

• Vanadium-catalyzed sulfur oxidation/kinetic resolution in the synthesis of enantiomerically pure alkyl aryl sulfoxides

  Drago, C., Caggiano, L. & Jackson, R. F. W., 2005, In: Angewandte Chemie-International Edition. 44, p. 7221-7223 3 p.

  Research output: Contribution to journal › Article › peer-review
  149 Citations (Scopus)
• 2003

  A novel silica catalysed stereoselective cyclic carbamate and carbonate rearrangement

  Caggiano, L., Davies, J., Fox, D. J., Moody, D. C. & Warren, S., 2003, In: Chemical Communications. 14, p. 1650-1651 2 p.

  Research output: Contribution to journal › Article › peer-review

  8 Citations (Scopus)

• Effects of allylic and homoallylic substituents on the ring closing metatheses reaction used to synthesise simplified eleuthesides

  Caggiano, L., Castoldi, D., Beumer, R., Bayon, P., Telser, J. & Gennari, C., 2003, In: Tetrahedron Letters. 44, p. 7913-7919 7 p.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Stereoselective substituted pyrrolidine and cyclic ether synthesis by PhS migration

  Caggiano, L., Davies, J., Fox, D. J., Moody, D. C. & Warren, S., 2003, In: Chemical Communications. 14, p. 1648-1649 2 p.

  Research output: Contribution to journal › Article › peer-review

  5 Citations (Scopus)
• 2002

  Asymmetric synthesis of tetrahydrofurans by competitive [1,2]-phenylsulfanyl (PhS) migrations under thermodynamic control

  Caggiano, L., Fox, D. J., House, D., Jones, Z. A., Kerr, F. & Warren, S., 2002, In: Journal of the Chemical Society - Perkin Transcriptions 1. 23, p. 2634-2645 12 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Asymmetric synthesis of tetrahydropyrans with competitive [1,2]-phenylsulfanyl (PhS) migrations

  Caggiano, L., Fox, D. J., House, D., Jones, Z. A., Kerr, F. & Warren, S., 2002, In: Journal of the Chemical Society - Perkin Transcriptions 1. 23, p. 2646-2651 6 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Silica gel catalysed generation of episulfonium ions: a mild method for the synthesis of heterocycles

  Caggiano, L., Fox, D. J. & Warren, S., 2002, In: Chemical Communications. p. 2528-2529 2 p.

  Research output: Contribution to journal › Article › peer-review

  17 Citations (Scopus)