Personal profile

Research interests

We have various research interests and our main goal is the efficient synthesis of simplified analogues
of natural products, compounds obtained from nature which display various biological activities, as potential leads for potential therapeutics.

Education/Academic qualification

Doctor of Philosophy, University of Cambridge

Bachelor of Science, University of Liverpool

Keywords

  • medicinal chemistry
  • drug design and synthesis

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Derivatives Chemical Compounds
Biological Products Chemical Compounds
Iodides Chemical Compounds
Cross Reactions Medicine & Life Sciences
Cells Chemical Compounds
Bioactivity Chemical Compounds
Cell Line Medicine & Life Sciences
Prenylation Medicine & Life Sciences

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Projects 2007 2018

Research Output 2002 2015

Design, Synthesis and Biological Evaluation of Narciclasine Analogues

Griffiths, N. J. Apr 2015 (Unpublished) 236 p.

Research output: ThesisDoctoral Thesis

File
Biological Products
Cell proliferation
Assays
Quinazolinones
Allylation
7 Citations

The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity

Ali Khan, M., Wood, P. J., Lamb-Guhren, N. M., Caggiano, L., Kociok-Köhn, G., Tosh, D. & Lewis, S. E. Jul 2014 In : Bioorganic & Medicinal Chemistry Letters. 24, 13, p. 2815-2819 5 p.

Research output: Contribution to journalArticle

Open Access
File
Biological Products
HT29 Cells
Functional groups
grandifloracin

Chalcone derivatives in cancer research and tissue engineering

Ciupa, A. 2013 (Unpublished)

Research output: ThesisDoctoral Thesis

File
Chalcone
Tissue engineering
Cells
Derivatives
Metals
16 Citations

Design, synthesis and antiproliferative activity of indole analogues of indanocine.

Tunbridge, G. A., Oram, J. & Caggiano, L. 2013 In : MedChemComm. 4, 11, p. 1452-1456

Research output: Contribution to journalArticle

Open Access
File
Cells
Cell Line
Neoplasms
indanocine
indole
2 Citations

Mild and efficient capture and functionalisation of CO2 using silver(I) oxide and application to 13C-labelled dialkyl carbonates

Tunbridge, G. A., Baruchello, R. & Caggiano, L. 14 Apr 2013 In : RSC Advances. 3, 14, p. 4613-4621 9 p.

Research output: Contribution to journalArticle

Open Access
File
Carbonates
Carbon Monoxide
Silver
Oxides
Iodides