Lorenzo Caggiano

Search results

• 2022

  Exploring Convergent Two-Step Synthetic Approaches to the Pancratistatin Framework

  Di Iulio, G. A., Mahon, M. F. & Caggiano, L., 19 Aug 2022, In: ChemistrySelect. 7, 31, e202202703.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancratistatin 100%
  • Indanone 42%
  • Narciclasine 25%
  • Schmidt Reaction 19%
  • Friedel-Crafts Acylation 18%
• 2020

  NADPH oxidase 1 is a novel pharmacological target for the development of an antiplatelet drug without bleeding side effects

  Vara, D., Tarafdar, A., Celikag, M., Patinha, D., Gulacsy, C. E., Hounslea, E., Warren, Z., Ferreira, B., Koeners, M. P., Caggiano, L. & Pula, G., 29 Sep 2020, In: FASEB Journal. 34, 10, p. 13969-13977 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2-acetylphenothiazine 100%
  • NADPH Oxidase 1 71%
  • Antithrombocytic Agent 62%
  • Platelet Aggregation Inhibitors 48%
  • Thrombin 45%
  6 Citations (SciVal)

• Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells

  Alexander, B. E., Sun, S., Palframan, M. J., Kociok-Köhn, G., Dibwe, D. F., Watanabe, S., Caggiano, L., Awale, S. & Lewis, S. E., 7 Jan 2020, In: ChemMedChem. 15, 1, p. 125-135 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human Activities 100%
  • Pancreatic Neoplasms 94%
  • Occurrence in Nature 82%
  • Biological Products 65%
  • Nutrient 52%
  3 Citations (SciVal)

  74 Downloads (Pure)

• Stuart Warren (24 Dec 1938-22 Mar 2020)

  Aggarwal, V. K., Armstrong, S. K., Caggiano, L., Chibale, K., Clayden, J., Coldham, I., Greeves, N., Hartley, R. C., Knight, J. G., Kuhnert, N., Mitchell, H. J., Nelson, A., O'Brien, P., Thomas, S. P. & Wyatt, P., 30 Sep 2020, In: Organic & Biomolecular Chemistry. 18, 37, p. 7236-7237 2 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity

  Ali Khan, M., Wood, P. J., Lamb-Guhren, N. M., Caggiano, L., Kociok-Köhn, G., Tosh, D. & Lewis, S. E., 1 Jul 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 13, p. 2815-2819 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Enone 100%
  • Antiproliferative 90%
  • Biological Products 89%
  • Occurrence in Nature 74%
  • HT29 Cells 56%
  6 Citations (SciVal)

  146 Downloads (Pure)
• 2013

  Book Review: An introduction to medicinal chemistry (5th edition)

  Caggiano, L., 15 Aug 2013, Chemistry World.

  Research output: Contribution to specialist publication › Other

• Design, synthesis and antiproliferative activity of indole analogues of indanocine

  Tunbridge, G. A., Oram, J. & Caggiano, L., Nov 2013, In: MedChemComm. 4, 11, p. 1452-1456 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • indanocine 100%
  • indole 54%
  • Antiproliferative 42%
  • Indole 39%
  • 50 Percent Growth Inhibition 28%
  13 Citations (SciVal)

  133 Downloads (Pure)

• Mild and efficient capture and functionalisation of CO₂ using silver(I) oxide and application to ¹³C-labelled dialkyl carbonates

  Tunbridge, G. A., Baruchello, R. & Caggiano, L., 14 Apr 2013, In: RSC Advances. 3, 14, p. 4613-4621 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ethylamine 100%
  • Carbonates 92%
  • Silver 88%
  • Oxides 69%
  • Iodide 64%
  306 Downloads (Pure)

• Multicellular aggregation of maltol-modified cells triggered by Fe³⁺ ions

  Ciupa, A., De Bank, P. A. & Caggiano, L., 7 Nov 2013, In: Chemical Communications. 49, 86, p. 10148-10150 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hydrazide 100%
  • Ions 86%
  • Agglomeration 82%
  • Ion 37%
  • Surface 30%
  2 Citations (SciVal)

  150 Downloads (Pure)

• Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

  Ciupa, A., De Bank, P. A., Mahon, M. F., Wood, P. J. & Caggiano, L., 1 Jun 2013, In: MedChemComm. 4, 6, p. 956-961 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Antiproliferative 100%
  • Lead 91%
  • X Ray Crystallography 68%
  • Confocal Microscopy 56%
  • Tubulin 53%
  13 Citations (SciVal)
• 2012

  Simple pyrazoline and pyrazole “turn on” fluorescent sensors selective for Cd²⁺ and Zn²⁺ in MeCN

  Ciupa, A., Mahon, M., De Bank, P. & Caggiano, L., 28 Nov 2012, In: Organic and Biomolecular Chemistry. 10, 44, p. 8753-8757 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • pyrazole 100%
  • Pyrazole 71%
  • ligands 69%
  • Ligands 48%
  • sensors 41%
  34 Citations (SciVal)

  279 Downloads (Pure)
• 2011

  Bi(OTf)₃-catalysed prenylation of electron-rich aryl ethers and phenols with isoprene: a direct route to prenylated derivatives

  Judd, K. E. & Caggiano, L., 21 Jul 2011, In: Organic and Biomolecular Chemistry. 9, 14, p. 5201-5210 10 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • isoprene 100%
  • Ethers 96%
  • Prenylation 86%
  • Phenols 83%
  • phenols 78%
  5 Citations (SciVal)

  307 Downloads (Pure)

• Design, synthesis and antiproliferative activity of urocanic-chalcone hybrid derivatives

  Ciupa, A., Griffiths, N. J., Light, S. K., Wood, P. J. & Caggiano, L., 1 Oct 2011, In: MedChemComm. 2, 10, p. 1011-1015 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chalcone 100%
  • Antiproliferative 66%
  • Occurrence in Nature 54%
  • Inhibitory Concentration 50 39%
  • Cell Line 39%
  4 Citations (SciVal)

  352 Downloads (Pure)
• 2009

  Application of Negishi Cross-Coupling to the Synthesis of the Cyclic Tripeptides OF4949-III and K-13

  Nolasco, L., Perez Gonzalez, M., Caggiano, L. & Jackson, R. F. W., 2009, In: Journal of Organic Chemistry. 74, 21, p. 8280-8289 10 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (SciVal)

• Efficient synthesis of tetrahydro-β-carbolin-1-one and dihydroisoquinolin-1-one derivatives as versatile intermediates

  Judd, K. E., Mahon, M. F. & Caggiano, L., Aug 2009, In: Synthesis. 2009, 16, p. 2809-2817 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Lactams 100%
  • Carboxylic acids 80%
  • Curtius Rearrangement 73%
  • Lactam 57%
  • Isocyanate 53%
  8 Citations (SciVal)

• Enantioselective oxidation of an alkyl aryl sulfide: Synthesis of (S)-(-)-methyl p-Bromophenyl sulfoxide

  Drago, C., Walker, E. J., Caggiano, L. & Jackson, R. F. W., 2009, In: Organic Syntheses. 86, p. 121-129 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  Ionisation of the zinc/iodine bond of alkylzinc iodides in dimethylformamide from theory and experiment

  Caggiano, L., Jackson, R. F. W., Meijer, A. J. H. M., Pickup, B. T. & Wilkinson, K. A., 2008, In: Chemistry - A European Journal. 14, 29, p. 8798 1 p.

  Research output: Contribution to journal › Article › peer-review

• Negishi cross-coupling reactions of alpha-amino acid-derived organozinc reagents and aromatic bromides

  Oswald, C. L., Carrillo-Marquez, T., Caggiano, L. & Jackson, R. F. W., 2008, In: Tetrahedron. 64, 4, p. 681-687 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Negishi Coupling 100%
  • Iodides 91%
  • Bromides 90%
  • palladium(II) acetate 87%
  • Cross Reactions 87%
  6 Citations (SciVal)

• Synthesis of β²-homophenylalanine derivatives by Negishi cross-coupling reactions

  Bartrum, H. E., Adams, H., Caggiano, L. & Jackson, R. F. W., 2008, In: Tetrahedron. 64, 17, p. 3701-3712 12 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-amino-4-phenylbutyric acid 100%
  • Negishi Coupling 66%
  • Cross Reactions 57%
  • Cross-Coupling Reaction 47%
  • Halide 36%
  3 Citations (SciVal)

• α-Fluorination of β-ketosulfones by Selectfluor™ F–TEDA–BF4

  Loghmani-Khouzani, H., Poorheravi, M. R., Sadeghi, M. M. M., Caggiano, L. & Jackson, R. F. W., 2008, In: Tetrahedron. 64, 30-31, p. 7419-7425 7 p.

  Research output: Contribution to journal › Article › peer-review

  • selectfluor 100%
  • Halogenation 55%
  • Fluorination 44%
  • Disulfides 22%
  • Disulfide 17%
  16 Citations (SciVal)
• 2007

  Stereoselective synthesis of 2,3-difunctionalised thioesters using nucleophilic epoxidation of 1-arylthio-1-nitroalkenes

  Evans, L. A., Adams, H., Barber, C. G., Caggiano, L. & Jackson, R. F. W., 2007, In: Organic and Biomolecular Chemistry. 5, p. 31356-3163 1808 p.

  Research output: Contribution to journal › Article › peer-review

  2 Citations (SciVal)
• 2006

  Effective asymmetric oxidation of enones and alkyl aryl sulfides

  Hinch, M., Jacques, O., Drago, C., Caggiano, L., Jackson, R. F. W., Dexter, C., Anson, M. S. & MacDonald, S. J. F., 2006, In: Journal of Molecular Catalysis A: Chemical. 251, 1-2, p. 123-128 6 p.

  Research output: Contribution to journal › Article › peer-review

  10 Citations (SciVal)

• Oxidative kinetic resolution of alky aryl sulfoxides

  Mohammadpoor-Baltork, I., Hill, M., Caggiano, L. & Jackson, R. F. W., 2006, In: Synlett. 20, p. 3540-3544 5 p.

  Research output: Contribution to journal › Article › peer-review

  3 Citations (SciVal)

• Synthesis of orthogonally protected biaryl amino acid derivatives

  Moreno, E., Nolasco, L. A., Caggiano, L. & Jackson, R. F. W., 2006, In: Organic and Biomolecular Chemistry. 4, p. 3639-3647 9 p.

  Research output: Contribution to journal › Article › peer-review

  3 Citations (SciVal)
• 2005

  A formal total synthesis of eleutherobin through an unprecedented kinetically controlled ring-closing-metathesis reaction of a densely functionalized diene

  Castoldi, D., Caggiano, L., Panigada, L., Sharon, O., Costa, A. M. & Gennari, C., 2005, In: Angewandte Chemie-International Edition. 44, p. 588-591 4 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (SciVal)

• A formal total synthesis of eleutherobin using the ring-closing metathesis (RCM) reaction of a densely functionalized diene as the key step: Investigation of the unusual kinetically controlled RCM stereochemistry

  Castoldi, D., Caggiano, L., Panigada, L., Sharon, O., Costa, A. M. & Gennari, C., 16 Dec 2005, In: Chemistry - A European Journal. 12, 1, p. 51-62 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stereochemistry 100%
  • Cyclization 93%
  • Isomers 79%
  • Ring Closing Metathesis 61%
  • Danishefsky Cycloaddition 55%

• Development and applications of amino ccid derived organometallics

  Rilatt, I., Caggiano, L. & Jackson, R. F., 2005, In: Synlett. 18, p. 2701-2719 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Proteinogenic Amino Acid 100%
  • Gamma-Amino Acid 98%
  • Aspartic Acid 71%
  • Alpha-Amino Acid 71%
  • Glutamic Acid 69%
  15 Citations (SciVal)

• New routes to b-cycloalkylalanine derivatives using serine-derived organozinc reagents

  Carrillo-Marquez, T., Caggiano, L., Jackson, R. F. W., Graboswka, U., Rae, A. & Tozer, M. J., 2005, In: Organic and Biomolecular Chemistry. 3, p. 4117-4123 7 p.

  Research output: Contribution to journal › Article › peer-review

  5 Citations (SciVal)

• Silicon-mediated transformations of functional groups (Book review)

  Caggiano, L., 2005, In: Applied Organometallic Chemistry. 19, 5, p. 699 1 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of novel, simplified, C-7 substituted eleutheside analogues with potent microtubule-stabilizing activity

  Castoldi, D., Caggiano, L., Bayon, P., Costa, A. M., Cappella, P., Sharon, O. & Gennari, C., 2005, In: Tetrahedron. 61, p. 2123-2139 17 p.

  Research output: Contribution to journal › Article › peer-review

• Vanadium-catalyzed sulfur oxidation/kinetic resolution in the synthesis of enantiomerically pure alkyl aryl sulfoxides

  Drago, C., Caggiano, L. & Jackson, R. F. W., 2005, In: Angewandte Chemie-International Edition. 44, p. 7221-7223 3 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (SciVal)
• 2003

  A novel silica catalysed stereoselective cyclic carbamate and carbonate rearrangement

  Caggiano, L., Davies, J., Fox, D. J., Moody, D. C. & Warren, S., 2003, In: Chemical Communications. 14, p. 1650-1651 2 p.

  Research output: Contribution to journal › Article › peer-review

  1 Citation (SciVal)

• Effects of allylic and homoallylic substituents on the ring closing metatheses reaction used to synthesise simplified eleuthesides

  Caggiano, L., Castoldi, D., Beumer, R., Bayon, P., Telser, J. & Gennari, C., 2003, In: Tetrahedron Letters. 44, p. 7913-7919 7 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (SciVal)

• Stereoselective substituted pyrrolidine and cyclic ether synthesis by PhS migration

  Caggiano, L., Davies, J., Fox, D. J., Moody, D. C. & Warren, S., 2003, In: Chemical Communications. 14, p. 1648-1649 2 p.

  Research output: Contribution to journal › Article › peer-review
• 2002

  Asymmetric synthesis of tetrahydrofurans by competitive [1,2]-phenylsulfanyl (PhS) migrations under thermodynamic control

  Caggiano, L., Fox, D. J., House, D., Jones, Z. A., Kerr, F. & Warren, S., 2002, In: Journal of the Chemical Society - Perkin Transactions 1. 23, p. 2634-2645 12 p.

  Research output: Contribution to journal › Article › peer-review

• Asymmetric synthesis of tetrahydropyrans with competitive [1,2]-phenylsulfanyl (PhS) migrations

  Caggiano, L., Fox, D. J., House, D., Jones, Z. A., Kerr, F. & Warren, S., 2002, In: Journal of the Chemical Society - Perkin Transactions 1. 23, p. 2646-2651 6 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (SciVal)

• Silica gel catalysed generation of episulfonium ions: a mild method for the synthesis of heterocycles

  Caggiano, L., Fox, D. J. & Warren, S., 2002, In: Chemical Communications. p. 2528-2529 2 p.

  Research output: Contribution to journal › Article › peer-review

  3 Citations (SciVal)